ATE375810T1 - Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer - Google Patents
Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmerInfo
- Publication number
- ATE375810T1 ATE375810T1 AT04779377T AT04779377T ATE375810T1 AT E375810 T1 ATE375810 T1 AT E375810T1 AT 04779377 T AT04779377 T AT 04779377T AT 04779377 T AT04779377 T AT 04779377T AT E375810 T1 ATE375810 T1 AT E375810T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- malonyl
- useful
- prophylaxis
- management
- Prior art date
Links
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical class NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 title 1
- 108010081805 Malonyl-CoA decarboxylase Proteins 0.000 title 1
- 102100029461 Malonyl-CoA decarboxylase, mitochondrial Human genes 0.000 title 1
- 239000003954 decarboxylase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000007726 management method Methods 0.000 abstract 3
- 238000011321 prophylaxis Methods 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 230000004129 fatty acid metabolism Effects 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000004153 glucose metabolism Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49210003P | 2003-08-01 | 2003-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE375810T1 true ATE375810T1 (de) | 2007-11-15 |
Family
ID=34115594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04779377T ATE375810T1 (de) | 2003-08-01 | 2004-07-28 | Cyanoamid-verbindungen als nützliche malonyl-coa decarboxylase-hemmer |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7285562B2 (de) |
| EP (1) | EP1648564B1 (de) |
| JP (1) | JP4727579B2 (de) |
| AT (1) | ATE375810T1 (de) |
| CA (1) | CA2533763C (de) |
| DE (1) | DE602004009582T2 (de) |
| ES (1) | ES2295930T3 (de) |
| WO (1) | WO2005011812A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7709510B2 (en) * | 2001-02-20 | 2010-05-04 | Chugai Seiyaku Kabushiki Kaisha | Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| NZ526883A (en) * | 2001-02-20 | 2005-11-25 | Chugai Pharmaceutical Co Ltd | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
| CN1964630A (zh) * | 2003-02-13 | 2007-05-16 | 耶希瓦大学艾伯塔·爱恩斯坦医学院 | 通过控制下丘脑的长链脂肪酰基－辅酶A(LC－CoA)的水平来调控食物摄取和葡萄糖产生 |
| EP2208495B1 (de) * | 2003-08-01 | 2011-12-14 | Chugai Seiyaku Kabushiki Kaisha | Azol-Verbindungen auf Cyanoguanidin-Basis als Malonyl-Coa Decarboxylase-Hemmer |
| CA2533749C (en) * | 2003-08-01 | 2012-07-10 | Chugai Seiyaku Kabushiki Kaisha | Piperidine compounds useful as malonyl-coa decarboxylase inhibitors |
| WO2005011812A1 (en) * | 2003-08-01 | 2005-02-10 | Chugai Seiyaku Kabushiki Kaisha | Cyanoamide compounds useful as malonyl-coa decarboxylase inhibithors |
| JP4727578B2 (ja) * | 2003-08-01 | 2011-07-20 | 中外製薬株式会社 | マロニル−ＣｏＡデカルボキシラーゼ阻害剤として有用な複素環式化合物 |
| WO2006041922A2 (en) * | 2004-10-08 | 2006-04-20 | Dara Biosciences, Inc. | Agents and methods for administration to the central nervous system |
| US20090012067A1 (en) * | 2005-02-14 | 2009-01-08 | Luciano Rossetti | Modulation of Hypothalamic Atp-Sensitive Potassium Channels |
| ATE485804T1 (de) * | 2007-03-15 | 2010-11-15 | Ivoclar Vivadent Ag | Dentalmaterialien auf der basis von radikalisch polymerisationsfähigen, n,o-funktionalisierten acrylsäure-hydroxamiden |
| US20130035325A1 (en) | 2009-11-16 | 2013-02-07 | The Regents Of The University Of California | Kinase inhibitors |
| PL2710005T3 (pl) | 2011-05-17 | 2017-07-31 | Principia Biopharma Inc. | Inhibitory kinazy tyrozynowej |
| WO2012158795A1 (en) | 2011-05-17 | 2012-11-22 | Principia Biopharma Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
| ES2770550T3 (es) * | 2011-05-17 | 2020-07-02 | Univ California | Inhibidores de quinasa |
| SI2892900T1 (en) | 2012-09-10 | 2018-01-31 | Principia Biopharma Inc. | Pyrazolopyrimidine compounds as kinase inhibitors |
| US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| CN112353806A (zh) | 2014-02-21 | 2021-02-12 | 普林斯匹亚生物制药公司 | Btk抑制剂的盐和固体形式 |
| CN105461722B (zh) * | 2014-09-04 | 2019-05-10 | 欣凯医药化工中间体（上海）有限公司 | 一种脱氮嘌呤类化合物及其衍生物及其制备方法和应用 |
| SG11201704808VA (en) | 2014-12-18 | 2017-07-28 | Principia Biopharma Inc | Treatment of pemphigus |
| WO2016210165A1 (en) | 2015-06-24 | 2016-12-29 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
| CN115054586B (zh) | 2016-06-29 | 2024-08-02 | 普林斯匹亚生物制药公司 | 改性的释放制剂 |
| US20210106584A1 (en) | 2019-10-14 | 2021-04-15 | Principia Biopharma Inc. | Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| US11814390B2 (en) | 2020-01-22 | 2023-11-14 | Principia Biopharma Inc. | Crystalline forms of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)-1H-pyrazolo[3,4-D]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| KR20220163285A (ko) | 2021-06-01 | 2022-12-09 | 주식회사 에즈큐리스 | Il-33단백질 저해용 화합물의 스크리닝 방법 및 상기 화합물을 포함하는 알러지성 질환 치료용 약학조성물 |
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| FR2784114B1 (fr) | 1998-09-18 | 2001-02-02 | Thomson Csf | Materiaux polymeres absorbant les composes organophosphores. procede de synthese de ces materiaux. capteurs chimiques comprenant ces materiaux |
| EP1034196B1 (de) | 1998-10-05 | 2005-01-12 | Promerus LLC | Katalysator und verfahren zur polymerisation von cycloolefinen |
| WO2000034344A1 (en) | 1998-12-09 | 2000-06-15 | The B.F.Goodrich Company | In mold addition polymerization of norbornene-type monomers using group 10 metal complexes |
| JP2002533318A (ja) | 1998-12-22 | 2002-10-08 | ニューロサーチ、アクティーゼルスカブ | イオンチャネル調節剤 |
| AU2871900A (en) | 1999-02-04 | 2000-08-25 | Millennium Pharmaceuticals, Inc. | G-protein coupled heptahelical receptor binding compounds and methods of use thereof |
| GB9904933D0 (en) | 1999-03-04 | 1999-04-28 | Glaxo Group Ltd | Compounds |
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| JP2004500332A (ja) | 1999-07-08 | 2004-01-08 | テュラリク インコーポレイテッド | Ｈｄｌコレステロール値を上昇させる組成物および方法 |
| KR100637564B1 (ko) * | 2001-01-26 | 2006-10-20 | 추가이 세이야쿠 가부시키가이샤 | 대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제 |
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| ES2274005T3 (es) | 2001-01-26 | 2007-05-16 | Chugai Seiyaku Kabushiki Kaisha | Inhibidores de malonyl-coa decarboxilasa usados como moduladores metabolicos. |
| NZ526883A (en) * | 2001-02-20 | 2005-11-25 | Chugai Pharmaceutical Co Ltd | Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators |
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-
2004
- 2004-07-28 WO PCT/US2004/024311 patent/WO2005011812A1/en not_active Ceased
- 2004-07-28 US US10/900,957 patent/US7285562B2/en not_active Expired - Fee Related
- 2004-07-28 CA CA2533763A patent/CA2533763C/en not_active Expired - Fee Related
- 2004-07-28 JP JP2006522611A patent/JP4727579B2/ja not_active Expired - Fee Related
- 2004-07-28 AT AT04779377T patent/ATE375810T1/de not_active IP Right Cessation
- 2004-07-28 DE DE602004009582T patent/DE602004009582T2/de not_active Expired - Lifetime
- 2004-07-28 ES ES04779377T patent/ES2295930T3/es not_active Expired - Lifetime
- 2004-07-28 EP EP04779377A patent/EP1648564B1/de not_active Expired - Lifetime
-
2007
- 2007-10-02 US US11/866,266 patent/US7897615B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7897615B2 (en) | 2011-03-01 |
| DE602004009582D1 (de) | 2007-11-29 |
| EP1648564B1 (de) | 2007-10-17 |
| DE602004009582T2 (de) | 2009-01-02 |
| CA2533763C (en) | 2012-11-20 |
| US20050026945A1 (en) | 2005-02-03 |
| EP1648564A1 (de) | 2006-04-26 |
| US20080161358A1 (en) | 2008-07-03 |
| ES2295930T3 (es) | 2008-04-16 |
| WO2005011812A1 (en) | 2005-02-10 |
| JP2007501233A (ja) | 2007-01-25 |
| US7285562B2 (en) | 2007-10-23 |
| JP4727579B2 (ja) | 2011-07-20 |
| CA2533763A1 (en) | 2005-02-10 |
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