ATE377596T1 - Piperazinverbindungen - Google Patents

Piperazinverbindungen

Info

Publication number
ATE377596T1
ATE377596T1 AT02736190T AT02736190T ATE377596T1 AT E377596 T1 ATE377596 T1 AT E377596T1 AT 02736190 T AT02736190 T AT 02736190T AT 02736190 T AT02736190 T AT 02736190T AT E377596 T1 ATE377596 T1 AT E377596T1
Authority
AT
Austria
Prior art keywords
group
hydrogen atom
piperazine compounds
alkyl group
rheumatism
Prior art date
Application number
AT02736190T
Other languages
English (en)
Inventor
Tatsuhiko Kodama
Masahiro Tamura
Toshiaki Oda
Yukiyoshi Yamazaki
Masahiro Nishikawa
Takeshi Doi
Yoshinori Kyotani
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Application granted granted Critical
Publication of ATE377596T1 publication Critical patent/ATE377596T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Hydrogenated Pyridines (AREA)
AT02736190T 2001-06-29 2002-06-27 Piperazinverbindungen ATE377596T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/893,681 US6432957B1 (en) 2001-06-29 2001-06-29 Piperazine derivative

Publications (1)

Publication Number Publication Date
ATE377596T1 true ATE377596T1 (de) 2007-11-15

Family

ID=25401910

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02736190T ATE377596T1 (de) 2001-06-29 2002-06-27 Piperazinverbindungen

Country Status (11)

Country Link
US (1) US6432957B1 (de)
EP (1) EP1400521B1 (de)
JP (1) JP4220897B2 (de)
KR (1) KR100878416B1 (de)
CN (1) CN1309720C (de)
AT (1) ATE377596T1 (de)
CA (1) CA2451562C (de)
DE (1) DE60223373T2 (de)
ES (1) ES2295350T3 (de)
TW (1) TWI226240B (de)
WO (1) WO2003002554A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6552188B2 (en) * 2001-06-29 2003-04-22 Kowa Co., Ltd. Unsymmetrical cyclic diamine compound
US6509329B1 (en) * 2001-06-29 2003-01-21 Kowa Co., Ltd. Cyclic diamine compound with 6-membered ring groups
US6632810B2 (en) * 2001-06-29 2003-10-14 Kowa Co., Ltd. Cyclic diamine compound with condensed-ring groups
WO2004032931A1 (ja) * 2002-10-11 2004-04-22 Kowa Co., Ltd. 癌の処置方法
AU2003280558A1 (en) * 2002-10-11 2004-05-04 Kowa Co., Ltd. Method for treatment of cancer
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
JP4634303B2 (ja) * 2003-10-10 2011-02-16 興和株式会社 血管新生抑制薬
US7572799B2 (en) * 2003-11-24 2009-08-11 Pfizer Inc Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors
GB0327323D0 (en) * 2003-11-24 2003-12-31 Pfizer Ltd Novel pharmaceuticals
US8071626B2 (en) * 2003-12-18 2011-12-06 Wallac Oy Chelating agents and highly luminescent and stable chelates and their use
EP1577289A1 (de) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen.
DK1742950T3 (da) * 2004-04-07 2009-03-16 Pfizer Ltd Pyrazolo-[4,3-D]-pyrimidiner
JPWO2006082834A1 (ja) * 2005-02-02 2008-06-26 興和株式会社 ケラチノサイト増殖に起因する疾患の予防・治療剤
EP1764094A1 (de) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neuartige multi-zyklische Verbindungen und deren Verwendung
EP1764096A1 (de) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität
EP1764095A1 (de) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue Nitrocatecholderivate mit Selectin-Ligand-Activität
EP1764093A1 (de) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Neue aromatische Verbindungen und deren medizinische Verwendung
EP1946756A1 (de) * 2007-01-17 2008-07-23 Revotar Biopharmaceuticals AG Verwendung von Entacapon für kosmetische, dermatologische und pharmazeutische Zusammensetzungen
CN102066554B (zh) * 2008-06-18 2016-11-16 国立大学法人京都大学 细胞粘着促进剂和促进细胞粘着的方法
AU2010299444B2 (en) 2009-09-24 2015-12-10 Anima Cell Metrology, Inc. Systems and methods for measuring translation of target proteins in cells
JP7027437B2 (ja) 2016-10-27 2022-03-01 エスカリア バイオサイエンシーズ，ビーブイ ＲＯＲ－γモジュレーター
EP3765009A4 (de) 2018-03-12 2021-11-10 Escalier Biosciences, BV Bicyclische ror-gamma-modulatoren
BR112020018718A2 (pt) 2018-03-12 2021-03-09 Escalier Biosciences B.V. Moduladores de ror-gama espirocíclicos

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1473262A (en) * 1974-11-20 1977-05-11 Delalande Sa Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application
FR2527608B1 (fr) * 1982-05-28 1986-10-10 Sandoz Sa Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments
US4876256A (en) * 1988-04-29 1989-10-24 Merck & Co., Inc. Alkylpiperazinylpyridines as hypoglycemic agents
IE911774A1 (en) * 1990-06-11 1991-12-18 Akzo Nv Pyridinylpiperazine derivatives
CA2184919C (en) * 1995-01-11 2000-03-14 Eui-Hwan Cho New piperazine derivatives and methods for the preparation thereof and compositions containing the same
JP3808921B2 (ja) 1995-11-20 2006-08-16 興和株式会社 細胞接着阻害剤
AU2446297A (en) * 1996-04-30 1997-11-19 Warner-Lambert Company Substituted piperazines and piperidines as central nervous system agents
JP2000509070A (ja) 1996-04-30 2000-07-18 ヘキスト・マリオン・ルセル・インコーポレイテツド ２，６―ジアルキル―４―シリル―フェノールを使用して血管細胞接着分子―１を阻害する方法および慢性炎症性疾患を治療する方法
US6686353B1 (en) * 1996-05-20 2004-02-03 Teijin Intellectual Property Center Limited Diarylalkyl cyclic diamine derivatives as chemokine receptor antagonists
JP3577183B2 (ja) 1996-06-17 2004-10-13 花王株式会社 動脈硬化症予防・治療剤
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate
JPH10147568A (ja) 1996-11-19 1998-06-02 Mitsui Chem Inc ナフタレン誘導体およびそれを有効成分として含有する医薬品
JPH10182550A (ja) 1996-12-25 1998-07-07 Mitsui Chem Inc ヒドロキシ安息香酸誘導体およびそれを有効成分として含有する医薬品
JP4139453B2 (ja) 1997-09-24 2008-08-27 興和株式会社 細胞接着阻害剤
HUP0104432A3 (en) * 1998-02-19 2003-04-28 Kowa Co Cyclic amide compounds and medicaments containing the same
JP2000319277A (ja) 1999-05-11 2000-11-21 Ono Pharmaceut Co Ltd 縮合ピラジン化合物およびその化合物を有効成分とする薬剤
US6509329B1 (en) * 2001-06-29 2003-01-21 Kowa Co., Ltd. Cyclic diamine compound with 6-membered ring groups

Also Published As

Publication number Publication date
US6432957B1 (en) 2002-08-13
CA2451562A1 (en) 2003-01-09
DE60223373D1 (de) 2007-12-20
JPWO2003002554A1 (ja) 2004-10-14
CN1309720C (zh) 2007-04-11
CA2451562C (en) 2010-02-09
CN1520408A (zh) 2004-08-11
HK1065032A1 (en) 2005-02-08
EP1400521B1 (de) 2007-11-07
DE60223373T2 (de) 2008-02-21
KR100878416B1 (ko) 2009-01-13
KR20040015739A (ko) 2004-02-19
ES2295350T3 (es) 2008-04-16
EP1400521A1 (de) 2004-03-24
JP4220897B2 (ja) 2009-02-04
WO2003002554A1 (en) 2003-01-09
TWI226240B (en) 2005-01-11
EP1400521A4 (de) 2005-04-06

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties