ATE376054T1 - Diacylglyzerin o-acyltransferase - Google Patents

Diacylglyzerin o-acyltransferase

Info

Publication number
ATE376054T1
ATE376054T1 AT98942283T AT98942283T ATE376054T1 AT E376054 T1 ATE376054 T1 AT E376054T1 AT 98942283 T AT98942283 T AT 98942283T AT 98942283 T AT98942283 T AT 98942283T AT E376054 T1 ATE376054 T1 AT E376054T1
Authority
AT
Austria
Prior art keywords
nucleic acid
well
acid compositions
applications
diacylglycerin
Prior art date
Application number
AT98942283T
Other languages
English (en)
Inventor
Robert Farese
Sylvaine Cases
Steven Smith
Sandra K Erickson
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE376054T1 publication Critical patent/ATE376054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT98942283T 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase ATE376054T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/103,754 US6344548B1 (en) 1998-06-24 1998-06-24 Diacylglycerol o-acyltransferase

Publications (1)

Publication Number Publication Date
ATE376054T1 true ATE376054T1 (de) 2007-11-15

Family

ID=22296862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942283T ATE376054T1 (de) 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase

Country Status (7)

Country Link
US (1) US6344548B1 (de)
EP (1) EP1088088B8 (de)
AT (1) ATE376054T1 (de)
AU (1) AU758438B2 (de)
CA (1) CA2330549C (de)
DE (1) DE69838592T2 (de)
WO (1) WO1999067403A1 (de)

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WO1998035044A1 (en) 1997-02-10 1998-08-13 National Research Council Of Canada Plant pyruvate dehydrogenase kinase gene
US6166176A (en) * 1998-03-17 2000-12-26 Immvarx, Inc. Cancer marker protein and peptides thereof
US7135617B2 (en) * 1998-07-02 2006-11-14 Calgene Llc Diacylglycerol acyl transferase proteins
AU1837600A (en) 1998-12-02 2000-06-19 E.I. Du Pont De Nemours And Company Plant diacylglycerol acyltransferases
AU2166400A (en) * 1998-12-04 2000-06-19 Calgene Llc Diacylglycerol acyl transferase proteins
US7015373B1 (en) * 1998-12-17 2006-03-21 National Research Council Of Canada Diacylglycerol acyltransferase gene from plants
CA2355845C (en) * 1998-12-17 2008-08-05 National Research Council Of Canada Diacylglycerol acyltransferase gene from plants
WO2000066749A1 (en) * 1999-05-04 2000-11-09 Cargill, Incorporated Plant acyltransferases
US6995301B1 (en) 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
US6552250B1 (en) 2000-06-14 2003-04-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Diacylglycerol O-acyltransferase
US6444427B1 (en) * 2000-07-11 2002-09-03 The Regents Of The University Of California Polymorphisms in a diacylglycerol acyltransferase gene, and methods of use thereof
EP1330552B1 (de) * 2000-10-31 2007-01-24 Michel Alphonse Julien Georges Marker-unterstützte auswahl von rindvieh für verbesserte milchproduktion unter verwendung des diacylglycerin-acyltransferase-gens dgat1
US20020119138A1 (en) 2001-02-26 2002-08-29 Sylvaine Cases Diacylglycerol o-acyltransferase 2alpha (DGAT2alpha)
US7045326B2 (en) 2001-02-23 2006-05-16 The Regents Of The University Of California Mono- and diacylglycerol acyltransferases and methods of use thereof
AU2002366803A1 (en) 2001-12-19 2003-07-09 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
AU2003259682A1 (en) * 2002-07-31 2004-02-16 Monsanto Technology, Llc Diacylglycerol acyltransferase nucleic acid sequences and associated products
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
AR044152A1 (es) * 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
US7825235B2 (en) * 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
KR20060114376A (ko) * 2004-01-30 2006-11-06 니뽄 다바코 산교 가부시키가이샤 식욕 감퇴 화합물
CA2580061C (en) * 2004-09-13 2014-11-25 Monsanto Technology Llc Promoters for regulating gene expression in plant seeds
US7550286B2 (en) 2004-11-04 2009-06-23 E. I. Du Pont De Nemours And Company Docosahexaenoic acid producing strains of Yarrowia lipolytica
US7273746B2 (en) * 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
RU2415946C2 (ru) * 2004-12-22 2011-04-10 Янссен Фармацевтика Н.В. Анализ диацилглицерин-ацилтрансферазы
AU2007272316B2 (en) 2006-07-14 2014-01-09 Commonwealth Scientific And Industrial Research Organisation Altering the fatty acid composition of rice
US8003620B2 (en) * 2006-08-04 2011-08-23 Isis Pharmaceuticals, Inc. Compositions and their uses directed to diacylglycerol acyltransferase 1
EP2147109B1 (de) 2007-05-24 2014-03-19 E. I. Du Pont de Nemours and Company Dgat-gene aus yarrowia lipolytica für erhöhte samenfettproduktion sowie veränderte fettsäureprofile in sojabohnen
US20110190165A1 (en) * 2008-05-16 2011-08-04 Randall Weselake High throughput methods of identifying neutral lipid synthases
EP2297310A2 (de) * 2008-05-23 2011-03-23 E. I. du Pont de Nemours and Company Neue dgat-gene für gesteigerte samenspeicherlipidproduktion und veränderte fettsäureprofile bei ölsamenpflanzen
AU2009248932B2 (en) 2008-05-23 2015-08-13 E. I. Du Pont De Nemours And Company DGAT genes from yarrowia lipolytica combined with plastidic phosphoglucomutase down regulation for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
US8153859B2 (en) 2008-05-23 2012-04-10 E.I. Du Pont De Nemours And Company DGAT genes from oleaginous organisms for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
AU2009273755A1 (en) * 2008-07-21 2010-01-28 Commonwealth Scientific And Industrial Research Organisation Improved vegetable oils and uses therefor
AU2009273754B2 (en) 2008-07-21 2016-07-14 Commonwealth Scientific And Industrial Research Organisation Improved cottonseed oil and uses
AR078829A1 (es) 2009-10-30 2011-12-07 Du Pont Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico
CA2780527C (en) 2009-11-23 2020-12-01 E. I. Du Pont De Nemours And Company Sucrose transporter genes for increasing plant seed lipids
MA34097B1 (fr) 2010-03-30 2013-03-05 Novartis Ag Utilisations d'inhibiteurs de dgat1
EP2585589B1 (de) 2010-06-28 2017-06-21 Commonwealth Scientific and Industrial Research Organisation Verfahren zur herstellung von lipiden
CA2860220C (en) 2011-12-22 2021-07-13 E. I. Du Pont De Nemours And Company Use of the soybean or medicago truncatula sucrose synthase promoter to increase plant seed oil content
UA119739C2 (uk) 2011-12-27 2019-08-12 Коммонвелт Сайнтіфік Енд Індастріел Рісерч Організейшн Метод отримання ліпідів
US11639507B2 (en) 2011-12-27 2023-05-02 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
US8809026B2 (en) 2011-12-27 2014-08-19 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
US10323209B2 (en) 2012-04-25 2019-06-18 Commonwealth Scientific And Industrial Research Organisation High oleic acid oils
US11312971B2 (en) 2012-10-30 2022-04-26 Agresearch Limited Enhanced acyltransferase polynucleotides, polypeptides and methods of use
CA2889980A1 (en) 2012-10-30 2014-05-08 Agresearch Limited Novel acyltransferase polynucleotides, poypeptides, and methods of use
PL2914726T3 (pl) 2012-10-30 2019-06-28 Agresearch Limited Udoskonalone polinukleotydy acylotransferazy, polipeptydy i sposoby stosowania
NZ708313A (en) 2012-12-21 2019-08-30 Nz Inst Plant & Food Res Ltd Regulation of gene expression via uorf of gdp-l-galactose phosphorylase (ggp) gene
WO2015164457A1 (en) 2014-04-22 2015-10-29 E. I. Du Pont De Nemours And Company Plastidic carbonic anhydrase genes for oil augmentation in seeds with increased dgat expression
EP4303288B1 (de) 2014-07-07 2025-09-10 Nuseed Global Innovation Ltd Verfahren zur herstellung von industriellen produkten aus pflanzlichen lipiden
MY192997A (en) 2015-07-10 2022-09-20 Ionis Pharmaceuticals Inc Modulators of diacyglycerol acyltransferase 2 (dgat2)
CN110462043A (zh) 2016-09-02 2019-11-15 联邦科学技术研究组织 具有修饰的性状的植物
CA3093970A1 (en) 2018-03-16 2019-09-19 Anji Pharmaceuticals Inc. Compositions and methods for treating severe constipation
WO2023085931A1 (en) 2021-11-11 2023-05-19 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatic organoids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3225997A (en) 1996-05-30 1998-01-05 Trustees Of Columbia University In The City Of New York, The Dna encoding acylcoenzyme a: cholesterol acyltransferase and uses thereof

Also Published As

Publication number Publication date
EP1088088B8 (de) 2007-11-21
DE69838592T2 (de) 2008-07-24
DE69838592D1 (de) 2007-11-29
EP1088088A1 (de) 2001-04-04
CA2330549A1 (en) 1999-12-29
EP1088088A4 (de) 2004-05-06
AU758438B2 (en) 2003-03-20
CA2330549C (en) 2010-04-20
WO1999067403A1 (en) 1999-12-29
US6344548B1 (en) 2002-02-05
EP1088088B1 (de) 2007-10-17
AU9037698A (en) 2000-01-10

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