DK1338596T3 - Fremgangsmåde til fremstilling af antibakterielt middel af carbapenemtypen - Google Patents

Fremgangsmåde til fremstilling af antibakterielt middel af carbapenemtypen

Info

Publication number
DK1338596T3
DK1338596T3 DK01982847T DK01982847T DK1338596T3 DK 1338596 T3 DK1338596 T3 DK 1338596T3 DK 01982847 T DK01982847 T DK 01982847T DK 01982847 T DK01982847 T DK 01982847T DK 1338596 T3 DK1338596 T3 DK 1338596T3
Authority
DK
Denmark
Prior art keywords
preparation
antibacterial agent
carbapenem antibacterial
carbapenem
salt
Prior art date
Application number
DK01982847T
Other languages
English (en)
Inventor
Takashi Kasai
Katsuhiko Fujimoto
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Application granted granted Critical
Publication of DK1338596T3 publication Critical patent/DK1338596T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20Sulfur atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02Preparation
    • C07D477/04Preparation by forming the ring or condensed ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D477/00Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02Preparation
    • C07D477/06Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08Bridged systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK01982847T 2000-11-20 2001-11-19 Fremgangsmåde til fremstilling af antibakterielt middel af carbapenemtypen DK1338596T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2000352178 2000-11-20

Publications (1)

Publication Number Publication Date
DK1338596T3 true DK1338596T3 (da) 2006-04-18

Family

ID=18825114

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01982847T DK1338596T3 (da) 2000-11-20 2001-11-19 Fremgangsmåde til fremstilling af antibakterielt middel af carbapenemtypen

Country Status (14)

Country Link
US (2) US7034150B2 (da)
EP (1) EP1338596B1 (da)
KR (1) KR100825243B1 (da)
CN (1) CN1247581C (da)
AT (1) ATE315568T1 (da)
AU (1) AU2002214325A1 (da)
CA (1) CA2429071A1 (da)
CY (1) CY1105598T1 (da)
DE (1) DE60116656T2 (da)
DK (1) DK1338596T3 (da)
ES (1) ES2256311T3 (da)
PT (1) PT1338596E (da)
TW (1) TWI290925B (da)
WO (1) WO2002040482A1 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101062A1 (ja) * 2005-03-22 2006-09-28 Daiichi Sankyo Company, Limited 1-アルキルピロリジン構造を有するカルバペネム誘導体の製造方法
CN101328178B (zh) * 2007-06-15 2010-10-13 山东轩竹医药科技有限公司 含有噻吩取代的巯基吡咯烷的培南衍生物
CN101357919B (zh) * 2007-06-22 2011-06-15 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯磺酰基的培南衍生物
CN101333219B (zh) * 2007-06-26 2010-10-13 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物
CN101367812B (zh) * 2007-06-28 2011-04-27 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基环戊烯酸取代的培南衍生物
CN101343271B (zh) * 2007-07-13 2011-01-12 山东轩竹医药科技有限公司 含有异噁唑烷酮的培南衍生物
JP6105288B2 (ja) * 2009-12-04 2017-03-29 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 薬物送達装置のペンニードル取外し装置
CN102002069A (zh) * 2010-11-12 2011-04-06 上海巴迪生物医药科技有限公司 一种合成培南类侧链的双环中间体的制备方法及其应用
CN105102424B (zh) * 2013-01-15 2020-09-11 默克专利股份公司 用于治疗关节病的酰基胍类

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4491541A (en) * 1982-11-10 1985-01-01 Farmitalia Carlo Erba Peptides
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
GB8809736D0 (en) * 1988-04-25 1988-06-02 Fujisawa Pharmaceutical Co New cephem compounds & process for preparation thereof
JP3091297B2 (ja) * 1992-01-10 2000-09-25 住友製薬株式会社 ピロリジン誘導体およびその製造方法
CN1095843C (zh) 1995-12-21 2002-12-11 三共株式会社 1-甲基碳代青霉烯衍生物
US5952338A (en) * 1996-07-05 1999-09-14 Takeda Chemical Industries, Ltd. Agent for prophylaxis and treatment of disturbance of visual function
JP2955276B2 (ja) 1997-06-19 1999-10-04 三共株式会社 1−メチルカルバペネム誘導体を含有する抗菌剤
WO1999002531A1 (en) * 1997-07-09 1999-01-21 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
US6063931A (en) * 1997-07-09 2000-05-16 Merck & Co., Inc. Process for synthesizing carbapenem side chain intermediates
JP4548335B2 (ja) * 2003-03-07 2010-09-22 味の素株式会社 腸管細胞のインスリン産生細胞への変換誘導剤、及び糖尿病治療剤

Also Published As

Publication number Publication date
ATE315568T1 (de) 2006-02-15
KR100825243B1 (ko) 2008-04-25
EP1338596A1 (en) 2003-08-27
HK1054745A1 (en) 2003-12-12
CA2429071A1 (en) 2002-05-23
EP1338596B1 (en) 2006-01-11
CN1247581C (zh) 2006-03-29
DE60116656T2 (de) 2006-09-21
US20060009508A1 (en) 2006-01-12
CN1486316A (zh) 2004-03-31
CY1105598T1 (el) 2010-07-28
WO2002040482A1 (en) 2002-05-23
KR20030097793A (ko) 2003-12-31
AU2002214325A1 (en) 2002-05-27
ES2256311T3 (es) 2006-07-16
DE60116656D1 (de) 2006-04-06
US7091363B2 (en) 2006-08-15
US7034150B2 (en) 2006-04-25
US20030225055A1 (en) 2003-12-04
EP1338596A4 (en) 2004-08-04
TWI290925B (en) 2007-12-11
PT1338596E (pt) 2006-05-31

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