DK1234025T3 - Humane enzymer fra metalloproteasefamilien - Google Patents

Humane enzymer fra metalloproteasefamilien

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Publication number
DK1234025T3
DK1234025T3 DK00981279T DK00981279T DK1234025T3 DK 1234025 T3 DK1234025 T3 DK 1234025T3 DK 00981279 T DK00981279 T DK 00981279T DK 00981279 T DK00981279 T DK 00981279T DK 1234025 T3 DK1234025 T3 DK 1234025T3
Authority
DK
Denmark
Prior art keywords
polypeptides
human enzymes
metalloprotease family
therapy
polynucleotides
Prior art date
Application number
DK00981279T
Other languages
English (en)
Inventor
Willy Deleersnijder
Rico Wiegers
Michael Weske
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Application granted granted Critical
Publication of DK1234025T3 publication Critical patent/DK1234025T3/da

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C12N9/6497—Endothelin-converting enzyme (3.4.24.71)
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24071—Endothelin-converting enzyme 1 (3.4.24.71)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • G—PHYSICS
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
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    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
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    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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DK00981279T 1999-11-19 2000-11-17 Humane enzymer fra metalloproteasefamilien DK1234025T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NL1013616 1999-11-19
EP99203862 1999-11-19
NL1015356 2000-05-31
EP00201937 2000-05-31
PCT/EP2000/011532 WO2001036610A1 (en) 1999-11-19 2000-11-17 Human enzymes of the metalloprotease family

Publications (1)

Publication Number Publication Date
DK1234025T3 true DK1234025T3 (da) 2008-11-17

Family

ID=27440008

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00981279T DK1234025T3 (da) 1999-11-19 2000-11-17 Humane enzymer fra metalloproteasefamilien

Country Status (12)

Country Link
US (5) US6855532B2 (da)
EP (1) EP1234025B1 (da)
JP (1) JP2003514525A (da)
CN (1) CN1250717C (da)
AT (1) ATE406438T1 (da)
AU (1) AU784327B2 (da)
CA (1) CA2392076A1 (da)
DE (1) DE60040089D1 (da)
DK (1) DK1234025T3 (da)
ES (1) ES2310527T3 (da)
IL (2) IL149416A0 (da)
WO (1) WO2001036610A1 (da)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020086405A1 (en) * 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
WO2001036610A1 (en) 1999-11-19 2001-05-25 Solvay Pharmaceuticals B.V. Human enzymes of the metalloprotease family
US6991916B2 (en) * 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
US7432061B2 (en) * 2002-05-31 2008-10-07 Biozyme, Inc. Assays for measuring matrix metalloproteinase activities
US20040014131A1 (en) * 2002-07-09 2004-01-22 Pfizer Inc. Assay methods
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
WO2012083106A1 (en) 2010-12-16 2012-06-21 Scion Neurostim, Llc Combination treatments
US8883144B2 (en) * 2010-09-02 2014-11-11 The Regents Of The University Of Colorado, A Body Corporate Treatment of pulmonary vascular remodeling with neprilysin
US11898187B2 (en) 2017-08-15 2024-02-13 Northwestern University Protein glycosylation sites by rapid expression and characterization of N-glycosyltransferases
WO2019204346A1 (en) 2018-04-16 2019-10-24 Northwestern University METHODS FOR CO-ACTIVATING IN VITRO NON-STANDARD AMINO ACID (nsAA) INCORPORATION AND GLYCOSYLATION IN CRUDE CELLLYSATES
CN113490748A (zh) 2019-02-25 2021-10-08 西北大学 来源于梭菌属提取物的无细胞蛋白质合成平台

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960700A (en) * 1986-12-24 1990-10-02 Genentech, Inc. Compositions and methods for the synthesis and assay of a mammalian enkephalinase
IL88535A0 (en) * 1987-12-04 1989-06-30 Dana Farber Cancer Inst Inc Common acute lymphoblastic leukemia antigen
EP0785273A1 (en) 1990-11-26 1997-07-23 Genetics Institute, Inc. Paired basic amino acid converting enzyme and DNA sequence encoding it
CA2100355A1 (en) * 1991-02-04 1992-08-05 Lynne H. Parker Botehlo Endothelin converting enzyme
DE19681565D2 (de) * 1996-07-22 1999-11-11 Goehrig Anja Bolzenschneider
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel
FR2777291B1 (fr) 1998-04-08 2000-07-07 Inst Nat Sante Rech Med Nouvelle metalloprotease membranaire nep ii et son utilisation pour le criblage d'inhibiteurs utiles en therapie
US20020086405A1 (en) 2000-09-25 2002-07-04 Inmaculada Silos-Santiago 56638, a novel human neprilysin protease and uses thereof
CA2260376A1 (en) * 1999-02-11 2000-08-11 Universite De Montreal New metalloproteases of the neprilysin family
DE19906310A1 (de) * 1999-02-16 2000-08-17 Solvay Pharm Gmbh Arzneimittel zur Behandlung von Bluthochdruck
AUPP948299A0 (en) * 1999-03-29 1999-04-22 Taylor, Stephen Dennis Adjustable mounting literature display system
EP1069188A1 (en) * 1999-07-15 2001-01-17 Sanofi-Synthelabo Three neprilysin-like membrane metallopeptidases
WO2001036610A1 (en) 1999-11-19 2001-05-25 Solvay Pharmaceuticals B.V. Human enzymes of the metalloprotease family
JP2001275687A (ja) 2000-04-04 2001-10-09 Masafumi Matsuo 膜結合型メタロプロテアーゼ及びその可溶性分泌型
HK1054571A1 (zh) 2000-05-04 2003-12-05 Sugen, Inc. 新的蛋白酶
US6991916B2 (en) 2000-07-14 2006-01-31 Pfizer Inc. Compounds for the treatment of sexual dysfunction
GB0017387D0 (en) * 2000-07-14 2000-08-30 Pfizer Ltd Novel enzyme
CA2416691A1 (en) 2000-07-21 2002-01-31 Incyte Genomics, Inc. Proteases
US20030119714A1 (en) 2000-12-15 2003-06-26 Naylor Alasdair Mark Treatment of male sexual dysfunction
IL155775A0 (en) 2000-12-15 2003-12-23 Pfizer Treatment of male sexual dysfunction
AR039352A1 (es) 2001-05-18 2005-02-16 Solvay Pharm Gmbh Uso de un compuesto que tiene actividad inhibitoria combinada y concurrente con endopeptidasa neutra y metaloproteasa igs5.
EP1308459A3 (en) 2001-11-05 2003-07-09 Research Association for Biotechnology Full-length cDNA sequences
WO2003040393A2 (en) 2001-11-06 2003-05-15 Decode Genetics Ehf. Nucleic acids encoding proteases
GB0130219D0 (en) 2001-12-18 2002-02-06 Pfizer Ltd Compounds for the treatment of sexual dysfunction
US7427611B2 (en) * 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7262184B2 (en) * 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
AR046454A1 (es) * 2003-11-18 2005-12-07 Solvay Pharm Gmbh Uso de un compuesto de acido benzazepin-n-acetico, composicion farmaceutica, y procedimiento para la produccion de dicha composicion farmaceutica

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ATE406438T1 (de) 2008-09-15
AU784327B2 (en) 2006-03-09
US7083965B2 (en) 2006-08-01
US20030180877A1 (en) 2003-09-25
US7189525B2 (en) 2007-03-13
US20080070259A1 (en) 2008-03-20
IL149416A0 (en) 2002-11-10
US7312321B2 (en) 2007-12-25
AU1858201A (en) 2001-05-30
EP1234025B1 (en) 2008-08-27
US20040224356A1 (en) 2004-11-11
EP1234025A1 (en) 2002-08-28
US20070148688A1 (en) 2007-06-28
US6855532B2 (en) 2005-02-15
CN1250717C (zh) 2006-04-12
US20060205018A1 (en) 2006-09-14
IL149416A (en) 2009-02-11
JP2003514525A (ja) 2003-04-22
HK1052026A1 (en) 2003-08-29
CA2392076A1 (en) 2001-05-25
WO2001036610A1 (en) 2001-05-25
ES2310527T3 (es) 2009-01-16
CN1399678A (zh) 2003-02-26
DE60040089D1 (de) 2008-10-09

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