IS2594B - Arýlmetýl-kabónýlamínó-þíasólafleiður og notkun þeirra sem æxlishemjandi efni - Google Patents

Arýlmetýl-kabónýlamínó-þíasólafleiður og notkun þeirra sem æxlishemjandi efni

Info

Publication number
IS2594B
IS2594B IS6264A IS6264A IS2594B IS 2594 B IS2594 B IS 2594B IS 6264 A IS6264 A IS 6264A IS 6264 A IS6264 A IS 6264A IS 2594 B IS2594 B IS 2594B
Authority
IS
Iceland
Prior art keywords
cabonylamino
arylmethyl
antineoplastic agents
thiazole derivatives
thiazole
Prior art date
Application number
IS6264A
Other languages
English (en)
Other versions
IS6264A (is
Inventor
Paolo Pervarello
Raffaella Amici
Manuela Villa
Barbara Salom
Anna Vulpetti
Mario Barasi
Original Assignee
Pharmacia Italia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa
Publication of IS6264A publication Critical patent/IS6264A/is
Publication of IS2594B publication Critical patent/IS2594B/is

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
IS6264A 1999-08-12 2002-02-11 Arýlmetýl-kabónýlamínó-þíasólafleiður og notkun þeirra sem æxlishemjandi efni IS2594B (is)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/372,832 US6114365A (en) 1999-08-12 1999-08-12 Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
PCT/IB2000/001423 WO2001014353A1 (en) 1999-08-12 2000-08-11 Arylmethyl-carbonylamino-thiazole derivatives and their use as antitumor agents

Publications (2)

Publication Number Publication Date
IS6264A IS6264A (is) 2002-02-11
IS2594B true IS2594B (is) 2010-03-15

Family

ID=23469806

Family Applications (1)

Application Number Title Priority Date Filing Date
IS6264A IS2594B (is) 1999-08-12 2002-02-11 Arýlmetýl-kabónýlamínó-þíasólafleiður og notkun þeirra sem æxlishemjandi efni

Country Status (36)

Country Link
US (3) US6114365A (is)
EP (1) EP1204649B1 (is)
JP (1) JP4864260B2 (is)
KR (2) KR100827563B1 (is)
CN (1) CN100410245C (is)
AP (1) AP1853A (is)
AT (1) ATE375987T1 (is)
AU (1) AU782882B2 (is)
BG (1) BG65484B1 (is)
BR (1) BR0013281A (is)
CA (1) CA2381097C (is)
CY (1) CY1107108T1 (is)
CZ (1) CZ303138B6 (is)
DE (1) DE60036803T2 (is)
DK (1) DK1204649T3 (is)
EA (1) EA005375B1 (is)
EE (1) EE04939B1 (is)
ES (1) ES2295056T3 (is)
GE (1) GEP20053475B (is)
HK (1) HK1054233B (is)
HR (1) HRP20020127B1 (is)
HU (1) HUP0202492A3 (is)
IL (2) IL147924A0 (is)
IS (1) IS2594B (is)
MA (1) MA25433A1 (is)
MX (1) MXPA02001508A (is)
NO (1) NO323576B1 (is)
NZ (1) NZ517236A (is)
OA (1) OA12047A (is)
PT (1) PT1204649E (is)
RS (1) RS50300B (is)
SI (1) SI1204649T1 (is)
SK (1) SK287373B6 (is)
UA (1) UA72538C2 (is)
WO (1) WO2001014353A1 (is)
ZA (1) ZA200201117B (is)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150921A1 (en) * 1996-02-09 2002-10-17 Francis Barany Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6407103B2 (en) 1998-04-21 2002-06-18 Bristol-Myers Squibb Pharma Company Indeno [1,2-c] pyrazol-4-ones and their uses
US6320050B1 (en) * 1999-03-29 2001-11-20 Hoffmann-La Roche Inc. Heteroaromatic glucokinase activators
US6610846B1 (en) * 1999-03-29 2003-08-26 Hoffman-La Roche Inc. Heteroaromatic glucokinase activators
US7125875B2 (en) * 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
PT1169038E (pt) 1999-04-15 2012-10-26 Bristol Myers Squibb Co Inibidores cíclicos da proteína tirosina cinase
US6114365A (en) * 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US20040048844A1 (en) * 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
US6291504B1 (en) 1999-10-20 2001-09-18 Dupont Pharmaceuticals Company Acylsemicarbazides and their uses
US20040019046A1 (en) * 2000-11-27 2004-01-29 Paolo Pevarello Phenylacetamido-pyrazole derivatives and their use as antitumor agents
AU2002228692A1 (en) * 2000-12-01 2002-06-11 Bristol-Myers Squibb Pharma Company 3-(2,4-dimethylthiazol-5-yl) indeno(1,2-c)pyrazol-4-one derivatives as cdk inhibitors
JP2004538247A (ja) 2000-12-08 2004-12-24 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー セミカルバジド及びサイクリン依存キナーゼ阻害剤
ES2257461T3 (es) 2000-12-21 2006-08-01 Bristol-Myers Squibb Company Inhibidores de tiazolilo de tirosina quinasas de la familia tec.
DE60208630T2 (de) 2001-05-11 2006-08-17 Pfizer Products Inc., Groton Thiazolderivate und ihre Verwendung als cdk-Inhibitoren
EP1724270A3 (en) 2001-07-19 2007-01-03 Pfizer Italia S.r.l. Phenylacetamido-thiazole derivatives, process for their preparation and their use as antitumor agents
CZ2004107A3 (cs) * 2001-07-19 2004-04-14 Pharmacia Italia S. P. A. Fenylacetamido-thiazolové deriváty, způsob jejich přípravy a jejich použití jako protinádorových farmaceutických prostředků
ATE440094T1 (de) * 2001-09-27 2009-09-15 Equispharm Co Ltd Fumagillolderivate und verfahren zu deren herstellung
RU2374236C2 (ru) * 2001-12-21 2009-11-27 Ново Нордиск А/С Амидные производные в качестве активаторов gk
AU2003243921B2 (en) * 2002-06-27 2009-05-07 Novo Nordisk A/S Aryl carbonyl derivatives as therapeutic agents
FR2850380B1 (fr) * 2003-01-23 2006-07-07 Sanofi Synthelabo Derives d'acylaminothiazole, leur preparation et leur utilisation en therapeutique
JP2006517577A (ja) * 2003-02-12 2006-07-27 ファイザー・インク 抗増殖性の２−（スルホ−フェニル）−アミノチアゾール誘導体
EP1597256A1 (en) * 2003-02-21 2005-11-23 Pfizer Inc. N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors
CN1794988B (zh) * 2003-03-31 2010-07-28 株式会社·R-技术上野 用于治疗血管渗透性过高疾病的组合物
WO2005014591A1 (en) * 2003-07-15 2005-02-17 L'oreal 2-acylamino or 2-sulfonylamino-1, 3-thiazoles as couplers for the oxidation dyeing of keratin fibres
FR2857664B1 (fr) * 2003-07-15 2007-12-14 Oreal Nouveaux derives thiazoles et utilisation de ces derives pour la teinture des fibres keratiniques
US7351727B2 (en) * 2003-09-02 2008-04-01 Bristol-Myers Squibb Company Inhibitors of 15-lipoxygenase
US20050074424A1 (en) * 2003-10-03 2005-04-07 Lev Salnikov Using polyion polymers with glucose infusion for a cancer selective chemotherapy compound and method
WO2005060956A1 (en) * 2003-12-12 2005-07-07 University Of Maryland, Baltimore IMMUNOMODULATORY COMPOUNDS THAT TARGET AND INHIBIT THE pY+3 BINDING SITE OF TYROSENE KINASE p56 LCK SH2 DOMAIN
WO2005066145A1 (en) 2004-01-06 2005-07-21 Novo Nordisk A/S Heteroaryl-ureas and their use as glucokinase activators
JP2007517840A (ja) * 2004-01-16 2007-07-05 サノフイ−アベンテイス アシルアミノチアゾール誘導体、それらの調製方法及び治療における該誘導体の使用
EP2298291A3 (en) 2004-06-18 2011-08-03 Agennix USA Inc. Kinase inhibitors for treating cancers
EP1621539A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
EP1621536A1 (en) * 2004-07-27 2006-02-01 Aventis Pharma S.A. Amino cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
ES2401138T3 (es) * 2004-08-13 2013-04-17 Genentech, Inc. Inhibidores basados en tiazol de enzimas que usan ATP
EP2096107A1 (en) 2004-12-23 2009-09-02 GPC Biotech AG Derivatives of squaric acid with anti-proliferative activity
US8541457B2 (en) * 2005-06-03 2013-09-24 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors
ES2382815T3 (es) * 2005-07-08 2012-06-13 Novo Nordisk A/S Dicicloalquilcarbamoil ureas como activadores de glucoquinasa
US7884210B2 (en) 2005-07-14 2011-02-08 Novo Nordisk A/S Ureido-thiazole glucokinase activators
EP1914234A1 (en) * 2006-10-16 2008-04-23 GPC Biotech Inc. Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
US8138185B2 (en) * 2007-01-09 2012-03-20 Novo Nordisk A/S Urea glucokinase activators
US8318778B2 (en) * 2007-01-11 2012-11-27 Novo Nordisk A/S Urea glucokinase activators
AU2008214679A1 (en) * 2007-02-13 2008-08-21 Ab Science Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
US8450348B2 (en) * 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
TWI437986B (zh) * 2008-01-31 2014-05-21 R Tech Ueno Ltd 噻唑衍生物及使用該衍生物作為ｖａｐ－１抑制劑之用途
US8232402B2 (en) 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
EP2112152A1 (en) 2008-04-22 2009-10-28 GPC Biotech AG Dihydropteridinones as Plk Inhibitors
EP2112150B1 (en) 2008-04-22 2013-10-16 Forma Therapeutics, Inc. Improved raf inhibitors
CA2743717A1 (en) 2008-11-13 2010-05-20 Link Medicine Corporation Azaquinolinone derivatives and uses thereof
UA103918C2 (en) * 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
TWI504598B (zh) * 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
EP2440556A1 (en) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
DE102009043260A1 (de) * 2009-09-28 2011-04-28 Merck Patent Gmbh Pyridinyl-imidazolonderivate
EP2325185A1 (en) 2009-10-28 2011-05-25 GPC Biotech AG Plk inhibitor
HU0900798D0 (en) 2009-12-21 2010-03-01 Vichem Chemie Kutato Kft 4-phenylamino-pyrimidine derivatives having protein kinase inhibitor activity
WO2012092471A2 (en) * 2010-12-29 2012-07-05 Development Center For Biotechnology Novel tubulin inhibitors and methods of using the same
RU2011122942A (ru) 2011-06-08 2012-12-20 Общество С Ограниченной Ответственностью "Асинэкс Медхим" Новые ингибиторы киназ
CN103387551B (zh) * 2012-05-11 2015-05-20 中国人民解放军军事医学科学院毒物药物研究所 噻唑类化合物及其用途
ES2661717T3 (es) 2012-08-23 2018-04-03 Virostatics Srl Derivados de aminopirimidina 4,6-disustituidos novedosos
SG10202004425XA (en) 2016-04-11 2020-06-29 Genfit Methods of treatment for cholestatic and fibrotic diseases
EP3720436A4 (en) 2017-12-06 2021-06-02 Lin Bioscience, Pty Ltd. TUBULIN INHIBITORS
CN111741944B (zh) * 2018-02-01 2025-01-03 悉尼大学 抗癌化合物
KR20210020866A (ko) 2018-06-12 2021-02-24 브이티브이 테라퓨틱스 엘엘씨 인슐린 또는 인슐린 유사체와 조합된 글루코키나제 활성제의 치료적 용도
JP2022524887A (ja) 2019-03-22 2022-05-10 ドイチェス クレブスフォルシュングスツェントルム ヒストンデアセチラーゼ１０の新規の阻害剤
EP3712127A1 (en) 2019-03-22 2020-09-23 Deutsches Krebsforschungszentrum Novel inhibitors of histone deacetylase 10
EP4015506A4 (en) * 2019-09-25 2023-08-30 Korea Institute of Radiological & Medical Sciences COMPOSITION FOR PREVENTING OR TREATING CANCER, CONTAINING A DERIVATIVE BASED ON TRIFLUOROMETHYLPHENYL PYRAZOLE AS ACTIVE PRINCIPLE
JP7720059B2 (ja) * 2020-02-10 2025-08-07 学校法人順天堂 ２型リアノジン受容体活性抑制剤
WO2021167840A1 (en) 2020-02-18 2021-08-26 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CN115322208B (zh) * 2021-05-10 2023-04-11 中国药科大学 2-氨基噻唑类衍生物及其制备方法和医药用途
US20250206730A1 (en) * 2022-03-22 2025-06-26 Autotelic Bio Inc. Thiazole derivative compound and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL263812A (is) * 1960-04-20
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
JPH1095777A (ja) * 1996-07-31 1998-04-14 Otsuka Pharmaceut Co Ltd チアゾール誘導体
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US6569878B1 (en) * 1997-10-27 2003-05-27 Agouron Pharmaceuticals Inc. Substituted 4-amino-thiazol-2-yl compounds as cyclin-dependent kinase inhibitors
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
CA2332325A1 (en) * 1998-06-18 1999-12-23 Bristol-Myers Squibb Company Carbon substituted aminothiazole inhibitors of cyclin dependent kinases
GB9823871D0 (en) * 1998-10-30 1998-12-23 Pharmacia & Upjohn Spa 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents
PT1169038E (pt) * 1999-04-15 2012-10-26 Bristol Myers Squibb Co Inibidores cíclicos da proteína tirosina cinase
US6114365A (en) 1999-08-12 2000-09-05 Pharmacia & Upjohn S.P.A. Arylmethyl-carbonylamino-thiazole derivatives, process for their preparation, and their use as antitumor agents
US6992081B2 (en) * 2000-03-23 2006-01-31 Elan Pharmaceuticals, Inc. Compounds to treat Alzheimer's disease
SE0102440D0 (sv) * 2001-07-05 2001-07-05 Astrazeneca Ab New compound
EP1321463B1 (en) * 2001-12-21 2007-08-08 Virochem Pharma Inc. Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections
TWI336696B (en) * 2003-01-27 2011-02-01 Astellas Pharma Inc Thiazole derivatives

Also Published As

Publication number Publication date
JP2003507461A (ja) 2003-02-25
IL147924A0 (en) 2002-08-14
KR20070074003A (ko) 2007-07-10
CA2381097C (en) 2009-06-16
DE60036803T2 (de) 2008-07-24
IL147924A (en) 2008-03-20
KR100827563B1 (ko) 2008-05-07
GEP20053475B (en) 2005-03-25
NO323576B1 (no) 2007-06-11
WO2001014353A1 (en) 2001-03-01
US6784198B1 (en) 2004-08-31
ZA200201117B (en) 2003-04-30
SK287373B6 (sk) 2010-08-09
NO20020683D0 (no) 2002-02-11
CZ2002486A3 (cs) 2002-11-13
JP4864260B2 (ja) 2012-02-01
HK1054233A1 (zh) 2003-11-21
EE04939B1 (et) 2007-12-17
SK1802002A3 (en) 2003-05-02
CZ303138B6 (cs) 2012-04-25
US20050004120A1 (en) 2005-01-06
UA72538C2 (en) 2005-03-15
DE60036803D1 (de) 2007-11-29
HUP0202492A2 (hu) 2002-11-28
YU9702A (sh) 2004-11-25
HK1054233B (zh) 2009-05-29
BG65484B1 (bg) 2008-09-30
SI1204649T1 (sl) 2008-02-29
MA25433A1 (fr) 2002-04-01
CN1425009A (zh) 2003-06-18
CN100410245C (zh) 2008-08-13
AP1853A (en) 2008-05-29
EA005375B1 (ru) 2005-02-24
PT1204649E (pt) 2008-01-10
DK1204649T3 (da) 2007-12-03
ES2295056T3 (es) 2008-04-16
NZ517236A (en) 2004-11-26
RS50300B (sr) 2009-09-08
CA2381097A1 (en) 2001-03-01
BR0013281A (pt) 2002-06-18
EE200200064A (et) 2003-04-15
MXPA02001508A (es) 2003-07-21
AU7440000A (en) 2001-03-19
KR100773709B1 (ko) 2007-11-09
KR20020060159A (ko) 2002-07-16
AP2002002441A0 (en) 2002-03-31
HRP20020127B1 (en) 2010-08-31
HRP20020127A2 (en) 2003-04-30
CY1107108T1 (el) 2012-10-24
EP1204649A1 (en) 2002-05-15
EA200200247A1 (ru) 2002-08-29
NO20020683L (no) 2002-04-10
ATE375987T1 (de) 2007-11-15
OA12047A (en) 2006-05-02
BG106481A (en) 2002-09-30
PL353588A1 (en) 2003-12-01
HUP0202492A3 (en) 2004-12-28
EP1204649B1 (en) 2007-10-17
IS6264A (is) 2002-02-11
AU782882B2 (en) 2005-09-08
US6114365A (en) 2000-09-05

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