IT1298574B1 - Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione - Google Patents

Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione

Info

Publication number
IT1298574B1
IT1298574B1 IT98MI000233A ITMI980233A IT1298574B1 IT 1298574 B1 IT1298574 B1 IT 1298574B1 IT 98MI000233 A IT98MI000233 A IT 98MI000233A IT MI980233 A ITMI980233 A IT MI980233A IT 1298574 B1 IT1298574 B1 IT 1298574B1
Authority
IT
Italy
Prior art keywords
extrusion
pharmaceutical compositions
spheronization
polymer
microparticles obtained
Prior art date
Application number
IT98MI000233A
Other languages
English (en)
Inventor
Fabio Carli
Massimo Bresciani
Tiziana Canal
Paolo Gambini
Original Assignee
Vectorpharma Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT98MI000233A priority Critical patent/IT1298574B1/it
Application filed by Vectorpharma Int filed Critical Vectorpharma Int
Priority to NZ506639A priority patent/NZ506639A/en
Priority to CA002319463A priority patent/CA2319463A1/en
Priority to BR9907682-9A priority patent/BR9907682A/pt
Priority to AT99910199T priority patent/ATE209905T1/de
Priority to AU29251/99A priority patent/AU738029B2/en
Priority to PCT/EP1999/000781 priority patent/WO1999039692A2/en
Priority to DE69900544T priority patent/DE69900544T2/de
Priority to PT99910199T priority patent/PT1051158E/pt
Priority to JP2000530192A priority patent/JP2002502809A/ja
Priority to DK99910199T priority patent/DK1051158T3/da
Priority to ES99910199T priority patent/ES2168855T3/es
Priority to EP99910199A priority patent/EP1051158B1/en
Priority to KR1020007008611A priority patent/KR20010040727A/ko
Publication of ITMI980233A1 publication Critical patent/ITMI980233A1/it
Application granted granted Critical
Publication of IT1298574B1 publication Critical patent/IT1298574B1/it
Priority to US09/601,642 priority patent/US6355273B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
IT98MI000233A 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione IT1298574B1 (it)

Priority Applications (15)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione
DK99910199T DK1051158T3 (da) 1998-02-06 1999-02-05 Farmaceutiske præparater i form af polymere mikropartikler fremstillet ved ekstrudering og sfæronisering
BR9907682-9A BR9907682A (pt) 1998-02-06 1999-02-05 Composições farmacêuticas na forma de micropartìculas poliméricas, obtidas por extrusão e formação de partìculas esféricas
AT99910199T ATE209905T1 (de) 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen
AU29251/99A AU738029B2 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
PCT/EP1999/000781 WO1999039692A2 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
NZ506639A NZ506639A (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
PT99910199T PT1051158E (pt) 1998-02-06 1999-02-05 Composicoes farmaceuticas sob a forma de microparticulas polimericas obtidas por extrusao e esferonizacao
JP2000530192A JP2002502809A (ja) 1998-02-06 1999-02-05 押出および球状化処理により得られた高分子微小粒子形態の医薬組成物
CA002319463A CA2319463A1 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
ES99910199T ES2168855T3 (es) 1998-02-06 1999-02-05 Composiciones farmaceuticas en forma de microparticulas polimericas obtenidas por extrusion y esferoidizacion.
EP99910199A EP1051158B1 (en) 1998-02-06 1999-02-05 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization
KR1020007008611A KR20010040727A (ko) 1998-02-06 1999-02-05 압출 및 구형화에 의해 수득된 폴리머계 마이크로 입자형태의 약학적 조성물
DE69900544T DE69900544T2 (de) 1998-02-06 1999-02-05 Pharmazeutische zusammensetzungen in form von polymeren mikropartikeln erhalten durch extrusion und bildung von kügelchen
US09/601,642 US6355273B1 (en) 1998-02-06 2000-08-04 Pharmaceutical compositions in form of polymeric microparticles obtained by extrusion and spheronization

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione

Publications (2)

Publication Number Publication Date
ITMI980233A1 ITMI980233A1 (it) 1999-08-06
IT1298574B1 true IT1298574B1 (it) 2000-01-12

Family

ID=11378855

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98MI000233A IT1298574B1 (it) 1998-02-06 1998-02-06 Composizioni farmaceutiche in forma di microparticelle a base polimerica ottenute mediante estrusione e sferonizzazione

Country Status (15)

Country Link
US (1) US6355273B1 (it)
EP (1) EP1051158B1 (it)
JP (1) JP2002502809A (it)
KR (1) KR20010040727A (it)
AT (1) ATE209905T1 (it)
AU (1) AU738029B2 (it)
BR (1) BR9907682A (it)
CA (1) CA2319463A1 (it)
DE (1) DE69900544T2 (it)
DK (1) DK1051158T3 (it)
ES (1) ES2168855T3 (it)
IT (1) IT1298574B1 (it)
NZ (1) NZ506639A (it)
PT (1) PT1051158E (it)
WO (1) WO1999039692A2 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1323400A (en) * 1998-10-27 2000-05-15 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
ITRN20000051A1 (it) 2000-12-22 2002-06-22 Ascor Chimici Srl Metodo e apparecchiatura per formare sferule composite contenenti principi attivi del tipo farmaceutico e/o integratori alimentari o cosmeti
DE60223382T2 (de) * 2001-06-29 2008-09-11 Eurand Pharmaceuticals Ltd., Bray Verfahren für die thermodynamische aktivierung von wasserlöslichen arzneimitteln, die in vernetzten polymeren geladen sind
WO2003041757A2 (en) * 2001-11-14 2003-05-22 Alza Corporation Catheter injectable depot compositions and uses thereof
US20070196415A1 (en) * 2002-11-14 2007-08-23 Guohua Chen Depot compositions with multiple drug release rate controls and uses thereof
CA2466632C (en) * 2001-11-14 2014-02-11 Alza Corporation Injectable depot compositions and uses thereof
US6572889B1 (en) * 2002-03-07 2003-06-03 Noveon Ip Holdings Corp. Controlled release solid dosage carbamazepine formulations
AU2002330390A1 (en) * 2002-03-20 2003-09-29 Hosokawa Micron Corporation Method of manufacturing chemical-containing composite particles
US20040001889A1 (en) * 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
WO2004011054A2 (en) * 2002-07-31 2004-02-05 Alza Corporation Injectable multimodal polymer depot compositions and uses thereof
KR20050038008A (ko) * 2002-07-31 2005-04-25 알자 코포레이션 주사용 저장형 조성물 및 이의 용도
KR20060129303A (ko) * 2003-12-23 2006-12-15 템렐 리미티드 약제학적 조성물을 위한 펠렛을 생산하는 방법
US20060142234A1 (en) * 2004-12-23 2006-06-29 Guohua Chen Injectable non-aqueous suspension
US8318230B2 (en) * 2005-05-02 2012-11-27 Henkel Ag & Co. Kgaa Use of debranched starch in extrusion-spheronization pharmaceutical pellets
CA2745456A1 (en) * 2008-12-05 2010-06-10 Bayer Animal Health Gmbh Extrudate having spicular active substances
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
ES2882639T3 (es) * 2017-12-28 2021-12-02 Imerys Usa Inc Copolímeros anfifílicos como modificadores de superficie para la producción de polvos de carbonato de calcio mejorados
CA3167217A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN116940358A (zh) 2021-01-12 2023-10-24 度勒科特公司 持续释放药物递送系统和有关的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4086346A (en) * 1974-04-06 1978-04-25 Bayer Aktiengesellschaft Preparation of melt-sprayed spherical phenacetin granules
IT1241417B (it) * 1990-03-06 1994-01-14 Vectorpharma Int Composizioni terapeutiche a rilascio controllato di farmaci supportatisu polimeri reticolati e rivestiti con film polimerici,e loro processodi preparazione
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
US5350584A (en) * 1992-06-26 1994-09-27 Merck & Co., Inc. Spheronization process using charged resins
CA2182282C (en) * 1994-02-16 2006-04-18 Jacqueline E. Briskin Process for preparing fine particle pharmaceutical formulations
DE19504831A1 (de) * 1995-02-14 1996-09-05 Basf Ag Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose

Also Published As

Publication number Publication date
ES2168855T3 (es) 2002-06-16
AU2925199A (en) 1999-08-23
BR9907682A (pt) 2000-11-14
NZ506639A (en) 2003-05-30
DE69900544D1 (de) 2002-01-17
WO1999039692A3 (en) 1999-09-23
WO1999039692A2 (en) 1999-08-12
PT1051158E (pt) 2002-05-31
EP1051158A2 (en) 2000-11-15
CA2319463A1 (en) 1999-08-12
AU738029B2 (en) 2001-09-06
ITMI980233A1 (it) 1999-08-06
ATE209905T1 (de) 2001-12-15
US6355273B1 (en) 2002-03-12
DE69900544T2 (de) 2002-08-22
KR20010040727A (ko) 2001-05-15
DK1051158T3 (da) 2002-04-02
EP1051158B1 (en) 2001-12-05
JP2002502809A (ja) 2002-01-29

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