ATE380880T1 - Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung - Google Patents

Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung

Info

Publication number
ATE380880T1
ATE380880T1 AT05769759T AT05769759T ATE380880T1 AT E380880 T1 ATE380880 T1 AT E380880T1 AT 05769759 T AT05769759 T AT 05769759T AT 05769759 T AT05769759 T AT 05769759T AT E380880 T1 ATE380880 T1 AT E380880T1
Authority
AT
Austria
Prior art keywords
bont
botulinum toxin
peptide substrates
substrates detected
detected
Prior art date
Application number
AT05769759T
Other languages
English (en)
Inventor
Marie-Claude Fournie-Zaluski
Bernard Roques
Original Assignee
Pharmaleads
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0404817A external-priority patent/FR2869908B1/fr
Application filed by Pharmaleads filed Critical Pharmaleads
Application granted granted Critical
Publication of ATE380880T1 publication Critical patent/ATE380880T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0802Tripeptides with the first amino acid being neutral
    • C07K5/0812Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10Tetrapeptides
    • C07K5/1002Tetrapeptides with the first amino acid being neutral
    • C07K5/1016Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486Metalloendopeptidases (3.4.24)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Photometry And Measurement Of Optical Pulse Characteristics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05769759T 2004-05-05 2005-05-04 Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung ATE380880T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0404817A FR2869908B1 (fr) 2004-05-05 2004-05-05 Substrat peptidique reconnu par la toxine botulique de type a, bont/a et son utilisation pour detecter et/ou doser ladite toxine ou des inhibiteurs de son activite
FR0501435 2005-02-11

Publications (1)

Publication Number Publication Date
ATE380880T1 true ATE380880T1 (de) 2007-12-15

Family

ID=35503734

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05769759T ATE380880T1 (de) 2004-05-05 2005-05-04 Mittels botulinumtoxin a (bont/a) erkennbare peptidsubstrate und verwendung

Country Status (8)

Country Link
US (1) US7875436B2 (de)
EP (1) EP1743034B1 (de)
AT (1) ATE380880T1 (de)
CA (1) CA2565678C (de)
DE (1) DE602005003817T2 (de)
ES (1) ES2297742T3 (de)
IL (1) IL179035A (de)
WO (1) WO2005121354A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8022172B2 (en) * 2001-08-28 2011-09-20 Allergan, Inc. Luminescence resonance energy transfer (LRET) assays for clostridial toxin activity
US7374896B2 (en) * 2001-08-28 2008-05-20 Allergan, Inc. GFP-SNAP25 fluorescence release assay for botulinum neurotoxin protease activity
DE602006014812D1 (de) 2005-04-05 2010-07-22 Allergan Inc Lostridientoxinaktivität
ES2351942T3 (es) 2005-04-05 2011-02-14 Allergan Inc Analisis de la actividad de una toxina clostridial.
US8753831B2 (en) * 2007-06-05 2014-06-17 City Of Hope Methods for detection of botulinum neurotoxin
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2963022B1 (fr) * 2010-07-21 2012-08-31 Pharmaleads Nouveaux substrats a fluorescence reprimee, leur preparation et leur utilisation pour l'identification, la detection et le dosage de legionella pneumophila
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
US10408837B2 (en) * 2013-12-09 2019-09-10 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Peptide substrates recognizable by type E botulinum neurotoxin
BR112019004935A2 (pt) 2016-09-13 2019-06-04 Allergan, Inc. composições de toxina clostridial não proteíca estabilizada

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2809733B1 (fr) * 2000-06-02 2004-04-30 Inst Nat Sante Rech Med Substrat peptidique reconnu par la toxine botulique de type bont/b et son utilisation pour doser et/ou detecter ladite toxine ou des inhibiteurs correspondants

Also Published As

Publication number Publication date
IL179035A0 (en) 2007-03-08
WO2005121354A2 (fr) 2005-12-22
EP1743034A2 (de) 2007-01-17
DE602005003817D1 (de) 2008-01-24
EP1743034B1 (de) 2007-12-12
WO2005121354A3 (fr) 2006-03-23
DE602005003817T2 (de) 2008-12-04
US7875436B2 (en) 2011-01-25
CA2565678C (fr) 2013-07-09
CA2565678A1 (fr) 2005-12-22
US20090208993A1 (en) 2009-08-20
ES2297742T3 (es) 2008-05-01
IL179035A (en) 2010-12-30

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