ATE373681T1 - Ester von hyaluronsäure mit rhein, herstellungsverfahren dafür und zusammensetzungen damit - Google Patents

Ester von hyaluronsäure mit rhein, herstellungsverfahren dafür und zusammensetzungen damit

Info

Publication number: ATE373681T1
Authority: AT; Austria
Prior art keywords: hyaluronic acid; esters; rhine; compositions; production method
Prior art date: 2004-02-26

Application number

AT05708619T

Other languages

English (en)

Inventor

Antonello Pietrangelo

Valter Travagli

Original Assignee

Medidom Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-26

Filing date

2005-02-25

Publication date

2007-10-15

2005-02-25 Application filed by Medidom Lab filed Critical Medidom Lab

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE373681T1 publication Critical patent/ATE373681T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 4
229920002674 hyaluronan Polymers 0.000 title abstract 4
229960003160 hyaluronic acid Drugs 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title abstract 2
239000000203 mixture Substances 0.000 title 1
150000002148 esters Chemical class 0.000 abstract 3
125000003158 alcohol group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Polymers & Plastics (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Materials For Medical Uses (AREA)
Medicinal Preparation (AREA)

AT05708619T 2004-02-26 2005-02-25 Ester von hyaluronsäure mit rhein, herstellungsverfahren dafür und zusammensetzungen damit ATE373681T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT000347A ITMI20040347A1 (it)	2004-02-26	2004-02-26	Nuovo farmaco di associazione

Publications (1)

Publication Number	Publication Date
ATE373681T1 true ATE373681T1 (de)	2007-10-15

Family

ID=34917538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05708619T ATE373681T1 (de)	2004-02-26	2005-02-25	Ester von hyaluronsäure mit rhein, herstellungsverfahren dafür und zusammensetzungen damit

Country Status (17)

Country	Link
US (1)	US7834173B2 (de)
EP (1)	EP1718679B1 (de)
JP (2)	JP4870068B2 (de)
CN (1)	CN100551932C (de)
AT (1)	ATE373681T1 (de)
BR (1)	BRPI0507622B8 (de)
CA (1)	CA2556942C (de)
DE (1)	DE602005002538T2 (de)
ES (1)	ES2293538T3 (de)
IL (1)	IL177072A (de)
IT (1)	ITMI20040347A1 (de)
PL (1)	PL1718679T3 (de)
PT (1)	PT1718679E (de)
RU (1)	RU2383554C2 (de)
SI (1)	SI1718679T1 (de)
UA (1)	UA91673C2 (de)
WO (1)	WO2005085293A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE20060049A1 (en) *	2006-01-25	2007-08-08	Eurand Pharmaceuticals Ltd	A novel drug delivery system: use of hyaluronic acid as a carrier moleclue for different classes of therapeutic active agents
ITMI20062134A1 (it) *	2006-11-08	2008-05-09	Cbb Net S A	Preparaziobne di esteri della diacereina con acido ialuronico e loro formulazioni per l'impiego farmaceutico
PT2097116E (pt) *	2006-12-22	2012-12-06	Medidom Lab	Sistema in situ para reparação de tecido intra-articular condral e ósseo
ITMI20072237A1 (it) *	2007-11-27	2009-05-28	Sigea Srl	Esteri misti butirrico-formico di polisaccaridi acidi, loro preparazione ed uso come dermocosmetici
WO2009133430A1 (en) *	2008-04-30	2009-11-05	Wockhardt Research Centre	Topical compositions of rhein or diacerein
US8722644B2 (en)	2010-01-04	2014-05-13	Holy Stone Healthcare Co., Ltd.	Mixture of hyaluronic acid for treating and preventing peptic ulcer and duodenal ulcer
JP2013533362A (ja) *	2010-07-29	2013-08-22	ユニバーシティオブジュネーブ	ヒアルロン酸の疎水性有機化合物とのエステル化用のプロセス
CN102603575B (zh) *	2012-01-04	2014-08-13	丛晓东	大精酸共晶物、其制备方法、纯化方法及其在制备治疗糖尿病并发症药物中的应用
GB2501943B (en) *	2012-05-10	2020-09-23	Zeiss Carl Meditec Ag	Ophthalmic viscoelastic device
RU2534789C1 (ru) *	2013-06-19	2014-12-10	Сергей Алексеевич Успенский	Твердофазный способ получения водорастворимого биоактивного нанокомпозита на основе модифицированной лимонной кислотой гиалуроновой кислоты и наночастиц золота
KR101486147B1 (ko) *	2013-07-09	2015-01-23	주식회사 엘지생활건강	Tslp 분비 저해능 및 이에 의한 알러지성 질환의 개선능을 가지는 조성물
MA41912A (fr) *	2015-04-07	2018-02-13	Hyalblue S R L	Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique
EP3813895B1 (de) *	2018-06-29	2025-07-30	Merz Pharma GmbH & Co. KGaA	Fettsäuregepfropfte hyaluronsäure, dermale füllstoffformulierungen damit, verfahren zur herstellung und verwendung davon
CN109833292A (zh) *	2019-02-23	2019-06-04	河南省人民医院	一种双醋瑞因滴眼液及其用途
CN112138169A (zh) *	2020-09-14	2020-12-29	广东药科大学	天然多糖在增加难溶性药物溶解度中的应用
WO2025173034A1 (en) *	2024-02-14	2025-08-21	Zydus Lifesciences Limited	Hyaluronic acid derivatives and their therapeutic use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4788187A (en) *	1983-04-29	1988-11-29	Rorer Pharmaceutical Corporation	Benzocyclobutene aminoalkylene ethers and thioethers, pharmaceutical composition and use
DE4120990C2 (de) *	1991-06-25	1995-07-27	Madaus Ag	Verfahren zur Herstellung von Diacetylrhein
US5573934A (en) *	1992-04-20	1996-11-12	Board Of Regents, The University Of Texas System	Gels for encapsulation of biological materials
NZ245989A (en) *	1992-02-28	1995-02-24	Lilly Industries Ltd	Anthraquinone derivatives and pharmaceutical compositions
EP0588255A1 (de) *	1992-09-12	1994-03-23	Dott Limited Company	Physiologisch aktive Peptidzusammensetzungen
CA2094203A1 (en) *	1993-04-16	1994-10-17	Derek A. Willoughby	Inhibition of angiogenesis
US5612321A (en) *	1995-06-22	1997-03-18	Hercules Incorporated	Antioxidant grafted polysaccharides
FR2751615B1 (fr) *	1996-07-23	1998-09-18	Otor Sa	Plateau et flan en matiere en feuille de carton
JP3322203B2 (ja) *	1997-01-31	2002-09-09	田辺製薬株式会社	医薬組成物
AU752280C (en) *	1998-05-20	2005-03-03	Chugai Seiyaku Kabushiki Kaisha	Conjugate of therapeutic agent for joint disease and hyaluronic acid.
ITMI20022745A1 (it) *	2002-12-23	2004-06-24	Coimex Scrl United Companies	Esteri misti dell'acido ialuronico ad attivita' citostatica e prodifferenziante e procedimento per la loro produzione.

2004
- 2004-02-26 IT IT000347A patent/ITMI20040347A1/it unknown
2005
- 2005-02-25 CA CA2556942A patent/CA2556942C/en not_active Expired - Fee Related
- 2005-02-25 CN CNB2005800036341A patent/CN100551932C/zh not_active Expired - Fee Related
- 2005-02-25 EP EP05708619A patent/EP1718679B1/de not_active Expired - Lifetime
- 2005-02-25 JP JP2007500318A patent/JP4870068B2/ja not_active Expired - Fee Related
- 2005-02-25 WO PCT/IB2005/000506 patent/WO2005085293A1/en not_active Ceased
- 2005-02-25 BR BRPI0507622A patent/BRPI0507622B8/pt not_active IP Right Cessation
- 2005-02-25 DE DE602005002538T patent/DE602005002538T2/de not_active Expired - Lifetime
- 2005-02-25 PL PL05708619T patent/PL1718679T3/pl unknown
- 2005-02-25 UA UAA200609263A patent/UA91673C2/ru unknown
- 2005-02-25 RU RU2006134015/04A patent/RU2383554C2/ru active
- 2005-02-25 US US10/590,625 patent/US7834173B2/en not_active Expired - Fee Related
- 2005-02-25 AT AT05708619T patent/ATE373681T1/de active
- 2005-02-25 PT PT05708619T patent/PT1718679E/pt unknown
- 2005-02-25 ES ES05708619T patent/ES2293538T3/es not_active Expired - Lifetime
- 2005-02-25 SI SI200530094T patent/SI1718679T1/sl unknown
2006
- 2006-07-25 IL IL177072A patent/IL177072A/en active IP Right Grant
2011
- 2011-07-21 JP JP2011160091A patent/JP2011252153A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
BRPI0507622B8 (pt)	2021-05-25
JP2007524753A (ja)	2007-08-30
EP1718679A1 (de)	2006-11-08
ITMI20040347A1 (it)	2004-05-26
EP1718679B1 (de)	2007-09-19
RU2006134015A (ru)	2008-04-10
JP4870068B2 (ja)	2012-02-08
US20070203094A1 (en)	2007-08-30
CN1914228A (zh)	2007-02-14
SI1718679T1 (sl)	2008-02-29
IL177072A (en)	2011-02-28
RU2383554C2 (ru)	2010-03-10
BRPI0507622A (pt)	2007-07-03
ES2293538T3 (es)	2008-03-16
CA2556942A1 (en)	2005-09-15
CN100551932C (zh)	2009-10-21
US7834173B2 (en)	2010-11-16
PL1718679T3 (pl)	2008-01-31
IL177072A0 (en)	2006-12-10
PT1718679E (pt)	2007-11-27
BRPI0507622B1 (pt)	2018-07-17
HK1099032A1 (zh)	2007-08-03
DE602005002538T2 (de)	2008-06-19
JP2011252153A (ja)	2011-12-15
UA91673C2 (ru)	2010-08-25
WO2005085293A1 (en)	2005-09-15
DE602005002538D1 (de)	2007-10-31
CA2556942C (en)	2012-05-29

Legal Events

Date

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Title

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2008-01-15

UEP

Publication of translation of european patent specification

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