ATE374821T1 - Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren - Google Patents

Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren

Info

Publication number
ATE374821T1
ATE374821T1 AT98911393T AT98911393T ATE374821T1 AT E374821 T1 ATE374821 T1 AT E374821T1 AT 98911393 T AT98911393 T AT 98911393T AT 98911393 T AT98911393 T AT 98911393T AT E374821 T1 ATE374821 T1 AT E374821T1
Authority
AT
Austria
Prior art keywords
mutations
atp
transposon
artificial chromosomes
derivative
Prior art date
Application number
AT98911393T
Other languages
English (en)
Inventor
Nancy L Craig
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE374821T1 publication Critical patent/ATE374821T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT98911393T 1997-02-20 1998-02-20 Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren ATE374821T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3795597P 1997-02-20 1997-02-20

Publications (1)

Publication Number Publication Date
ATE374821T1 true ATE374821T1 (de) 2007-10-15

Family

ID=21897265

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98911393T ATE374821T1 (de) 1997-02-20 1998-02-20 Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren

Country Status (5)

Country Link
US (2) US6420524B1 (de)
EP (1) EP1036183B1 (de)
AT (1) ATE374821T1 (de)
DE (1) DE69838510T2 (de)
WO (1) WO1998037205A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6299850B1 (en) 1999-03-16 2001-10-09 The United States Of America As Represented By The Department Of Energy Carbon activation process for increased surface accessibility in electrochemical capacitors
US6562624B2 (en) 1999-03-17 2003-05-13 Paradigm Genetics, Inc. Methods and materials for the rapid and high volume production of a gene knock-out library in an organism
US6673567B2 (en) * 2000-03-23 2004-01-06 E. I. Du Pont De Nemours And Company Method of determination of gene function
ATE361994T1 (de) * 2000-07-07 2007-06-15 Aventis Pharma Inc Transposon-vermittelte multiplexsequenzierung
US20040172667A1 (en) 2002-06-26 2004-09-02 Cooper Richard K. Administration of transposon-based vectors to reproductive organs
US7527966B2 (en) 2002-06-26 2009-05-05 Transgenrx, Inc. Gene regulation in transgenic animals using a transposon-based vector
US8071364B2 (en) 2003-12-24 2011-12-06 Transgenrx, Inc. Gene therapy using transposon-based vectors
WO2005100585A2 (en) 2004-03-30 2005-10-27 Epicentre Methods for obtaining directionally truncated polypeptides
ES2358204T3 (es) 2004-05-26 2011-05-06 Bayer Schering Pharma Aktiengesellschaft Adenovirus quiméricos para uso en el tratamiento del cáncer.
EP1819823A2 (de) * 2004-12-01 2007-08-22 Bayer Schering Pharma Aktiengesellschaft Herstellung von replikationskompetenten viren zur therapeutischen verwendung
US8883453B2 (en) * 2007-04-30 2014-11-11 University Of Maryland Codon specific mutagenesis
WO2010036976A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of antibodies
WO2010036978A2 (en) 2008-09-25 2010-04-01 Transgenrx, Inc. Novel vectors for production of growth hormone
EP2417263B1 (de) 2009-04-09 2015-09-23 ProteoVec Holding L.L.C. Herstellung von proteinen unter verwendung von vektoren auf transposonbasis
KR102272932B1 (ko) 2013-10-25 2021-07-05 싸이오서스 테라퓨틱스 엘티디. 이종 유전자로 무장된 종양살상 아데노바이러스
DK3288573T3 (da) 2015-04-30 2020-03-16 Psioxus Therapeutics Ltd Onkolytisk adenovirus, der koder for et b7-protein
US11155622B2 (en) 2015-12-17 2021-10-26 Psioxus Therapeutics Limited Virus encoding an anti-TCR-complex antibody or fragment
KR102491752B1 (ko) 2016-08-29 2023-01-26 싸이오서스 테라퓨틱스 엘티디. 이중특이성 T 세포 세포 관여자(BiTE)가 보강된 아데노바이러스
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
US20200255829A1 (en) 2017-11-02 2020-08-13 Arbor Biotechnologies, Inc. Novel crispr-associated transposon systems and components
WO2020181264A1 (en) 2019-03-07 2020-09-10 The Trustees Of Columbia University In The City Of New York Rna-guided dna integration using tn7-like transposons
JP2024509047A (ja) * 2021-01-28 2024-02-29 アーバー バイオテクノロジーズ， インコーポレイテッド Ｃｒｉｓｐｒ関連トランスポゾンシステム及びその使用方法
US20250197458A1 (en) * 2022-02-09 2025-06-19 Cornell University Adaptations for high efficiency i-f3-crispr-cas systems for guide rna-directed transposition in human cells
CN118638859A (zh) * 2024-05-10 2024-09-13 中国科学院动物研究所 活性dna转座子系统及其使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5677170A (en) 1994-03-02 1997-10-14 The Johns Hopkins University In vitro transposition of artificial transposons

Also Published As

Publication number Publication date
EP1036183B1 (de) 2007-10-03
US20020188105A1 (en) 2002-12-12
DE69838510D1 (de) 2007-11-15
DE69838510T2 (de) 2008-07-03
EP1036183A1 (de) 2000-09-20
US6420524B1 (en) 2002-07-16
WO1998037205A1 (en) 1998-08-27

Similar Documents

Publication Publication Date Title
DE69838510D1 (de) Mutationen in atp-abhängigen transpositionsproteinen die die zielortspezifität reduzieren
Li et al. Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene.
Kawakami et al. Excision of the tol2 transposable element of the medaka fish, Oryzias latipes, in zebrafish, Danio rerio
Dianov et al. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
Bergbauer et al. CpG-methylation regulates a class of Epstein-Barr virus promoters
Krause et al. Complexes at the replication origin of Bacillus subtilis with homologous and heterologous DnaA protein
DE69636866D1 (en) Reverse "two-hybrid"-systeme
JP7852942B2 (ja) 活性ｄｎａトランスポゾンシステム及びその使用方法
Hamlin et al. A revisionist replicon model for higher eukaryotic genomes
Mekler et al. Quantification of the affinities of CRISPR–Cas9 nucleases for cognate protospacer adjacent motif (PAM) sequences
CA3026321A1 (en) Using programmable dna binding proteins to enhance targeted genome modification
IL145607A0 (en) Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
Handen et al. Intronic enhancer activity of the eosinophil-derived neurotoxin (RNS2) and eosinophil cationic protein (RNS3) genes is mediated by an NFAT-1 consensus binding sequence
Morin et al. CRISPR/Cas9 in the chicken embryo
Antequera et al. CpG islands: A historical perspective
Weng et al. Single‐base editing of rs12603332 on chromosome 17q21 with a cytosine base editor regulates ORMDL3 and ATF6α expression
Kadyrov et al. A phage T4 site‐specific endonuclease, SegE, is responsible for a non‐reciprocal genetic exchange between T‐even‐related phages
Lukomski et al. Left-handed Z-DNA and in vivo supercoil density in the Escherichia coli chromosome.
Liu et al. Mutational switching of a yeast tRNA synthetase into a mammalian-like synthetase cytokine
Muñoz-Santos et al. Generation of genetically modified mice using CRISPR/Cas9
TWI843749B (zh) ＰａＣａｓ９核酸酶
Okada et al. The variable region gene assembly mechanism
Gruissem et al. Transcription of 5 S RNA genes in vitro is feedback-inhibited by HeLa 5 S RNA.
Zielke et al. Involvement of the cgtA gene function in stimulation of DNA repair in Escherichia coli and Vibrio harveyi
Olaru et al. Beyond the 12/23 rule of VDJ recombination independent of the Rag proteins

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties