ATE377596T1 - Piperazinverbindungen - Google Patents
PiperazinverbindungenInfo
- Publication number
- ATE377596T1 ATE377596T1 AT02736190T AT02736190T ATE377596T1 AT E377596 T1 ATE377596 T1 AT E377596T1 AT 02736190 T AT02736190 T AT 02736190T AT 02736190 T AT02736190 T AT 02736190T AT E377596 T1 ATE377596 T1 AT E377596T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- hydrogen atom
- piperazine compounds
- alkyl group
- rheumatism
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 206010003210 Arteriosclerosis Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000008595 infiltration Effects 0.000 abstract 1
- 238000001764 infiltration Methods 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- -1 piperazine compound Chemical class 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/893,681 US6432957B1 (en) | 2001-06-29 | 2001-06-29 | Piperazine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377596T1 true ATE377596T1 (de) | 2007-11-15 |
Family
ID=25401910
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02736190T ATE377596T1 (de) | 2001-06-29 | 2002-06-27 | Piperazinverbindungen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6432957B1 (de) |
| EP (1) | EP1400521B1 (de) |
| JP (1) | JP4220897B2 (de) |
| KR (1) | KR100878416B1 (de) |
| CN (1) | CN1309720C (de) |
| AT (1) | ATE377596T1 (de) |
| CA (1) | CA2451562C (de) |
| DE (1) | DE60223373T2 (de) |
| ES (1) | ES2295350T3 (de) |
| TW (1) | TWI226240B (de) |
| WO (1) | WO2003002554A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6552188B2 (en) * | 2001-06-29 | 2003-04-22 | Kowa Co., Ltd. | Unsymmetrical cyclic diamine compound |
| US6632810B2 (en) | 2001-06-29 | 2003-10-14 | Kowa Co., Ltd. | Cyclic diamine compound with condensed-ring groups |
| US6509329B1 (en) * | 2001-06-29 | 2003-01-21 | Kowa Co., Ltd. | Cyclic diamine compound with 6-membered ring groups |
| WO2004032931A1 (ja) * | 2002-10-11 | 2004-04-22 | Kowa Co., Ltd. | 癌の処置方法 |
| AU2003280558A1 (en) * | 2002-10-11 | 2004-05-04 | Kowa Co., Ltd. | Method for treatment of cancer |
| EP1620437B1 (de) | 2003-04-29 | 2009-06-17 | Pfizer Limited | 5,7-diaminopyrazolo¬4,3-d pyrimidine zur verwendung in der behandlung von bluthochdruck |
| JP4634303B2 (ja) * | 2003-10-10 | 2011-02-16 | 興和株式会社 | 血管新生抑制薬 |
| GB0327323D0 (en) * | 2003-11-24 | 2003-12-31 | Pfizer Ltd | Novel pharmaceuticals |
| US7572799B2 (en) * | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
| US8071626B2 (en) * | 2003-12-18 | 2011-12-06 | Wallac Oy | Chelating agents and highly luminescent and stable chelates and their use |
| EP1577289A1 (de) | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Nicht-glykosylierte/-glykosidische/-peptidische keine Moleküle als Selektininhibitoren für die Behandlung entzündlicher Erkrankungen. |
| ES2317209T3 (es) * | 2004-04-07 | 2009-04-16 | Pfizer Inc. | Pirazolo(4,3-) pirimidinas. |
| US20090042901A1 (en) * | 2005-02-02 | 2009-02-12 | Kowa Co., Ltd. | Agent for prevention/therapy of disease caused by keratinocyte growth |
| EP1764096A1 (de) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Neue Phloroglucinolderivate mit Selectin-Ligand-Aktivität |
| EP1764095A1 (de) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Neue Nitrocatecholderivate mit Selectin-Ligand-Activität |
| EP1764094A1 (de) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Neuartige multi-zyklische Verbindungen und deren Verwendung |
| EP1764093A1 (de) * | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Neue aromatische Verbindungen und deren medizinische Verwendung |
| EP1946756A1 (de) * | 2007-01-17 | 2008-07-23 | Revotar Biopharmaceuticals AG | Verwendung von Entacapon für kosmetische, dermatologische und pharmazeutische Zusammensetzungen |
| CN102066554B (zh) * | 2008-06-18 | 2016-11-16 | 国立大学法人京都大学 | 细胞粘着促进剂和促进细胞粘着的方法 |
| EP2480890B1 (de) | 2009-09-24 | 2018-02-28 | Anima Biotech Inc. | Verfahren zur messung der translation von zielproteinen in zellen |
| US10905687B2 (en) * | 2016-10-27 | 2021-02-02 | Escalier Biosciences B.V. | Substituted piperazines as ROR-gamma modulators |
| BR112020018718A2 (pt) | 2018-03-12 | 2021-03-09 | Escalier Biosciences B.V. | Moduladores de ror-gama espirocíclicos |
| JP2021517563A (ja) | 2018-03-12 | 2021-07-26 | エスカリア バイオサイエンシーズ，ビーブイ | 二環式ＲＯＲγモジュレーター |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1473262A (en) * | 1974-11-20 | 1977-05-11 | Delalande Sa | Derivatives of n-3,4,5-trimethoxy cinnamoyl-piperazine their process of preparation and their therapeutic application |
| FR2527608B1 (fr) * | 1982-05-28 | 1986-10-10 | Sandoz Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments |
| US4876256A (en) * | 1988-04-29 | 1989-10-24 | Merck & Co., Inc. | Alkylpiperazinylpyridines as hypoglycemic agents |
| IE911774A1 (en) * | 1990-06-11 | 1991-12-18 | Akzo Nv | Pyridinylpiperazine derivatives |
| CN1128139C (zh) * | 1995-01-11 | 2003-11-19 | 三进制药株式会社 | 新哌嗪衍生物及其制造方法 |
| JP3808921B2 (ja) * | 1995-11-20 | 2006-08-16 | 興和株式会社 | 細胞接着阻害剤 |
| WO1997041108A1 (en) * | 1996-04-30 | 1997-11-06 | Warner-Lambert Company | Substituted piperazines and piperidines as central nervous system agents |
| WO1997040837A1 (en) | 1996-04-30 | 1997-11-06 | Hoechst Marion Roussel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2,6-di-alkyl-4-silyl-phenols |
| EP0914319B1 (de) * | 1996-05-20 | 2001-11-21 | Teijin Limited | Cyclischer diarylalkyl diaminederivate als antogoniste von chemokinerezeptoren |
| JP3577183B2 (ja) | 1996-06-17 | 2004-10-13 | 花王株式会社 | 動脈硬化症予防・治療剤 |
| DE19637237A1 (de) * | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
| JPH10147568A (ja) | 1996-11-19 | 1998-06-02 | Mitsui Chem Inc | ナフタレン誘導体およびそれを有効成分として含有する医薬品 |
| JPH10182550A (ja) | 1996-12-25 | 1998-07-07 | Mitsui Chem Inc | ヒドロキシ安息香酸誘導体およびそれを有効成分として含有する医薬品 |
| JP4139453B2 (ja) | 1997-09-24 | 2008-08-27 | 興和株式会社 | 細胞接着阻害剤 |
| JP4388228B2 (ja) * | 1998-02-19 | 2009-12-24 | 興和株式会社 | 環状アミド化合物 |
| JP2000319277A (ja) | 1999-05-11 | 2000-11-21 | Ono Pharmaceut Co Ltd | 縮合ピラジン化合物およびその化合物を有効成分とする薬剤 |
| US6509329B1 (en) * | 2001-06-29 | 2003-01-21 | Kowa Co., Ltd. | Cyclic diamine compound with 6-membered ring groups |
-
2001
- 2001-06-29 US US09/893,681 patent/US6432957B1/en not_active Expired - Fee Related
-
2002
- 2002-06-27 EP EP02736190A patent/EP1400521B1/de not_active Expired - Lifetime
- 2002-06-27 KR KR1020037016481A patent/KR100878416B1/ko not_active Expired - Fee Related
- 2002-06-27 JP JP2003508935A patent/JP4220897B2/ja not_active Expired - Fee Related
- 2002-06-27 WO PCT/JP2002/006491 patent/WO2003002554A1/ja not_active Ceased
- 2002-06-27 CN CNB028128222A patent/CN1309720C/zh not_active Expired - Fee Related
- 2002-06-27 DE DE60223373T patent/DE60223373T2/de not_active Expired - Lifetime
- 2002-06-27 AT AT02736190T patent/ATE377596T1/de not_active IP Right Cessation
- 2002-06-27 ES ES02736190T patent/ES2295350T3/es not_active Expired - Lifetime
- 2002-06-27 CA CA2451562A patent/CA2451562C/en not_active Expired - Fee Related
- 2002-06-28 TW TW091114338A patent/TWI226240B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE60223373D1 (de) | 2007-12-20 |
| EP1400521A4 (de) | 2005-04-06 |
| TWI226240B (en) | 2005-01-11 |
| CN1309720C (zh) | 2007-04-11 |
| KR100878416B1 (ko) | 2009-01-13 |
| CA2451562A1 (en) | 2003-01-09 |
| US6432957B1 (en) | 2002-08-13 |
| CN1520408A (zh) | 2004-08-11 |
| EP1400521A1 (de) | 2004-03-24 |
| JPWO2003002554A1 (ja) | 2004-10-14 |
| KR20040015739A (ko) | 2004-02-19 |
| ES2295350T3 (es) | 2008-04-16 |
| EP1400521B1 (de) | 2007-11-07 |
| CA2451562C (en) | 2010-02-09 |
| WO2003002554A1 (en) | 2003-01-09 |
| HK1065032A1 (en) | 2005-02-08 |
| JP4220897B2 (ja) | 2009-02-04 |
| DE60223373T2 (de) | 2008-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |