ATE373682T1 - Embolische zusammensetzungen - Google Patents

Embolische zusammensetzungen

Info

Publication number
ATE373682T1
ATE373682T1 AT01918602T AT01918602T ATE373682T1 AT E373682 T1 ATE373682 T1 AT E373682T1 AT 01918602 T AT01918602 T AT 01918602T AT 01918602 T AT01918602 T AT 01918602T AT E373682 T1 ATE373682 T1 AT E373682T1
Authority
AT
Austria
Prior art keywords
embolic
crosslinked
compositions
macromers
embolic compositions
Prior art date
Application number
AT01918602T
Other languages
English (en)
Inventor
Dennis Goupil
Hassan Chaouk
Troy Holland
Bruktawit Asfaw
Stephen Goodrich
Lucas Latini
Original Assignee
Biocure Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocure Inc filed Critical Biocure Inc
Application granted granted Critical
Publication of ATE373682T1 publication Critical patent/ATE373682T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
    • A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
    • A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/34—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C08F271/02—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00 on to polymers of monomers containing heterocyclic nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F277/00—Macromolecular compounds obtained by polymerising monomers on to polymers of carbocyclic or heterocyclic monomers as defined respectively in group C08F32/00 or in group C08F34/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/12—Polymers provided for in subclasses C08C or C08F
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F290/00—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups
    • C08F290/08—Macromolecular compounds obtained by polymerising monomers on to polymers modified by introduction of aliphatic unsaturated end or side groups on to polymers modified by introduction of unsaturated side groups
    • C08F290/14—Polymers provided for in subclass C08G
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00—Chemical modification by after-treatment
    • C08F8/30—Introducing nitrogen atoms or nitrogen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/08—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Biological Depolymerization Polymers (AREA)
AT01918602T 2000-03-13 2001-03-13 Embolische zusammensetzungen ATE373682T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18897500P 2000-03-13 2000-03-13
US25469700P 2000-12-11 2000-12-11

Publications (1)

Publication Number Publication Date
ATE373682T1 true ATE373682T1 (de) 2007-10-15

Family

ID=26884649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01918602T ATE373682T1 (de) 2000-03-13 2001-03-13 Embolische zusammensetzungen

Country Status (8)

Country Link
US (6) US6676971B2 (de)
EP (1) EP1263803B1 (de)
JP (1) JP4871476B2 (de)
AT (1) ATE373682T1 (de)
AU (2) AU4566001A (de)
CA (1) CA2403218C (de)
DE (1) DE60130544T2 (de)
WO (1) WO2001068720A1 (de)

Families Citing this family (220)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
WO2001068720A1 (en) 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
WO2001072281A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
US7223279B2 (en) 2000-04-21 2007-05-29 Vascular Control Systems, Inc. Methods for minimally-invasive, non-permanent occlusion of a uterine artery
ATE344677T1 (de) * 2000-08-02 2006-11-15 Aesculap Ag & Co Kg Medizintechnisches produkt, verfahren zu seiner herstellung und bereitstellung für die chirurgie
US9080146B2 (en) * 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002072166A1 (en) * 2001-03-13 2002-09-19 Biocure, Inc. Compositions for drug delivery
WO2002078549A2 (en) 2001-03-28 2002-10-10 Vascular Control Systems, Inc. Method and apparatus for the detection and ligation of uterine arteries
US7354444B2 (en) 2001-03-28 2008-04-08 Vascular Control Systems, Inc. Occlusion device with deployable paddles for detection and occlusion of blood vessels
US20020193813A1 (en) * 2001-05-04 2002-12-19 Concentric Medical Hydrogel filament vaso-occlusive device
US20030014075A1 (en) * 2001-07-16 2003-01-16 Microvention, Inc. Methods, materials and apparatus for deterring or preventing endoleaks following endovascular graft implanation
AU2002359410A1 (en) * 2001-11-16 2003-06-10 Biocure, Inc. Methods for initiating in situ formation of hydrogels
EP1469902A4 (de) * 2002-02-01 2006-08-23 Robert J Goldman Multifunktionaler katheter und dessen verwendung
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
US8062251B2 (en) * 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7207996B2 (en) 2002-04-04 2007-04-24 Vascular Control Systems, Inc. Doppler directed suturing and compression device and method
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
US7105031B2 (en) * 2002-04-26 2006-09-12 Medtronic Vascular, Inc. Balloon-tipped, multi-lumen catheter for endoluminal repair of endoluminal leaks in aortic or aorto-iliac endoluminal grafts
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US20040037887A1 (en) 2002-06-12 2004-02-26 Scimed Life Systems, Inc. Bulking agent
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US6884905B2 (en) 2002-07-23 2005-04-26 Biosphere Medical Degradable carbamate-containing bis(acryloyl) crosslinkers, and degradable crosslinked hydrogels comprising them
US7842377B2 (en) * 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US7449236B2 (en) 2002-08-09 2008-11-11 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US20060165804A1 (en) * 2002-09-25 2006-07-27 Lewis Andrew L Polymer compositions for administration to animals
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7404821B2 (en) 2003-01-30 2008-07-29 Vascular Control Systems, Inc. Treatment for post partum hemorrhage
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
CN1747721A (zh) * 2003-02-12 2006-03-15 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
CN103393605B (zh) * 2003-02-12 2018-05-29 生物相容英国有限公司 用于实体瘤的化学栓塞治疗的组合物
ES2298724T3 (es) * 2003-02-21 2008-05-16 Biocompatibles Uk Limited Suministro de un ains a partir de agentes embolicos.
JP4909071B2 (ja) * 2003-03-24 2012-04-04 プルーローメッド， インコーポレイテッド 逆感熱性ポリマーを使用する一時的な塞栓形成
WO2004087007A2 (en) * 2003-03-25 2004-10-14 Biocure, Inc. Hydrogel string medical device
US20040202694A1 (en) * 2003-04-11 2004-10-14 Vascular Control Systems, Inc. Embolic occlusion of uterine arteries
US7396540B2 (en) * 2003-04-25 2008-07-08 Medtronic Vascular, Inc. In situ blood vessel and aneurysm treatment
US7022747B2 (en) 2003-04-29 2006-04-04 Basf Corporation Method for creating microsphere polymers and particles
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
WO2005025456A1 (en) * 2003-09-02 2005-03-24 University Of Florida Polymeric reconstrainable, repositionable, detachable, percutaneous endovascular stentgraft
US20050107867A1 (en) * 2003-11-17 2005-05-19 Taheri Syde A. Temporary absorbable venous occlusive stent and superficial vein treatment method
US7325546B2 (en) 2003-11-20 2008-02-05 Vascular Control Systems, Inc. Uterine artery occlusion device with cervical receptacle
EP2335650B1 (de) 2003-12-11 2012-10-03 Isto Technologies Inc. Teilchenförmiges Knorpelsystem
US20050158272A1 (en) * 2004-01-07 2005-07-21 Trivascular, Inc. Methods, compositions and devices for embolizing body lumens
US8052669B2 (en) 2004-02-25 2011-11-08 Femasys Inc. Methods and devices for delivery of compositions to conduits
US8048086B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US8048101B2 (en) 2004-02-25 2011-11-01 Femasys Inc. Methods and devices for conduit occlusion
US9238127B2 (en) 2004-02-25 2016-01-19 Femasys Inc. Methods and devices for delivering to conduit
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
DE102004014633A1 (de) * 2004-03-22 2005-10-13 Aesculap Ag & Co. Kg Zusammensetzung zur Adhäsionsprophylaxe
US8067073B2 (en) * 2004-03-25 2011-11-29 Boston Scientific Scimed, Inc. Thermoplastic medical device
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
JP4655505B2 (ja) * 2004-04-28 2011-03-23 東レ株式会社 架橋生分解性粒子およびその製造方法
CA2565721C (en) * 2004-05-06 2015-10-06 Bioresponse, L.L.C. Diindolymethane formulations for the treatment of leiomyomas
US20050266043A1 (en) * 2004-05-27 2005-12-01 Medtronic Vascular, Inc. Methods and compounds for treatment of aneurysmal tissue
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
WO2006004941A2 (en) * 2004-06-29 2006-01-12 Biocure, Inc. Biomaterial
US20070258939A1 (en) * 2004-08-03 2007-11-08 Biocamparibles Uk Limited Drug Delivery from Embolic Agents
WO2006013376A2 (en) * 2004-08-04 2006-02-09 Biocompatibles Uk Limited Drug delivery of a cox inhibitor from embolic agents
US20060045900A1 (en) * 2004-08-27 2006-03-02 Robert Richard Embolization
US20060052822A1 (en) * 2004-08-31 2006-03-09 Mirizzi Michael S Apparatus and material composition for permanent occlusion of a hollow anatomical structure
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
ATE503465T1 (de) 2004-10-25 2011-04-15 Celonova Biosciences Germany Gmbh Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US9114162B2 (en) * 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US7780645B2 (en) * 2004-10-26 2010-08-24 Codman & Shurtleff, Inc. Method of delivering embolic particles to an aneurysm
US7201918B2 (en) * 2004-11-16 2007-04-10 Microvention, Inc. Compositions, systems and methods for treatment of defects in blood vessels
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
CA2881343A1 (en) * 2004-12-08 2006-06-15 Shire Regenerative Medicine, Inc. Methods and compositions for enhancing vascular access
WO2006062871A2 (en) * 2004-12-08 2006-06-15 Pervasis Therapeutics, Inc. Materials and methods for minimally-invasive administration of a cell-containing flowable composition
US7989486B2 (en) * 2004-12-30 2011-08-02 Bioresponse, L.L.C. Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associated conditions
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
CN101146484B (zh) 2005-01-25 2015-04-08 泰科医疗集团有限合伙公司 用于永久性闭塞中空解剖结构的结构
US20060178696A1 (en) * 2005-02-04 2006-08-10 Porter Stephen C Macroporous materials for use in aneurysms
WO2006086442A2 (en) * 2005-02-08 2006-08-17 Case Western Reserve University Method of detecting abnormal tissue
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
CN101268183B (zh) * 2005-04-21 2011-11-30 麻省理工学院 改变对外源和内源免疫原（包括同系和非同系细胞、组织或器官）的免疫应答的材料和方法
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
CN101878757A (zh) * 2005-06-21 2010-11-10 渗透治疗有限公司 用于增强血管通路的方法和组合物
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8361454B2 (en) * 2005-07-01 2013-01-29 The Nippon Synthetic Chemical Industry Co., Ltd. PVA particle for temporary embolic material and production process thereof, and temporary embolic material
JP5292533B2 (ja) * 2005-08-26 2013-09-18 ジンマー・インコーポレイテッド インプラントおよび関節疾患の治療、置換および治療方法
US20070078480A1 (en) * 2005-10-04 2007-04-05 Boston Scientific Scimed, Inc. Self-expanding biodegradable or water-soluble vaso-occlusive devices
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
CA2634176A1 (en) * 2005-10-26 2007-05-03 Biocure, Inc. Hydrogel spinal disc implants with swellable articles
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US7501179B2 (en) 2005-12-21 2009-03-10 Boston Scientific Scimed, Inc. Block copolymer particles
US20070149641A1 (en) * 2005-12-28 2007-06-28 Goupil Dennis W Injectable bone cement
JP5075130B2 (ja) * 2006-01-24 2012-11-14 バイオコンパティブルズ ユーケー リミテッド ポリマー粒子を薬物で負荷する方法
ATE520427T1 (de) * 2006-01-30 2011-09-15 Biosphere Medical Inc Poröse intravaskuläre embolisierungsteilchen und verfahren zu deren herstellung
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US20070244544A1 (en) * 2006-04-14 2007-10-18 Medtronic Vascular, Inc. Seal for Enhanced Stented Valve Fixation
US9017361B2 (en) 2006-04-20 2015-04-28 Covidien Lp Occlusive implant and methods for hollow anatomical structure
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
US8242179B2 (en) * 2006-06-23 2012-08-14 Surmodics, Inc. Hydrogel-based joint repair system and method
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
CN101583367B (zh) * 2006-11-07 2013-05-01 夏尔再生医学公司 用于治疗和控制血管生成介导的疾病的材料和方法
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US7720533B2 (en) * 2006-12-20 2010-05-18 Zimmer Orthobiologicals, Inc. Apparatus and method for delivering a biocompatible material to a surgical site
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
EP2134297B1 (de) * 2007-04-12 2017-03-08 Zimmer, Inc. Vorrichtung zur gewebereparatur
US9717584B2 (en) * 2007-04-13 2017-08-01 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US20080255678A1 (en) * 2007-04-13 2008-10-16 Cully Edward H Medical apparatus and method of making the same
US9642693B2 (en) * 2007-04-13 2017-05-09 W. L. Gore & Associates, Inc. Medical apparatus and method of making the same
US20080287633A1 (en) * 2007-05-18 2008-11-20 Drumheller Paul D Hydrogel Materials
WO2008156705A1 (en) * 2007-06-13 2008-12-24 Pervasis Therapeutics, Inc. Methods and devices for minimally-invasive delivery of cell-containing flowable compositions
CN105943208B (zh) * 2007-06-25 2019-02-15 微仙美国有限公司 自扩展假体
US8480651B2 (en) * 2007-08-02 2013-07-09 Covidien Lp Cannula system
US7887846B2 (en) * 2007-08-07 2011-02-15 E. I. Du Pont De Nemours And Company Process for preparation of swellable and degradable microspheres
JP5179308B2 (ja) * 2007-10-03 2013-04-10 株式会社クラレ ポリビニルアセタール
WO2009046281A2 (en) * 2007-10-05 2009-04-09 Boston Scientific Scimed, Inc. Injectable particles
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20090123519A1 (en) * 2007-11-12 2009-05-14 Surmodics, Inc. Swellable hydrogel matrix and methods
CN101903051B (zh) 2007-12-21 2013-07-31 微温森公司 用于生物医药用途的水凝胶细丝
CN102215900A (zh) * 2008-02-29 2011-10-12 普拉罗美德公司 用热敏聚合物进行的局部栓塞
US20110201926A1 (en) * 2008-02-29 2011-08-18 Pluromed, Inc. Local embolization via heating of thermosensitive polymers
US20090226531A1 (en) * 2008-03-07 2009-09-10 Allergan, Inc. Methods and composition for intraocular delivery of therapeutic sirna
US8114436B2 (en) * 2008-03-25 2012-02-14 Boston Scientific Scimed, Inc. Compositions and methods for delivery of embolics
EP2265185A4 (de) * 2008-04-04 2011-05-04 Curaseal Inc Implantierbare fistelverschlussvorrichtung
US8246876B2 (en) * 2008-08-18 2012-08-21 Cook Medical Technologies Llc Embolization particles and method for making same
JP5787405B2 (ja) * 2008-09-04 2015-09-30 キュラシール インコーポレイテッド 複数の腸内瘻孔処置用拡張可能デバイス
US12171463B2 (en) 2008-10-03 2024-12-24 Femasys Inc. Contrast agent generation and injection system for sonographic imaging
US10070888B2 (en) 2008-10-03 2018-09-11 Femasys, Inc. Methods and devices for sonographic imaging
US9554826B2 (en) 2008-10-03 2017-01-31 Femasys, Inc. Contrast agent injection system for sonographic imaging
WO2010048177A2 (en) * 2008-10-20 2010-04-29 IMDS, Inc. Systems and methods for aneurysm treatment and vessel occlusion
WO2010062678A2 (en) * 2008-10-30 2010-06-03 David Liu Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
BRPI1014645B1 (pt) 2009-04-30 2020-07-07 Technip France método e sistema para compartilhar linhas de amarração
US20120123355A1 (en) * 2009-07-30 2012-05-17 Cook Medical Technologied Erodible embolization material
US20110065809A1 (en) * 2009-09-15 2011-03-17 Medtronic, Inc. Polymerization of Multifunctional Azides, and Polymers Therefrom
WO2011038291A1 (en) 2009-09-24 2011-03-31 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
CN102791183B (zh) * 2009-10-26 2015-07-08 微排放器公司 由可膨胀的聚合物构成的栓塞装置
JP5864429B2 (ja) 2009-11-09 2016-02-17 スポットライト テクノロジー パートナーズ エルエルシーＳｐｏｔｌｉｇｈｔ Ｔｅｃｈｎｏｌｏｇｙ Ｐａｒｔｎｅｒｓ Ｌｌｃ 架橋ヒドロゲル組成物、ヒドロゲル組成物の形成方法、及びキット
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
JP5950307B2 (ja) * 2010-01-13 2016-07-13 ビショフ、ゲオルグ 腸を一時的に閉塞するための組成物
US7955301B1 (en) 2010-01-27 2011-06-07 Warsaw Orthopedic, Inc. Injection shut off valve with pressure actuator for delivery of compositions
US9050274B2 (en) * 2010-01-28 2015-06-09 Warsaw Orthopedic, Inc. Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents
US9486500B2 (en) 2010-01-28 2016-11-08 Warsaw Orthopedic, Inc. Osteoimplant and methods for making
US9125902B2 (en) * 2010-01-28 2015-09-08 Warsaw Orthopedic, Inc. Methods for treating an intervertebral disc using local analgesics
US9232805B2 (en) 2010-06-29 2016-01-12 Biocure, Inc. In-situ forming hydrogel wound dressings containing antimicrobial agents
GB201101429D0 (en) * 2011-01-27 2011-03-16 Biocompatibles Uk Ltd Drug delivery system
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
US9511077B2 (en) 2011-04-25 2016-12-06 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for wound healing
US9592243B2 (en) 2011-04-25 2017-03-14 Warsaw Orthopedic, Inc. Medical devices and methods comprising an anabolic agent for treatment of an injury
CN103874466B (zh) 2011-06-16 2016-10-05 库拉希尔公司 用于瘘治疗的装置及相关方法
CN103841903B (zh) 2011-06-17 2017-06-09 库拉希尔公司 用于瘘治疗的装置及方法
US10137280B2 (en) * 2011-06-30 2018-11-27 Incube Labs, Llc System and method for treatment of hemorrhagic stroke
AT511671A1 (de) * 2011-07-13 2013-01-15 Bischof Georg Dr Zusammensetzung zur erzeugung einer vorübergehenden okklusion des darms eines säugetiers
WO2013151991A1 (en) 2012-04-02 2013-10-10 Surmodics, Inc. Hydrophilic polymeric coatings for medical articles with visualization moiety
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
EP2861257B1 (de) 2012-06-14 2021-12-08 Microvention, Inc. Polymere behandlungszusammensetzungen
BR112015008245B1 (pt) 2012-10-15 2022-09-27 Microvention, Inc Composições poliméricas de tratamento
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
WO2014152488A2 (en) 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
GB2521997A (en) 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) * 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
FR3017295B1 (fr) * 2014-02-07 2018-01-12 Guerbet Composition destinee a vectoriser un agent anticancereux
CN106659874B (zh) 2014-03-26 2021-01-05 文科罗斯公司 静脉疾病治疗
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
JP6599361B2 (ja) 2014-04-29 2019-10-30 マイクロベンション インコーポレイテッド 活性剤を含むポリマー
US10092663B2 (en) 2014-04-29 2018-10-09 Terumo Corporation Polymers
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
WO2016139606A1 (en) 2015-03-02 2016-09-09 Accurate Medical Therapeutics Ltd. Preventing non-target embolization
EP4299019A3 (de) * 2015-04-01 2024-03-06 Boston Scientific Scimed, Inc. Systeme zur bereitstellung von gelembolie
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
US9987362B2 (en) * 2015-05-06 2018-06-05 Zoetis Services Llc Hydrogel formulation with mild adhesion
FR3039767B1 (fr) 2015-08-04 2017-09-08 Guerbet Sa Composition destinee a vectoriser un agent anticancereux
GB201515602D0 (en) * 2015-09-03 2015-10-21 Biocompatibles Uk Ltd Polymers and microspheres
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
US20170216346A1 (en) * 2016-01-28 2017-08-03 Cook Medical Technologies Llc Injectable compositions and methods of use thereof
ES2865433T3 (es) 2016-05-04 2021-10-15 Accurate Medical Therapeutics Ltd Cabezal de microcatéter de embolización que tiene un patrón ranurado
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
AU2018273988C1 (en) 2017-05-26 2025-11-13 Bruin Biosciences, Inc. Chemoembolization agents
CN111200976B (zh) 2017-10-09 2023-07-07 微仙美国有限公司 放射性液体栓塞
CN107812232A (zh) * 2017-11-08 2018-03-20 华威（深圳）医疗器械有限责任公司 可显影羧基改性聚乙烯醇微球栓塞剂及其制备工艺
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
US12558308B2 (en) 2017-12-18 2026-02-24 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
US11730865B2 (en) * 2018-05-15 2023-08-22 Incept, Llc Embolic compositions and methods
EP3793537A1 (de) 2018-05-16 2021-03-24 Spirox, Inc. Implantat zur freisetzung eines arzneimittels gegen allergische rhinitis
GB201810784D0 (en) * 2018-06-29 2018-08-15 Biocompatibles Uk Ltd Radiopaque polymers
US11702498B2 (en) 2018-06-29 2023-07-18 Biocompatibles Uk Limited Radiopaque polymers
CN112823000A (zh) 2018-10-12 2021-05-18 联邦高等教育系统匹兹堡大学 用于试剂递送的小聚合物载体
CA3120558A1 (en) * 2018-11-21 2020-05-28 Kuraray Co., Ltd. Monodisperse hydrogel particles
US12433600B2 (en) 2019-05-23 2025-10-07 Argon Medical Devices, Inc. Embolization catheter for reflux free delivery of microspheres
WO2020247151A1 (en) 2019-06-05 2020-12-10 Boston Scientific Scimed, Inc. Click chemistry capturable platinum-based antineoplastic agents
US20210022743A1 (en) * 2019-07-22 2021-01-28 Boston Scientific Scimed, Inc. In vivo crosslinking of embolic hydrogels using bioorthogonal click chemistry
CN115379866A (zh) * 2020-03-31 2022-11-22 泰尔茂株式会社 栓塞剂
US12678448B2 (en) 2020-07-06 2026-07-14 University of Pittsburgh—of the Commonwealth System of Higher Education Polymeric carriers for delivery of therapeutic agents
CA3191526A1 (en) * 2020-09-04 2022-03-10 Suresh S. Pai Liquid embolic compositions with controlled release of radiopaque and therapeutic compounds and methods of using the same
WO2022060993A1 (en) * 2020-09-16 2022-03-24 Said Farha System and method for integrated blood vessel embolization and localized drug delivery
JP7761746B2 (ja) * 2021-07-12 2025-10-28 ボストン サイエンティフィック サイムド，インコーポレイテッド 放射線不透過性組成物
US20230037198A1 (en) * 2021-07-29 2023-02-02 Varian Medical Systems, Inc. Apparatuses and methods for producing embolic particles with activated loading sites
CN113797383A (zh) * 2021-09-28 2021-12-17 迪格瑞医疗科技(苏州)有限公司 一种高弹性、高载药量的栓塞微球及其制备方法
CN116115818B (zh) * 2021-11-12 2024-06-28 重庆百迈腾世医药科技有限公司 活性金属微球、基于活性金属微球的复合栓塞剂及其应用
JP2025501572A (ja) 2021-12-23 2025-01-22 ボストン サイエンティフィック メディカル デバイス リミテッド 化学塞栓用組成物とそれを使用する治療方法
CN115501378B (zh) * 2022-09-23 2023-08-22 江南大学 一种改性聚乙烯醇栓塞微球及其制备方法
CN118286496A (zh) * 2023-01-05 2024-07-05 上海拓脉医疗科技有限公司 栓塞微球的制备方法
WO2025049713A1 (en) * 2023-08-31 2025-03-06 Fluidx Medical Technology, Inc. Polyelectrolyte hydrogel formulations and methods for making and using the same
CN119033992B (zh) * 2024-08-30 2025-06-20 南京康友医疗科技有限公司 一种具有互穿聚合物网络结构的栓塞微球及其制备方法

