ATE377413T1 - Verfahren für die thermodynamische aktivierung von wasserlöslichen arzneimitteln, die in vernetzten polymeren geladen sind - Google Patents
Verfahren für die thermodynamische aktivierung von wasserlöslichen arzneimitteln, die in vernetzten polymeren geladen sindInfo
- Publication number
- ATE377413T1 ATE377413T1 AT02754615T AT02754615T ATE377413T1 AT E377413 T1 ATE377413 T1 AT E377413T1 AT 02754615 T AT02754615 T AT 02754615T AT 02754615 T AT02754615 T AT 02754615T AT E377413 T1 ATE377413 T1 AT E377413T1
- Authority
- AT
- Austria
- Prior art keywords
- cross
- water
- drug
- water soluble
- linked polymers
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 6
- 229940079593 drug Drugs 0.000 title abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 3
- 229920006037 cross link polymer Polymers 0.000 title abstract 2
- 230000004913 activation Effects 0.000 title 1
- 239000002131 composite material Substances 0.000 abstract 2
- 239000013078 crystal Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IE20010628 | 2001-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377413T1 true ATE377413T1 (de) | 2007-11-15 |
Family
ID=11042810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02754615T ATE377413T1 (de) | 2001-06-29 | 2002-06-03 | Verfahren für die thermodynamische aktivierung von wasserlöslichen arzneimitteln, die in vernetzten polymeren geladen sind |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US8889182B2 (de) |
| EP (1) | EP1414414B1 (de) |
| JP (1) | JP2005503360A (de) |
| AT (1) | ATE377413T1 (de) |
| AU (1) | AU2002321061B2 (de) |
| CA (1) | CA2452575C (de) |
| DE (1) | DE60223382T2 (de) |
| DK (1) | DK1414414T3 (de) |
| ES (1) | ES2295379T3 (de) |
| NZ (1) | NZ530826A (de) |
| WO (1) | WO2003002097A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
| EP1494649B1 (de) * | 2002-04-12 | 2012-01-04 | Alkermes Pharma Ireland Limited | Nanopartikuläre megestrol- formulierungen |
| DE602004000260T2 (de) | 2003-07-22 | 2006-08-24 | Arena Pharmaceuticals, Inc., San Diego | Diaryl- und arylheteroarylharnstoffderivate als modulatoren des 5-ht2a-serotoninrezeptors, die sich zur prophylaxe und behandlung von damit im zusammenhang stehenden erkrankungen eignen |
| US7535456B2 (en) * | 2004-04-30 | 2009-05-19 | Hillcrest Laboratories, Inc. | Methods and devices for removing unintentional movement in 3D pointing devices |
| GB0516604D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Rapidly dispersing/disintegrating compositions |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| JP5393677B2 (ja) | 2007-08-15 | 2014-01-22 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ＨＴ２Ａセロトニン受容体に関連した障害の治療のための５−ＨＴ２Ａセロトニン受容体のモジュレーターとしてのイミダゾ［１，２−ａ］ピリジン誘導体 |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| KR20110020782A (ko) * | 2008-04-24 | 2011-03-03 | 이브스트라, 인코포레이티드 | 장용 폴리머 중에 분산된 프로게스토겐 및 에스트로겐을 포함하는 경구 피임약 제형 |
| US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
| CA2741731A1 (en) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Compositions of a 5-ht2a serotonin receptor modulator useful for the treatment of disorders related thereto |
| ITMI20120092A1 (it) * | 2012-01-26 | 2013-07-27 | Micro Macinazione S A | Compositi di inclusione farmaco-carrier preparati con processo di attivazione meccano-chimica mediante mulini a getto di fluido ad alta energia |
| US10022355B2 (en) | 2015-06-12 | 2018-07-17 | Axovant Sciences Gmbh | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of REM sleep behavior disorder |
| BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2634004B2 (de) | 1976-07-29 | 1978-08-10 | Bernhard Dr. 8000 Muenchen Lippold | Verfahren zur Beschleunigung der Auflösung und Verbesserung der Löslichkeit von schlechtlöslichen zur peroralen Verabreichung bestimmten Arzneistoffen |
| DE3320583A1 (de) | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung |
| GB8403359D0 (en) * | 1984-02-08 | 1984-03-14 | Erba Farmitalia | Pharmaceutical compositions |
| US5225192A (en) * | 1988-10-17 | 1993-07-06 | Vectorpharma International S.P.A. | Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate |
| IT1227626B (it) * | 1988-11-28 | 1991-04-23 | Vectorpharma Int | Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione |
| IT1241417B (it) * | 1990-03-06 | 1994-01-14 | Vectorpharma Int | Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione |
| IT1246188B (it) * | 1990-07-27 | 1994-11-16 | Resa Farma | Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute. |
| IT1298574B1 (it) * | 1998-02-06 | 2000-01-12 | Vectorpharma Int | Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione |
-
2002
- 2002-06-03 DE DE60223382T patent/DE60223382T2/de not_active Expired - Lifetime
- 2002-06-03 AU AU2002321061A patent/AU2002321061B2/en not_active Ceased
- 2002-06-03 US US10/481,938 patent/US8889182B2/en not_active Expired - Lifetime
- 2002-06-03 EP EP02754615A patent/EP1414414B1/de not_active Expired - Lifetime
- 2002-06-03 DK DK02754615T patent/DK1414414T3/da active
- 2002-06-03 NZ NZ530826A patent/NZ530826A/en not_active IP Right Cessation
- 2002-06-03 ES ES02754615T patent/ES2295379T3/es not_active Expired - Lifetime
- 2002-06-03 WO PCT/EP2002/006052 patent/WO2003002097A1/en not_active Ceased
- 2002-06-03 JP JP2003508336A patent/JP2005503360A/ja active Pending
- 2002-06-03 CA CA2452575A patent/CA2452575C/en not_active Expired - Fee Related
- 2002-06-03 AT AT02754615T patent/ATE377413T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003002097A1 (en) | 2003-01-09 |
| EP1414414B1 (de) | 2007-11-07 |
| AU2002321061B2 (en) | 2006-08-24 |
| DK1414414T3 (da) | 2008-03-03 |
| CA2452575C (en) | 2010-11-02 |
| US20040213840A1 (en) | 2004-10-28 |
| JP2005503360A (ja) | 2005-02-03 |
| ES2295379T3 (es) | 2008-04-16 |
| US8889182B2 (en) | 2014-11-18 |
| DE60223382D1 (de) | 2007-12-20 |
| DE60223382T2 (de) | 2008-09-11 |
| CA2452575A1 (en) | 2003-01-09 |
| NZ530826A (en) | 2004-09-24 |
| EP1414414A1 (de) | 2004-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |