ATE375352T1 - Thienopyridazinon-derivate als modulatoren von autoimmunkrankheiten - Google Patents

Thienopyridazinon-derivate als modulatoren von autoimmunkrankheiten

Info

Publication number: ATE375352T1
Authority: AT; Austria
Prior art keywords: sup; sub; alkyl; optionally substituted; nitrogen
Prior art date: 2003-01-17

Application number

AT04702471T

Other languages

English (en)

Inventor

Martin E Cooper

Simon D Guile

Anthony H Ingall

Rukhsana T Rasul

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-17

Filing date

2004-01-15

Publication date

2007-10-15

2004-01-15 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2007-10-15 Application granted granted Critical

2007-10-15 Publication of ATE375352T1 publication Critical patent/ATE375352T1/de

Links

208000023275 Autoimmune disease Diseases 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
229910052757 nitrogen Inorganic materials 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
239000005864 Sulphur Chemical group 0.000 abstract 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
125000005842 heteroatom Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
239000001301 oxygen Substances 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004122 cyclic group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Vascular Medicine (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)

AT04702471T 2003-01-17 2004-01-15 Thienopyridazinon-derivate als modulatoren von autoimmunkrankheiten ATE375352T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE0300120A SE0300120D0 (sv)	2003-01-17	2003-01-17	Novel compounds

Publications (1)

Publication Number	Publication Date
ATE375352T1 true ATE375352T1 (de)	2007-10-15

Family

ID=20290155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04702471T ATE375352T1 (de)	2003-01-17	2004-01-15	Thienopyridazinon-derivate als modulatoren von autoimmunkrankheiten

Country Status (22)

Country	Link
US (2)	US7064126B2 (de)
EP (1)	EP1587809B1 (de)
JP (1)	JP4589298B2 (de)
KR (1)	KR20050092759A (de)
CN (1)	CN100358900C (de)
AT (1)	ATE375352T1 (de)
AU (1)	AU2004205617B2 (de)
BR (1)	BRPI0406780A (de)
CA (1)	CA2512736A1 (de)
DE (1)	DE602004009407T2 (de)
ES (1)	ES2293208T3 (de)
IL (1)	IL169363A (de)
IS (1)	IS2503B (de)
MX (1)	MXPA05007494A (de)
NO (1)	NO20053827L (de)
NZ (1)	NZ541216A (de)
PL (1)	PL378223A1 (de)
RU (1)	RU2331646C2 (de)
SE (1)	SE0300120D0 (de)
UA (1)	UA80175C2 (de)
WO (1)	WO2004065393A1 (de)
ZA (1)	ZA200505273B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0117583D0 (en) *	2001-07-19	2001-09-12	Astrazeneca Ab	Novel compounds
GB0118479D0 (en) *	2001-07-28	2001-09-19	Astrazeneca Ab	Novel compounds
SE0300120D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
SE0300119D0 (sv)	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
PL378221A1 (pl)	2003-01-17	2006-03-20	Astrazeneca Ab	Tienopirydazynony i ich zastosowanie w modulacji choroby autoimmunologicznej
CN1925855B (zh)	2003-12-19	2010-06-16	普莱希科公司	开发Ret调节剂的化合物和方法
US7498342B2 (en)	2004-06-17	2009-03-03	Plexxikon, Inc.	Compounds modulating c-kit activity
MX2007014377A (es)	2005-05-17	2008-02-06	Plexxikon Inc	Inhibidores de proteina cinasa de derivados de pirrol (2,3-b) piridina.
PL2395004T3 (pl)	2005-06-22	2016-08-31	Plexxikon Inc	Pochodne pirolo[2,3-b]pirydyny jako inhibitory kinazy białkowej
EP2527345B1 (de) *	2006-10-16	2015-12-16	Thesan Pharmaceuticals, Inc.	Therapeutische Pyrazolylthienopyridine
WO2008063888A2 (en)	2006-11-22	2008-05-29	Plexxikon, Inc.	Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20081581A1 (es)	2006-12-21	2008-11-12	Plexxikon Inc	COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
US7872018B2 (en)	2006-12-21	2011-01-18	Plexxikon, Inc.	Compounds and methods for kinase modulation, and indications therefor
WO2008079909A1 (en)	2006-12-21	2008-07-03	Plexxikon, Inc.	Pyrrolo [2,3-b] pyridines as kinase modulators
MX2010000617A (es)	2007-07-17	2010-05-17	Plexxikon Inc	Compuestos y metodos para modulacion de cinasa, e indicaciones de estos.
EA031116B1 (ru)	2009-04-03	2018-11-30	Ф. Хоффманн-Ля Рош Аг	КРИСТАЛЛИЧЕСКИЕ ПОЛИМОРФНЫЕ ФОРМЫ {3-[5-(4-ХЛОРФЕНИЛ)-1H-ПИРРОЛО[2,3-b]ПИРИДИН-3-КАРБОНИЛ]-2,4-ДИФТОРФЕНИЛ}АМИДА ПРОПАН-1-СУЛЬФОНОВОЙ КИСЛОТЫ
US8329724B2 (en)	2009-08-03	2012-12-11	Hoffmann-La Roche Inc.	Process for the manufacture of pharmaceutically active compounds
UA105813C2 (uk)	2009-11-06	2014-06-25	Плексікон, Інк.	Сполуки-інгібітори кіназ та фармацевтична композиція (варіанти)
PL2672967T3 (pl)	2011-02-07	2019-04-30	Plexxikon Inc	Związki i sposoby modulacji kinaz i wskazania ku temu
TWI558702B (zh)	2011-02-21	2016-11-21	普雷辛肯公司	醫藥活性物質的固態形式
JO3407B1 (ar)	2012-05-31	2019-10-20	Eisai R&D Man Co Ltd	مركبات رباعي هيدرو بيرازولو بيريميدين
US9150570B2 (en)	2012-05-31	2015-10-06	Plexxikon Inc.	Synthesis of heterocyclic compounds
US9200005B2 (en) *	2013-03-13	2015-12-01	AbbVie Deutschland GmbH & Co. KG	Inhibitor compounds of phosphodiesterase type 10A
KR102228034B1 (ko) *	2013-10-21	2021-03-16	제노스코	치환된 피리미딘 화합물 및 syk 억제제로서의 이의 용도

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3620860A1 (de) *	1986-06-21	1987-12-23	Basf Ag	Substituierte acrylsaeureester und fungizide, die diese verbindungen enthalten
WO1999029695A1 (en) *	1997-12-05	1999-06-17	Astrazeneca Uk Limited	Novel compounds
US6469014B1 (en) *	1997-05-28	2002-10-22	Astrazeneca Ab	Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
SE9702001D0 (sv) *	1997-05-28	1997-05-28	Astra Pharma Prod	Novel compounds
US6232320B1 (en) *	1998-06-04	2001-05-15	Abbott Laboratories	Cell adhesion-inhibiting antiinflammatory compounds
PT1107973E (pt)	1998-08-28	2004-03-31	Astrazeneca Ab	Novas tieno¬2,3-d\| pirimidinodionas processo para a sua preparacao e sua utilizacao em terapia
GB0117583D0 (en)	2001-07-19	2001-09-12	Astrazeneca Ab	Novel compounds
GB0118479D0 (en)	2001-07-28	2001-09-19	Astrazeneca Ab	Novel compounds
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
PL378221A1 (pl) *	2003-01-17	2006-03-20	Astrazeneca Ab	Tienopirydazynony i ich zastosowanie w modulacji choroby autoimmunologicznej
SE0300120D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds

2003
- 2003-01-17 SE SE0300120A patent/SE0300120D0/xx unknown
2004
- 2004-01-15 MX MXPA05007494A patent/MXPA05007494A/es active IP Right Grant
- 2004-01-15 KR KR1020057013124A patent/KR20050092759A/ko not_active Abandoned
- 2004-01-15 BR BR0406780-0A patent/BRPI0406780A/pt not_active IP Right Cessation
- 2004-01-15 EP EP04702471A patent/EP1587809B1/de not_active Expired - Lifetime
- 2004-01-15 UA UAA200506375A patent/UA80175C2/uk unknown
- 2004-01-15 DE DE602004009407T patent/DE602004009407T2/de not_active Expired - Lifetime
- 2004-01-15 CA CA002512736A patent/CA2512736A1/en not_active Abandoned
- 2004-01-15 PL PL378223A patent/PL378223A1/pl unknown
- 2004-01-15 AT AT04702471T patent/ATE375352T1/de not_active IP Right Cessation
- 2004-01-15 AU AU2004205617A patent/AU2004205617B2/en not_active Ceased
- 2004-01-15 JP JP2006500749A patent/JP4589298B2/ja not_active Expired - Fee Related
- 2004-01-15 CN CNB2004800071016A patent/CN100358900C/zh not_active Expired - Fee Related
- 2004-01-15 WO PCT/SE2004/000051 patent/WO2004065393A1/en not_active Ceased
- 2004-01-15 ES ES04702471T patent/ES2293208T3/es not_active Expired - Lifetime
- 2004-01-15 NZ NZ541216A patent/NZ541216A/en not_active IP Right Cessation
- 2004-01-15 US US10/542,194 patent/US7064126B2/en not_active Expired - Fee Related
- 2004-01-15 RU RU2005121493/04A patent/RU2331646C2/ru not_active IP Right Cessation
2005
- 2005-06-23 IL IL169363A patent/IL169363A/en not_active IP Right Cessation
- 2005-06-29 ZA ZA200505273A patent/ZA200505273B/xx unknown
- 2005-08-15 NO NO20053827A patent/NO20053827L/no not_active Application Discontinuation
- 2005-08-15 IS IS7982A patent/IS2503B/is unknown
2006
- 2006-06-06 US US11/447,343 patent/US20060223809A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BRPI0406780A (pt)	2006-01-17
DE602004009407T2 (de)	2008-07-24
WO2004065393A1 (en)	2004-08-05
EP1587809A1 (de)	2005-10-26
KR20050092759A (ko)	2005-09-22
IL169363A0 (en)	2007-07-04
US7064126B2 (en)	2006-06-20
IS7982A (is)	2005-08-15
UA80175C2 (en)	2007-08-27
RU2005121493A (ru)	2006-02-20
MXPA05007494A (es)	2005-09-21
EP1587809B1 (de)	2007-10-10
CN100358900C (zh)	2008-01-02
IL169363A (en)	2011-02-28
CA2512736A1 (en)	2004-08-05
AU2004205617A1 (en)	2004-08-05
IS2503B (is)	2009-04-15
HK1081958A1 (en)	2006-05-26
CN1761670A (zh)	2006-04-19
SE0300120D0 (sv)	2003-01-17
JP2006515373A (ja)	2006-05-25
PL378223A1 (pl)	2006-03-20
JP4589298B2 (ja)	2010-12-01
ES2293208T3 (es)	2008-03-16
US20060223809A1 (en)	2006-10-05
RU2331646C2 (ru)	2008-08-20
NO20053827D0 (no)	2005-08-15
AU2004205617B2 (en)	2007-03-08
US20060052380A1 (en)	2006-03-09
ZA200505273B (en)	2006-04-26
NZ541216A (en)	2008-05-30
DE602004009407D1 (de)	2007-11-22
NO20053827L (no)	2005-10-17

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Date	Code	Title	Description
2008-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE375352T1 (de)	2007-10-15	Thienopyridazinon-derivate als modulatoren von autoimmunkrankheiten
IS2598B (is)	2010-03-15	Þíenópýrimidíndíón og notkun þeirra í mótun sjálfnæmissjúkdóma
MXPA05007496A (es)	2005-09-21	Tienopirimidindionas y su uso en la modulacion de enfermedades autoinmunes.
EA200600811A1 (ru)	2006-10-27	НОВЫЕ ПРОИЗВОДНЫЕ ТЕТРАГИДРОСПИРО {ПИПЕРИДИН-2,7'-ПИРРОЛО [3,2-b]ПИРИДИНА} И НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ПРИМЕНЕНИЕ ДЛЯ ЛЕЧЕНИЯ РАССТРОЙСТВ, СВЯЗАННЫХ С 5-HT-РЕЦЕПТОРОМ
EA200600892A1 (ru)	2006-12-29	Новые хинолиновые производные
DE60041973D1 (de)	2009-05-20	Substituierte piperidin-verbindungen als modulatoren der chemokine receptor aktivität
HUP0500543A2 (hu)	2005-09-28	Piridonszármazékok mint aP2 inhibitorok és a vegyületeket tartalmazó gyógyszerkészítmények
NO305209B1 (no)	1999-04-19	N-alkyl-2-substituerte ATP-analoger, slike forbindelser til fremstilling av terapeutikum, farmas°ytisk preparat inneholdende slike forbindelser, og deres anvendelse
ATE390421T1 (de)	2008-04-15	Aminoheterocyclen als vr-1 antagonisten zur behandlung von schmerzen
ATE334988T1 (de)	2006-08-15	Thieno 2,3-döpyrimidinediones als inhibitoren von t-zellen-proliferation
ATE90089T1 (de)	1993-06-15	Heterocyclische verbindungen mit therapeutischer wirkung.
MXPA03011638A (es)	2004-04-02	Nuevos derivados de 4-piperazinil indol con afinidad por el receptor 5-ht6.
HUP0402307A2 (hu)	2005-02-28	Kisméretű szerves molekulák a sejtproliferáció szabályozásához és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0203971A2 (hu)	2003-03-28	Imidazoimidazolok és -triazolok mint gyulladásellenes szerek és ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
HUP0500096A2 (hu)	2005-05-30	Kondenzált heterociklusos vegyületek és analógjaik mint a nukleáris hormon receptor funkció modulátorai, eljárás előállításukra és ezeket hatóanyagként tartalmazó gyógyszerkészítmények
AR035235A1 (es)	2004-05-05	Derivados heterocicliloxi-,-tioxi- y -aminobenzazol como ligandos de 5-hidroxitriptamina-6, un procedimiento para su preparacion, composicion farmaceutica, y el uso de dichos derivados para la manufactura de un medicamento
EA200601194A1 (ru)	2006-10-27	Новые производные бензофурана, используемые для профилактики или лечения нарушений, связанных с 5-ht-рецептором
ES2196308T3 (es)	2003-12-16	Derivado de 2-cianoiminoimidazol que inhiben la pde iv.
BR9812239A (pt)	2000-07-18	Composto, formulação farmacêutica, uso do composto, processos para o tratamento de distúrbios, para o tratamento de distúrbios mediados por 5-hidroxitriptamina, e, para a preparação do composto
EA200100090A2 (ru)	2001-08-27	Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
EA200001101A1 (ru)	2001-06-25	НОВЫЕ ДИГИДРОФУРО[3,4-b]ХИНОЛИН-1-ОНЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
BR0313000A (pt)	2005-07-12	Compostos, composição farmacêutica e método para efetuar a inibição da enzima pde4, realçar a cognição e/ou tratar a psicose em um paciente
DE60309206D1 (de)	2006-11-30	Neue piperidinderivate als modulatoren vonchemokinrezeptor ccr5
DE69825879D1 (de)	2004-09-30	Pharmazeutische zusammensetzungen welche aryl-substituierte olefinische amin-verbindungen enthalten
DK1178047T3 (da)	2004-05-24	Diazabicyclooctanderivater og terapeutiske anvendelser deraf