ATE377603T1 - Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor - Google Patents
Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptorInfo
- Publication number
- ATE377603T1 ATE377603T1 AT03760857T AT03760857T ATE377603T1 AT E377603 T1 ATE377603 T1 AT E377603T1 AT 03760857 T AT03760857 T AT 03760857T AT 03760857 T AT03760857 T AT 03760857T AT E377603 T1 ATE377603 T1 AT E377603T1
- Authority
- AT
- Austria
- Prior art keywords
- pharmaceutically acceptable
- tetracyclic
- compound
- arylsulfonylindoles
- affinity
- Prior art date
Links
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 title 1
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- -1 arylsulfonyl indoles Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Anesthesiology (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN478CH2002 | 2002-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE377603T1 true ATE377603T1 (de) | 2007-11-15 |
Family
ID=29798513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03760857T ATE377603T1 (de) | 2002-06-21 | 2003-06-19 | Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US7649097B2 (de) |
| EP (1) | EP1523486B1 (de) |
| JP (1) | JP4473120B2 (de) |
| CN (1) | CN100378108C (de) |
| AT (1) | ATE377603T1 (de) |
| AU (1) | AU2003249582B2 (de) |
| BR (1) | BR0312176A (de) |
| CA (1) | CA2490254C (de) |
| DE (1) | DE60317333T2 (de) |
| DK (1) | DK1523486T3 (de) |
| ES (1) | ES2297216T3 (de) |
| MX (1) | MXPA04012832A (de) |
| NZ (1) | NZ537770A (de) |
| RU (1) | RU2340619C2 (de) |
| WO (1) | WO2004000849A2 (de) |
| ZA (1) | ZA200409886B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100776118B1 (ko) | 2002-11-28 | 2007-11-15 | 수벤 라이프 사이언시스 리미티드 | 엔-아릴술포닐-3-아미노알콕시인돌 |
| AU2003292510B2 (en) * | 2002-12-18 | 2009-04-23 | Suven Life Sciences Limited | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| EP1704154B1 (de) * | 2004-01-02 | 2009-05-06 | Suven Life Sciences Limited | Neue indeno[2,1-a]indene und isoindol[2,1-a]indol |
| WO2005094897A2 (en) * | 2004-04-01 | 2005-10-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
| BRPI0520054B1 (pt) * | 2005-03-08 | 2018-07-10 | Suven Life Sciences Limited | Processo para a preparação de benzotiazinoindolas substituídas |
| JP7644122B2 (ja) | 2019-12-26 | 2025-03-11 | ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド | アリールシクロヘキシルアミン誘導体及び精神障害の処置におけるそれらの使用 |
| PL4084791T3 (pl) | 2020-02-18 | 2025-04-22 | Gilgamesh Pharmaceuticals, Inc. | Specyficzne tryptaminy do zastosowania w leczeniu zaburzeń nastroju |
| JP7766623B2 (ja) | 2020-05-19 | 2025-11-10 | サイビン アイアールエル リミテッド | 重水素化トリプタミン誘導体および使用方法 |
| WO2021250435A1 (en) | 2020-06-12 | 2021-12-16 | Beckley Psytech Limited | Pharmaceutical composition comprising 5-methoxy-n,n-dimethyltryptamine |
| WO2022153268A1 (en) | 2021-01-15 | 2022-07-21 | Beckley Psytech Limited | Tryptamine analogues |
| EP4396162A4 (de) | 2021-09-03 | 2025-11-12 | Alexander Shulgin Res Institute Inc | Asymmetrische allyltryptamine |
| US12264131B2 (en) | 2022-08-19 | 2025-04-01 | Beckley Psytech Limited | Pharmaceutically acceptable salts and compositions thereof |
| GB202212116D0 (en) | 2022-08-19 | 2022-10-05 | Beckley Psytech Ltd | Pharmaceutically acceptable salts and Compositions thereof |
| US12246005B2 (en) | 2023-06-13 | 2025-03-11 | Beckley Psytech Limited | 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations |
| US12180158B1 (en) | 2023-08-03 | 2024-12-31 | Gilgamesh Pharmaceuticals, Inc. | Crystalline fumarate salts of n-ethyl-2-(5-fluoro-1H-indol-3-yl)-n-methylethan-1-amine |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3481953A (en) * | 1967-12-18 | 1969-12-02 | American Home Prod | 1-arylsulfonyl-3-(2-substituted ethyl) indoles |
| ZA795239B (en) | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| ZA815541B (en) * | 1980-08-12 | 1983-03-30 | Glaxo Group Ltd | Heterocyclic compounds |
| GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| GB8819024D0 (en) | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| IL96891A0 (en) | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| CA2042295A1 (fr) | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
| SI9111010B (sl) | 1990-06-07 | 2005-02-28 | Astrazeneca Ab | 3,5-disubstituirani indolni derivati kot "5-HT1-podobni" receptorski agonisti |
| SK278998B6 (sk) | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| GB9113802D0 (en) | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
| US5206382A (en) * | 1991-06-27 | 1993-04-27 | Fidia Georgetown Institute For The Neurosciences | Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders |
| FR2686878B1 (fr) * | 1992-01-30 | 1995-06-30 | Sanofi Elf | Derives du n-sulfonyl oxo-2 indole, leur preparation, les compositions pharmaceutiques en contenant. |
| GB9210400D0 (en) | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| KR940007001A (ko) | 1992-09-16 | 1994-04-26 | 최승주 | 새로운 n-신나모일-2-메틸-5-메톡시-3-인돌 아세트산 에스테르, 그 제조방법 및 이를 함유하는 약학적 제제 |
| US6281355B1 (en) * | 1997-12-03 | 2001-08-28 | Taisho Pharmaceutical Co., Ltd. | Nitrogen-containing tetracyclic compounds |
| JP2000026471A (ja) | 1998-07-10 | 2000-01-25 | Nippon Soda Co Ltd | １１−ホルミル−インドロ［１，２−ｂ］［１，２］ベンズイソチアゾールおよび農園芸用殺菌剤 |
| GB9820113D0 (en) * | 1998-09-15 | 1998-11-11 | Merck Sharp & Dohme | Therapeutic agents |
| DE69930308T2 (de) * | 1998-12-11 | 2006-11-30 | Virginia Commonwealth University | Selektive 5-ht 6-rezeptor-liganden |
| CZ305838B6 (cs) | 2001-03-29 | 2016-04-06 | Eli Lilly And Company | N-(2-arylethyl)benzylaminy jako antagonisté receptoru 5-HT6 |
-
2003
- 2003-06-19 BR BR0312176-3A patent/BR0312176A/pt not_active IP Right Cessation
- 2003-06-19 DE DE60317333T patent/DE60317333T2/de not_active Expired - Lifetime
- 2003-06-19 DK DK03760857T patent/DK1523486T3/da active
- 2003-06-19 CN CNB038146029A patent/CN100378108C/zh not_active Expired - Fee Related
- 2003-06-19 AT AT03760857T patent/ATE377603T1/de active
- 2003-06-19 ES ES03760857T patent/ES2297216T3/es not_active Expired - Lifetime
- 2003-06-19 WO PCT/IN2003/000222 patent/WO2004000849A2/en not_active Ceased
- 2003-06-19 JP JP2004515418A patent/JP4473120B2/ja not_active Expired - Fee Related
- 2003-06-19 NZ NZ537770A patent/NZ537770A/en not_active IP Right Cessation
- 2003-06-19 EP EP03760857A patent/EP1523486B1/de not_active Expired - Lifetime
- 2003-06-19 AU AU2003249582A patent/AU2003249582B2/en not_active Ceased
- 2003-06-19 CA CA2490254A patent/CA2490254C/en not_active Expired - Fee Related
- 2003-06-19 US US10/519,219 patent/US7649097B2/en not_active Expired - Fee Related
- 2003-06-19 MX MXPA04012832A patent/MXPA04012832A/es active IP Right Grant
- 2003-06-19 RU RU2005101344/04A patent/RU2340619C2/ru not_active IP Right Cessation
-
2004
- 2004-12-07 ZA ZA200409886A patent/ZA200409886B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2490254A1 (en) | 2003-12-31 |
| ZA200409886B (en) | 2006-07-26 |
| BR0312176A (pt) | 2005-04-05 |
| JP2005535621A (ja) | 2005-11-24 |
| MXPA04012832A (es) | 2005-05-27 |
| AU2003249582B2 (en) | 2006-08-03 |
| AU2003249582A1 (en) | 2004-01-06 |
| CN100378108C (zh) | 2008-04-02 |
| NZ537770A (en) | 2007-03-30 |
| HK1074843A1 (en) | 2005-11-25 |
| CA2490254C (en) | 2011-11-01 |
| RU2340619C2 (ru) | 2008-12-10 |
| ES2297216T3 (es) | 2008-05-01 |
| EP1523486A2 (de) | 2005-04-20 |
| JP4473120B2 (ja) | 2010-06-02 |
| DK1523486T3 (da) | 2008-03-03 |
| DE60317333D1 (de) | 2007-12-20 |
| US20050203154A1 (en) | 2005-09-15 |
| CN1662544A (zh) | 2005-08-31 |
| US7649097B2 (en) | 2010-01-19 |
| EP1523486B1 (de) | 2007-11-07 |
| DE60317333T2 (de) | 2008-08-28 |
| WO2004000849A3 (en) | 2004-03-25 |
| WO2004000849A2 (en) | 2003-12-31 |
| RU2005101344A (ru) | 2005-08-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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