ATE375338T1 - Verfahren zur aufreinigung von lanzoprazol - Google Patents
Verfahren zur aufreinigung von lanzoprazolInfo
- Publication number
- ATE375338T1 ATE375338T1 AT03793375T AT03793375T ATE375338T1 AT E375338 T1 ATE375338 T1 AT E375338T1 AT 03793375 T AT03793375 T AT 03793375T AT 03793375 T AT03793375 T AT 03793375T AT E375338 T1 ATE375338 T1 AT E375338T1
- Authority
- AT
- Austria
- Prior art keywords
- lanzoprazole
- purification
- lansoprazole
- provides
- present
- Prior art date
Links
- MJIHNNLFOKEZEW-UHFFFAOYSA-N lansoprazole Chemical compound CC1=C(OCC(F)(F)F)C=CN=C1CS(=O)C1=NC2=CC=CC=C2N1 MJIHNNLFOKEZEW-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title 1
- 229960003174 lansoprazole Drugs 0.000 abstract 3
- 239000012535 impurity Substances 0.000 abstract 1
- 150000003457 sulfones Chemical class 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40484502P | 2002-08-21 | 2002-08-21 | |
| US41805602P | 2002-10-11 | 2002-10-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE375338T1 true ATE375338T1 (de) | 2007-10-15 |
Family
ID=31949873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03793375T ATE375338T1 (de) | 2002-08-21 | 2003-08-21 | Verfahren zur aufreinigung von lanzoprazol |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6909004B2 (de) |
| EP (1) | EP1501824B1 (de) |
| JP (2) | JP2006500380A (de) |
| AT (1) | ATE375338T1 (de) |
| AU (1) | AU2003258335A1 (de) |
| DE (1) | DE60316791T2 (de) |
| ES (1) | ES2294358T3 (de) |
| IL (1) | IL166985A (de) |
| PT (1) | PT1501824E (de) |
| WO (1) | WO2004018454A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1465890B1 (de) | 2002-11-18 | 2007-04-04 | Teva Pharmaceutical Industries Ltd. | Stabiles lansoprazol, enthaltend mehr als 500 ppm bis zu 3000 ppm wasser und mehr als 200 ppm bis zu 5000 ppm alkohol |
| US7678816B2 (en) | 2003-02-05 | 2010-03-16 | Teva Pharmaceutical Industries Ltd. | Method of stabilizing lansoprazole |
| EP1904457B1 (de) * | 2005-06-08 | 2017-09-06 | Rigel Pharmaceuticals, Inc. | Zusammensetzungen und verfahren zur inhibierung des jak-pfades |
| KR100758600B1 (ko) * | 2006-01-05 | 2007-09-13 | 주식회사 대웅제약 | 란소프라졸 결정형 ａ의 제조방법 |
| WO2008035189A1 (en) * | 2006-09-22 | 2008-03-27 | Orchid Chemicals & Pharmaceuticals Limited | A method for the purification of lansoprazole |
| WO2008087665A2 (en) * | 2007-01-18 | 2008-07-24 | Matrix Laboratories Ltd | Process for preparation of lansoprazole |
| WO2010117756A2 (en) * | 2009-03-31 | 2010-10-14 | Dr. Reddy's Laboratories Ltd | Substituted benzimidazole pharmaceutical formulations |
| WO2010146428A1 (en) * | 2009-06-15 | 2010-12-23 | Orchid Chemicals And Pharmaceuticals Ltd. | An improved process for the preparation of rabeprazole |
| CA2795110C (en) * | 2010-03-31 | 2015-06-09 | Ranbaxy Laboratories Limited | Process for the preparation of dexlansoprazole |
| CN103012369B (zh) * | 2011-05-23 | 2014-04-23 | 中山大学 | 兰索拉唑n晶型及其制备方法和应用 |
| CN102180866B (zh) * | 2011-05-23 | 2013-03-13 | 中山大学 | 兰索拉唑晶型及其制备方法和应用 |
| EP2723728A1 (de) * | 2011-06-21 | 2014-04-30 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von dexlansoprazol |
| UA118715C2 (uk) | 2012-11-05 | 2019-02-25 | Монсанто Текнолоджи Ллс | Гербіцидні композиції з низькою леткістю |
| CN109265442A (zh) * | 2018-10-12 | 2019-01-25 | 河南精康制药有限公司 | 一种原料药兰索拉唑的精制方法 |
| CN112834627B (zh) * | 2019-11-22 | 2022-05-20 | 扬子江药业集团有限公司 | 高效液相色谱法分离测定注射用兰索拉唑有关物质的方法 |
| WO2024075017A1 (en) | 2022-10-04 | 2024-04-11 | Zabirnyk Arsenii | Inhibition of aortic valve calcification |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6150978A (ja) | 1984-08-16 | 1986-03-13 | Takeda Chem Ind Ltd | ピリジン誘導体およびその製造法 |
| CA1327010C (en) | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| US5433959A (en) | 1986-02-13 | 1995-07-18 | Takeda Chemical Industries, Ltd. | Stabilized pharmaceutical composition |
| US5026560A (en) | 1987-01-29 | 1991-06-25 | Takeda Chemical Industries, Ltd. | Spherical granules having core and their production |
| DK171989B1 (da) | 1987-08-04 | 1997-09-08 | Takeda Chemical Industries Ltd | Fremgangsmåde til fremstilling af 2-(2-pyridylmethylsulfinyl)-benzimidazoler |
| ES2036948B1 (es) | 1991-11-21 | 1994-09-01 | Genesis Para La Investigacion | Procedimiento de obtencion de compuestos derivados de piridina. |
| ES2063705B1 (es) | 1993-06-14 | 1995-07-16 | S A L V A T Lab Sa | Intermedio para la sintesis de lansoprazol y su procedimiento de obtencion. |
| TW385306B (en) * | 1996-11-14 | 2000-03-21 | Takeda Chemical Industries Ltd | Method for producing crystals of benzimidazole derivatives |
| US6313303B1 (en) | 1997-07-11 | 2001-11-06 | Eisai Co., Ltd. | Process for the preparation of pyridine derivatives |
| GB9805558D0 (en) | 1998-03-17 | 1998-05-13 | Knoll Ag | Chemical process` |
| SI20019A (sl) | 1998-07-13 | 2000-02-29 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola |
| US6166213A (en) | 1998-08-11 | 2000-12-26 | Merck & Co., Inc. | Omeprazole process and compositions thereof |
| JP3926936B2 (ja) | 1998-11-16 | 2007-06-06 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | スルホキシド誘導体・アセトン錯体およびその製造法 |
| KR100362947B1 (ko) | 1999-09-21 | 2002-11-30 | 주식회사 대웅 | 설폭시드 화합물의 제조방법 |
| ES2163372B1 (es) | 2000-03-13 | 2003-05-01 | Esteve Quimica Sa | Procedimiento de oxidacion de un grupo tioeter a sulfoxido. |
| CN1876647A (zh) * | 2001-02-02 | 2006-12-13 | 特瓦制药工业有限公司 | 苯并咪唑化合物产品 |
| US20040138466A1 (en) * | 2001-02-02 | 2004-07-15 | Ilya Avrutov | Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1H-benzimidazoles |
-
2003
- 2003-08-21 AT AT03793375T patent/ATE375338T1/de not_active IP Right Cessation
- 2003-08-21 DE DE60316791T patent/DE60316791T2/de not_active Expired - Lifetime
- 2003-08-21 US US10/646,059 patent/US6909004B2/en not_active Expired - Fee Related
- 2003-08-21 JP JP2004531171A patent/JP2006500380A/ja not_active Withdrawn
- 2003-08-21 WO PCT/US2003/026544 patent/WO2004018454A1/en not_active Ceased
- 2003-08-21 ES ES03793375T patent/ES2294358T3/es not_active Expired - Lifetime
- 2003-08-21 PT PT03793375T patent/PT1501824E/pt unknown
- 2003-08-21 AU AU2003258335A patent/AU2003258335A1/en not_active Abandoned
- 2003-08-21 EP EP03793375A patent/EP1501824B1/de not_active Expired - Lifetime
-
2005
- 2005-02-20 IL IL166985A patent/IL166985A/en not_active IP Right Cessation
- 2005-03-18 US US11/083,652 patent/US7060837B2/en not_active Expired - Fee Related
- 2005-03-18 US US11/083,485 patent/US7622588B2/en not_active Expired - Fee Related
- 2005-03-18 US US11/084,269 patent/US7022859B2/en not_active Expired - Fee Related
-
2009
- 2009-12-28 JP JP2009297316A patent/JP2010083897A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US7060837B2 (en) | 2006-06-13 |
| US20050165059A1 (en) | 2005-07-28 |
| PT1501824E (pt) | 2007-11-28 |
| DE60316791D1 (de) | 2007-11-22 |
| JP2010083897A (ja) | 2010-04-15 |
| US20040192923A1 (en) | 2004-09-30 |
| EP1501824A1 (de) | 2005-02-02 |
| IL166985A (en) | 2010-04-15 |
| JP2006500380A (ja) | 2006-01-05 |
| WO2004018454A8 (en) | 2005-03-31 |
| US7022859B2 (en) | 2006-04-04 |
| EP1501824B1 (de) | 2007-10-10 |
| DE60316791T2 (de) | 2008-07-24 |
| WO2004018454A1 (en) | 2004-03-04 |
| AU2003258335A1 (en) | 2004-03-11 |
| US20050165060A1 (en) | 2005-07-28 |
| ES2294358T3 (es) | 2008-04-01 |
| US6909004B2 (en) | 2005-06-21 |
| US7622588B2 (en) | 2009-11-24 |
| US20050165061A1 (en) | 2005-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |