ATE373708T1 - Ein homeobox-faktor der insulin-expression in pankreatischen inselnzellen stimuliert - Google Patents
Ein homeobox-faktor der insulin-expression in pankreatischen inselnzellen stimuliertInfo
- Publication number
- ATE373708T1 ATE373708T1 AT94923995T AT94923995T ATE373708T1 AT E373708 T1 ATE373708 T1 AT E373708T1 AT 94923995 T AT94923995 T AT 94923995T AT 94923995 T AT94923995 T AT 94923995T AT E373708 T1 ATE373708 T1 AT E373708T1
- Authority
- AT
- Austria
- Prior art keywords
- transcription factor
- insulin expression
- stimulates insulin
- factor proteins
- antibodies
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
- 102000004877 Insulin Human genes 0.000 title 1
- 108090001061 Insulin Proteins 0.000 title 1
- 229940125396 insulin Drugs 0.000 title 1
- 102000040945 Transcription factor Human genes 0.000 abstract 3
- 108091023040 Transcription factor Proteins 0.000 abstract 3
- 229940088597 hormone Drugs 0.000 abstract 2
- 239000005556 hormone Substances 0.000 abstract 2
- 210000004153 islets of langerhan Anatomy 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000003556 assay Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10693693A | 1993-08-16 | 1993-08-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373708T1 true ATE373708T1 (de) | 2007-10-15 |
Family
ID=22314040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94923995T ATE373708T1 (de) | 1993-08-16 | 1994-07-21 | Ein homeobox-faktor der insulin-expression in pankreatischen inselnzellen stimuliert |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5741673A (de) |
| EP (1) | EP0714438B1 (de) |
| JP (1) | JP3802051B2 (de) |
| AT (1) | ATE373708T1 (de) |
| CA (1) | CA2169631C (de) |
| DE (1) | DE69435026D1 (de) |
| WO (1) | WO1995005463A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5858973A (en) * | 1994-02-23 | 1999-01-12 | The General Hospital Corporation | Transcription factor and uses therefor |
| US5849989A (en) * | 1994-10-07 | 1998-12-15 | Ontogeny, Inc. | Insulin promoter factor, and uses related thereto |
| US5955579A (en) * | 1995-05-09 | 1999-09-21 | Strang Cancer Prevention Center | Islet-specific homeoprotein and transcriptional regulator of insulin gene expression, HOXB13 |
| WO1997020075A1 (en) * | 1995-11-30 | 1997-06-05 | Research Development Foundation | Screening assay for compounds stimulating somatostatin and insulin production |
| US20010007656A1 (en) * | 1996-11-08 | 2001-07-12 | Fatima Bosch | Treatment of diabetes with transcription factor gene |
| US6274310B1 (en) * | 1997-06-24 | 2001-08-14 | The General Hospital Corporation | Compositions and methods for detecting pancreatic disease |
| US6183956B1 (en) * | 1998-03-31 | 2001-02-06 | Tularik, Incorporated | High throughput in vitro screening assays for transcription modulators |
| US6967019B2 (en) * | 1999-04-06 | 2005-11-22 | The Regents Of The University Of California | Production of pancreatic islet cells and delivery of insulin |
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| GB0206357D0 (en) * | 2002-03-18 | 2002-05-01 | Univ Bath | Cells |
| ATE457355T1 (de) | 2002-05-24 | 2010-02-15 | Medtronic Inc | Verfahren und dna-konstrukte zur produktion von polypeptiden mit hoher ausbeute |
| US7655403B2 (en) * | 2006-12-02 | 2010-02-02 | Texas Scottish Rite Hospital For Children | CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis |
| CN105555950B (zh) | 2013-06-13 | 2021-03-05 | 奥尔吉尼西丝有限公司 | 细胞群体、转分化的方法及其使用方法 |
| MA41296A (fr) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | Procédés de transdifférenciation et procédés d'utilisation de ceux-ci |
| SG11201911256UA (en) | 2017-05-08 | 2020-01-30 | Orgenesis Ltd | Transdifferentiated cell populations and methods of use thereof |
| CN117417427B (zh) * | 2023-09-11 | 2024-05-07 | 江苏省人民医院（南京医科大学第一附属医院） | 一种检测内源性自体胰岛素介导的胰岛素抗体的试剂盒 |
-
1994
- 1994-07-21 AT AT94923995T patent/ATE373708T1/de not_active IP Right Cessation
- 1994-07-21 DE DE69435026T patent/DE69435026D1/de not_active Expired - Lifetime
- 1994-07-21 CA CA002169631A patent/CA2169631C/en not_active Expired - Fee Related
- 1994-07-21 EP EP94923995A patent/EP0714438B1/de not_active Expired - Lifetime
- 1994-07-21 JP JP50696795A patent/JP3802051B2/ja not_active Expired - Fee Related
- 1994-07-21 WO PCT/US1994/008336 patent/WO1995005463A1/en not_active Ceased
-
1996
- 1996-01-05 US US08/583,672 patent/US5741673A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0714438A1 (de) | 1996-06-05 |
| DE69435026D1 (de) | 2007-10-31 |
| JPH09501831A (ja) | 1997-02-25 |
| WO1995005463A1 (en) | 1995-02-23 |
| US5741673A (en) | 1998-04-21 |
| EP0714438B1 (de) | 2007-09-19 |
| CA2169631C (en) | 2005-01-11 |
| CA2169631A1 (en) | 1995-02-23 |
| JP3802051B2 (ja) | 2006-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |