ATE381560T1 - Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sind - Google Patents
Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sindInfo
- Publication number
- ATE381560T1 ATE381560T1 AT01988048T AT01988048T ATE381560T1 AT E381560 T1 ATE381560 T1 AT E381560T1 AT 01988048 T AT01988048 T AT 01988048T AT 01988048 T AT01988048 T AT 01988048T AT E381560 T1 ATE381560 T1 AT E381560T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- heterocyclic derivatives
- orexin receptor
- derivatives suitable
- benzazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2000/013289 WO2002051232A2 (en) | 2000-12-27 | 2000-12-27 | Novel benzazepines and related heterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381560T1 true ATE381560T1 (de) | 2008-01-15 |
Family
ID=8164232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01988048T ATE381560T1 (de) | 2000-12-27 | 2001-12-19 | Neue benzazepine und ähnliche heterocyclische derivate,die als orexin rezeptor antagonisten geeignet sind |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7192950B2 (de) |
| EP (1) | EP1347967B1 (de) |
| JP (1) | JP4219166B2 (de) |
| KR (1) | KR100849569B1 (de) |
| CN (1) | CN1261430C (de) |
| AT (1) | ATE381560T1 (de) |
| AU (1) | AU2002240855B2 (de) |
| BR (1) | BR0116505A (de) |
| CA (1) | CA2431982C (de) |
| DE (1) | DE60132017T2 (de) |
| ES (1) | ES2296825T3 (de) |
| HU (1) | HUP0301665A3 (de) |
| IL (2) | IL155806A0 (de) |
| MX (1) | MXPA03004779A (de) |
| NO (1) | NO326158B1 (de) |
| NZ (1) | NZ525613A (de) |
| WO (2) | WO2002051232A2 (de) |
| ZA (1) | ZA200303697B (de) |
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| US7321065B2 (en) * | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
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| GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
| GB201601301D0 (en) * | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
| MX2018009656A (es) | 2016-02-12 | 2019-02-20 | Astrazeneca Ab | Piperidinas halo-sustituidas como moduladores de los receptores de orexinas. |
| US20190151304A1 (en) | 2016-05-10 | 2019-05-23 | Inserm (Institut National De La Santé Et De La Rechercjae Médicale | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory |
| AR109950A1 (es) | 2016-10-14 | 2019-02-06 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| GB201718256D0 (en) * | 2017-11-03 | 2017-12-20 | Heptares Therapeutics Ltd | Ox1 antagonists |
| AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| JP2025530213A (ja) | 2022-09-09 | 2025-09-11 | ミリックス ファーマ リミテッド | Ｎｍｔ阻害剤を含む抗体薬物コンジュゲート及びその使用 |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| CN119977904A (zh) * | 2025-02-18 | 2025-05-13 | 合肥工业大学 | 一种苯并氧（碳/硫）氮杂䓬类化合物及其在医学上的应用 |
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|---|---|---|---|---|
| US3236838A (en) * | 1964-06-09 | 1966-02-22 | Hoffmann La Roche | Certain 1-substituted-benzodiazepin-2-one compounds |
| US3480714A (en) * | 1966-02-07 | 1969-11-25 | Ciba Geigy Corp | N-substituted isoquinolines as antiprotozoal agents |
| CO5140073A1 (es) | 1998-10-08 | 2002-03-22 | Smithkline Beecham Plc | Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina |
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2000
- 2000-12-27 WO PCT/EP2000/013289 patent/WO2002051232A2/en not_active Ceased
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2001
- 2001-12-19 US US10/450,420 patent/US7192950B2/en not_active Expired - Fee Related
- 2001-12-19 BR BR0116505-4A patent/BR0116505A/pt not_active IP Right Cessation
- 2001-12-19 CA CA2431982A patent/CA2431982C/en not_active Expired - Fee Related
- 2001-12-19 ES ES01988048T patent/ES2296825T3/es not_active Expired - Lifetime
- 2001-12-19 WO PCT/EP2001/015074 patent/WO2002051838A1/en not_active Ceased
- 2001-12-19 IL IL15580601A patent/IL155806A0/xx active IP Right Grant
- 2001-12-19 AU AU2002240855A patent/AU2002240855B2/en not_active Ceased
- 2001-12-19 JP JP2002552933A patent/JP4219166B2/ja not_active Expired - Fee Related
- 2001-12-19 DE DE60132017T patent/DE60132017T2/de not_active Expired - Lifetime
- 2001-12-19 EP EP01988048A patent/EP1347967B1/de not_active Expired - Lifetime
- 2001-12-19 NZ NZ525613A patent/NZ525613A/en not_active IP Right Cessation
- 2001-12-19 HU HU0301665A patent/HUP0301665A3/hu unknown
- 2001-12-19 KR KR1020037008764A patent/KR100849569B1/ko not_active Expired - Fee Related
- 2001-12-19 MX MXPA03004779A patent/MXPA03004779A/es active IP Right Grant
- 2001-12-19 AT AT01988048T patent/ATE381560T1/de active
- 2001-12-19 CN CNB018208762A patent/CN1261430C/zh not_active Expired - Fee Related
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- 2003-05-08 IL IL155806A patent/IL155806A/en not_active IP Right Cessation
- 2003-05-13 ZA ZA200303697A patent/ZA200303697B/en unknown
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Also Published As
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|---|---|
| CA2431982C (en) | 2010-07-20 |
| ES2296825T3 (es) | 2008-05-01 |
| CN1261430C (zh) | 2006-06-28 |
| JP4219166B2 (ja) | 2009-02-04 |
| IL155806A (en) | 2008-03-20 |
| EP1347967A1 (de) | 2003-10-01 |
| IL155806A0 (en) | 2003-12-23 |
| DE60132017T2 (de) | 2008-12-04 |
| KR100849569B1 (ko) | 2008-07-31 |
| JP2004516324A (ja) | 2004-06-03 |
| CA2431982A1 (en) | 2002-07-04 |
| NO20032905D0 (no) | 2003-06-24 |
| US7192950B2 (en) | 2007-03-20 |
| BR0116505A (pt) | 2004-02-03 |
| HUP0301665A2 (en) | 2008-07-28 |
| WO2002051232A2 (en) | 2002-07-04 |
| ZA200303697B (en) | 2004-08-13 |
| MXPA03004779A (es) | 2003-09-25 |
| EP1347967B1 (de) | 2007-12-19 |
| AU2002240855B2 (en) | 2006-08-17 |
| CN1481380A (zh) | 2004-03-10 |
| KR20030069199A (ko) | 2003-08-25 |
| HUP0301665A3 (en) | 2008-12-29 |
| NZ525613A (en) | 2005-01-28 |
| NO20032905L (no) | 2003-06-24 |
| WO2002051838A1 (en) | 2002-07-04 |
| US20040058912A1 (en) | 2004-03-25 |
| DE60132017D1 (de) | 2008-01-31 |
| NO326158B1 (no) | 2008-10-13 |
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