ATE376423T1 - Gelierende wässrige pharmazeutische zusammensetzungen - Google Patents

Gelierende wässrige pharmazeutische zusammensetzungen

Info

Publication number
ATE376423T1
ATE376423T1 AT01956809T AT01956809T ATE376423T1 AT E376423 T1 ATE376423 T1 AT E376423T1 AT 01956809 T AT01956809 T AT 01956809T AT 01956809 T AT01956809 T AT 01956809T AT E376423 T1 ATE376423 T1 AT E376423T1
Authority
AT
Austria
Prior art keywords
aqueous pharmaceutical
pharmaceutical composition
administration
geling
pharmaceutical compositions
Prior art date
Application number
AT01956809T
Other languages
English (en)
Inventor
Hidekazu Suzuki
Takahiro Wada
Masanobu Kirita
Masanobu Takeuchi
Original Assignee
Wakamoto Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wakamoto Pharma Co Ltd filed Critical Wakamoto Pharma Co Ltd
Application granted granted Critical
Publication of ATE376423T1 publication Critical patent/ATE376423T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01956809T 2000-08-08 2001-08-08 Gelierende wässrige pharmazeutische zusammensetzungen ATE376423T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000240455A JP3450805B2 (ja) 2000-08-08 2000-08-08 水性医薬組成物

Publications (1)

Publication Number Publication Date
ATE376423T1 true ATE376423T1 (de) 2007-11-15

Family

ID=18731808

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01956809T ATE376423T1 (de) 2000-08-08 2001-08-08 Gelierende wässrige pharmazeutische zusammensetzungen

Country Status (13)

Country Link
US (2) US20030194441A1 (de)
EP (1) EP1312366B1 (de)
JP (1) JP3450805B2 (de)
KR (1) KR20030040384A (de)
CN (1) CN1446092A (de)
AT (1) ATE376423T1 (de)
AU (1) AU2001278696A1 (de)
CA (1) CA2421787A1 (de)
DE (1) DE60131088T2 (de)
HU (1) HUP0302690A3 (de)
NO (1) NO20030533L (de)
RU (1) RU2003106395A (de)
WO (1) WO2002011734A1 (de)

Families Citing this family (38)

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Publication number Priority date Publication date Assignee Title
AU2003264498A1 (en) * 2002-09-18 2004-04-08 Wakamoto Pharmaceutical Co., Ltd. Transparent and reversibly heat-gelling aqueous compositions
US7220431B2 (en) 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US20050085446A1 (en) * 2003-04-14 2005-04-21 Babu M.K. M. Fluoroquinolone formulations and methods of making and using the same
JP2005008625A (ja) * 2003-05-23 2005-01-13 Santen Pharmaceut Co Ltd キノロン系抗菌化合物を含有する点眼液
KR20120005052A (ko) * 2003-08-21 2012-01-13 수캄포 아게 안과용 조성물
EP1681065A4 (de) * 2003-10-31 2011-12-28 Wakamoto Pharma Co Ltd Zusammensetzung auf wasserbasis mit reversibler thermogelierung
JP2005263792A (ja) * 2004-02-19 2005-09-29 Santen Pharmaceut Co Ltd 澄明なラタノプロスト点眼液
WO2005079809A1 (ja) * 2004-02-19 2005-09-01 Santen Pharmaceutical Co., Ltd. 澄明なラタノプロスト点眼液
US7658947B2 (en) * 2004-06-25 2010-02-09 Kimberly-Clark Worldwide, Inc. Thermo-gelling composition
JP2007277095A (ja) * 2004-07-02 2007-10-25 Wakamoto Pharmaceut Co Ltd アジスロマイシン含有可逆性熱ゲル化水性組成物
JP2006036660A (ja) * 2004-07-23 2006-02-09 Wakamoto Pharmaceut Co Ltd 難溶性薬物含有水性懸濁熱ゲル製剤
US20060089384A1 (en) * 2004-10-25 2006-04-27 Minno George E Ophthalmic compositions and methods of using the same
WO2006047418A1 (en) * 2004-10-25 2006-05-04 Alimera Sciences, Inc. Ophthalmic compositions and methods of using the same
US20080014274A1 (en) * 2006-07-14 2008-01-17 Wyeth Enhanced stability phenylephrine liquid compositions
CN101130083B (zh) * 2007-08-07 2010-05-19 山东博士伦福瑞达制药有限公司 一种眼用组合物及其制作方法和用途
ITMI20080289A1 (it) * 2008-02-22 2009-08-23 S I F I Societa Industria Farmaceutica Italia Composizioni di gemifloxacina con elevata efficacia su patologie oculari
EP2143422A1 (de) * 2008-07-11 2010-01-13 S.I.F.I - Società Industria Farmaceutica Italiana - S.P.A. Ophthalmische Zusammensetzungen enthaltend Gemifloxacin zur Behandlung von Augeninfektionen
US7842725B2 (en) 2008-07-24 2010-11-30 Ecolab USA, Inc. Foaming alcohol compositions with selected dimethicone surfactants
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
WO2010101989A1 (en) * 2009-03-03 2010-09-10 Alcon Research, Ltd. PHARMACEUTICAL COMPOSITION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE
CN102340993A (zh) * 2009-03-03 2012-02-01 爱尔康研究有限公司 向眼部递送受体酪氨酸激酶抑制性(RTKi)化合物的药物组合物
DE102009021372A1 (de) * 2009-05-14 2010-11-18 Ursapharm Arzneimittel Gmbh Phosphatfreie pharmazeutische Zusammensetzung zur Glaukombehandlung
KR20180027611A (ko) * 2010-01-07 2018-03-14 리전츠 오브 더 유니버스티 오브 미네소타 목시플록사신을 귀에 도포하기 위한 방법 및 조성물
CN101843625B (zh) * 2010-03-30 2012-02-08 重庆巴仕迪动物药业有限公司 兽用复方氧氟沙星注射液及其制备方法
CN103140215A (zh) * 2010-07-21 2013-06-05 爱尔康研究有限公司 具有提高的溶解度特征的药物组合物
US9937258B2 (en) * 2013-07-17 2018-04-10 Dow Global Technologies Llc Composition for application to a nasal mucosa comprising a methylcellulose
CN104000777B (zh) * 2014-05-21 2016-06-01 丽珠医药集团股份有限公司 一种左氧氟沙星制剂
CN104784101A (zh) * 2015-03-05 2015-07-22 中国药科大学制药有限公司 一种曲尼司特凝胶和软膏剂的处方及制备方法
CN110913867B (zh) 2017-04-25 2021-06-11 若素制药株式会社 热凝胶化人工泪液
US20180318319A1 (en) 2017-05-04 2018-11-08 Ocular Science, Inc. Compositions and Methods for Treating Eyes and Methods of Preparation
CN109260152A (zh) * 2018-11-13 2019-01-25 禹州市中医院 一种盐酸洛美沙星滴耳液
CN113242734A (zh) * 2018-11-26 2021-08-10 艾葳生物科技有限公司 用于药物递送的药用生物可溶凝胶
US11071724B2 (en) 2019-05-17 2021-07-27 Ocular Science, Inc. Compositions and methods for treating presbyopia
ES2905793T3 (es) 2019-07-23 2022-04-12 Nicox Ophthalmics Inc Procedimiento para la preparación de suspensiones acuosas estériles oftálmicas de nanocristales de propionato de fluticasona de Forma A
JP2023534927A (ja) 2020-07-06 2023-08-15 エコラボ ユーエスエー インコーポレイティド 構造化アルコキシル化シロキサンを含む起泡性アルコール／水混合組成物
EP4176032A1 (de) 2020-07-06 2023-05-10 Ecolab USA Inc. Schäumende alkohol/wasser-mischzusammensetzungen mit einer kombination aus alkylsiloxan und einem hydrotrop/solubilisierungsmittel
US12152220B2 (en) 2020-07-06 2024-11-26 Ecolab Usa Inc. PEG-modified castor oil based compositions for microemulsifying and removing multiple oily soils
CN117338787A (zh) * 2023-11-24 2024-01-05 南京恒道医药科技股份有限公司 一种眼用药物组合物及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2053678T3 (es) 1987-11-13 1994-08-01 Asta Medica Ag Procedimiento para preparar un medicamento con contenido de azelastina para la aplicacion nasal y/u ocular.
ES2141775T3 (es) * 1993-04-16 2000-04-01 Wakamoto Pharma Co Ltd Composicion medicinal a base de agua termicamente gelificante reversible.
WO1996011672A1 (en) * 1994-10-13 1996-04-25 Wakamoto Pharmaceutical Co., Ltd. Lyophilized preparation providing reversibly thermogelling water-base medicinal composition
WO1996022088A1 (en) * 1995-01-20 1996-07-25 Wakamoto Pharmaceutical Co., Ltd. Anti-inflammatory eyedrops
ZA966579B (en) * 1995-08-04 1998-02-02 Wakamoto Pharma Co Ltd O/W emulsion composition for eye drops.
WO1998030221A1 (fr) * 1997-01-10 1998-07-16 Wakamoto Pharmaceutical Co., Ltd. Composition de type emulsion huile/eau a usage ophtalmique et contenant du difluprednate
AU9281698A (en) * 1997-10-01 1999-04-23 Wakamoto Pharmaceutical Co., Ltd. O/w emulsion compositions
US6171616B1 (en) * 1998-04-13 2001-01-09 Shin-Etsu Chemical Co., Ltd. Solid preparation and a method of manufacturing it
WO1999059634A1 (en) * 1998-05-15 1999-11-25 Wakamoto Pharmaceutical Co., Ltd. Anti-inflammatory eye drops
AU4061599A (en) * 1998-06-10 1999-12-30 Wakamoto Pharmaceutical Co., Ltd. Aqueous preparations containing hardly soluble drug
JP2001048807A (ja) * 1999-08-04 2001-02-20 Wakamoto Pharmaceut Co Ltd 難溶性薬物を水に溶解してなる製剤
WO2001037838A1 (en) * 1999-11-24 2001-05-31 Wakamoto Pharmaceutical Co., Ltd. Ophthalmic aqueous preparation
JP4541504B2 (ja) 2000-06-14 2010-09-08 沢井製薬株式会社 トラニラストまたはその薬理学的に許容される塩を有効成分として含有する安定な水溶液製剤
JP2002097129A (ja) * 2000-07-21 2002-04-02 Rohto Pharmaceut Co Ltd 点眼剤

Also Published As

Publication number Publication date
CA2421787A1 (en) 2003-02-04
EP1312366A4 (de) 2006-04-26
WO2002011734A1 (fr) 2002-02-14
NO20030533D0 (no) 2003-02-03
RU2003106395A (ru) 2004-07-27
EP1312366A1 (de) 2003-05-21
EP1312366A8 (de) 2003-11-12
US20030194441A1 (en) 2003-10-16
AU2001278696A1 (en) 2002-02-18
JP2003160473A (ja) 2003-06-03
US7612115B2 (en) 2009-11-03
DE60131088T2 (de) 2008-07-31
HUP0302690A3 (en) 2004-06-28
DE60131088D1 (de) 2007-12-06
JP3450805B2 (ja) 2003-09-29
US20060172969A1 (en) 2006-08-03
NO20030533L (no) 2003-02-26
CN1446092A (zh) 2003-10-01
KR20030040384A (ko) 2003-05-22
EP1312366B1 (de) 2007-10-24
HUP0302690A2 (hu) 2003-11-28

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Legal Events

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