ATE374821T1 - Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren - Google Patents

Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren

Info

Publication number
ATE374821T1
ATE374821T1 AT98911393T AT98911393T ATE374821T1 AT E374821 T1 ATE374821 T1 AT E374821T1 AT 98911393 T AT98911393 T AT 98911393T AT 98911393 T AT98911393 T AT 98911393T AT E374821 T1 ATE374821 T1 AT E374821T1
Authority
AT
Austria
Prior art keywords
mutations
atp
transposon
artificial chromosomes
derivative
Prior art date
Application number
AT98911393T
Other languages
English (en)
Inventor
Nancy L Craig
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE374821T1 publication Critical patent/ATE374821T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT98911393T 1997-02-20 1998-02-20 Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren ATE374821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3795597P 1997-02-20 1997-02-20

Publications (1)

Publication Number Publication Date
ATE374821T1 true ATE374821T1 (de) 2007-10-15

Family

ID=21897265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911393T ATE374821T1 (de) 1997-02-20 1998-02-20 Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren

Country Status (5)

Country Link
US (2) US6420524B1 (de)
EP (1) EP1036183B1 (de)
AT (1) ATE374821T1 (de)
DE (1) DE69838510T2 (de)
WO (1) WO1998037205A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6299850B1 (en) 1999-03-16 2001-10-09 The United States Of America As Represented By The Department Of Energy Carbon activation process for increased surface accessibility in electrochemical capacitors
US6562624B2 (en) 1999-03-17 2003-05-13 Paradigm Genetics, Inc. Methods and materials for the rapid and high volume production of a gene knock-out library in an organism
US6673567B2 (en) * 2000-03-23 2004-01-06 E. I. Du Pont De Nemours And Company Method of determination of gene function
NZ523507A (en) * 2000-07-07 2005-01-28 Aventis Pharma Inc High throughput, possibly automated, process for transposition-mediated sequencing of target DNA fragments in which the amount of non-target DNA sequence is minimised
US20040172667A1 (en) 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
WO2005062881A2 (en) * 2003-12-24 2005-07-14 Transgenrx, Inc. Gene therapy using transposon-based vectors
US7727744B2 (en) 2004-03-30 2010-06-01 Epicentre Technologies Corporation Methods for obtaining directionally truncated polypeptides
US7510868B2 (en) 2004-05-26 2009-03-31 Paul Harden Chimeric adenoviruses for use in cancer treatment
WO2006060314A2 (en) * 2004-12-01 2006-06-08 Bayer Schering Pharma Aktiengesellschaft Generation of replication competent viruses for therapeutic use
US8883453B2 (en) * 2007-04-30 2014-11-11 University Of Maryland Codon specific mutagenesis
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
US9157097B2 (en) 2008-09-25 2015-10-13 Proteovec Holding, L.L.C. Vectors for production of growth hormone
EP2417263B1 (de) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Herstellung von proteinen unter verwendung von vektoren auf transposonbasis
AU2014338864C1 (en) 2013-10-25 2020-07-16 Akamis Bio Limited Oncolytic adenoviruses armed with heterologous genes
PE20180241A1 (es) 2015-04-30 2018-01-31 Psioxus Therapeutics Ltd Adenovirus oncolitico que codifica una proteina b7
EA201891022A1 (ru) 2015-12-17 2019-01-31 Псайоксус Терапьютикс Лимитед Вирус, кодирующий антитело к комплексу tcr или фрагмент указанного антитела
CN119614520A (zh) 2016-08-29 2025-03-14 阿卡米斯生物公司 携带双特异性t细胞衔接器的腺病毒
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
WO2019090175A1 (en) 2017-11-02 2019-05-09 Arbor Biotechnologies, Inc. Novel crispr-associated transposon systems and components
CA3132197A1 (en) 2019-03-07 2020-09-10 The Trustees Of Columbia University In The City Of New York Rna-guided dna integration using tn7-like transposons
WO2022162623A1 (en) * 2021-01-28 2022-08-04 Arbor Biotechnologies, Inc. Crispr-associated transposon systems and methods of using same
US20250197458A1 (en) * 2022-02-09 2025-06-19 Cornell University Adaptations for high efficiency i-f3-crispr-cas systems for guide rna-directed transposition in human cells
CN118638859A (zh) * 2024-05-10 2024-09-13 中国科学院动物研究所 活性dna转座子系统及其使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons

Also Published As

Publication number Publication date
DE69838510D1 (de) 2007-11-15
US6420524B1 (en) 2002-07-16
US20020188105A1 (en) 2002-12-12
DE69838510T2 (de) 2008-07-03
EP1036183A1 (de) 2000-09-20
EP1036183B1 (de) 2007-10-03
WO1998037205A1 (en) 1998-08-27

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