ATE381557T1 - Rho-kinase inhibitoren - Google Patents
Rho-kinase inhibitorenInfo
- Publication number
- ATE381557T1 ATE381557T1 AT03705859T AT03705859T ATE381557T1 AT E381557 T1 ATE381557 T1 AT E381557T1 AT 03705859 T AT03705859 T AT 03705859T AT 03705859 T AT03705859 T AT 03705859T AT E381557 T1 ATE381557 T1 AT E381557T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase inhibitors
- rho kinase
- rho
- compounds
- treating
- Prior art date
Links
- 239000003590 rho kinase inhibitor Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000029078 coronary artery disease Diseases 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 102000000568 rho-Associated Kinases Human genes 0.000 abstract 1
- 108010041788 rho-Associated Kinases Proteins 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34998602P | 2002-01-23 | 2002-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381557T1 true ATE381557T1 (de) | 2008-01-15 |
Family
ID=27613348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03705859T ATE381557T1 (de) | 2002-01-23 | 2003-01-23 | Rho-kinase inhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6943172B2 (de) |
| EP (1) | EP1470122B1 (de) |
| JP (1) | JP4423043B2 (de) |
| AT (1) | ATE381557T1 (de) |
| CA (1) | CA2473910C (de) |
| DE (1) | DE60318177T2 (de) |
| ES (1) | ES2298497T3 (de) |
| MX (1) | MXPA04007196A (de) |
| WO (1) | WO2003062227A1 (de) |
Families Citing this family (108)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03008659A (es) * | 2001-03-23 | 2005-04-08 | Bayer Ag | Inhibidores de rho-cinasa. |
| US20030125344A1 (en) * | 2001-03-23 | 2003-07-03 | Bayer Corporation | Rho-kinase inhibitors |
| DE60320933D1 (de) * | 2002-01-10 | 2008-06-26 | Bayer Healthcare Ag | Rho-kinase inhibitoren |
| MXPA04007196A (es) * | 2002-01-23 | 2005-06-08 | Bayer Pharmaceuticals Corp | Inhibidores de rho-quinasa. |
| JP4469179B2 (ja) * | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体 |
| DE10226943A1 (de) * | 2002-06-17 | 2004-01-08 | Bayer Ag | Phenylaminopyrimidine und ihre Verwendung |
| CA2530389A1 (en) * | 2003-07-02 | 2005-01-13 | Biofocus Discovery Limited | Pyrazine and pyridine derivatives as rho kinase inhibitors |
| EA010485B1 (ru) | 2003-07-23 | 2008-10-30 | Байер Фамэсьютиклс Копэрейшн | Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты) |
| EP1689722A2 (de) | 2003-10-10 | 2006-08-16 | Bayer Pharmaceuticals Corporation | Pyrimidinderivate zur behandlung von hyperproliferativen erkrankungen |
| DE10357510A1 (de) * | 2003-12-09 | 2005-07-07 | Bayer Healthcare Ag | Heteroarylsubstituierte Benzole |
| DE102004017438A1 (de) * | 2004-04-08 | 2005-11-03 | Bayer Healthcare Ag | Hetaryloxy-substituierte Phenylaminopyrimidine |
| DE102004020570A1 (de) | 2004-04-27 | 2005-11-24 | Bayer Healthcare Ag | Substituierte Phenylaminopyrimidine |
| WO2006053014A2 (en) * | 2004-11-09 | 2006-05-18 | Baylor College Of Medicine | Selective inhibition of rock1 in cardiac therapy |
| GB0500226D0 (en) * | 2005-01-07 | 2005-02-16 | Biofocus Discovery Ltd | Compounds which bind to the active site of protein kinase enzymes |
| KR20080004488A (ko) * | 2005-03-10 | 2008-01-09 | 바이엘 파마슈티칼스 코포레이션 | 과다증식성 장애 치료용 피리미딘 유도체 |
| EP1902731B1 (de) | 2005-06-21 | 2013-04-10 | Kowa Company, Ltd. | Mittel zur prävention oder heilmittel für glaukom |
| PT1905452E (pt) | 2005-07-12 | 2013-07-16 | Kowa Co | Agente para a prevenção ou tratamento do glaucoma |
| JP2007161608A (ja) * | 2005-12-09 | 2007-06-28 | Fujifilm Finechemicals Co Ltd | Ｎ−（ヘテロ）アリール置換含窒素ヘテロアリール化合物の製造方法 |
| EP1962853A1 (de) | 2005-12-22 | 2008-09-03 | Alcon Research, Ltd. | (indazol-5-yl)-pyrazine und (1,3-dihydro-indol-2-on)-pyrazine zur behandlung rho-kinase-vermittelter erkrankungen und leiden |
| US7867999B1 (en) | 2005-12-22 | 2011-01-11 | Alcon Research, Ltd. | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions |
| RU2008152195A (ru) * | 2006-06-15 | 2010-07-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | 2-анилино-4-(гетероциклил)аминопиримидины, как ингибиторы протеинкиназы с-альфа |
| EP2044061A2 (de) * | 2006-07-20 | 2009-04-08 | Mehmet Kahraman | Benzothiophen-hemmer der rho-kinase |
| JP2008063278A (ja) * | 2006-09-07 | 2008-03-21 | Fujifilm Finechemicals Co Ltd | １−ピリジン−４−イル−インドール類の製造方法 |
| AR064420A1 (es) | 2006-12-21 | 2009-04-01 | Alcon Mfg Ltd | Composiciones farmaceuticas oftalmicas que comprenden una cantidad efectiva de analogos de 6-aminoimidazo[1,2b]piridazinas, utiles para el tratamiento del glaucoma y/o controlar la presion intraocular normal o elevada(iop). |
| KR20210070407A (ko) | 2007-08-29 | 2021-06-14 | 센주 세이야꾸 가부시키가이샤 | 각막 내피 세포 접착 촉진제 |
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-
2003
- 2003-01-23 MX MXPA04007196A patent/MXPA04007196A/es active IP Right Grant
- 2003-01-23 WO PCT/US2003/001840 patent/WO2003062227A1/en not_active Ceased
- 2003-01-23 JP JP2003562105A patent/JP4423043B2/ja not_active Expired - Fee Related
- 2003-01-23 EP EP03705859A patent/EP1470122B1/de not_active Expired - Lifetime
- 2003-01-23 DE DE60318177T patent/DE60318177T2/de not_active Expired - Lifetime
- 2003-01-23 ES ES03705859T patent/ES2298497T3/es not_active Expired - Lifetime
- 2003-01-23 CA CA2473910A patent/CA2473910C/en not_active Expired - Fee Related
- 2003-01-23 AT AT03705859T patent/ATE381557T1/de not_active IP Right Cessation
- 2003-01-23 US US10/349,176 patent/US6943172B2/en not_active Expired - Fee Related
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2005
- 2005-04-22 US US11/111,704 patent/US20050209261A1/en not_active Abandoned
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2012
- 2012-08-06 US US13/567,863 patent/US20120302587A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1470122A1 (de) | 2004-10-27 |
| EP1470122B1 (de) | 2007-12-19 |
| DE60318177D1 (de) | 2008-01-31 |
| US20040002507A1 (en) | 2004-01-01 |
| WO2003062227A1 (en) | 2003-07-31 |
| CA2473910C (en) | 2011-03-15 |
| MXPA04007196A (es) | 2005-06-08 |
| CA2473910A1 (en) | 2003-07-31 |
| US20120302587A1 (en) | 2012-11-29 |
| ES2298497T3 (es) | 2008-05-16 |
| DE60318177T2 (de) | 2008-10-09 |
| US6943172B2 (en) | 2005-09-13 |
| JP2005523894A (ja) | 2005-08-11 |
| JP4423043B2 (ja) | 2010-03-03 |
| US20050209261A1 (en) | 2005-09-22 |
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