ATE381260T1 - Transgene hergestellte antithrombin iii und deren mutanten - Google Patents

Transgene hergestellte antithrombin iii und deren mutanten

Info

Publication number
ATE381260T1
ATE381260T1 AT00932348T AT00932348T ATE381260T1 AT E381260 T1 ATE381260 T1 AT E381260T1 AT 00932348 T AT00932348 T AT 00932348T AT 00932348 T AT00932348 T AT 00932348T AT E381260 T1 ATE381260 T1 AT E381260T1
Authority
AT
Austria
Prior art keywords
mutants
antithrombin iii
atiii
produced antithrombin
transgenicly
Prior art date
Application number
AT00932348T
Other languages
English (en)
Inventor
Harry Meade
Paul Bourdon
Original Assignee
Gtc Biotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gtc Biotherapeutics Inc filed Critical Gtc Biotherapeutics Inc
Application granted granted Critical
Publication of ATE381260T1 publication Critical patent/ATE381260T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00932348T 1999-05-13 2000-05-12 Transgene hergestellte antithrombin iii und deren mutanten ATE381260T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13417499P 1999-05-13 1999-05-13

Publications (1)

Publication Number Publication Date
ATE381260T1 true ATE381260T1 (de) 2008-01-15

Family

ID=22462098

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00932348T ATE381260T1 (de) 1999-05-13 2000-05-12 Transgene hergestellte antithrombin iii und deren mutanten

Country Status (7)

Country Link
EP (1) EP1194033B1 (de)
AT (1) ATE381260T1 (de)
AU (1) AU782069B2 (de)
CA (1) CA2368608A1 (de)
DE (1) DE60037513T2 (de)
ES (1) ES2299425T3 (de)
WO (1) WO2000069256A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005112968A2 (en) * 2004-04-30 2005-12-01 Gtc Biotherapeutics, Inc. Method of using recombinant human antithrombin for neurocognitive disorders
DK2175877T3 (da) 2007-07-20 2012-04-16 Univ Paris Sud Xi Anvendelse af muterede antitrombiner til behandling eller forebyggelse af koagulationssygdomme
WO2010081878A1 (en) * 2009-01-16 2010-07-22 Universite Paris-Sud Xi Mutated antithrombins, a process for preparing the same and their use as drugs
US9593166B2 (en) 2013-03-14 2017-03-14 Bayer Healthcare Llc Monoclonal antibodies against antithrombin β
ES2992695B2 (es) * 2023-06-15 2025-07-23 Fundacion Para La Formacion E Investig Sanitarias De La Region De Murcia [Ffiis Antidoto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3901917A1 (de) * 1989-01-24 1990-07-26 Behringwerke Ag Mutanten von humanem antithrombin iii
ES2146648T3 (es) * 1993-03-09 2000-08-16 Genzyme Corp Procedimiento de aislamiento de proteinas de la leche.
IT1266561B1 (it) * 1993-07-22 1997-01-09 Mini Ricerca Scient Tecnolog Analoghi di un polipeptide anti-trombinico e procedimento per la loro preparazione
AU3479495A (en) * 1994-09-30 1996-04-26 Ppl Therapeutics (Scotland) Ltd Alpha-1-antitrypsin and antithrombine-iii variants
US5843705A (en) * 1995-02-21 1998-12-01 Genzyme Transgenic Corporation Transgenically produced antithrombin III
KR20010052345A (ko) * 1998-05-12 2001-06-25 수잔 씨 복 인간 항트롬빈 3 및 그에 관련된 방법
WO2000020026A2 (en) * 1998-10-08 2000-04-13 Children's Hospital Compositions and methods for inhibiting angiogenesis

Also Published As

Publication number Publication date
DE60037513D1 (de) 2008-01-31
AU5008300A (en) 2000-12-05
CA2368608A1 (en) 2000-11-23
EP1194033A4 (de) 2004-07-14
ES2299425T3 (es) 2008-06-01
WO2000069256A1 (en) 2000-11-23
EP1194033B1 (de) 2007-12-19
EP1194033A1 (de) 2002-04-10
AU782069B2 (en) 2005-06-30
DE60037513T2 (de) 2009-02-05

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Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties