ATE376556T1 - Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel - Google Patents

Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel

Info

Publication number
ATE376556T1
ATE376556T1 AT04804195T AT04804195T ATE376556T1 AT E376556 T1 ATE376556 T1 AT E376556T1 AT 04804195 T AT04804195 T AT 04804195T AT 04804195 T AT04804195 T AT 04804195T AT E376556 T1 ATE376556 T1 AT E376556T1
Authority
AT
Austria
Prior art keywords
peptide fragment
base
composition
sensitive
protecting group
Prior art date
Application number
AT04804195T
Other languages
English (en)
Inventor
Martin Guinn
Lewis Hodges
David A Johnston
Hendrick Moorlag
Mark Schwindt
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE376556T1 publication Critical patent/ATE376556T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04804195T 2003-12-31 2004-12-22 Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel ATE376556T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US53365403P 2003-12-31 2003-12-31

Publications (1)

Publication Number Publication Date
ATE376556T1 true ATE376556T1 (de) 2007-11-15

Family

ID=34738869

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804195T ATE376556T1 (de) 2003-12-31 2004-12-22 Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel

Country Status (6)

Country Link
US (1) US7439222B2 (de)
EP (1) EP1701969B1 (de)
AT (1) ATE376556T1 (de)
DE (1) DE602004009710T2 (de)
ES (1) ES2295961T3 (de)
WO (1) WO2005063791A2 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063792A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Methods for recovering cleaved peptide from a support
WO2005063800A2 (en) * 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Peptide synthesis using decanting filter
EP1701976A2 (de) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptidsynthese und entschützung mit cosolvenz
PT1737889E (pt) 2004-10-19 2010-12-13 Lonza Ag Método para síntese de péptidos em fase sólida
ES2325644B1 (es) 2005-12-30 2010-06-28 Universidad Del Pais Vasco (Upv/Ehu) Hexapeptidos no proteolizables inhibidores de la glicoproteina 41 del virus del sida.
CA2651070A1 (en) 2006-05-03 2007-11-15 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
CN101970469B (zh) * 2008-01-08 2015-05-20 Csir公司 外源蛋白或肽的制备方法
PL219569B1 (pl) 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
US10308677B2 (en) 2014-12-19 2019-06-04 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
US9969769B2 (en) 2014-12-19 2018-05-15 Cem Corporation Coupling method for peptide synthesis at elevated temperatures
EP4166664A1 (de) 2015-03-13 2023-04-19 Chugai Seiyaku Kabushiki Kaisha Modifizierte aminoacyl-trna-synthetase und verwendung davon
JP7187323B2 (ja) 2017-01-31 2022-12-12 中外製薬株式会社 無細胞翻訳系におけるペプチドの合成方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2019117274A1 (ja) * 2017-12-15 2019-06-20 中外製薬株式会社 ペプチドの製造方法、及び塩基の処理方法
EP3613757A1 (de) * 2018-08-20 2020-02-26 Wntresearch AB Lösungsphasenwege für wnt-hexapeptide
EP3878836B1 (de) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha Verfahren zur herstellung von o-substituierten serinderivaten
WO2020111238A1 (ja) 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
EP3939962A4 (de) 2019-03-15 2022-12-28 Chugai Seiyaku Kabushiki Kaisha Verfahren zur herstellung eines aromatischen aminosäurederivates
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras

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Publication number Priority date Publication date Assignee Title
US4108846A (en) * 1977-02-01 1978-08-22 Hoffmann-La Roche Inc. Solid phase synthesis with base N alpha-protecting group cleavage
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
DK492788D0 (da) 1988-09-02 1988-09-05 Morten Meldal Peptidsynteseapparat
JPH0794468B2 (ja) * 1992-02-28 1995-10-11 株式会社島津製作所 固相法ペプチド合成用クリーベイジ処理装置
IE921942A1 (en) 1992-06-16 1993-12-29 Gary A Siwruk John S Eynon Liquid phase synthesis of peptides and peptide derivatives
KR100358209B1 (ko) * 1992-07-20 2003-01-24 듀크 유니버시티 Hiv복제를저해하는조성물
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
BR9407947A (pt) * 1993-11-02 1996-11-26 Affymax Tech Nv Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv
DK0733645T3 (da) * 1993-12-08 2003-07-14 Mitsubishi Pharma Corp Syntetisk peptid, lungeoverfladeaktivt stof indeholdende dette og præparat mod respiratory distress syndrome
US5869451A (en) 1995-06-07 1999-02-09 Glaxo Group Limited Peptides and compounds that bind to a receptor
NZ506839A (en) 1998-03-09 2003-05-30 Zealand Pharma As Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
WO1999048513A1 (en) 1998-03-23 1999-09-30 Trimeris, Inc. Methods and compositions for peptide synthesis
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis

Also Published As

Publication number Publication date
US20050165217A1 (en) 2005-07-28
US7439222B2 (en) 2008-10-21
DE602004009710T2 (de) 2008-08-07
WO2005063791A3 (en) 2005-09-09
WO2005063791A2 (en) 2005-07-14
WO2005063791B1 (en) 2005-11-10
ES2295961T3 (es) 2008-04-16
EP1701969A2 (de) 2006-09-20
DE602004009710D1 (de) 2007-12-06
EP1701969B1 (de) 2007-10-24

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