ATE378333T1 - Als biomarker geeignete cumarine - Google Patents
Als biomarker geeignete cumarineInfo
- Publication number
- ATE378333T1 ATE378333T1 AT03743381T AT03743381T ATE378333T1 AT E378333 T1 ATE378333 T1 AT E378333T1 AT 03743381 T AT03743381 T AT 03743381T AT 03743381 T AT03743381 T AT 03743381T AT E378333 T1 ATE378333 T1 AT E378333T1
- Authority
- AT
- Austria
- Prior art keywords
- cumarins
- biomarkers
- cumarins suitable
- Prior art date
Links
- 239000000090 biomarker Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0205281.9A GB0205281D0 (en) | 2002-03-06 | 2002-03-06 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE378333T1 true ATE378333T1 (de) | 2007-11-15 |
Family
ID=9932424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03743381T ATE378333T1 (de) | 2002-03-06 | 2003-03-05 | Als biomarker geeignete cumarine |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7569337B2 (de) |
| EP (1) | EP1483262B1 (de) |
| JP (2) | JP4247123B2 (de) |
| KR (1) | KR20040095257A (de) |
| CN (1) | CN1628114A (de) |
| AR (1) | AR038723A1 (de) |
| AT (1) | ATE378333T1 (de) |
| AU (1) | AU2003210418A1 (de) |
| BR (1) | BR0308211A (de) |
| CA (1) | CA2472298A1 (de) |
| CO (1) | CO5611123A2 (de) |
| DE (1) | DE60317476T2 (de) |
| EC (1) | ECSP045255A (de) |
| ES (1) | ES2294304T3 (de) |
| GB (1) | GB0205281D0 (de) |
| MX (1) | MXPA04008570A (de) |
| NO (1) | NO20044174L (de) |
| PE (1) | PE20030890A1 (de) |
| PL (1) | PL370916A1 (de) |
| PT (1) | PT1483262E (de) |
| RU (1) | RU2004129733A (de) |
| TW (1) | TW200400049A (de) |
| WO (1) | WO2003074519A1 (de) |
| ZA (1) | ZA200405175B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
| JP2007504283A (ja) * | 2003-05-20 | 2007-03-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | β−アミロイド斑に作用物質を結合させる方法 |
| JP2007084526A (ja) * | 2004-11-26 | 2007-04-05 | Nagasaki Univ | アミロイド関連疾患診断用組成物 |
| EP1815872A4 (de) * | 2004-11-26 | 2011-06-15 | Univ Nagasaki | Zusammensetzung für die diagnose von amyloid-assoziierter erkrankung |
| TW200803903A (en) * | 2006-04-28 | 2008-01-16 | Nihon Mediphysics Co Ltd | Novel compound having affinity to amyloid |
| RU2008150377A (ru) * | 2006-05-19 | 2010-06-27 | Нихон Меди-Физикс Ко., Лтд. (Jp) | Новое соединение, обладающее сродством к амилоиду |
| TW200811175A (en) * | 2006-06-21 | 2008-03-01 | Nihon Mediphysics Co Ltd | Novel compound with affinity with amyloid |
| AU2007261985B2 (en) * | 2006-06-21 | 2012-04-19 | Nihon Medi-Physics Co., Ltd. | Novel compound having affinity for amyloid |
| EP2119458B9 (de) | 2007-02-13 | 2013-08-21 | Nihon Medi-Physics Co., Ltd. | Verfahren zur herstellung eines abbildungsmittels zur strahlendiagnose |
| EP2213672A4 (de) * | 2007-10-24 | 2012-05-02 | Nihon Mediphysics Co Ltd | Neue verbindung mit affinität zu amyloid |
| KR20100089858A (ko) * | 2007-10-30 | 2010-08-12 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법 |
| KR20100101577A (ko) * | 2007-10-30 | 2010-09-17 | 니혼 메디피직스 가부시키가이샤 | 신규 아밀로이드 친화성 화합물의 사용 및 제조 방법 |
| JP6193881B2 (ja) * | 2011-12-30 | 2017-09-06 | ピーティーシー セラピューティクス， インコーポレイテッド | 脊髄性筋萎縮症を治療するための化合物 |
| EP2804852A2 (de) | 2012-01-20 | 2014-11-26 | Regents Of The University Of Minnesota | Therapeutische verbindungen |
| CA2862084C (en) * | 2012-01-26 | 2021-05-11 | Ptc Therapeutics, Inc. | 1h-isochromen-1-one derivatives and compositions thereof for treating spinal muscular atrophy |
| ES2697174T3 (es) | 2012-02-10 | 2019-01-22 | Ptc Therapeutics Inc | Compuestos para tratar atrofia muscular espinal |
| KR102099997B1 (ko) * | 2012-03-01 | 2020-04-13 | 피티씨 테라퓨틱스, 인크. | 척수성 근위축증을 치료하기 위한 화합물 |
| US9914722B2 (en) | 2012-03-23 | 2018-03-13 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
| CN104987328A (zh) * | 2012-05-23 | 2015-10-21 | 复旦大学 | 7-氧、硫或氮杂取代香豆素及其衍生物和用途 |
| WO2015105657A1 (en) | 2013-12-19 | 2015-07-16 | Ptc Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| KR20220100719A (ko) | 2015-12-10 | 2022-07-15 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 또는 개선을 위한 조성물 |
| CA3043755A1 (en) | 2016-11-28 | 2018-05-31 | Ptc Therapeutics, Inc. | Methods for modulating rna splicing |
| CN109476674B (zh) | 2016-12-22 | 2021-12-10 | 伊鲁米纳剑桥有限公司 | 香豆素化合物及其作为荧光标记物的用途 |
| CN108061725B (zh) * | 2017-02-16 | 2020-04-21 | 昆明医科大学 | 1,8-萘啶基荧光分子探针在氯胺酮娱乐性滥用神经机制研究及成瘾程度诊断中的应用 |
| AU2018282154B2 (en) | 2017-06-05 | 2022-04-07 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| KR20200017476A (ko) | 2017-06-14 | 2020-02-18 | 피티씨 테라퓨틱스, 인크. | Rna 스플라이싱의 변경 방법 |
| CA3067591A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | Methods for treating huntington's disease |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| AU2019243048A1 (en) | 2018-03-27 | 2020-10-15 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| WO2020005882A1 (en) | 2018-06-27 | 2020-01-02 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating huntington's disease |
| BR112020026534A2 (pt) | 2018-06-27 | 2021-03-23 | Ptc Therapeutics, Inc. | Compostos de heteroarila para o tratamento da doença de huntington |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
| MY209343A (en) | 2019-03-01 | 2025-07-03 | Illumina Cambridge Ltd | Exocyclic amine substituted coumarin compounds and uses as fluorescent labels |
| CN114245794B (zh) | 2019-05-13 | 2024-09-13 | Ptc医疗公司 | 用于治疗亨廷顿氏病的化合物 |
| CN112300201B (zh) * | 2020-12-07 | 2021-11-23 | 南京林业大学 | 一种三聚茚基香豆素-咔咯-卟啉四元体系星型化合物的合成及其制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH390250A (de) * | 1958-06-19 | 1965-07-30 | Geigy Ag J R | Verfahren zur Herstellung von fluoreszierenden Farbstoffen |
| DE2030507C3 (de) * | 1970-06-20 | 1975-05-22 | Bayer Ag, 5090 Leverkusen | Oxazolyl-cumarine, deren Herstellung und Verwendung |
| JPS5529110B2 (de) * | 1972-12-25 | 1980-08-01 | ||
| DE2410634A1 (de) * | 1974-03-06 | 1975-09-18 | Basf Ag | 3-benzofurylcumarine |
| DE2411969A1 (de) * | 1974-03-13 | 1975-09-25 | Bayer Ag | Farbstofflaser |
| DE2525986A1 (de) * | 1975-06-11 | 1977-05-05 | Bayer Ag | Cumarinverbindungen |
| LU78311A1 (de) * | 1977-10-13 | 1979-06-01 | Ciba Geigy Ag | Neue cumarinfarbstoffe,deren herstellung und verwendung |
| US4892922A (en) * | 1987-11-30 | 1990-01-09 | Eastman Kodak Company | Polyester polymer containing the residue of a benzopyran colorant compound and shaped articles produced therefrom |
| JPH01169327A (ja) * | 1987-12-25 | 1989-07-04 | Mitsui Toatsu Chem Inc | 紫外線検知用樹脂組成物 |
| JP2999841B2 (ja) * | 1991-04-03 | 2000-01-17 | 三井化学株式会社 | 発光スクリーン用樹脂組成物 |
| EP0527433B1 (de) | 1991-08-13 | 1997-01-08 | Bayer Corporation | Fluoreszierendes Etikett |
| JPH073179A (ja) * | 1993-06-15 | 1995-01-06 | Nippon Kayaku Co Ltd | インクジェットプリント用インク組成物及びこれを用いる染色法 |
| JP4028155B2 (ja) | 2000-04-11 | 2007-12-26 | 日本カーバイド工業株式会社 | 蛍光性再帰反射シート |
| GB0205281D0 (en) * | 2002-03-06 | 2002-04-17 | Novartis Ag | Organic compounds |
-
2002
- 2002-03-06 GB GBGB0205281.9A patent/GB0205281D0/en not_active Ceased
-
2003
- 2003-03-04 AR ARP030100711A patent/AR038723A1/es unknown
- 2003-03-04 TW TW092104534A patent/TW200400049A/zh unknown
- 2003-03-04 PE PE2003000207A patent/PE20030890A1/es not_active Application Discontinuation
- 2003-03-05 CN CNA038032163A patent/CN1628114A/zh active Pending
- 2003-03-05 PT PT03743381T patent/PT1483262E/pt unknown
- 2003-03-05 AT AT03743381T patent/ATE378333T1/de not_active IP Right Cessation
- 2003-03-05 US US10/506,381 patent/US7569337B2/en not_active Expired - Fee Related
- 2003-03-05 DE DE60317476T patent/DE60317476T2/de not_active Expired - Fee Related
- 2003-03-05 PL PL03370916A patent/PL370916A1/xx not_active Application Discontinuation
- 2003-03-05 BR BR0308211-3A patent/BR0308211A/pt not_active IP Right Cessation
- 2003-03-05 KR KR10-2004-7013763A patent/KR20040095257A/ko not_active Ceased
- 2003-03-05 WO PCT/EP2003/002251 patent/WO2003074519A1/en not_active Ceased
- 2003-03-05 ES ES03743381T patent/ES2294304T3/es not_active Expired - Lifetime
- 2003-03-05 AU AU2003210418A patent/AU2003210418A1/en not_active Abandoned
- 2003-03-05 MX MXPA04008570A patent/MXPA04008570A/es active IP Right Grant
- 2003-03-05 EP EP03743381A patent/EP1483262B1/de not_active Expired - Lifetime
- 2003-03-05 JP JP2003572987A patent/JP4247123B2/ja not_active Expired - Fee Related
- 2003-03-05 CA CA002472298A patent/CA2472298A1/en not_active Abandoned
- 2003-03-05 RU RU2004129733/04A patent/RU2004129733A/ru not_active Application Discontinuation
-
2004
- 2004-06-29 ZA ZA200405175A patent/ZA200405175B/en unknown
- 2004-08-27 EC EC2004005255A patent/ECSP045255A/es unknown
- 2004-09-15 CO CO04091787A patent/CO5611123A2/es not_active Application Discontinuation
- 2004-09-30 NO NO20044174A patent/NO20044174L/no not_active Application Discontinuation
-
2008
- 2008-11-27 JP JP2008302570A patent/JP2009102322A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040095257A (ko) | 2004-11-12 |
| NO20044174L (no) | 2004-09-30 |
| US7569337B2 (en) | 2009-08-04 |
| JP4247123B2 (ja) | 2009-04-02 |
| BR0308211A (pt) | 2004-12-21 |
| DE60317476T2 (de) | 2008-05-21 |
| CA2472298A1 (en) | 2003-09-12 |
| PL370916A1 (en) | 2005-06-13 |
| MXPA04008570A (es) | 2004-12-06 |
| PE20030890A1 (es) | 2003-12-05 |
| ECSP045255A (es) | 2004-09-28 |
| GB0205281D0 (en) | 2002-04-17 |
| JP2005526749A (ja) | 2005-09-08 |
| AU2003210418A1 (en) | 2003-09-16 |
| CO5611123A2 (es) | 2006-02-28 |
| CN1628114A (zh) | 2005-06-15 |
| JP2009102322A (ja) | 2009-05-14 |
| TW200400049A (en) | 2004-01-01 |
| US20050169837A1 (en) | 2005-08-04 |
| DE60317476D1 (de) | 2007-12-27 |
| ES2294304T3 (es) | 2008-04-01 |
| RU2004129733A (ru) | 2005-06-27 |
| EP1483262B1 (de) | 2007-11-14 |
| WO2003074519A1 (en) | 2003-09-12 |
| ZA200405175B (en) | 2005-06-21 |
| PT1483262E (pt) | 2008-02-11 |
| EP1483262A1 (de) | 2004-12-08 |
| AR038723A1 (es) | 2005-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1483262 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |