ATE240316T1 - Heteroaromatische amide als inhibitoren von faktor xa - Google Patents
Heteroaromatische amide als inhibitoren von faktor xaInfo
- Publication number
- ATE240316T1 ATE240316T1 AT99967352T AT99967352T ATE240316T1 AT E240316 T1 ATE240316 T1 AT E240316T1 AT 99967352 T AT99967352 T AT 99967352T AT 99967352 T AT99967352 T AT 99967352T AT E240316 T1 ATE240316 T1 AT E240316T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- inhibitors
- heteroaromatic amides
- heteroaromatic
- amides
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- -1 heteroaromatic amides Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11345298P | 1998-12-23 | 1998-12-23 | |
| PCT/US1999/029887 WO2000039117A1 (en) | 1998-12-23 | 1999-12-15 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240316T1 true ATE240316T1 (de) | 2003-05-15 |
Family
ID=22349511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967352T ATE240316T1 (de) | 1998-12-23 | 1999-12-15 | Heteroaromatische amide als inhibitoren von faktor xa |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1140905B1 (de) |
| JP (1) | JP2002533453A (de) |
| AT (1) | ATE240316T1 (de) |
| AU (1) | AU2364600A (de) |
| CA (1) | CA2358095A1 (de) |
| DE (1) | DE69907963T2 (de) |
| ES (1) | ES2196917T3 (de) |
| WO (1) | WO2000039117A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL133625A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| JP2002506462A (ja) | 1997-06-26 | 2002-02-26 | イーライ・リリー・アンド・カンパニー | 抗血栓物質 |
| EP1014962A4 (de) | 1997-06-26 | 2007-06-27 | Lilly Co Eli | Antitrombotische mitteln |
| CA2294240A1 (en) | 1997-06-26 | 1999-01-07 | Trelia Joyce Craft | Antithrombotic agents |
| NZ503809A (en) | 1997-12-19 | 2002-04-26 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants |
| CA2361149A1 (en) | 1998-12-23 | 2000-07-06 | Eli Lilly And Company | Aromatic amides |
| EP1140881B1 (de) | 1998-12-23 | 2006-05-17 | Eli Lilly And Company | Antithrombotische amide |
| ATE261941T1 (de) | 1998-12-24 | 2004-04-15 | Lilly Co Eli | Heterocyclische amide als inhibitoren von faktor xa |
| CA2375920A1 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Compounds |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| TWI288745B (en) | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| RU2251419C2 (ru) * | 2000-06-21 | 2005-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные бензотиазола |
| ATE374765T1 (de) | 2000-07-27 | 2007-10-15 | Lilly Co Eli | Substituierte heterocyclische amide |
| DE60114640T2 (de) | 2000-08-17 | 2006-07-20 | Eli Lilly And Co., Indianapolis | Antithrombosemittel |
| DE60118774T2 (de) | 2000-11-22 | 2007-03-15 | Astellas Pharma Inc. | Substituierte phenolderivate und deren salze als hemmstoffe von koagulations faktor x |
| AU2001297648A1 (en) | 2000-11-28 | 2002-08-28 | Eli Lilly And Company | Substituted carboxamides as inhibitors of factor xa |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| EP1456175A1 (de) | 2001-12-07 | 2004-09-15 | Eli Lilly And Company | Substituierte heterozyklische karboxamide mit antithrombotischer aktivität |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| CN100513398C (zh) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 作为因子viia抑制剂的2-(2-羟基联苯-3-基)-1h-苯并咪唑-5-甲脒衍生物 |
| AR044688A1 (es) * | 2003-06-12 | 2005-09-21 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor |
| ES2327684T3 (es) | 2003-07-24 | 2009-11-02 | Euro-Celtique S.A. | Compuestos heteroaril-tetrahidropiridilo utiles para el tratamiento o la prevencion del dolor. |
| MXPA06001331A (es) | 2003-08-01 | 2006-05-04 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor. |
| MXPA06003123A (es) | 2003-09-22 | 2006-05-31 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor. |
| SI1664041T1 (sl) | 2003-09-22 | 2008-12-31 | Euro Celtique Sa | Fenil-karboksamidne spojine, uporabne za tretiranje bolečine |
| SE0401343D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| PL2485731T4 (pl) * | 2009-10-06 | 2017-07-31 | Millennium Pharmaceuticals, Inc. | Związki heterocykliczne użyteczne jako inhibitory PDK1 |
| JP2019142776A (ja) * | 2016-06-24 | 2019-08-29 | 石原産業株式会社 | Ｎ−（４−ピリジル）ベンズアミド化合物又はその塩を有効成分として含有する有害生物防除剤 |
| US20220298141A1 (en) * | 2019-08-21 | 2022-09-22 | Kalvista Pharmaceuticals Limited | Enzyme inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| CA2294240A1 (en) * | 1997-06-26 | 1999-01-07 | Trelia Joyce Craft | Antithrombotic agents |
-
1999
- 1999-12-15 AT AT99967352T patent/ATE240316T1/de not_active IP Right Cessation
- 1999-12-15 JP JP2000591028A patent/JP2002533453A/ja not_active Withdrawn
- 1999-12-15 CA CA002358095A patent/CA2358095A1/en not_active Abandoned
- 1999-12-15 AU AU23646/00A patent/AU2364600A/en not_active Abandoned
- 1999-12-15 WO PCT/US1999/029887 patent/WO2000039117A1/en not_active Ceased
- 1999-12-15 EP EP99967352A patent/EP1140905B1/de not_active Expired - Lifetime
- 1999-12-15 ES ES99967352T patent/ES2196917T3/es not_active Expired - Lifetime
- 1999-12-15 DE DE69907963T patent/DE69907963T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69907963D1 (de) | 2003-06-18 |
| JP2002533453A (ja) | 2002-10-08 |
| CA2358095A1 (en) | 2000-07-06 |
| EP1140905B1 (de) | 2003-05-14 |
| DE69907963T2 (de) | 2004-05-19 |
| EP1140905A1 (de) | 2001-10-10 |
| WO2000039117A1 (en) | 2000-07-06 |
| AU2364600A (en) | 2000-07-31 |
| ES2196917T3 (es) | 2003-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |