ATE377048T1 - Abbaubare polyacetal-polymere - Google Patents
Abbaubare polyacetal-polymereInfo
- Publication number
- ATE377048T1 ATE377048T1 AT01968589T AT01968589T ATE377048T1 AT E377048 T1 ATE377048 T1 AT E377048T1 AT 01968589 T AT01968589 T AT 01968589T AT 01968589 T AT01968589 T AT 01968589T AT E377048 T1 ATE377048 T1 AT E377048T1
- Authority
- AT
- Austria
- Prior art keywords
- polymers
- polyacetal polymers
- degradable polyacetal
- degradable
- favorable
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title abstract 5
- 229930182556 Polyacetal Natural products 0.000 title abstract 4
- 229920006324 polyoxymethylene Polymers 0.000 title abstract 4
- 230000002349 favourable effect Effects 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2/00—Addition polymers of aldehydes or cyclic oligomers thereof or of ketones; Addition copolymers thereof with less than 50 molar percent of other substances
- C08G2/30—Chemical modification by after-treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Polyurethanes Or Polyureas (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23037700P | 2000-09-06 | 2000-09-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377048T1 true ATE377048T1 (de) | 2007-11-15 |
Family
ID=22864985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01968589T ATE377048T1 (de) | 2000-09-06 | 2001-09-06 | Abbaubare polyacetal-polymere |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7220414B2 (de) |
| EP (1) | EP1315777B1 (de) |
| AT (1) | ATE377048T1 (de) |
| AU (1) | AU2001288829A1 (de) |
| CA (1) | CA2453050A1 (de) |
| DE (1) | DE60131177T2 (de) |
| ES (1) | ES2294026T3 (de) |
| WO (1) | WO2002020663A2 (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| US7160924B2 (en) * | 2002-07-19 | 2007-01-09 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
| ATE377048T1 (de) * | 2000-09-06 | 2007-11-15 | Ap Pharma Inc | Abbaubare polyacetal-polymere |
| US6590059B2 (en) | 2001-05-11 | 2003-07-08 | Ap Pharma, Inc. | Bioerodible polyorthoesters from dioxolane-based diketene acetals |
| US6939561B2 (en) * | 2001-06-28 | 2005-09-06 | Wisconsin Alumni Research Foundation | Methods and compositions for polyene antibiotics with reduced toxicity |
| US6524606B1 (en) | 2001-11-16 | 2003-02-25 | Ap Pharma, Inc. | Bioerodible polyorthoesters containing amine groups |
| EP1468036B1 (de) * | 2002-01-14 | 2008-10-08 | The General Hospital Corporation | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
| AU2003230761A1 (en) * | 2002-03-29 | 2003-10-13 | Abbott Laboratories | Polymeric micelle formulations of hydrophobic compounds and methods |
| EP1534269B1 (de) | 2002-07-19 | 2013-10-30 | The General Hospital Corporation | Oxim-konjugate und verfahren zu ihrer bildung und verwendung |
| US7045589B2 (en) | 2002-11-15 | 2006-05-16 | A.P. Pharma, Inc. | Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them |
| US6878374B2 (en) | 2003-02-25 | 2005-04-12 | Nitto Denko Corporation | Biodegradable polyacetals |
| US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
| US7048925B2 (en) | 2003-08-28 | 2006-05-23 | Nitto Denko Corporation | Acid-sensitive polyacetals and methods |
| JP5537763B2 (ja) * | 2003-09-05 | 2014-07-02 | ザ ジェネラル ホスピタル コーポレイション | 放出システムとしてのポリアセタール薬物抱合体 |
| EP1667732B1 (de) | 2003-09-29 | 2010-04-21 | Nitto Denko Corporation | Biologisch abbaubare polyacetale für die in-vivo-abgabe von polynucleotiden |
| US7651682B2 (en) * | 2003-10-29 | 2010-01-26 | Gentis, Inc. | Polymerizable emulsions for tissue engineering |
| GB0329654D0 (en) * | 2003-12-23 | 2004-01-28 | Smith & Nephew | Tunable segmented polyacetal |
| US7446099B2 (en) | 2004-02-27 | 2008-11-04 | Nitto Denko Corporation | Compositions and methods for biodegradable polymer-peptide mediated transfection |
| DE102004023117A1 (de) * | 2004-05-11 | 2005-12-08 | A. u. K. Müller GmbH & Co KG | Elektromagnetventil für flüssige Medien, insbesondere Heißwasser |
| US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
| WO2006044986A1 (en) * | 2004-10-18 | 2006-04-27 | Nitto Denko Corporation | Intracellular peptide delivery |
| US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
| WO2006105148A2 (en) * | 2005-03-31 | 2006-10-05 | Ap Pharma, Inc. | Peg-poly(ortho ester) graft copolymers and pharmaceutical compositions |
| JP2008534747A (ja) * | 2005-03-31 | 2008-08-28 | エーピー ファーマ， インコーポレイテッド | Ｐｅｇ−ポリアセタールグラフトコポリマーおよびｐｅｇ−ポリアセタール−ｐｏｅグラフトコポリマーならびに医薬組成物 |
| CN101495149A (zh) * | 2005-03-31 | 2009-07-29 | 阿帕医药有限公司 | Peg-聚缩醛二嵌段和三嵌段共聚物以及药物组合物 |
| US7588754B2 (en) * | 2005-05-10 | 2009-09-15 | Nitto Denko Corporation | Biodegradable polyacetals and methods |
| US20060263328A1 (en) * | 2005-05-19 | 2006-11-23 | Sang Van | Hydrophilic polymers with pendant functional groups and method thereof |
| JP2009504929A (ja) * | 2005-08-18 | 2009-02-05 | スミス アンド ネフュー ピーエルシー | 高強度デバイス及び複合材料 |
| AU2006281246A1 (en) * | 2005-08-18 | 2007-02-22 | Smith & Nephew, Plc | Multimodal high strength devices and composites |
| US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
| AU2007325001B2 (en) | 2006-11-30 | 2014-04-10 | Smith & Nephew, Inc. | Fiber reinforced composite material |
| WO2008106640A1 (en) * | 2007-03-01 | 2008-09-04 | Cedars-Sinai Medical Center | Antioxidant polymers containing [1,2]-dithiolane moieties and uses thereof |
| EP2142353A1 (de) | 2007-04-18 | 2010-01-13 | Smith & Nephew PLC | Expansionsformen von formgedächtnis-polymeren |
| JP5680957B2 (ja) | 2007-04-19 | 2015-03-04 | スミス アンド ネフュー インコーポレーテッドＳｍｉｔｈ ＆ Ｎｅｐｈｅｗ，Ｉｎｃ． | グラフト固定 |
| ATE547129T1 (de) | 2007-04-19 | 2012-03-15 | Smith & Nephew Inc | Multimodale formgedächtnis-polymere |
| US8658148B2 (en) * | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| US9028874B2 (en) * | 2008-01-03 | 2015-05-12 | Cedars-Sinai Medical Center | Antioxidant nanosphere comprising [1,2]-dithiolane moieties |
| US8603531B2 (en) * | 2008-06-02 | 2013-12-10 | Cedars-Sinai Medical Center | Nanometer-sized prodrugs of NSAIDs |
| ES2529060T3 (es) | 2008-11-24 | 2015-02-16 | Cedars-Sinai Medical Center | Derivados antioxidantes de la camptotecina y nanoesferas antineoplásicas antioxidantes de los mismos |
| KR20110102420A (ko) * | 2008-12-10 | 2011-09-16 | 메르사나 테라퓨틱스, 인코포레이티드 | 생분해성 및 생체적합성 캄토테신-중합체 접합체의 약학 제제 |
| US8347887B2 (en) | 2008-12-23 | 2013-01-08 | Ams Research Corporation | Devices and methods for reversal of permanent sterilization |
| WO2012129070A2 (en) | 2011-03-24 | 2012-09-27 | Unversity Of Florida Research Foundation, Inc. | Acetal metathesis polymerization |
| EP2508544A1 (de) * | 2011-04-04 | 2012-10-10 | Argon Pharma S.L. | Abbaubare Polyacatylpolymere |
| TWI603741B (zh) | 2011-06-10 | 2017-11-01 | 梅爾莎納醫療公司 | 蛋白質-聚合物-藥物共軛體 |
| US8815226B2 (en) | 2011-06-10 | 2014-08-26 | Mersana Therapeutics, Inc. | Protein-polymer-drug conjugates |
| US20140017265A1 (en) * | 2012-07-05 | 2014-01-16 | Mersana Therapeutics, Inc. | Terminally Modified Polymers and Conjugates Thereof |
| ES2726850T3 (es) | 2013-10-11 | 2019-10-09 | Mersana Therapeutics Inc | Conjugados de proteína-polímero-fármaco |
| KR102355745B1 (ko) | 2013-10-11 | 2022-01-26 | 아사나 바이오사이언시스 엘엘씨 | 단백질-폴리머-약물 접합체 |
| EP3227348A4 (de) * | 2014-12-04 | 2018-07-18 | The Trustees of Columbia University in the City of New York | Biologisch abbaubare wärmeempfindliche polymere und verwendungen davon |
| WO2017189953A1 (en) | 2016-04-29 | 2017-11-02 | Children's Medical Center Corporation | Poly(ketals) and related compositions and methods |
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-
2001
- 2001-09-06 AT AT01968589T patent/ATE377048T1/de not_active IP Right Cessation
- 2001-09-06 DE DE60131177T patent/DE60131177T2/de not_active Expired - Fee Related
- 2001-09-06 ES ES01968589T patent/ES2294026T3/es not_active Expired - Lifetime
- 2001-09-06 EP EP01968589A patent/EP1315777B1/de not_active Expired - Lifetime
- 2001-09-06 AU AU2001288829A patent/AU2001288829A1/en not_active Abandoned
- 2001-09-06 WO PCT/US2001/027664 patent/WO2002020663A2/en not_active Ceased
- 2001-09-06 CA CA002453050A patent/CA2453050A1/en not_active Abandoned
- 2001-09-06 US US09/949,162 patent/US7220414B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60131177T2 (de) | 2008-08-07 |
| US20020082362A1 (en) | 2002-06-27 |
| WO2002020663A2 (en) | 2002-03-14 |
| ES2294026T3 (es) | 2008-04-01 |
| CA2453050A1 (en) | 2002-03-14 |
| EP1315777B1 (de) | 2007-10-31 |
| EP1315777A2 (de) | 2003-06-04 |
| WO2002020663A3 (en) | 2002-05-10 |
| DE60131177D1 (de) | 2007-12-13 |
| AU2001288829A1 (en) | 2002-03-22 |
| US7220414B2 (en) | 2007-05-22 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |