ATE373717T1 - Pde8a und seine verwendung - Google Patents
Pde8a und seine verwendungInfo
- Publication number
- ATE373717T1 ATE373717T1 AT01968819T AT01968819T ATE373717T1 AT E373717 T1 ATE373717 T1 AT E373717T1 AT 01968819 T AT01968819 T AT 01968819T AT 01968819 T AT01968819 T AT 01968819T AT E373717 T1 ATE373717 T1 AT E373717T1
- Authority
- AT
- Austria
- Prior art keywords
- nucleic acid
- acid molecules
- novel pde
- proteins
- pna
- Prior art date
Links
- 102100024228 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Human genes 0.000 title 1
- 101001117261 Homo sapiens High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A Proteins 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 150000007523 nucleic acids Chemical class 0.000 abstract 3
- 108091093037 Peptide nucleic acid Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- -1 antibodies Substances 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23244500P | 2000-09-12 | 2000-09-12 | |
| US24050000P | 2000-10-12 | 2000-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE373717T1 true ATE373717T1 (de) | 2007-10-15 |
Family
ID=26925998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01968819T ATE373717T1 (de) | 2000-09-12 | 2001-09-12 | Pde8a und seine verwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7138259B2 (de) |
| EP (1) | EP1317553B1 (de) |
| AT (1) | ATE373717T1 (de) |
| AU (1) | AU2001289034A1 (de) |
| DE (1) | DE60130565D1 (de) |
| WO (1) | WO2002022661A2 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60130565D1 (de) * | 2000-09-12 | 2007-10-31 | Univ Bern | Pde8a und seine verwendung |
| EP1439221B1 (de) * | 2002-12-17 | 2007-01-24 | F. Hoffmann-La Roche Ag | PDE Kern Konstrukt |
| DK1664289T3 (da) * | 2003-09-05 | 2011-02-14 | Univ Bern | Cycliske nucleotid-specifikke phosphodiesteraser fra Leishmania og anvendelser deraf |
| EP1668024A4 (de) * | 2003-09-29 | 2008-07-02 | Topigen Pharma Inc | Oligonukleotidzusammensetzungen und verfahren zur behandlung von krankheiten einschliesslich entzündlicher leiden |
| US20090105281A1 (en) * | 2006-04-27 | 2009-04-23 | Paul Epstein | Methods of treating inflammation |
| KR20090035662A (ko) | 2006-05-19 | 2009-04-10 | 토피겐 파마슈티컬스 인코포레이티드 | 포스포디에스테라아제의 발현에 영향을 미치는 올리고누클레오티드 |
| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP2024500919A (ja) * | 2020-12-23 | 2024-01-10 | ジェンザイム・コーポレーション | 重水素化コロニー刺激因子－１受容体（ｃｓｆ－１ｒ）阻害剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4358535A (en) * | 1980-12-08 | 1982-11-09 | Board Of Regents Of The University Of Washington | Specific DNA probes in diagnostic microbiology |
| GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4965188A (en) * | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| DE3513168A1 (de) * | 1985-04-12 | 1986-10-16 | Thomas 8000 München Dandekar | Biosensor bestehend aus einem halbleiter auf silizium oder kohlenstoffbasis (elektronischer teil) und nukleinbasen (od. anderen biol. monomeren) |
| US5194428A (en) * | 1986-05-23 | 1993-03-16 | Worcester Foundation For Experimental Biology | Inhibition of influenza virus replication by oligonucleotide phosphorothioates |
| US5110802A (en) * | 1987-07-14 | 1992-05-05 | City Of Hope | Oligonucleotide phosphonates and method of inhibiting a human immunodeficiency virus in vitro utilizing said oligonucleotide phosphonates |
| US5080548A (en) * | 1990-07-05 | 1992-01-14 | Columbia Trailer Co., Inc. | Trailer dumper |
| US5539082A (en) * | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5798246A (en) * | 1996-03-25 | 1998-08-25 | Incyte Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase |
| US6080548A (en) * | 1997-11-19 | 2000-06-27 | Incyte Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterases |
| US5932465A (en) * | 1997-10-16 | 1999-08-03 | Icos Corporation | Phosphodiesterase 8A |
| US5922595A (en) * | 1997-12-09 | 1999-07-13 | Incyte Pharmaceuticals, Inc. | Cyclic GMP phosphodiesterase |
| US6686196B2 (en) * | 2000-05-03 | 2004-02-03 | University Of Washington | Recombinant, modified adenoviral vectors for tumor specific gene expression and uses thereof |
| DE60130565D1 (de) * | 2000-09-12 | 2007-10-31 | Univ Bern | Pde8a und seine verwendung |
-
2001
- 2001-09-12 DE DE60130565T patent/DE60130565D1/de not_active Expired - Lifetime
- 2001-09-12 EP EP01968819A patent/EP1317553B1/de not_active Expired - Lifetime
- 2001-09-12 WO PCT/US2001/028503 patent/WO2002022661A2/en not_active Ceased
- 2001-09-12 US US10/380,437 patent/US7138259B2/en not_active Expired - Fee Related
- 2001-09-12 AU AU2001289034A patent/AU2001289034A1/en not_active Abandoned
- 2001-09-12 AT AT01968819T patent/ATE373717T1/de not_active IP Right Cessation
-
2006
- 2006-06-01 US US11/421,658 patent/US7598067B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002022661A2 (en) | 2002-03-21 |
| EP1317553A2 (de) | 2003-06-11 |
| EP1317553B1 (de) | 2007-09-19 |
| US20050058998A1 (en) | 2005-03-17 |
| AU2001289034A1 (en) | 2002-03-26 |
| DE60130565D1 (de) | 2007-10-31 |
| US20070116705A1 (en) | 2007-05-24 |
| US7138259B2 (en) | 2006-11-21 |
| US7598067B2 (en) | 2009-10-06 |
| WO2002022661A3 (en) | 2003-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |