ATE374200T1 - 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen - Google Patents
7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungenInfo
- Publication number
- ATE374200T1 ATE374200T1 AT03709984T AT03709984T ATE374200T1 AT E374200 T1 ATE374200 T1 AT E374200T1 AT 03709984 T AT03709984 T AT 03709984T AT 03709984 T AT03709984 T AT 03709984T AT E374200 T1 ATE374200 T1 AT E374200T1
- Authority
- AT
- Austria
- Prior art keywords
- jun
- treatment
- azaindole
- neurodegenerative disorders
- inhibitors
- Prior art date
Links
- MVXVYAKCVDQRLW-UHFFFAOYSA-N 1h-pyrrolo[2,3-b]pyridine Chemical compound C1=CN=C2NC=CC2=C1 MVXVYAKCVDQRLW-UHFFFAOYSA-N 0.000 title abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 2
- 108091000080 Phosphotransferase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000020233 phosphotransferase Human genes 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0207491A GB0207491D0 (en) | 2002-03-28 | 2002-03-28 | Inhibitors |
| GB0217330A GB0217330D0 (en) | 2002-07-25 | 2002-07-25 | Inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE374200T1 true ATE374200T1 (de) | 2007-10-15 |
Family
ID=28676498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03709984T ATE374200T1 (de) | 2002-03-28 | 2003-03-17 | 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7534800B2 (de) |
| EP (1) | EP1490364B1 (de) |
| JP (1) | JP2005534618A (de) |
| KR (1) | KR20040111445A (de) |
| CN (1) | CN100368411C (de) |
| AT (1) | ATE374200T1 (de) |
| AU (1) | AU2003214412A1 (de) |
| CA (1) | CA2480317A1 (de) |
| DE (1) | DE60316542T2 (de) |
| IL (1) | IL164187A0 (de) |
| WO (1) | WO2003082868A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10037759A1 (de) * | 2000-08-03 | 2002-07-04 | Gruenenthal Gmbh | Screeningverfahren |
| DE60316542T2 (de) | 2002-03-28 | 2008-07-03 | Eisai R&D Management Co., Ltd. | 7-azaindole als inhibitoren c-jun n-terminaler kinasen zur behandlung neurodegenerativer störungen |
| GB0305142D0 (en) | 2003-03-06 | 2003-04-09 | Eisai London Res Lab Ltd | Synthesis |
| EP2295433A3 (de) | 2003-03-06 | 2011-07-06 | Eisai R&D Management Co., Ltd. | JNK Inhibitoren |
| US7612086B2 (en) * | 2003-05-16 | 2009-11-03 | Eisai R & D Management Co. Ltd. | JNK inhibitors |
| CN1925855B (zh) | 2003-12-19 | 2010-06-16 | 普莱希科公司 | 开发Ret调节剂的化合物和方法 |
| GB0330042D0 (en) * | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
| GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
| GB0405055D0 (en) * | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
| US7498342B2 (en) | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
| BRPI0512330A (pt) * | 2004-06-21 | 2008-02-26 | Hoffmann La Roche | derivados de pirazol-pirimidina |
| SE0401655D0 (sv) * | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | New compounds |
| US7626021B2 (en) | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| RU2389728C2 (ru) * | 2004-07-27 | 2010-05-20 | Сгкс Фармасьютиклз, Инк. | Модуляторы киназы на основе производных пирролопиридина |
| US7709645B2 (en) | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| WO2006015123A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| CA2573573A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7361764B2 (en) * | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| CN101027302B (zh) * | 2004-07-27 | 2011-05-11 | Sgx药物公司 | 吡咯并吡啶激酶调节剂 |
| JP4953457B2 (ja) | 2004-10-27 | 2012-06-13 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロゲステロン受容体モジュレーターとしてのピリジンイミダゾール及びアザ−インドール |
| FR2884821B1 (fr) * | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | Pyrrolopyridines substitues, compositions les contenant, procede de fabrication et utilisation |
| US7846941B2 (en) | 2005-05-17 | 2010-12-07 | Plexxikon, Inc. | Compounds modulating c-kit and c-fms activity and uses therefor |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| FR2887881B1 (fr) * | 2005-07-01 | 2009-10-09 | Pierre Fabre Medicament Sa | Inhibiteurs de proteines kinases |
| GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
| WO2007067537A1 (en) * | 2005-12-07 | 2007-06-14 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| WO2009012283A1 (en) | 2007-07-17 | 2009-01-22 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CN101945877B (zh) | 2008-02-25 | 2013-07-03 | 霍夫曼-拉罗奇有限公司 | 吡咯并吡嗪激酶抑制剂 |
| JP5368485B2 (ja) | 2008-02-25 | 2013-12-18 | エフ.ホフマン−ラ ロシュ アーゲー | ピロロピラジンキナーゼインヒビター |
| CA2712507A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| ES2372908T3 (es) | 2008-02-25 | 2012-01-27 | F. Hoffmann-La Roche Ag | Inhibidores de la pirrolopirazina quinasa. |
| WO2009106444A1 (en) | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
| JP5370957B2 (ja) | 2008-08-20 | 2013-12-18 | 学校法人日本大学 | アポトーシス抑制剤 |
| US8592448B2 (en) | 2008-11-20 | 2013-11-26 | OSI Pharmaceuticals, LLC | Substituted pyrrolo[2,3-b]-pyridines and -pyrazines |
| MY172424A (en) | 2009-04-03 | 2019-11-25 | Hoffmann La Roche | Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof |
| CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| US8518945B2 (en) | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
| EP2569315A1 (de) | 2010-05-14 | 2013-03-20 | OSI Pharmaceuticals, LLC | Kondensierte bicyclische kinasehemmer |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| EP2571881A1 (de) | 2010-05-20 | 2013-03-27 | F.Hoffmann-La Roche Ag | Pyrrolopyrazinderivate als syk- und jak-hemmer |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| AR085279A1 (es) | 2011-02-21 | 2013-09-18 | Plexxikon Inc | Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| CN105712992B (zh) * | 2012-09-29 | 2018-10-26 | 上海科州药物研发有限公司 | 作为cMet抑制剂的化合物及其制备方法和用途 |
| EP2738172A1 (de) * | 2012-11-28 | 2014-06-04 | Almirall, S.A. | Neue bizyklische Verbindungen als CRAC-Kanalmodulatoren |
| US9206188B2 (en) * | 2013-04-18 | 2015-12-08 | Arrien Pharmaceuticals Llc | Substituted pyrrolo[2,3-b]pyridines as ITK and JAK inhibitors |
| US10155727B2 (en) | 2014-08-15 | 2018-12-18 | Janssen Pharmaceuticals, Inc. | Pyrazoles |
| WO2016025917A1 (en) | 2014-08-15 | 2016-02-18 | Janssen Pharmaceuticals, Inc. | Triazoles as nr2b receptor inhibitors |
| AU2016291158B2 (en) | 2015-07-09 | 2020-04-30 | Janssen Pharmaceutica Nv | Substituted 4-azaindoles and their use as GluN2B receptor modulators |
| US10071988B2 (en) | 2016-02-10 | 2018-09-11 | Janssen Pharmaceutica Nv | Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators |
| TW201819376A (zh) | 2016-10-06 | 2018-06-01 | 比利時商健生藥品公司 | 經取代之1H-咪唑並[4,5-b]吡啶-2(3H)-酮及其作為GLUN2B受體調節劑之用途 |
| PL3558321T3 (pl) | 2016-12-23 | 2023-10-23 | Felicitex Therapeutics, Inc. | Pochodne chinolin jako inhibitory kinaz dyrk1a i/lub dyrk1b |
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| BR112021025141A2 (pt) | 2019-06-14 | 2022-01-25 | Janssen Pharmaceutica Nv | Pirazolo-piridinas heteroaromáticas substituídas e seu uso como moduladores do receptor glun2b |
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| TW202112774A (zh) | 2019-06-14 | 2021-04-01 | 比利時商健生藥品公司 | 經取代之吡唑并-吡啶醯胺及其作為glun2b受體調節劑之用途 |
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-
2003
- 2003-03-17 DE DE60316542T patent/DE60316542T2/de not_active Expired - Fee Related
- 2003-03-17 KR KR10-2004-7015415A patent/KR20040111445A/ko not_active Ceased
- 2003-03-17 CN CNB038121034A patent/CN100368411C/zh not_active Expired - Fee Related
- 2003-03-17 IL IL16418703A patent/IL164187A0/xx unknown
- 2003-03-17 CA CA002480317A patent/CA2480317A1/en not_active Abandoned
- 2003-03-17 JP JP2003580333A patent/JP2005534618A/ja active Pending
- 2003-03-17 US US10/509,128 patent/US7534800B2/en not_active Expired - Fee Related
- 2003-03-17 AT AT03709984T patent/ATE374200T1/de not_active IP Right Cessation
- 2003-03-17 EP EP03709984A patent/EP1490364B1/de not_active Expired - Lifetime
- 2003-03-17 AU AU2003214412A patent/AU2003214412A1/en not_active Abandoned
- 2003-03-17 WO PCT/GB2003/001112 patent/WO2003082868A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005534618A (ja) | 2005-11-17 |
| US20050272761A1 (en) | 2005-12-08 |
| EP1490364A1 (de) | 2004-12-29 |
| CA2480317A1 (en) | 2003-10-09 |
| CN100368411C (zh) | 2008-02-13 |
| WO2003082868A1 (en) | 2003-10-09 |
| AU2003214412A1 (en) | 2003-10-13 |
| CN1656094A (zh) | 2005-08-17 |
| EP1490364B1 (de) | 2007-09-26 |
| KR20040111445A (ko) | 2004-12-31 |
| DE60316542T2 (de) | 2008-07-03 |
| US7534800B2 (en) | 2009-05-19 |
| IL164187A0 (en) | 2005-12-18 |
| DE60316542D1 (de) | 2007-11-08 |
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