ATE376556T1 - Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel - Google Patents

Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel

Info

Publication number
ATE376556T1
ATE376556T1 AT04804195T AT04804195T ATE376556T1 AT E376556 T1 ATE376556 T1 AT E376556T1 AT 04804195 T AT04804195 T AT 04804195T AT 04804195 T AT04804195 T AT 04804195T AT E376556 T1 ATE376556 T1 AT E376556T1
Authority
AT
Austria
Prior art keywords
peptide fragment
base
composition
sensitive
protecting group
Prior art date
Application number
AT04804195T
Other languages
English (en)
Inventor
Martin Guinn
Lewis Hodges
David A Johnston
Hendrick Moorlag
Mark Schwindt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE376556T1 publication Critical patent/ATE376556T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04804195T 2003-12-31 2004-12-22 Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel ATE376556T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53365403P 2003-12-31 2003-12-31

Publications (1)

Publication Number Publication Date
ATE376556T1 true ATE376556T1 (de) 2007-11-15

Family

ID=34738869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804195T ATE376556T1 (de) 2003-12-31 2004-12-22 Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel

Country Status (6)

Country Link
US (1) US7439222B2 (de)
EP (1) EP1701969B1 (de)
AT (1) ATE376556T1 (de)
DE (1) DE602004009710T2 (de)
ES (1) ES2295961T3 (de)
WO (1) WO2005063791A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1701970A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Verfahren zur wiedergewinnung eines gespaltenen peptides von einem träger
EP1701976A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptidsynthese und entschützung mit cosolvenz
EP1701971A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptidsynthese unter anwendung eines dekantierungsfilters
CN101094867B (zh) 2004-10-19 2011-08-24 隆萨股份公司 用于固相肽合成的方法
ES2325644B1 (es) 2005-12-30 2010-06-28 Universidad Del Pais Vasco (Upv/Ehu) Hexapeptidos no proteolizables inhibidores de la glicoproteina 41 del virus del sida.
US8022181B2 (en) 2006-05-03 2011-09-20 Mallinckrodt Llc Composition and method for the release of protected peptides from a resin
US20100285532A1 (en) * 2008-01-08 2010-11-11 Eldie Berger Production of heterologous proteins or peptides
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
TWI640541B (zh) 2011-12-28 2018-11-11 中外製藥股份有限公司 Peptide compound having an annular portion and pharmaceutical composition thereof
HUE034308T2 (en) 2013-03-21 2018-02-28 Sanofi Aventis Deutschland Preparation of hydantoin-containing peptide products
CN105102427B (zh) 2013-03-21 2018-09-07 赛诺菲-安万特德国有限公司 含有环状酰亚胺的肽产物的合成
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US10308677B2 (en) * 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US10815489B2 (en) 2015-03-13 2020-10-27 Chugai Seiyaku Kabushiki Kaisha Modified aminoacyl-tRNA synthetase and use thereof
US12391971B2 (en) 2017-01-31 2025-08-19 Chugai Seiyaku Kabushiki Kaisha Method for synthesizing peptides in cell-free translation system
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
CN111479819B (zh) * 2017-12-15 2024-06-14 中外制药株式会社 制备肽的方法和处理碱的方法
EP3613757A1 (de) * 2018-08-20 2020-02-26 Wntresearch AB Lösungsphasenwege für wnt-hexapeptide
EP3878836B1 (de) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha Verfahren zur herstellung von o-substituierten serinderivaten
WO2020111238A1 (ja) 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
CN113692401A (zh) 2019-03-15 2021-11-23 中外制药株式会社 芳香族氨基酸衍生物的制备方法
JP6880352B1 (ja) 2019-11-07 2021-06-02 中外製薬株式会社 Ｋｒａｓ阻害作用を有する環状ペプチド化合物

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US4108846A (en) * 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
DK492788D0 (da) 1988-09-02 1988-09-05 Morten Meldal Peptidsynteseapparat
JPH0794468B2 (ja) * 1992-02-28 1995-10-11 株式会社島津製作所 固相法ペプチド合成用クリーベイジ処理装置
IE921942A1 (en) 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
AU688733B2 (en) * 1992-07-20 1998-03-19 Duke University Compounds which inhibit HIV replication
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
BR9407947A (pt) * 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
PT733645E (pt) * 1993-12-08 2003-07-31 Mitsubishi Pharma Corp Novo peptido sintetico tensoactivo pulmonar que o contem e medicamento para sindroma da insuficiencia respiratoria
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
AU757658B2 (en) 1998-03-09 2003-02-27 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
BR9909018A (pt) 1998-03-23 2001-10-16 Trimeris Inc Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis

Also Published As

Publication number Publication date
WO2005063791A2 (en) 2005-07-14
ES2295961T3 (es) 2008-04-16
US7439222B2 (en) 2008-10-21
WO2005063791A3 (en) 2005-09-09
EP1701969B1 (de) 2007-10-24
DE602004009710T2 (de) 2008-08-07
WO2005063791B1 (en) 2005-11-10
US20050165217A1 (en) 2005-07-28
DE602004009710D1 (de) 2007-12-06
EP1701969A2 (de) 2006-09-20

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