ATE375987T1 - Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel - Google Patents

Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel

Info

Publication number
ATE375987T1
ATE375987T1 AT00962760T AT00962760T ATE375987T1 AT E375987 T1 ATE375987 T1 AT E375987T1 AT 00962760 T AT00962760 T AT 00962760T AT 00962760 T AT00962760 T AT 00962760T AT E375987 T1 ATE375987 T1 AT E375987T1
Authority
AT
Austria
Prior art keywords
arylmethyl
carbonylamino
tumor agents
thiazole derivatives
thiazole
Prior art date
Application number
AT00962760T
Other languages
English (en)
Inventor
Paolo Pevarello
Raffaella Amici
Manuela Villa
Barbara Salom
Anna Vulpetti
Mario Varasi
Original Assignee
Pfizer Italia Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Italia Srl filed Critical Pfizer Italia Srl
Application granted granted Critical
Publication of ATE375987T1 publication Critical patent/ATE375987T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
AT00962760T 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel ATE375987T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/372,832 US6114365A (en) 1999-08-12 1999-08-12 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents

Publications (1)

Publication Number Publication Date
ATE375987T1 true ATE375987T1 (de) 2007-11-15

Family

ID=23469806

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00962760T ATE375987T1 (de) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel

Country Status (36)

Country Link
US (3) US6114365A (de)
EP (1) EP1204649B1 (de)
JP (1) JP4864260B2 (de)
KR (2) KR100827563B1 (de)
CN (1) CN100410245C (de)
AP (1) AP1853A (de)
AT (1) ATE375987T1 (de)
AU (1) AU782882B2 (de)
BG (1) BG65484B1 (de)
BR (1) BR0013281A (de)
CA (1) CA2381097C (de)
CY (1) CY1107108T1 (de)
CZ (1) CZ303138B6 (de)
DE (1) DE60036803T2 (de)
DK (1) DK1204649T3 (de)
EA (1) EA005375B1 (de)
EE (1) EE04939B1 (de)
ES (1) ES2295056T3 (de)
GE (1) GEP20053475B (de)
HK (1) HK1054233B (de)
HR (1) HRP20020127B1 (de)
HU (1) HUP0202492A3 (de)
IL (2) IL147924A0 (de)
IS (1) IS2594B (de)
MA (1) MA25433A1 (de)
MX (1) MXPA02001508A (de)
NO (1) NO323576B1 (de)
NZ (1) NZ517236A (de)
OA (1) OA12047A (de)
PT (1) PT1204649E (de)
RS (1) RS50300B (de)
SI (1) SI1204649T1 (de)
SK (1) SK287373B6 (de)
UA (1) UA72538C2 (de)
WO (1) WO2001014353A1 (de)
ZA (1) ZA200201117B (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6407103B2 (en) 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6610846B1 (en) * 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
US6320050B1 (en) * 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
PL215901B1 (pl) 1999-04-15 2014-02-28 Bristol Myers Squibb Co Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
AU2002215053A1 (en) * 2000-11-27 2002-06-24 Pharmacia Italia S.P.A. Phenylacetamido- pyrazole derivatives and their use as antitumor agents
WO2002044174A2 (en) * 2000-12-01 2002-06-06 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno[1,2-c]pyrazol-4-one derivatives as cdk inhibitors
US6849631B2 (en) 2000-12-08 2005-02-01 Bristol Myers Squibb Pharma Company Semicarbazides and their uses
CA2433018A1 (en) * 2000-12-21 2002-06-27 Joel C. Barrish Thiazolyl inhibitors of tec family tyrosine kinases
EP1256578B1 (de) * 2001-05-11 2006-01-11 Pfizer Products Inc. Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
ATE345341T1 (de) * 2001-07-19 2006-12-15 Pfizer Italia Srl Phenylacetamido-thiazole verbindungen, verfahren zu ihren herstellung und ihre anwendung als antitumor mittel
EP1724270A3 (de) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole Verbindungen, Verfahren zu ihren Herstellung und ihre Anwendung als antitumor Mittel
EP1436286B1 (de) * 2001-09-27 2009-08-19 Equispharm Co., Ltd. Fumagillolderivate und verfahren zu deren herstellung
WO2003055482A1 (en) * 2001-12-21 2003-07-10 Novo Nordisk A/S Amide derivatives as gk activators
BR0312023A (pt) * 2002-06-27 2005-03-22 Novo Nordisk As Composto, composto ativador da glicose cinase, método para evitar a hipoglicemia, uso de um composto, e, composição farmacêutica
FR2850380B1 (fr) * 2003-01-23 2006-07-07 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
WO2004072070A1 (en) * 2003-02-12 2004-08-26 Pfizer Inc. Antiproliferative 2-(sulfo-phenyl)-aminothiazole derivatives
JP2006518368A (ja) * 2003-02-21 2006-08-10 ファイザー・インク プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体
JP4758337B2 (ja) * 2003-03-31 2011-08-24 株式会社アールテック・ウエノ 血管透過性亢進疾患を治療する方法
WO2005014591A1 (en) * 2003-07-15 2005-02-17 L'oreal 2-acylamino or 2-sulfonylamino-1, 3-thiazoles as couplers for the oxidation dyeing of keratin fibres
FR2857664B1 (fr) * 2003-07-15 2007-12-14 Oreal Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques
US7351727B2 (en) * 2003-09-02 2008-04-01 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
US20050074424A1 (en) * 2003-10-03 2005-04-07 Lev Salnikov Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method
WO2005060956A1 (en) * 2003-12-12 2005-07-07 University Of Maryland, Baltimore IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
JP4834840B2 (ja) * 2004-01-06 2011-12-14 ノヴォ ノルディスク アー／エス ヘテロアリール尿素およびグルコキナーゼ活性化剤としてのその使用
NZ548531A (en) * 2004-01-16 2010-01-29 Sanofi Aventis Acylaminothiazole derivatives, preparation method thereof and use of same in therapeutics
EP2298291A3 (de) 2004-06-18 2011-08-03 Agennix USA Inc. Kinasehemmer zur Behandlung von Krebs
EP1621536A1 (de) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren
EP1621539A1 (de) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren
SG155222A1 (en) * 2004-08-13 2009-09-30 Genentech Inc Thiazole based inhibitors of atp-utilizing enzymes
EP1674457B1 (de) 2004-12-23 2009-06-03 GPC Biotech AG Quadratsäurederivate mit antiproliferativer Wirkung
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
ES2382815T3 (es) * 2005-07-08 2012-06-13 Novo Nordisk A/S Dicicloalquilcarbamoil ureas como activadores de glucoquinasa
US7884210B2 (en) 2005-07-14 2011-02-08 Novo Nordisk A/S Ureido-thiazole glucokinase activators
EP1914234A1 (de) * 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidinen und ihre Verwendung als kinase Inhibitoren
WO2008084043A1 (en) * 2007-01-09 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
WO2008084044A1 (en) 2007-01-11 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
NZ578944A (en) * 2007-02-13 2011-03-31 Ab Science PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS SUCH AS 4-(4-Methyl-piperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-phenyl]-benzamide AS KINASE INHIBITORS
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
WO2009151683A2 (en) 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2112152A1 (de) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones als Plk-Inhibitoren
EP2112150B1 (de) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Verbesserte Raf-Inhibitoren
JP2012508768A (ja) 2008-11-13 2012-04-12 リンク・メディスン・コーポレーション アザキノリノン誘導体及びその使用
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
AR075899A1 (es) * 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
EP2440556A1 (de) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Phosphatidylinositol 3-kinasehemmer
DE102009043260A1 (de) * 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
EP2325185A1 (de) 2009-10-28 2011-05-25 GPC Biotech AG Plk-Inhibitor
HU0900798D0 (en) 2009-12-21 2010-03-01 Vichem Chemie Kutato Kft 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
US8883793B2 (en) 2010-12-29 2014-11-11 Development Center For Biotechnology Tubulin inhibitors and methods of using the same
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
CN103387551B (zh) * 2012-05-11 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 噻唑类化合物及其用途
BR112015003655A2 (pt) 2012-08-23 2017-07-04 Virostatics Srl composto; uso de um composto; e composição farmacêutica
EA202191466A1 (ru) 2016-04-11 2021-12-31 Женфит Способы лечения холестатических и фибротических заболеваний
EP3720436A4 (de) 2017-12-06 2021-06-02 Lin Bioscience, Pty Ltd. Tubulinhemmer
WO2019148244A1 (en) * 2018-02-01 2019-08-08 The University Of Sydney Anti-cancer compounds
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
EP3712127A1 (de) 2019-03-22 2020-09-23 Deutsches Krebsforschungszentrum Neuartige inhibitoren der histon-deacetylase 10
JP2022524887A (ja) 2019-03-22 2022-05-10 ドイチェス クレブスフォルシュングスツェントルム ヒストンデアセチラーゼ１０の新規の阻害剤
JP2022550109A (ja) * 2019-09-25 2022-11-30 コリア インスティチュート オブ レディオロジカル アンド メディカル サイエンシズ 新規なトリフルオロメチルフェニルピラゾール誘導体を有効成分として含有する癌の予防または治療用組成物
WO2021162054A1 (ja) * 2020-02-10 2021-08-19 学校法人順天堂 ２型リアノジン受容体活性抑制剤
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CN115322208B (zh) * 2021-05-10 2023-04-11 中国药科大学 2-氨基噻唑类衍生物及其制备方法和医药用途
AU2023239988A1 (en) * 2022-03-22 2024-10-10 Autotelic Bio Inc. Thiazole derivative compound and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1252204B (de) * 1960-04-20 1967-10-19 Ortho Pharmaceutical Corporation, Raritan, N. J. (V. St. A.) Verfahren zur Herstellung von 2,4-Dinitropyrrolderivaten
JPH1095777A (ja) * 1996-07-31 1998-04-14 Otsuka Pharmaceut Co Ltd チアゾール誘導体
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
NZ503788A (en) * 1997-10-27 2002-11-26 Agouron Pharma 4-aminothiazole derivatives and their use as inhibitors of cyclin-dependent kinases
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
CA2332325A1 (en) * 1998-06-18 1999-12-23 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
PL215901B1 (pl) * 1999-04-15 2014-02-28 Bristol Myers Squibb Co Cykliczny inhibitor bialkowych kinaz tyrozynowych, jego zastosowanie oraz kompozycja farmaceutyczna zawierajaca taki zwiazek
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6992081B2 (en) * 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
SE0102440D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compound
EP1321463B1 (de) * 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren
EP1587800A1 (de) * 2003-01-27 2005-10-26 Astellas Pharma Inc. Thiazolderivate und ihre verwendung als vap-1 inhibitoren

Also Published As

Publication number Publication date
CZ303138B6 (cs) 2012-04-25
HRP20020127A2 (en) 2003-04-30
IS6264A (is) 2002-02-11
EA005375B1 (ru) 2005-02-24
US6114365A (en) 2000-09-05
CN1425009A (zh) 2003-06-18
OA12047A (en) 2006-05-02
MA25433A1 (fr) 2002-04-01
SI1204649T1 (sl) 2008-02-29
NZ517236A (en) 2004-11-26
PT1204649E (pt) 2008-01-10
YU9702A (sh) 2004-11-25
WO2001014353A1 (en) 2001-03-01
PL353588A1 (en) 2003-12-01
DK1204649T3 (da) 2007-12-03
RS50300B (sr) 2009-09-08
KR100827563B1 (ko) 2008-05-07
KR20020060159A (ko) 2002-07-16
BG106481A (en) 2002-09-30
HUP0202492A3 (en) 2004-12-28
IS2594B (is) 2010-03-15
IL147924A0 (en) 2002-08-14
EP1204649B1 (de) 2007-10-17
EE200200064A (et) 2003-04-15
MXPA02001508A (es) 2003-07-21
US20050004120A1 (en) 2005-01-06
EE04939B1 (et) 2007-12-17
AP2002002441A0 (en) 2002-03-31
HK1054233A1 (zh) 2003-11-21
ES2295056T3 (es) 2008-04-16
KR100773709B1 (ko) 2007-11-09
AU7440000A (en) 2001-03-19
US6784198B1 (en) 2004-08-31
JP4864260B2 (ja) 2012-02-01
JP2003507461A (ja) 2003-02-25
AP1853A (en) 2008-05-29
UA72538C2 (en) 2005-03-15
KR20070074003A (ko) 2007-07-10
DE60036803D1 (de) 2007-11-29
NO323576B1 (no) 2007-06-11
CZ2002486A3 (cs) 2002-11-13
CA2381097C (en) 2009-06-16
SK1802002A3 (en) 2003-05-02
IL147924A (en) 2008-03-20
CY1107108T1 (el) 2012-10-24
BG65484B1 (bg) 2008-09-30
BR0013281A (pt) 2002-06-18
EP1204649A1 (de) 2002-05-15
HK1054233B (zh) 2009-05-29
EA200200247A1 (ru) 2002-08-29
GEP20053475B (en) 2005-03-25
HRP20020127B1 (en) 2010-08-31
CA2381097A1 (en) 2001-03-01
ZA200201117B (en) 2003-04-30
HUP0202492A2 (hu) 2002-11-28
SK287373B6 (sk) 2010-08-09
NO20020683D0 (no) 2002-02-11
AU782882B2 (en) 2005-09-08
NO20020683L (no) 2002-04-10
CN100410245C (zh) 2008-08-13
DE60036803T2 (de) 2008-07-24

Similar Documents

Publication Publication Date Title
ATE375987T1 (de) Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
DE60039539D1 (de) 4-aminopiperidin-derivate und ihre verwendung als arzneimittel
ATE299503T1 (de) Pyridin-3-carbonsäurederivate und ihre verwendung als zwischenprodukte
ATE348805T1 (de) 2-acyl-indolderivate und deren verwendung als antitumormittel
DE59710422D1 (de) Acylmercapto-triazolyl-derivate und ihre verwendung als mikrobizide
DE50008597D1 (de) Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel
DE69926800D1 (de) Benzoheterozyklen und ihre verwendung als mek inhibitoren
DE59710580D1 (de) Thiocyano-triazolyl-derivate und ihre verwendung als mikrobizide
ATE254123T1 (de) Benzazolderivate und ihre verwendung als jnk modulatoren
DE69836346D1 (de) Heteroaryl aminoguanidin- und alkoxyguanidinderivate und ihre verwendung als proteasehemmer
DE60031513D1 (de) Phenyl- und pyridinyl-derivate verwendbar als neurokinin-1-antagonisten
DE60139477D1 (de) 2-cyanopyrrolidin-derivate und ihre verwendung als arzneimittel
ATA5422000A (de) Oximderivate und ihre verwendung als latente säuren
EE200200251A (et) Uued N-asabitsükloamiidi derivaadid ja nende kasutamine
ATE279396T1 (de) Imidazolderivate und ihre verwendung als somatostatin rezeptorliganden
DE60001840D1 (de) Chinuclidin-derivate und deren verwendung als muscarin-m3-rezeptoren-liganden
DE69818248D1 (de) Chinolin- und chinazolin-derivate als crf antagonisten
DE60016326D1 (de) Wasser-absorbierende Zusammensetzung und ihre Verwendung
ATE332294T1 (de) Dihydro-1,3,5-triazin-diamin-derivate und ihre therapeutische verwendung
DE69826693D1 (de) Amidinoderivate und ihre verwendung als thrombininhibitoren
DE60032898D1 (de) Arylthiazolidindion- und aryloxazolidinderivate
DE60037183D1 (de) Neue amidinbenzylamin-derivate und ihre verwendung als thrombin-inhibitoren
ATE264315T1 (de) Aminothiazolderivate und ihre verwendung als crf- rezeptor-liganden
EE200200135A (et) D4 antagonistidena toimivad tienoisoksasolüül- jatienüülpürrasolüülfenoksü-asendatud propüülderivaadid
ATE221529T1 (de) Oxadiazolinderivate und ihre verwendung als insektizide

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1204649

Country of ref document: EP

EEIH Change in the person of patent owner