ATE348819T1 - Ein verfahren zur synthese von ritonavir - Google Patents
Ein verfahren zur synthese von ritonavirInfo
- Publication number
- ATE348819T1 ATE348819T1 AT00964626T AT00964626T ATE348819T1 AT E348819 T1 ATE348819 T1 AT E348819T1 AT 00964626 T AT00964626 T AT 00964626T AT 00964626 T AT00964626 T AT 00964626T AT E348819 T1 ATE348819 T1 AT E348819T1
- Authority
- AT
- Austria
- Prior art keywords
- ritonavir
- stages
- process described
- synthesis
- btc
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 5
- NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 title abstract 2
- NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 title abstract 2
- 229960000311 ritonavir Drugs 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 230000007613 environmental effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- AIDS & HIV (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Silicon Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Carbon And Carbon Compounds (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI001950A IT1313624B1 (it) | 1999-09-21 | 1999-09-21 | Procedimento per la sintesi del ritonavir |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE348819T1 true ATE348819T1 (de) | 2007-01-15 |
Family
ID=11383628
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00964626T ATE348819T1 (de) | 1999-09-21 | 2000-09-18 | Ein verfahren zur synthese von ritonavir |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6407252B1 (de) |
| EP (1) | EP1133485B1 (de) |
| JP (1) | JP2003509504A (de) |
| KR (1) | KR100708581B1 (de) |
| AT (1) | ATE348819T1 (de) |
| AU (1) | AU7554600A (de) |
| DE (1) | DE60032453T2 (de) |
| ES (1) | ES2278631T3 (de) |
| HU (1) | HUP0104259A3 (de) |
| IT (1) | IT1313624B1 (de) |
| WO (1) | WO2001021603A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006090270A1 (en) * | 2005-02-28 | 2006-08-31 | Ranbaxy Laboratories Limited | Acid addition salt of 2-isopropyl-4-(((n-methyl)amino)methyl)thiazole and its?use in the preparation of ritonavir |
| WO2009105430A1 (en) * | 2008-02-19 | 2009-08-27 | Regents Of The University Of Minnesota | Treating cancer with desthiazolyl ritonavir |
| US8598216B1 (en) * | 2010-12-17 | 2013-12-03 | Abbvie Inc. | Ritonavir bis-hydrochloride |
| CN108218808A (zh) * | 2018-04-04 | 2018-06-29 | 盐城迪赛诺制药有限公司 | 一种利托那韦的制备方法 |
| CA3098739A1 (en) | 2019-11-11 | 2021-05-11 | Andrus Research Inc. | Deployable fairing for transport vehicle |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5539122A (en) | 1989-05-23 | 1996-07-23 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5354866A (en) | 1989-05-23 | 1994-10-11 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| DE69305093T2 (de) | 1992-12-29 | 1997-04-17 | Abbott Lab | Inhibitoren der retroviralen protease |
| US5559158A (en) * | 1993-10-01 | 1996-09-24 | Abbott Laboratories | Pharmaceutical composition |
| US5491253A (en) | 1993-10-22 | 1996-02-13 | Abbott Laboratories | Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane |
| EP0748801B1 (de) | 1994-03-02 | 2001-12-19 | Daicel Chemical Industries, Ltd. | 2-isoxazolin-derivate, verfahren zu deren herstellung sowie verfahren zur herstellung von verwandten verbindungen |
| EP0773921B1 (de) * | 1994-07-29 | 1999-12-01 | Abbott Laboratories | Verfahren zur herstellung eines substituierten 2,5-diamino-3-hydroxy hexanes |
| US5567823A (en) * | 1995-06-06 | 1996-10-22 | Abbott Laboratories | Process for the preparation of an HIV protease inhibiting compound |
| US6022989A (en) | 1996-06-28 | 2000-02-08 | Abbott Laboratories | Process for the preparation of an activated amino acid |
| US5932766A (en) | 1997-05-30 | 1999-08-03 | Abbott Laboratories | Process for the preparation of substituted keto-enamines |
| US5959118A (en) | 1997-08-29 | 1999-09-28 | Abbott Laboratories | Process for the preparation of 5-hydroxymethylthiazoles |
-
1999
- 1999-09-21 IT IT1999MI001950A patent/IT1313624B1/it active
-
2000
- 2000-09-18 ES ES00964626T patent/ES2278631T3/es not_active Expired - Lifetime
- 2000-09-18 KR KR1020017006272A patent/KR100708581B1/ko not_active Expired - Fee Related
- 2000-09-18 JP JP2001524982A patent/JP2003509504A/ja not_active Withdrawn
- 2000-09-18 EP EP00964626A patent/EP1133485B1/de not_active Expired - Lifetime
- 2000-09-18 AT AT00964626T patent/ATE348819T1/de not_active IP Right Cessation
- 2000-09-18 AU AU75546/00A patent/AU7554600A/en not_active Abandoned
- 2000-09-18 US US09/856,455 patent/US6407252B1/en not_active Expired - Fee Related
- 2000-09-18 HU HU0104259A patent/HUP0104259A3/hu unknown
- 2000-09-18 WO PCT/IT2000/000368 patent/WO2001021603A1/en not_active Ceased
- 2000-09-18 DE DE60032453T patent/DE60032453T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU7554600A (en) | 2001-04-24 |
| US6407252B1 (en) | 2002-06-18 |
| JP2003509504A (ja) | 2003-03-11 |
| EP1133485B1 (de) | 2006-12-20 |
| ITMI991950A0 (it) | 1999-09-21 |
| KR20010086449A (ko) | 2001-09-12 |
| WO2001021603A1 (en) | 2001-03-29 |
| HUP0104259A2 (en) | 2002-08-28 |
| ITMI991950A1 (it) | 2001-03-21 |
| KR100708581B1 (ko) | 2007-04-18 |
| DE60032453D1 (de) | 2007-02-01 |
| IT1313624B1 (it) | 2002-09-09 |
| EP1133485A1 (de) | 2001-09-19 |
| DE60032453T2 (de) | 2007-10-04 |
| HUP0104259A3 (en) | 2002-12-28 |
| ES2278631T3 (es) | 2007-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE153332T1 (de) | Verfahren zur herstellung von oxetanonen | |
| ATE189273T1 (de) | Verfahren zur elektrochemischen synthese von n- acetylcystein aus cystein | |
| DE69840678D1 (de) | Verfahren zur produktion von purinnukleosiden durch fermentation | |
| CY1106620T1 (el) | Μεθοδος για την παραγωγη τριπεπτιδιων | |
| DE69433010D1 (de) | Verfahren zur darstellung von oligonukleotiden | |
| EP2502935A3 (de) | Verbesserte Antikörper mit veränderter Effektorfunktion und Verfahren zu ihrer Herstellung | |
| DE50311311D1 (de) | Verfahren zur telomerisation von 1,3-butadien | |
| ATE317912T1 (de) | Verfahren zur herstellung von beta-lactamen | |
| BR0113820A (pt) | Compostos | |
| DE60032453D1 (de) | Ein verfahren zur synthese von ritonavir | |
| AU580350B2 (en) | Process for synthesising peptides | |
| DE69840035D1 (de) | Chimäres protein welches eine intramolekulare chap zur insulinproduktion | |
| ATE373635T1 (de) | Verfahren zur herstellung von acylphenylalaninen | |
| ATE260894T1 (de) | Verfahren zur herstellung von dialkyl-, diaryl- und arylalkylaminoschwefel-trifluoriden | |
| WO2003002730A3 (fr) | Methode de detection de l'activite de la calpaine 3 dans un echantillon biologique et peptides pour la mise en oeuvre de ladite methode | |
| AU2003205563A1 (en) | Method for producing acrylic acid | |
| ATE206691T1 (de) | Verfahren zur herstellung von hexamminkobaltnitrat | |
| DK0403150T3 (da) | Fremgangsmåde til fremstilling af tigogenin-beta-cellobiosid | |
| ATE381536T1 (de) | Verfahren zur herstellung von n-methyl-n'- nitroguanidin | |
| ATE253030T1 (de) | Verfahren zur herstellung von 1,1,4,4- tetramethoxybuten-2 | |
| ATE161269T1 (de) | Verfahren zur herstellung von peptiden und neue zwischenverbindungen dazu | |
| ATE428677T1 (de) | Rückgewinnung und recycling chiraler weinsäureverbindungen zur racematspaltung | |
| EP1471068A4 (de) | Verfahren zur totalsynthese von ecteinascidinen und zwischenprodukte dafür | |
| ATE328106T1 (de) | Verfahren für die biotransformation von colchicon-verbindungen in die entsprechenden 3-glykosyl- derivate | |
| DE50002865D1 (de) | Verfahren zur herstellung von benzofuranonoximen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |