ATE381328T1 - Heterosubstituierte taxan-c10-acetate als antitumormittel - Google Patents
Heterosubstituierte taxan-c10-acetate als antitumormittelInfo
- Publication number
- ATE381328T1 ATE381328T1 AT01906951T AT01906951T ATE381328T1 AT E381328 T1 ATE381328 T1 AT E381328T1 AT 01906951 T AT01906951 T AT 01906951T AT 01906951 T AT01906951 T AT 01906951T AT E381328 T1 ATE381328 T1 AT E381328T1
- Authority
- AT
- Austria
- Prior art keywords
- heterosubstituted
- acetate
- taxan
- tumor agent
- substituent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17966900P | 2000-02-02 | 2000-02-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381328T1 true ATE381328T1 (de) | 2008-01-15 |
Family
ID=22657495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01906951T ATE381328T1 (de) | 2000-02-02 | 2001-02-02 | Heterosubstituierte taxan-c10-acetate als antitumormittel |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US6664275B2 (de) |
| EP (1) | EP1165068B1 (de) |
| JP (1) | JP2003521514A (de) |
| KR (1) | KR20020002488A (de) |
| CN (1) | CN1362876A (de) |
| AT (1) | ATE381328T1 (de) |
| AU (1) | AU776767B2 (de) |
| BR (1) | BR0104350A (de) |
| CA (1) | CA2368502A1 (de) |
| CZ (1) | CZ20013523A3 (de) |
| DE (1) | DE60131927D1 (de) |
| HK (1) | HK1047896A1 (de) |
| HU (1) | HUP0200750A3 (de) |
| IL (1) | IL145639A (de) |
| MX (1) | MXPA01009924A (de) |
| NO (1) | NO20014756L (de) |
| NZ (1) | NZ514406A (de) |
| PL (1) | PL350027A1 (de) |
| TW (1) | TWI257390B (de) |
| WO (1) | WO2001056564A1 (de) |
| ZA (1) | ZA200108052B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0200750A3 (en) * | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
| US6638973B2 (en) * | 2000-02-02 | 2003-10-28 | Fsu Research Foundation, Inc. | Taxane formulations |
| KR20050032110A (ko) | 2002-08-02 | 2005-04-06 | 이뮤노젠 아이엔씨 | 신규의 효능을 갖는 탁산을 포함하는 세포독성제 및 그치료용도 |
| US7390898B2 (en) * | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| EP1785416A3 (de) | 2003-09-25 | 2007-05-30 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-OH-Taxan-Analogen und Herstellungsverfahren dafür |
| EP1894921A3 (de) * | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-OH-Taxan-Analoga und Herstellungsverfahren dafür |
| CN1712399B (zh) * | 2004-06-24 | 2010-08-11 | 中国医学科学院药物研究所 | 紫杉醇和免疫增强剂胞壁酰二肽共轭物的制备及用途 |
| KR100627436B1 (ko) * | 2005-10-18 | 2006-09-22 | 주식회사 시드컴 | 차량용 요일체킹장치 |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| KR20100021403A (ko) * | 2007-03-19 | 2010-02-24 | 인플라블록 팔라큐티칼스, 인크. | 코발라민 탁산 생체접합체 |
| KR20150136137A (ko) * | 2008-04-10 | 2015-12-04 | 아브락시스 바이오사이언스, 엘엘씨 | 소수성 탁산 유도체의 조성물 및 그의 용도 |
| CA2721153C (en) * | 2008-04-10 | 2018-10-02 | Abraxis Bioscience, Llc | Compositions of hydrophobic taxane derivatives and uses thereof |
| US9132423B2 (en) | 2010-01-29 | 2015-09-15 | Micronics, Inc. | Sample-to-answer microfluidic cartridge |
| JP5922104B2 (ja) | 2010-05-27 | 2016-05-24 | シェンヅェン サルブリス ファーマシューティカルズ カンパニー リミテッドＳｈｅｎｚｈｅｎ Ｓａｌｕｂｒｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｃｏ．， Ｌｔｄ | デューアル機能性の抱合体の化学合成及び抗腫瘍及び抗腫瘍転移作用 |
| WO2014100743A2 (en) | 2012-12-21 | 2014-06-26 | Micronics, Inc. | Low elasticity films for microfluidic use |
| EP2935559B1 (de) | 2012-12-21 | 2020-09-16 | PerkinElmer Health Sciences, Inc. | Fluoreszenznachweissystem |
| EP2935908B1 (de) | 2012-12-21 | 2019-08-14 | PerkinElmer Health Sciences, Inc. | Fluidkreisläufe und zugehörige herstellungsverfahren |
| US10386377B2 (en) | 2013-05-07 | 2019-08-20 | Micronics, Inc. | Microfluidic devices and methods for performing serum separation and blood cross-matching |
| EP2994543B1 (de) | 2013-05-07 | 2018-08-15 | Micronics, Inc. | Vorrichtung zur herstellung und analyse von nukleinsäuren |
| EP2994532B1 (de) | 2013-05-07 | 2017-11-15 | Micronics, Inc. | Verfahren zur herstellung von nukleinsäurehaltigen proben mittels tonmineralien und alkalischen lösungen |
| US11300578B2 (en) | 2016-09-19 | 2022-04-12 | Roche Molecular Systems, Inc. | Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system |
| JP7813728B2 (ja) | 2020-06-12 | 2026-02-13 | エフ． ホフマン－ラ ロシュ アーゲー | 診断装置上のベイを評価するためのシステムおよび方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US5350866A (en) | 1991-09-23 | 1994-09-27 | Bristol-Myers Squibb Company | 10-desacetoxytaxol derivatives |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| PT552041E (pt) | 1992-01-15 | 2000-12-29 | Squibb & Sons Inc | Processo enzimaticos para a resolucao de misturas enantiomericas de compostos uteis como intermediarios para a preparacao de taxanos |
| US5272171A (en) | 1992-02-13 | 1993-12-21 | Bristol-Myers Squibb Company | Phosphonooxy and carbonate derivatives of taxol |
| US5939561A (en) | 1992-03-10 | 1999-08-17 | Rhone-Poulence Rorer S.A. | Process for the preparation of β-phenylisoserine and β-lactam and their analogues |
| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| FR2702212B1 (fr) | 1993-03-02 | 1995-04-07 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5703247A (en) | 1993-03-11 | 1997-12-30 | Virginia Tech Intellectual Properties, Inc. | 2-Debenzoyl-2-acyl taxol derivatives and methods for making same |
| EP0982302B1 (de) | 1993-06-11 | 2004-04-14 | PHARMACIA & UPJOHN COMPANY | Delta 6,7-Taxol Derivate antineoplastische Verwendung und diese enthaltende pharmazeutische Zusammenstellungen |
| IL109926A (en) | 1993-06-15 | 2000-02-29 | Bristol Myers Squibb Co | Methods for the preparation of taxanes and microorganisms and enzymes utilized therein |
| TW397866B (en) | 1993-07-14 | 2000-07-11 | Bristol Myers Squibb Co | Enzymatic processes for the resolution of enantiomeric mixtures of compounds useful as intermediates in the preparation of taxanes |
| FR2711369B1 (fr) * | 1993-10-20 | 1995-11-17 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions qui les contiennent. |
| WO1996013495A1 (en) | 1994-10-28 | 1996-05-09 | The Research Foundation Of State University Of New York | Taxoid derivatives, their preparation and their use as antitumor agents |
| MA23823A1 (fr) | 1995-03-27 | 1996-10-01 | Aventis Pharma Sa | Nouveaux taxoides, leur preparation et les compositions qui les contiennent |
| US5780653A (en) | 1995-06-07 | 1998-07-14 | Vivorx Pharmaceuticals, Inc. | Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers |
| WO1997009979A1 (en) | 1995-09-13 | 1997-03-20 | Florida State University | Radiosensitizing taxanes and their pharmaceutical preparations |
| US5714645A (en) * | 1995-10-31 | 1998-02-03 | Kuraray Co., Ltd. | Process for producing all trans-form polyprenols |
| US5756536A (en) * | 1995-11-03 | 1998-05-26 | Purdue Research Foundation | Microbial transformation of taxol and cephalomannine |
| US5899043A (en) * | 1995-12-18 | 1999-05-04 | Engineering Certifiers Ltd. | Ductile-failure anchors for concrete elements |
| US5767297A (en) | 1997-02-05 | 1998-06-16 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| AU724499B2 (en) | 1996-05-06 | 2000-09-21 | Florida State University | 1-deoxy baccatin III, 1-deoxy taxol and 1-deoxy taxol analogs and method for the preparation thereof |
| EP0930309A4 (de) | 1996-07-15 | 2001-09-26 | Yakult Honsha Kk | Taxan-derivate und diese enthaltende arzneimittel |
| US5811452A (en) | 1997-01-08 | 1998-09-22 | The Research Foundation Of State University Of New York | Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof |
| US5912264A (en) | 1997-03-03 | 1999-06-15 | Bristol-Myers Squibb Company | 6-halo-or nitrate-substituted paclitaxels |
| CA2206739C (en) | 1997-06-03 | 2006-10-10 | Ensuiko Sugar Refining Co., Ltd. | Taxoid derivative and method of producing thereof |
| SE9702776D0 (sv) * | 1997-07-22 | 1997-07-22 | Pharmacia & Upjohn Ab | Method of preparing pharmaceutical compositions |
| US7288665B1 (en) | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| HUP0200750A3 (en) * | 2000-02-02 | 2005-02-28 | Univ Florida State Res Found | C10 heterosubstituted acetate taxanes as antitumor agents and pharmaceutical compositions containing them and their use |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
-
2001
- 2001-02-02 HU HU0200750A patent/HUP0200750A3/hu unknown
- 2001-02-02 HK HK03100167.4A patent/HK1047896A1/zh unknown
- 2001-02-02 JP JP2001556255A patent/JP2003521514A/ja not_active Withdrawn
- 2001-02-02 EP EP01906951A patent/EP1165068B1/de not_active Expired - Lifetime
- 2001-02-02 CA CA002368502A patent/CA2368502A1/en not_active Abandoned
- 2001-02-02 IL IL145639A patent/IL145639A/en not_active IP Right Cessation
- 2001-02-02 NZ NZ514406A patent/NZ514406A/en unknown
- 2001-02-02 PL PL01350027A patent/PL350027A1/xx not_active Application Discontinuation
- 2001-02-02 CZ CZ20013523A patent/CZ20013523A3/cs unknown
- 2001-02-02 DE DE60131927T patent/DE60131927D1/de not_active Expired - Lifetime
- 2001-02-02 KR KR1020017012585A patent/KR20020002488A/ko not_active Abandoned
- 2001-02-02 MX MXPA01009924A patent/MXPA01009924A/es active IP Right Grant
- 2001-02-02 BR BR0104350-1A patent/BR0104350A/pt not_active IP Right Cessation
- 2001-02-02 AT AT01906951T patent/ATE381328T1/de not_active IP Right Cessation
- 2001-02-02 CN CN01800315A patent/CN1362876A/zh active Pending
- 2001-02-02 AU AU34792/01A patent/AU776767B2/en not_active Ceased
- 2001-02-02 US US09/775,912 patent/US6664275B2/en not_active Expired - Fee Related
- 2001-02-02 WO PCT/US2001/003553 patent/WO2001056564A1/en not_active Ceased
- 2001-03-27 TW TW090102213A patent/TWI257390B/zh not_active IP Right Cessation
- 2001-10-01 ZA ZA200108052A patent/ZA200108052B/en unknown
- 2001-10-01 NO NO20014756A patent/NO20014756L/no not_active Application Discontinuation
-
2003
- 2003-06-27 US US10/609,301 patent/US6872837B2/en not_active Expired - Fee Related
-
2005
- 2005-02-28 US US11/068,166 patent/US7157474B2/en not_active Expired - Fee Related
-
2006
- 2006-12-04 US US11/566,439 patent/US20070249707A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU776767B2 (en) | 2004-09-23 |
| US6872837B2 (en) | 2005-03-29 |
| US20070249707A1 (en) | 2007-10-25 |
| EP1165068A1 (de) | 2002-01-02 |
| IL145639A0 (en) | 2002-06-30 |
| IL145639A (en) | 2007-02-11 |
| CA2368502A1 (en) | 2001-08-09 |
| MXPA01009924A (es) | 2003-08-01 |
| US20050143447A1 (en) | 2005-06-30 |
| HK1047896A1 (zh) | 2003-03-14 |
| EP1165068B1 (de) | 2007-12-19 |
| US6664275B2 (en) | 2003-12-16 |
| BR0104350A (pt) | 2002-01-02 |
| AU3479201A (en) | 2001-08-14 |
| US20040024051A1 (en) | 2004-02-05 |
| HUP0200750A2 (hu) | 2002-07-29 |
| CZ20013523A3 (cs) | 2002-03-13 |
| PL350027A1 (en) | 2002-10-21 |
| ZA200108052B (en) | 2003-12-01 |
| JP2003521514A (ja) | 2003-07-15 |
| US20020068755A1 (en) | 2002-06-06 |
| TWI257390B (en) | 2006-07-01 |
| NO20014756D0 (no) | 2001-10-01 |
| WO2001056564A1 (en) | 2001-08-09 |
| NO20014756L (no) | 2001-11-29 |
| US7157474B2 (en) | 2007-01-02 |
| CN1362876A (zh) | 2002-08-07 |
| KR20020002488A (ko) | 2002-01-09 |
| NZ514406A (en) | 2005-01-28 |
| DE60131927D1 (de) | 2008-01-31 |
| HUP0200750A3 (en) | 2005-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |