ATE376054T1 - Diacylglyzerin o-acyltransferase - Google Patents

Diacylglyzerin o-acyltransferase

Info

Publication number
ATE376054T1
ATE376054T1 AT98942283T AT98942283T ATE376054T1 AT E376054 T1 ATE376054 T1 AT E376054T1 AT 98942283 T AT98942283 T AT 98942283T AT 98942283 T AT98942283 T AT 98942283T AT E376054 T1 ATE376054 T1 AT E376054T1
Authority
AT
Austria
Prior art keywords
nucleic acid
well
acid compositions
applications
diacylglycerin
Prior art date
Application number
AT98942283T
Other languages
English (en)
Inventor
Robert Farese
Sylvaine Cases
Steven Smith
Sandra K Erickson
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Application granted granted Critical
Publication of ATE376054T1 publication Critical patent/ATE376054T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
AT98942283T 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase ATE376054T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/103,754 US6344548B1 (en) 1998-06-24 1998-06-24 Diacylglycerol o-acyltransferase

Publications (1)

Publication Number Publication Date
ATE376054T1 true ATE376054T1 (de) 2007-11-15

Family

ID=22296862

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98942283T ATE376054T1 (de) 1998-06-24 1998-08-28 Diacylglyzerin o-acyltransferase

Country Status (7)

Country Link
US (1) US6344548B1 (de)
EP (1) EP1088088B8 (de)
AT (1) ATE376054T1 (de)
AU (1) AU758438B2 (de)
CA (1) CA2330549C (de)
DE (1) DE69838592T2 (de)
WO (1) WO1999067403A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69816059T2 (de) 1997-02-10 2004-04-22 National Research Council Of Canada, Ottawa Gen, das für das pyruvat dehydrogenase kinase von pflanzen kodiert
US6166176A (en) * 1998-03-17 2000-12-26 Immvarx, Inc. Cancer marker protein and peptides thereof
US7135617B2 (en) * 1998-07-02 2006-11-14 Calgene Llc Diacylglycerol acyl transferase proteins
CA2703147C (en) 1998-12-02 2014-07-29 Karlene H. Butler Plant diacylglycerol acyltransferases
WO2000032793A2 (en) * 1998-12-04 2000-06-08 Calgene Llc Plant cell derived diacylglycerol acyltransferases
ATE340861T1 (de) * 1998-12-17 2006-10-15 Ca Nat Research Council Diacylglyzerin-acyltransferase gen aus pflanzen
US7015373B1 (en) 1998-12-17 2006-03-21 National Research Council Of Canada Diacylglycerol acyltransferase gene from plants
US6995301B1 (en) 1999-05-04 2006-02-07 Cargill, Incorporated Plant acyltransferases
CA2372632C (en) * 1999-05-04 2011-02-15 Basil S. Shorrosh Plant acyltransferases
US6552250B1 (en) 2000-06-14 2003-04-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Diacylglycerol O-acyltransferase
US6444427B1 (en) 2000-07-11 2002-09-03 The Regents Of The University Of California Polymorphisms in a diacylglycerol acyltransferase gene, and methods of use thereof
AU2002224229B2 (en) * 2000-10-31 2007-11-29 Wouter Herman Robert Coppieters Marker assisted selection of bovine for improved milk production using diacylglycerol acyltransferase gene DGAT1
US7045326B2 (en) 2001-02-23 2006-05-16 The Regents Of The University Of California Mono- and diacylglycerol acyltransferases and methods of use thereof
US20020119138A1 (en) 2001-02-26 2002-08-29 Sylvaine Cases Diacylglycerol o-acyltransferase 2alpha (DGAT2alpha)
WO2003053363A2 (en) * 2001-12-19 2003-07-03 Millennium Pharmaceuticals, Inc. Human diacylglycerol acyltransferase 2 (dgat2) family members and uses therefor
MXPA05001239A (es) * 2002-07-31 2005-06-08 Monsanto Technology Llc Secuencias de acidos nucleicos de diacilglicerol aciltransferasa y productos asociados.
US20040185559A1 (en) 2003-03-21 2004-09-23 Isis Pharmaceuticals Inc. Modulation of diacylglycerol acyltransferase 1 expression
AR044152A1 (es) * 2003-05-09 2005-08-24 Bayer Corp Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad
US7825235B2 (en) * 2003-08-18 2010-11-02 Isis Pharmaceuticals, Inc. Modulation of diacylglycerol acyltransferase 2 expression
JP2007519605A (ja) * 2004-01-30 2007-07-19 日本たばこ産業株式会社 食欲抑制薬
AU2005285015B2 (en) 2004-09-13 2010-11-18 Monsanto Technology Llc Promoter molecules for use in plants
US7588931B2 (en) 2004-11-04 2009-09-15 E. I. Du Pont De Nemours And Company High arachidonic acid producing strains of Yarrowia lipolytica
US7273746B2 (en) * 2004-11-04 2007-09-25 E.I. Dupont De Nemours And Company Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
RU2415946C2 (ru) * 2004-12-22 2011-04-10 Янссен Фармацевтика Н.В. Анализ диацилглицерин-ацилтрансферазы
CN105123532B (zh) 2006-07-14 2018-12-18 联邦科学技术研究组织 改变水稻的脂肪酸组成
EP2057177B1 (de) 2006-08-04 2012-11-21 Isis Pharmaceuticals, Inc. Zusammensetzungen und ihre verwendung in bezug auf diacylglycerol-acyltransferase 1
US8143473B2 (en) * 2007-05-24 2012-03-27 E. I. Du Pont De Nemours And Company DGAT genes from Yarrowia lipolytica for increased seed storage lipid production and altered fatty acid profiles in soybean
WO2009137938A1 (en) * 2008-05-16 2009-11-19 The Governors Of The University Of Alberta High throughput methods of identifying neutral lipid synthases
BRPI0908642A2 (pt) 2008-05-23 2020-06-23 E.I. Du Pont De Mours And Company Polinucleotídeo recombinante, construção de dna recombinante, método para aumentar o teor total de ácido graxo de uma semente, produto ou subproduto, método para produzir uma semente de oleaginosa com um teor total de ácidos graxos aumentado e método para produzir um produto a partir de uma semente de oleaginosa
US8143476B2 (en) * 2008-05-23 2012-03-27 E I Du Pont De Nemours And Company DGAT genes from Yarrowia lipolytica combined with plastidic phosphoglucomutase down regulation for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
CA2723427C (en) 2008-05-23 2018-01-23 E. I. Du Pont De Nemours And Company Novel dgat genes for increased seed storage lipid production and altered fatty acid profiles in oilseed plants
CA2768737A1 (en) * 2008-07-21 2010-01-28 Commonwealth Scientific And Industrial Research Organisation Improved vegetable oils and uses therefor
CN102202498B (zh) 2008-07-21 2016-09-07 澳大利亚联邦科学与工业研究组织 改良的棉籽油及应用
AR078829A1 (es) 2009-10-30 2011-12-07 Du Pont Plantas y semillas con niveles alterados de compuesto de almacenamiento, construcciones relacionadas y metodos relacionados con genes que codifican proteinas similares a las aldolasas bacterianas de la clase ii del acido 2,4- dihidroxi-hept-2-eno-1,7-dioico
WO2011062748A1 (en) 2009-11-23 2011-05-26 E.I. Du Pont De Nemours And Company Sucrose transporter genes for increasing plant seed lipids
US9061012B2 (en) 2010-03-30 2015-06-23 Novartis Ag Uses of DGAT1 inhibitors
ES2640100T3 (es) 2010-06-28 2017-10-31 Commonwealth Scientific And Industrial Research Organisation Métodos para producir lípidos
US10036030B2 (en) 2011-12-22 2018-07-31 E I Du Pont De Nemours And Company Use of the soybean sucrose synthase promoter to increase plant seed lipid content
CA3203397A1 (en) 2011-12-27 2013-07-04 Nuseed Global Innovation Ltd Processes for producing lipids
US11639507B2 (en) 2011-12-27 2023-05-02 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
US8809026B2 (en) 2011-12-27 2014-08-19 Commonwealth Scientific And Industrial Research Organisation Processes for producing lipids
CA2871503C (en) 2012-04-25 2023-08-29 Commonwealth Scientific And Industrial Research Organisation High oleic acid oils
WO2014068439A2 (en) 2012-10-30 2014-05-08 Agresearch Limited Improved acyltransferase polynucleotides, polypeptides, and methods of use
US11312971B2 (en) 2012-10-30 2022-04-26 Agresearch Limited Enhanced acyltransferase polynucleotides, polypeptides and methods of use
MX359167B (es) 2012-10-30 2018-09-18 Agresearch Ltd Polinucleotidos, polipeptidos y metodos de uso novedosos de aciltransferasa.
AU2013365731B2 (en) 2012-12-21 2018-11-22 The New Zealand Institute For Plant And Food Research Limited Regulation of gene expression
AR100159A1 (es) 2014-04-22 2016-09-14 Du Pont Genes de anhidrasa carbónica plastídica para el incremento de aceite en semillas con expresión incrementada de dgat
WO2016004473A1 (en) 2014-07-07 2016-01-14 Commonwealth Scientific And Industrial Research Organisation Processes for producing industrial products from plant lipids
PE20180800A1 (es) 2015-07-10 2018-05-09 Ionis Pharmaceuticals Inc Moduladores de diaciglicerol aciltransferasa 2 (dgat2)
US11859193B2 (en) 2016-09-02 2024-01-02 Nuseed Global Innovation Ltd. Plants with modified traits
PE20210158A1 (es) 2018-03-16 2021-01-26 Anji Pharmaceuticals Inc Composiciones y metodos para tratar el estrenimiento grave
WO2023085931A1 (en) 2021-11-11 2023-05-19 Koninklijke Nederlandse Akademie Van Wetenschappen Hepatic organoids

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045439A1 (en) 1996-05-30 1997-12-04 The Trustees Of Columbia University In The City Of New York Dna encoding acylcoenzyme a: cholesterol acyltransferase and uses thereof

Also Published As

Publication number Publication date
CA2330549C (en) 2010-04-20
WO1999067403A1 (en) 1999-12-29
AU758438B2 (en) 2003-03-20
EP1088088A1 (de) 2001-04-04
US6344548B1 (en) 2002-02-05
CA2330549A1 (en) 1999-12-29
EP1088088A4 (de) 2004-05-06
EP1088088B1 (de) 2007-10-17
DE69838592D1 (de) 2007-11-29
EP1088088B8 (de) 2007-11-21
DE69838592T2 (de) 2008-07-24
AU9037698A (en) 2000-01-10

Similar Documents

Publication Publication Date Title
DE69838592D1 (de) Diacylglyzerin o-acyltransferase
DE69939426D1 (de) Diacylglycerin o-acyltransferase
BR9910251A (pt) Estimulação hematopoiética
GR3033630T3 (en) Gene expression elements and the production of chimeric mouse-human antibodies.
HU9403536D0 (en) Dna sequences used in the production of recombinant human bssl/cel in transgenic non-human mammals, and the produced bssl/cel used in infant formulas
ATE333893T1 (de) Gentherapie für gaucher-krankheit
IT8021351A0 (it) Processo per il trattamento di peci nella produzione di manufatti abase di carbonio.
DE69836514D1 (de) Elektrodenkörper, mit diesem versehener Akkumulator, sowie Herstellung des Elektrodenkörpers und des Akkumulators
AU2003266214A1 (en) Human coagulation factor vii polypeptides
ID25950A (id) Katalis-katalis untuk memproduksi aldehid tidak jenuh dan asam karboksilat tidak jenuh dan proses untuk produksi aldehid tidak jenuh dan asam karboksilat tidak jenuh menggunakan katalis
DE69916856D1 (de) Micropartikeln zur verwendung in nadellosen injektion
TW200407425A (en) Human coagulation factor VII polypeptides
DE69334211D1 (de) Multidrug resistenz gen
DE69901177D1 (de) Platinkomplex, dessen herstellung und dessen therapeutische verwendung
DE3675887D1 (de) Elektronisch leitfaehige stickstoffpolymere, verfahren zur herstellung derselben, elektrochronische anzeigezelle, und diese polymere verwendender elektrochemischer generator.
ID30116A (id) Turunan-turunan piridopiranoazepin, pembuatannya dan penggunaan terapinya
ATE268379T1 (de) Enzym mit aminopeptidaseactivität
DE69613329D1 (de) Enzym enthaltendes Granulat, Herstellungsmethode und das Granulat enthaltende Zusammensetzungen
DK0885296T3 (da) Et enzym med galactanaseaktivitet
DE3485826D1 (de) Herstellung und verwendung polymerer kugeln.
ATE316140T1 (de) Protein, das die spaltung von beta-carotin katalysiert
BG105779A (bg) Човешки антибиотични протеини
DE3677848D1 (de) Chromosomale dna-sequenz, expressionsvektor fuer menschlichen gewebeplasminogen aktivierenden faktor mit diesem transfektierte, gezuechtete zellen, sowie verfahren zur herstellung des genannten aktivierungsfaktors.
DE3586952D1 (de) Fibrinophiler urokinase-komplex und dessen herstellung.
ITRM930818A0 (it) Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties