ATE240316T1 - Heteroaromatische amide als inhibitoren von faktor xa - Google Patents
Heteroaromatische amide als inhibitoren von faktor xaInfo
- Publication number
- ATE240316T1 ATE240316T1 AT99967352T AT99967352T ATE240316T1 AT E240316 T1 ATE240316 T1 AT E240316T1 AT 99967352 T AT99967352 T AT 99967352T AT 99967352 T AT99967352 T AT 99967352T AT E240316 T1 ATE240316 T1 AT E240316T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- inhibitors
- heteroaromatic amides
- heteroaromatic
- amides
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title 1
- -1 heteroaromatic amides Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11345298P | 1998-12-23 | 1998-12-23 | |
| PCT/US1999/029887 WO2000039117A1 (en) | 1998-12-23 | 1999-12-15 | HETEROROAROMATIC AMIDES AS INHIBITOR OF FACTOR Xa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE240316T1 true ATE240316T1 (de) | 2003-05-15 |
Family
ID=22349511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99967352T ATE240316T1 (de) | 1998-12-23 | 1999-12-15 | Heteroaromatische amide als inhibitoren von faktor xa |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1140905B1 (de) |
| JP (1) | JP2002533453A (de) |
| AT (1) | ATE240316T1 (de) |
| AU (1) | AU2364600A (de) |
| CA (1) | CA2358095A1 (de) |
| DE (1) | DE69907963T2 (de) |
| ES (1) | ES2196917T3 (de) |
| WO (1) | WO2000039117A1 (de) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6372759B1 (en) | 1997-06-26 | 2002-04-16 | Eli Lilly And Company | Antithrombotic agents |
| US6313151B1 (en) | 1997-06-26 | 2001-11-06 | Eli Lilly And Company | Antithrombotic agents |
| IL133621A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| IL133625A0 (en) | 1997-06-26 | 2001-04-30 | Lilly Co Eli | Antithrombotic agents |
| SK9432000A3 (en) | 1997-12-19 | 2001-02-12 | Schering Ag | Ortho-anthranilamide derivatives as anti-coagulants, pharmaceutical composition containing such derivatives and use thereof |
| DE69919212T2 (de) | 1998-12-23 | 2005-07-28 | Eli Lilly And Co., Indianapolis | Aromatische amiden |
| US6610704B1 (en) | 1998-12-23 | 2003-08-26 | Eli Lilly And Company | Antithrombotic amides |
| DE69915687T2 (de) | 1998-12-24 | 2005-02-10 | Eli Lilly And Co., Indianapolis | Heterocyclische amide als inhibitoren von faktor xa |
| CA2375920A1 (en) | 1999-06-14 | 2000-12-21 | Eli Lilly And Company | Compounds |
| AU776053B2 (en) | 2000-03-31 | 2004-08-26 | Astellas Pharma Inc. | Diazepan derivatives or salts thereof |
| TWI290136B (en) | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| DE10023492A1 (de) * | 2000-05-09 | 2001-11-22 | Schering Ag | Aza- und Polyazanthranylamide und deren Verwendung als Arzneimittel |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030304D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| DE60132777T2 (de) * | 2000-06-21 | 2009-02-12 | F. Hoffmann-La Roche Ag | Benzothiazolderivate zur behandlung von alzheimer und parkinson |
| DE60130771T2 (de) | 2000-07-27 | 2008-07-17 | Eli Lilly And Co., Indianapolis | Substituierte heterocyclische amide |
| US6924296B2 (en) | 2000-08-17 | 2005-08-02 | Eli Lilly And Company | Antithrombotic agents |
| WO2002042270A1 (en) | 2000-11-22 | 2002-05-30 | Yamanouchi Pharmaceutical Co., Ltd. | Substituted benzene derivatives or salts thereof |
| EP1379506A2 (de) | 2000-11-28 | 2004-01-14 | Eli Lilly And Company | Substituierte carbonsäureamide |
| US6878714B2 (en) | 2001-01-12 | 2005-04-12 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| US7102009B2 (en) | 2001-01-12 | 2006-09-05 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
| US20030134836A1 (en) | 2001-01-12 | 2003-07-17 | Amgen Inc. | Substituted arylamine derivatives and methods of use |
| US6864255B2 (en) | 2001-04-11 | 2005-03-08 | Amgen Inc. | Substituted triazinyl amide derivatives and methods of use |
| WO2003000657A1 (en) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| US7449457B2 (en) | 2001-12-07 | 2008-11-11 | Eli Lilly And Company | Substituted heterocyclic carboxamides with antithrombotic activity |
| US7307088B2 (en) | 2002-07-09 | 2007-12-11 | Amgen Inc. | Substituted anthranilic amide derivatives and methods of use |
| US7262194B2 (en) | 2002-07-26 | 2007-08-28 | Euro-Celtique S.A. | Therapeutic agents useful for treating pain |
| PT1569912E (pt) | 2002-12-03 | 2015-09-15 | Pharmacyclics Llc | Derivados 2-(2-hidroxibifenil-3-il)-1h-benzoimidazole-5- carboxamidina como inibidores do fator viia |
| MY142655A (en) * | 2003-06-12 | 2010-12-15 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| DK1648879T3 (da) | 2003-07-24 | 2009-02-23 | Euro Celtique Sa | Heteroaryl-tetrahydropyridyl-forbindelser, der er anvendelige til behandling eller forebyggelse af smerte |
| PL1942106T3 (pl) | 2003-08-01 | 2012-02-29 | Euro Celtique Sa | Środki lecznicze użyteczne do leczenia bólu |
| DK1664041T3 (da) | 2003-09-22 | 2008-10-27 | Euro Celtique Sa | Phenylcarboxamidforbindelser, der er egnede til behandling af smerter |
| CN1863790A (zh) | 2003-09-22 | 2006-11-15 | 欧洲凯尔特公司 | 用于治疗疼痛的治疗药 |
| SE0401343D0 (sv) * | 2004-05-25 | 2004-05-25 | Astrazeneca Ab | Therapeutic compounds: Pyridine N oxide as scaffold |
| US8247556B2 (en) | 2005-10-21 | 2012-08-21 | Amgen Inc. | Method for preparing 6-substituted-7-aza-indoles |
| US9546165B2 (en) * | 2009-10-06 | 2017-01-17 | Sunesis Pharmaceuticals, Inc. | Heterocyclic compounds useful as PDK1 inhibitors |
| JP2019142776A (ja) * | 2016-06-24 | 2019-08-29 | 石原産業株式会社 | Ｎ−（４−ピリジル）ベンズアミド化合物又はその塩を有効成分として含有する有害生物防除剤 |
| KR20220050944A (ko) * | 2019-08-21 | 2022-04-25 | 칼비스타 파마슈티컬즈 리미티드 | 효소 저해제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA928276B (en) * | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
| US6372759B1 (en) * | 1997-06-26 | 2002-04-16 | Eli Lilly And Company | Antithrombotic agents |
-
1999
- 1999-12-15 AT AT99967352T patent/ATE240316T1/de not_active IP Right Cessation
- 1999-12-15 AU AU23646/00A patent/AU2364600A/en not_active Abandoned
- 1999-12-15 JP JP2000591028A patent/JP2002533453A/ja not_active Withdrawn
- 1999-12-15 DE DE69907963T patent/DE69907963T2/de not_active Expired - Fee Related
- 1999-12-15 ES ES99967352T patent/ES2196917T3/es not_active Expired - Lifetime
- 1999-12-15 WO PCT/US1999/029887 patent/WO2000039117A1/en not_active Ceased
- 1999-12-15 EP EP99967352A patent/EP1140905B1/de not_active Expired - Lifetime
- 1999-12-15 CA CA002358095A patent/CA2358095A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE69907963T2 (de) | 2004-05-19 |
| ES2196917T3 (es) | 2003-12-16 |
| EP1140905A1 (de) | 2001-10-10 |
| EP1140905B1 (de) | 2003-05-14 |
| WO2000039117A1 (en) | 2000-07-06 |
| AU2364600A (en) | 2000-07-31 |
| DE69907963D1 (de) | 2003-06-18 |
| JP2002533453A (ja) | 2002-10-08 |
| CA2358095A1 (en) | 2000-07-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |