ATE376830T1 - Benzo(b(thiophenderivate und verfahren zu deren herstellung - Google Patents
Benzo(b(thiophenderivate und verfahren zu deren herstellungInfo
- Publication number
- ATE376830T1 ATE376830T1 AT02700711T AT02700711T ATE376830T1 AT E376830 T1 ATE376830 T1 AT E376830T1 AT 02700711 T AT02700711 T AT 02700711T AT 02700711 T AT02700711 T AT 02700711T AT E376830 T1 ATE376830 T1 AT E376830T1
- Authority
- AT
- Austria
- Prior art keywords
- thiophene
- bromomethyl
- benzo
- production
- thiophene derivatives
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical class C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- -1 3,4-Disubstituted-benzo[b]thiophene Chemical class 0.000 abstract 1
- SWCYQEDINMUYPH-UHFFFAOYSA-N 3-(bromomethyl)-4-chloro-1-benzothiophene Chemical compound ClC1=CC=CC2=C1C(CBr)=CS2 SWCYQEDINMUYPH-UHFFFAOYSA-N 0.000 abstract 1
- DAXBQSUETMJEHT-UHFFFAOYSA-N 3-(bromomethyl)-4-fluoro-1-benzothiophene Chemical compound FC1=CC=CC2=C1C(CBr)=CS2 DAXBQSUETMJEHT-UHFFFAOYSA-N 0.000 abstract 1
- GMGKVIRHSVJGTA-UHFFFAOYSA-N 3-(bromomethyl)-4-methoxy-1-benzothiophene Chemical compound COC1=CC=CC2=C1C(CBr)=CS2 GMGKVIRHSVJGTA-UHFFFAOYSA-N 0.000 abstract 1
- CFTWJYBTHFPDMQ-UHFFFAOYSA-N 4-bromo-3-(bromomethyl)-1-benzothiophene Chemical compound C1=CC(Br)=C2C(CBr)=CSC2=C1 CFTWJYBTHFPDMQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004953 trihalomethyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/64—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001046275 | 2001-02-22 | ||
| JP2001135927 | 2001-05-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE376830T1 true ATE376830T1 (de) | 2007-11-15 |
Family
ID=26609879
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02700711T ATE376830T1 (de) | 2001-02-22 | 2002-02-22 | Benzo(b(thiophenderivate und verfahren zu deren herstellung |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6884896B2 (de) |
| EP (2) | EP1792614A1 (de) |
| JP (1) | JP3999128B2 (de) |
| KR (1) | KR100922485B1 (de) |
| CN (1) | CN100457750C (de) |
| AT (1) | ATE376830T1 (de) |
| AU (1) | AU2002233698B2 (de) |
| CA (1) | CA2406913C (de) |
| DE (1) | DE60223227T8 (de) |
| ES (1) | ES2292712T3 (de) |
| NO (1) | NO328158B1 (de) |
| NZ (1) | NZ522150A (de) |
| PL (1) | PL358494A1 (de) |
| PT (1) | PT1362854E (de) |
| WO (1) | WO2002066457A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1944415B (zh) * | 2001-02-22 | 2011-04-13 | 帝人株式会社 | 苯并[b]噻吩衍生物及其制备方法 |
| CL2004001034A1 (es) * | 2003-05-14 | 2005-03-28 | Teijin Pharma Ltd | Formas cristalinas de acido 4-(1-((,etilbenzotiofen-3-il)me til)benzimidazol-2-iltio)butanoico; procedimiento de preparacion de las formas cristalinas; composicion farmaceutica; y su uso para el tratamiento de enfermedades inflamatorias, alergicas, r |
| CN1871029A (zh) * | 2003-08-22 | 2006-11-29 | 帝人制药株式会社 | 含有类糜蛋白酶抑制剂作为有效成分的药物 |
| US7169807B2 (en) * | 2004-04-09 | 2007-01-30 | Allergan, Inc. | 10-Hydroxy-11-dihydroprostaglandin analogs as selective EP4 agonists |
| DE102004021637A1 (de) * | 2004-05-03 | 2005-12-01 | Merck Patent Gmbh | Dihydrobenzothiophene |
| WO2006052026A1 (ja) * | 2004-11-12 | 2006-05-18 | Teijin Pharma Limited | ベンズイミダゾール誘導体の酸性塩及びその結晶 |
| TW200734320A (en) | 2005-10-27 | 2007-09-16 | Teijin Pharma Ltd | 3-Hydroxymethylbenzo [b] thiophen derivatives and a process for producing 3-hydroxymethylbenzo [b] thiophen derivatives |
| EP1947097A1 (de) | 2005-10-27 | 2008-07-23 | Teijin Pharma Limited | Benzo[b]thiophenderivat und verfahren zu dessen herstellung |
| UA95788C2 (en) | 2005-12-15 | 2011-09-12 | Ф. Хоффманн-Ля Рош Аг | Fused pyrrole derivatives |
| NZ708031A (en) | 2012-11-14 | 2018-04-27 | Teijin Pharma Ltd | Pyridine derivative |
| JP6804520B2 (ja) * | 2016-03-31 | 2020-12-23 | 富士フイルム富山化学株式会社 | ５−ブロモメチル−１−ベンゾチオフェンの製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1174411A (en) * | 1966-03-02 | 1969-12-17 | Aspro Nicholas Ltd | Novel Benzothiophen Compounds, Compositions containing them and processes for their manufacture |
| US3910955A (en) * | 1970-12-21 | 1975-10-07 | Aspro Nicholas Ltd | Benzothiophene-ethylamines |
| US4255196A (en) * | 1979-02-23 | 1981-03-10 | Rohm And Haas Company | Lithographic ink of reduced volatile solvent content for reducing atmospheric pollution |
| DE69525763T2 (de) * | 1994-04-11 | 2002-10-02 | Chugai Seiyaku K.K., Tokio/Tokyo | 4,6-DI-t-BUTYL-2,3-DIHYDROBENZOTHIOPHENE, DIE LDL OXIDATION HEMMEN |
| PL203730B1 (pl) * | 1998-07-15 | 2009-11-30 | Teijin Ltd | Pochodna tiobenzimidazolu, kompozycja farmaceutyczna i jej zastosowanie |
| PT1078923E (pt) * | 1999-08-02 | 2006-07-31 | Hoffmann La Roche | Processo para a preparacao de derivados de benzotiofeno |
| NZ520028A (en) * | 2000-01-17 | 2004-07-30 | Teijin Ltd | Benzimidazole derivatives |
| JP2001199968A (ja) * | 2000-01-18 | 2001-07-24 | Teijin Ltd | アミノベンズイミダゾール誘導体 |
| GB0001439D0 (en) * | 2000-01-21 | 2000-03-08 | R P Adam Limited | Method of controlling microbiological activity in water storage tanks and apparatus for use in such method |
| JP3999131B2 (ja) * | 2001-05-07 | 2007-10-31 | 帝人株式会社 | ３−ヒドロキシメチル−ベンゾ［ｂ］チオフェン誘導体、及びその製造方法 |
-
2002
- 2002-02-22 AU AU2002233698A patent/AU2002233698B2/en not_active Ceased
- 2002-02-22 CA CA2406913A patent/CA2406913C/en not_active Expired - Fee Related
- 2002-02-22 ES ES02700711T patent/ES2292712T3/es not_active Expired - Lifetime
- 2002-02-22 EP EP06076752A patent/EP1792614A1/de not_active Withdrawn
- 2002-02-22 EP EP02700711A patent/EP1362854B1/de not_active Expired - Lifetime
- 2002-02-22 PL PL02358494A patent/PL358494A1/xx not_active IP Right Cessation
- 2002-02-22 NZ NZ522150A patent/NZ522150A/xx unknown
- 2002-02-22 WO PCT/JP2002/001611 patent/WO2002066457A1/ja not_active Ceased
- 2002-02-22 CN CNB028012909A patent/CN100457750C/zh not_active Expired - Fee Related
- 2002-02-22 JP JP2002565972A patent/JP3999128B2/ja not_active Expired - Fee Related
- 2002-02-22 AT AT02700711T patent/ATE376830T1/de not_active IP Right Cessation
- 2002-02-22 US US10/258,173 patent/US6884896B2/en not_active Expired - Fee Related
- 2002-02-22 DE DE60223227T patent/DE60223227T8/de active Active
- 2002-02-22 KR KR1020027014185A patent/KR100922485B1/ko not_active Expired - Fee Related
- 2002-02-22 PT PT02700711T patent/PT1362854E/pt unknown
- 2002-10-21 NO NO20025053A patent/NO328158B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPWO2002066457A1 (ja) | 2004-06-17 |
| PT1362854E (pt) | 2008-01-21 |
| NO328158B1 (no) | 2009-12-21 |
| US20030176490A1 (en) | 2003-09-18 |
| EP1362854A1 (de) | 2003-11-19 |
| CA2406913A1 (en) | 2002-08-29 |
| DE60223227T2 (de) | 2008-08-14 |
| DE60223227D1 (de) | 2007-12-13 |
| WO2002066457A1 (en) | 2002-08-29 |
| HK1057215A1 (en) | 2004-03-19 |
| AU2002233698B2 (en) | 2007-11-08 |
| NZ522150A (en) | 2006-03-31 |
| KR100922485B1 (ko) | 2009-10-20 |
| NO20025053L (no) | 2002-11-29 |
| CN1461301A (zh) | 2003-12-10 |
| CN100457750C (zh) | 2009-02-04 |
| EP1792614A1 (de) | 2007-06-06 |
| JP3999128B2 (ja) | 2007-10-31 |
| PL358494A1 (en) | 2004-08-09 |
| EP1362854A4 (de) | 2004-06-09 |
| ES2292712T3 (es) | 2008-03-16 |
| KR20030005293A (ko) | 2003-01-17 |
| US6884896B2 (en) | 2005-04-26 |
| CA2406913C (en) | 2011-04-19 |
| DE60223227T8 (de) | 2008-11-27 |
| EP1362854B1 (de) | 2007-10-31 |
| NO20025053D0 (no) | 2002-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1362854 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |