ATE545647T1 - 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat - Google Patents

5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat

Info

Publication number: ATE545647T1
Authority: AT; Austria
Prior art keywords: alkyl; tetrahydro; alkoxy; halogen; imidazoä1
Prior art date: 2006-12-22

Application number

AT07859469T

Other languages

English (en)

Inventor

Hamed Aissaoui

Christoph Boss

Markus Gude

Ralf Koberstein

Thierry Sifferlen

Original Assignee

Actelion Pharmaceuticals Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-22

Filing date

2007-12-20

Publication date

2012-03-15

2007-12-20 Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd

2012-03-15 Application granted granted Critical

2012-03-15 Publication of ATE545647T1 publication Critical patent/ATE545647T1/de

Links

125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
WROMFHICINADER-UHFFFAOYSA-N 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine Chemical class C1NCCN2C=NC=C21 WROMFHICINADER-UHFFFAOYSA-N 0.000 abstract 1
229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
125000004849 alkoxymethyl group Chemical group 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
-1 cyano, hydroxymethyl Chemical group 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings

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Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Addiction (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Psychology (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Reproductive Health (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Hematology (AREA)

AT07859469T 2006-12-22 2007-12-20 5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat ATE545647T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IB2006055019		2006-12-22
PCT/IB2007/055245 WO2008078291A1 (en)	2006-12-22	2007-12-20	5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives

Publications (1)

Publication Number	Publication Date
ATE545647T1 true ATE545647T1 (de)	2012-03-15

Family

ID=39273168

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07859469T ATE545647T1 (de)	2006-12-22	2007-12-20	5,6,7,8-tetrahydro-imidazoä1,5-aüpyrazinderivat

Country Status (15)

Country	Link
US (1)	US8188082B2 (de)
EP (1)	EP2125823B1 (de)
JP (1)	JP2010513466A (de)
KR (1)	KR20090106538A (de)
CN (1)	CN101568542B (de)
AT (1)	ATE545647T1 (de)
AU (1)	AU2007337659A1 (de)
BR (1)	BRPI0720522A2 (de)
CA (1)	CA2669561A1 (de)
ES (1)	ES2380391T3 (de)
MA (1)	MA31002B1 (de)
MX (1)	MX2009006553A (de)
NO (1)	NO20092715L (de)
RU (1)	RU2009127842A (de)
WO (1)	WO2008078291A1 (de)

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WO2008078291A1 (en)	2006-12-22	2008-07-03	Actelion Pharmaceuticals Ltd	5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
US7775298B2 (en)	2007-10-29	2010-08-17	Abergeldie Holdings Pty Ltd/Abergeldie Plant Pty Ltd	Drilling assemblies and methods of drilling
CN101468988A (zh) *	2007-12-26	2009-07-01	上海恒瑞医药有限公司	哌嗪类衍生物,其制备方法及其在医药上的应用
CN102076694A (zh) *	2008-06-25	2011-05-25	埃科特莱茵药品有限公司	5，6，7，8-四氢-咪唑并[1，5-a]吡嗪化合物
ME03452B (de)	2009-10-23	2020-01-20	Janssen Pharmaceutica Nv	Disubstituierte octahy-dropyrrolo [3,4-c]pyrrole als orexinrezeptormodulatoren
CN102258508A (zh) *	2011-04-14	2011-11-30	威海迪素制药有限公司	芳基丙烯酸衍生物抗癫痫的用途
CA2863413A1 (en)	2012-02-07	2013-08-15	Eolas Therapeutics, Inc.	Substituted prolines / piperidines as orexin receptor antagonists
US9440982B2 (en)	2012-02-07	2016-09-13	Eolas Therapeutics, Inc.	Substituted prolines/piperidines as orexin receptor antagonists
CN103980281B (zh) *	2014-05-27	2016-06-08	天津市斯芬克司药物研发有限公司	一种咪唑吡嗪化合物及其制备方法
UY36272A (es)	2014-08-13	2016-02-29	Eolas Therapeutics Inc	Difluoropirrolidinas como moduladores de los receptores de orexinas
AU2017217931B2 (en)	2016-02-12	2020-10-22	Astrazeneca Ab	Halo-substituted piperidines as orexin receptor modulators
MD3426251T2 (ro)	2016-03-10	2022-09-30	Janssen Pharmaceutica Nv	Metode de tratament al depresiei utilizând antagoniști ai receptorului orexină-2
CN105753788A (zh) *	2016-04-08	2016-07-13	西南科技大学	一种1-取代-2-苯基-4-碘咪唑的制备方法
WO2017194548A1 (en)	2016-05-10	2017-11-16	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases
MY202326A (en)	2017-09-14	2024-04-24	Daiichi Sankyo Co Ltd	Compound having cyclic structure
CN108101930B (zh) *	2017-12-22	2020-10-30	武汉大学	一类含有苯并噻二唑并噻吩单元的小分子受体材料及其制备方法与应用
RU2020131507A (ru) *	2018-03-29	2022-05-04	Боард Оф Реджентс, Де Юниверсити Оф Техас Систем	Имидазопиперазиновые ингибиторы белков-активаторов транскрипции
WO2019195846A1 (en)	2018-04-06	2019-10-10	Board Of Regents, The University Of Texas System	Imidazopiperazinone inhibitors of transcription activating proteins
GB201908511D0 (en)	2019-06-13	2019-07-31	Adorx Therapeutics Ltd	Hydroxamate compounds
CA3193745A1 (en) *	2020-10-02	2022-04-07	Kang Le	Imidazopiperazine inhibitors of transcription activating proteins
EP4221708A4 (de)	2020-10-02	2024-11-06	Board of Regents, The University of Texas System	Imidazopiperazinhemmer von transkriptionsaktivierenden proteinen
CN121851016A (zh) *	2021-04-21	2026-04-14	长春金赛药业有限责任公司	含咪唑稠环类衍生物、其制备方法及其在医药上的应用
CN119855819B (zh) *	2022-10-19	2025-10-28	长春金赛药业有限责任公司	一种nk3r拮抗剂的晶型及其制备方法和应用
WO2025224168A1 (en)	2024-04-24	2025-10-30	Idorsia Pharmaceuticals Ltd	Aryl sulfone and sulfanone derivatives as orexin receptor modulators

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Publication number	Priority date	Publication date	Assignee	Title
BRPI0109200B8 (pt) *	2000-03-14	2021-05-25	Actelion Pharmaceuticals Ltd	compostos e composições farmacêuticas
EP1288202A4 (de) *	2000-05-11	2003-07-02	Banyu Pharma Co Ltd	N-acyltetrahydroisochinolin-derivate
WO2002051232A2 (en)	2000-12-27	2002-07-04	Actelion Pharmaceuticals Ltd.	Novel benzazepines and related heterocyclic derivatives
GB0124463D0 (en) *	2001-10-11	2001-12-05	Smithkline Beecham Plc	Compounds
CA2460051A1 (en)	2002-07-09	2004-01-15	Actelion Pharmaceuticals Ltd.	7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2h-pyrrolo[2,1-b]-quinazolinone derivatives
DK1537114T3 (da) *	2002-08-07	2006-11-13	Novartis Ag	Organiske forbindelser som midler til behandling af aldosteronmedierede tilstande
ES2327737T3 (es)	2003-03-26	2009-11-03	Actelion Pharmaceuticals Ltd.	Derivados de tetrahidroisoquinolil acetamida para uso como antagonistas de receptores de orexina.
AU2004275488A1 (en) *	2003-09-26	2005-04-07	Actelion Pharmaceuticals Ltd	Pyridine derivatives and use thereof as urotensin II antagonists
CA2557163C (en)	2004-03-01	2011-08-16	Idorsia Pharmaceuticals Ltd	Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
AU2007226203A1 (en)	2006-03-15	2007-09-20	Actelion Pharmaceuticals Ltd	Tetrahydroisoquinoline derivatives to enhance memory function
DE602007012072D1 (de)	2006-04-26	2011-03-03	Actelion Pharmaceuticals Ltd	Orantagonisten
ATE458740T1 (de) *	2006-08-28	2010-03-15	Actelion Pharmaceuticals Ltd	1,4,5,6,7,8-hexahydro-1,2,5-triaza-azulen- derivate als orexinrezeptor-antagonisten
WO2008078291A1 (en)	2006-12-22	2008-07-03	Actelion Pharmaceuticals Ltd	5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives
PE20091010A1 (es)	2007-10-10	2009-08-08	Actelion Pharmaceuticals Ltd	Derivados de tetrahidroquinolina
CN102076694A (zh) *	2008-06-25	2011-05-25	埃科特莱茵药品有限公司	5，6，7，8-四氢-咪唑并[1，5-a]吡嗪化合物

2007
- 2007-12-20 WO PCT/IB2007/055245 patent/WO2008078291A1/en not_active Ceased
- 2007-12-20 JP JP2009542373A patent/JP2010513466A/ja active Pending
- 2007-12-20 AU AU2007337659A patent/AU2007337659A1/en not_active Abandoned
- 2007-12-20 KR KR1020097015261A patent/KR20090106538A/ko not_active Ceased
- 2007-12-20 RU RU2009127842/04A patent/RU2009127842A/ru not_active Application Discontinuation
- 2007-12-20 CN CN2007800478100A patent/CN101568542B/zh not_active Expired - Fee Related
- 2007-12-20 ES ES07859469T patent/ES2380391T3/es active Active
- 2007-12-20 EP EP07859469A patent/EP2125823B1/de active Active
- 2007-12-20 MX MX2009006553A patent/MX2009006553A/es not_active Application Discontinuation
- 2007-12-20 AT AT07859469T patent/ATE545647T1/de active
- 2007-12-20 BR BRPI0720522-8A patent/BRPI0720522A2/pt not_active IP Right Cessation
- 2007-12-20 CA CA002669561A patent/CA2669561A1/en not_active Abandoned
- 2007-12-20 US US12/520,693 patent/US8188082B2/en not_active Expired - Fee Related
2009
- 2009-06-17 MA MA32006A patent/MA31002B1/fr unknown
- 2009-07-20 NO NO20092715A patent/NO20092715L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP2125823A1 (de)	2009-12-02
WO2008078291A1 (en)	2008-07-03
US8188082B2 (en)	2012-05-29
MA31002B1 (fr)	2009-12-01
JP2010513466A (ja)	2010-04-30
ES2380391T3 (es)	2012-05-11
EP2125823B1 (de)	2012-02-15
CA2669561A1 (en)	2008-07-03
NO20092715L (no)	2009-07-20
KR20090106538A (ko)	2009-10-09
BRPI0720522A2 (pt)	2014-01-07
CN101568542A (zh)	2009-10-28
AU2007337659A1 (en)	2008-07-03
US20100093740A1 (en)	2010-04-15
MX2009006553A (es)	2009-06-26
CN101568542B (zh)	2013-03-27
RU2009127842A (ru)	2011-01-27

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