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1566330A (en) * 1977-02-16 1980-04-30 Farmaceutici Italia Anthracycline glycosides
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
JPS63242272A (ja) * 1987-03-31 1988-10-07 テルモ株式会社 バルーンカテーテルのバルーン拡張用組成物
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
ATE130517T1 (de) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
US5529914A (en) * 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5047055A (en) 1990-12-21 1991-09-10 Pfizer Hospital Products Group, Inc. Hydrogel intervertebral disc nucleus
JP2576292B2 (ja) * 1991-01-29 1997-01-29 株式会社日立製作所 復水器及びそれを用いた発電プラント
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
TW272976B (de) * 1993-08-06 1996-03-21 Ciba Geigy Ag
US5394727A (en) * 1993-08-18 1995-03-07 Aluminum Company Of America Method of forming a metal container body
JPH10509696A (ja) 1994-10-12 1998-09-22 フォーカル， インコーポレイテッド 生分解性ポリマーを介する標的化送達
AU4438696A (en) * 1995-02-03 1996-08-21 Novartis Ag Crosslinked polymers
ES2161825T3 (es) 1995-03-07 2001-12-16 Ethicon Inc Medio para aumentar la funcion del esfinter de expansion controlada.
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
ATE284715T1 (de) 1995-07-27 2005-01-15 Micro Therapeutics Inc Embolisierende zubereitungen
US5667767A (en) 1995-07-27 1997-09-16 Micro Therapeutics, Inc. Compositions for use in embolizing blood vessels
US5580568A (en) 1995-07-27 1996-12-03 Micro Therapeutics, Inc. Cellulose diacetate compositions for use in embolizing blood vessels
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
US5833652A (en) 1995-09-18 1998-11-10 Y. Pierre Gobin Component mixing catheter
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US5702361A (en) * 1996-01-31 1997-12-30 Micro Therapeutics, Inc. Method for embolizing blood vessels
US5902599A (en) 1996-02-20 1999-05-11 Massachusetts Institute Of Technology Biodegradable polymer networks for use in orthopedic and dental applications
AU712953B2 (en) 1996-03-11 1999-11-18 Focal, Inc. Polymeric delivery of radionuclides and radiopharmaceuticals
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
AU2814697A (en) 1996-07-29 1998-02-20 Micro Therapeutics, Inc. Novel methods for embolizing vascular sites with an embolizing composition comprising dimethylsulfoxide
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
AR008108A1 (es) * 1996-08-01 1999-12-09 Novartis Ag Un metodo para formar un articulo polimerico absorbente de radiacion, un articulo polimerico asi formado, y un metodo para formar un tintepolimerico
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US5785642A (en) 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
AU4672597A (en) 1996-10-18 1998-05-15 Micro Therapeutics, Inc. Method for treating urinary reflux
US5981826A (en) 1997-05-05 1999-11-09 Georgia Tech Research Corporation Poly(vinyl alcohol) cryogel
US6153211A (en) 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
US6265509B1 (en) * 1997-07-30 2001-07-24 Novartis Ag Crosslinked polymers
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
AU8877098A (en) 1997-09-05 1999-03-29 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising contrast agent for chemoembolization
US6037366A (en) 1997-09-11 2000-03-14 Prohold Medical Technologies, Inc. Composition for creating vascular occlusions
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
CA2322954C (en) 1998-03-06 2011-06-07 Biosepra Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6818018B1 (en) * 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
ATE502670T1 (de) 1998-08-14 2011-04-15 Incept Llc Apparat für die in-situ-bildung von hydrogelen
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6231613B1 (en) 1998-12-15 2001-05-15 Enteric Medical Technologies, Inc. Methods for soft tissue augmentation in mammals
EP1148895B1 (de) 1999-02-05 2004-11-17 The Regents of the University of California Thermoreversibles polymer für intralumenalimplantate
AU3503700A (en) 1999-02-25 2000-09-14 Scimed Life Systems, Inc. Medical devices comprising hydrogel polymers having improved mechanical properties
US6303100B1 (en) 1999-03-19 2001-10-16 Micro Therapeutics, Inc. Methods for inhibiting the formation of potential endoleaks associated with endovascular repair of abdominal aortic aneurysms
US6203779B1 (en) 1999-03-19 2001-03-20 Charlie Ricci Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
EP1173517A4 (de) 1999-04-26 2006-06-28 California Inst Of Techn Hydrogele die sich in situ formen
ES2383122T3 (es) 1999-08-27 2012-06-18 Angiodevice International Gmbh Dispositivo de polímero biocompatible
AU771498B2 (en) 1999-09-10 2004-03-25 Genzyme Corporation Hydrogels for orthopedic repair
JP2003516810A (ja) 1999-11-15 2003-05-20 バイオキュア・インコーポレーテッド 分解性ポリ（ビニルアルコール）ヒドロゲル
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
EP1255823A4 (de) 2000-01-28 2007-10-31 Azopax Therapeutics Llc Proteinpolymere mit langsamer freisetzung
WO2001068720A1 (en) * 2000-03-13 2001-09-20 Biocure, Inc. Embolic compositions
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
WO2001070289A2 (en) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
ATE327783T1 (de) 2000-03-20 2006-06-15 Biosphere Medical Inc Injizierbare mikrokügelchen für den gewebeaufbau
WO2001072281A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for active embolization
JP2004522808A (ja) 2000-08-23 2004-07-29 フェアーソン・メディカル・インコーポレーテッド 新規のポリマー化合物

Also Published As

Publication number Publication date
WO2001068720A1 (en) 2001-09-20
US6676971B2 (en) 2004-01-13
CA2403218C (en) 2011-10-18
JP2003527402A (ja) 2003-09-16
EP1263803A1 (de) 2002-12-11
EP1263803B1 (de) 2007-09-19
USRE47121E1 (en) 2018-11-13
JP4871476B2 (ja) 2012-02-08
AU2001245660B2 (en) 2006-06-15
US20010036451A1 (en) 2001-11-01
DE60130544T2 (de) 2008-06-26
US20030223956A1 (en) 2003-12-04
DE60130544D1 (de) 2007-10-31
USRE47873E1 (en) 2020-02-25
US8221735B2 (en) 2012-07-17
AU4566001A (en) 2001-09-24
USRE48302E1 (en) 2020-11-10
CA2403218A1 (en) 2001-09-20
US20090209658A1 (en) 2009-08-20

Similar Documents

Publication Publication Date Title
DE60130544D1 (de) Embolische zusammensetzungen
DE60115212D1 (de) Biomedizinische artikel aus hydrogel
CA2323925A1 (en) Crosslinkable macromers bearing initiator groups
DZ3415A1 (fr) Guanidinobenzamides comme mc4-r agonistes.
BR9913517A (pt) Composição, dispositivo, e, uso de uma composição
ATE517932T1 (de) Aus der schmelze verarbeitbare polymerzusammensetzung, die fluorpolymer mit langkettenverzweigungen enthält
TW200631604A (en) Ophthalmic compositions comprising polyether substituted polymers
ATE400352T1 (de) Herstellung von polymergegenständen mit hydrophiler oberfläche
BR0110067A (pt) Composição polimérica para canos
CA2289540A1 (en) Polyolefin block copolymer viscosity modifier
PT1313453E (pt) Vectores particulados destinados a melhorar a absorção oral de princípios activos
ATE362776T1 (de) Quellbare hydrogelbildende polymere mit geringem feinstaubanteil
ES2191871T3 (es) Composicion espesada acuosa y utilizacion.
GB2443150A (en) Children's washable paint
DE60006951D1 (de) Verfahren zur herstellung von alkylierten diphenylaminzusammensetzungen
IL115181A (en) Contrast agent consisting of repeating biodegradable units its use and preparation
DE69315207D1 (de) Die Farbstoffübertragung hemmende Waschmittelzusammensetzungen
EP1437380A4 (de) Polymeres hydrogel
EP1325949A3 (de) Verwendung fluorierter Flüssigkeiten
EP0819755A3 (de) Öl-Konzentrate von Polymeren mit verbesserter Viskosität
ATE337367T1 (de) Fluorelastomerer kaltschrumpfgegenstand
PL366468A1 (en) Stabilizer compositions for halogenated polymers, the use thereof and polymers containing said compositions
ATE362512T1 (de) Stickstoffhaltige polymere umfassende reinigungsmittelzusammensetzung
BR0009325B1 (pt) composições moldadas de policarbonato modificadas por polìmero de enxerto, uso das mesmas e corpos moldados.
AR033421A1 (es) Liquidos hidratantes suaves con atributos de enjuage tipo jabon.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties