ATE381623T1 - Verfahren zur expression von protein mit darin integrierter unnatürlicher aminosäure - Google Patents
Verfahren zur expression von protein mit darin integrierter unnatürlicher aminosäureInfo
- Publication number
- ATE381623T1 ATE381623T1 AT03809875T AT03809875T ATE381623T1 AT E381623 T1 ATE381623 T1 AT E381623T1 AT 03809875 T AT03809875 T AT 03809875T AT 03809875 T AT03809875 T AT 03809875T AT E381623 T1 ATE381623 T1 AT E381623T1
- Authority
- AT
- Austria
- Prior art keywords
- amino acid
- trna synthetase
- unnatural amino
- tyrosyl
- tyrosine
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 101710146427 Probable tyrosine-tRNA ligase, cytoplasmic Proteins 0.000 abstract 3
- 102000018378 Tyrosine-tRNA ligase Human genes 0.000 abstract 3
- 101710107268 Tyrosine-tRNA ligase, mitochondrial Proteins 0.000 abstract 3
- 150000003667 tyrosine derivatives Chemical class 0.000 abstract 3
- 108020004485 Nonsense Codon Proteins 0.000 abstract 2
- 230000037434 nonsense mutation Effects 0.000 abstract 2
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 1
- 241000204031 Mycoplasma Species 0.000 abstract 1
- 108091060545 Nonsense suppressor Proteins 0.000 abstract 1
- 241000191940 Staphylococcus Species 0.000 abstract 1
- 210000004102 animal cell Anatomy 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002318846 | 2002-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE381623T1 true ATE381623T1 (de) | 2008-01-15 |
Family
ID=32211789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03809875T ATE381623T1 (de) | 2002-10-31 | 2003-10-31 | Verfahren zur expression von protein mit darin integrierter unnatürlicher aminosäure |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7566555B2 (de) |
| EP (1) | EP1557469B1 (de) |
| JP (1) | JP4467435B2 (de) |
| AT (1) | ATE381623T1 (de) |
| CA (1) | CA2503749A1 (de) |
| DE (1) | DE60318240T2 (de) |
| WO (1) | WO2004039989A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2452818C (en) | 2001-08-01 | 2010-06-29 | Japan Science And Technology Agency | Tyrosyl-trna synthetase variants |
| JP2008035702A (ja) * | 2004-11-26 | 2008-02-21 | Institute Of Physical & Chemical Research | 蛋白質間相互作用の検出方法 |
| WO2007061136A1 (ja) | 2005-11-24 | 2007-05-31 | Riken | 非天然型アミノ酸を組み込んだタンパク質の製造方法 |
| EP1992698B1 (de) * | 2006-02-22 | 2018-09-05 | Riken | Verfahren zur synthese von suppressor-trna, dna-konstrukt und herstellung von protein mit darin integrierter nichtnatürlicher aminosäure unter verwendung des dna-konstrukts |
| WO2008001947A1 (en) * | 2006-06-28 | 2008-01-03 | Riken | MUTANT SepRS, AND METHOD FOR SITE-SPECIFIC INTRODUCTION OF PHOSPHOSERINE INTO PROTEIN BY USING THE SAME |
| JP2010502221A (ja) * | 2006-09-08 | 2010-01-28 | アンブルックス，インコーポレイテッド | 脊椎動物細胞による非天然アミノ酸の部位特異的組み込み |
| JP5399906B2 (ja) * | 2006-09-08 | 2014-01-29 | アンブルックス，インコーポレイテッド | 脊椎動物細胞用のハイブリッドサプレッサーｔｒｎａ |
| EP2064333B1 (de) * | 2006-09-08 | 2014-02-26 | Ambrx, Inc. | Unterdrücker-trna-transkription für wirbeltierzellen |
| WO2008073184A2 (en) * | 2006-10-18 | 2008-06-19 | The Scripps Research Institute | Genetic incorporation of unnatural amino acids into proteins in mammalian cells |
| JP5322195B2 (ja) * | 2007-03-30 | 2013-10-23 | 独立行政法人理化学研究所 | 光反応性官能基を有する非天然型アミノ酸組み込みタンパク質の合成方法 |
| CN104651381A (zh) | 2008-01-03 | 2015-05-27 | 巴斯夫酶有限责任公司 | 转移酶和氧化还原酶、编码它们的核酸以及其制备和应用方法 |
| WO2009099073A1 (ja) * | 2008-02-07 | 2009-08-13 | The University Of Tokyo | 非天然塩基を含む改変ｔＲＮＡ及びその用途 |
| US20090286968A1 (en) | 2008-04-25 | 2009-11-19 | Auburn University | 2-Quinoxalinol Salen Compounds and Uses Thereof |
| WO2018145020A1 (en) | 2017-02-03 | 2018-08-09 | The Medical College Of Wisconsin, Inc. | Kras peptide vaccine compositions and method of use |
| EP3868882A1 (de) * | 2020-02-21 | 2021-08-25 | European Molecular Biology Laboratory | Archaeale pyrrolysyl-trna-synthetasen zur orthogonalen verwendung |
| CN111304234A (zh) * | 2020-02-27 | 2020-06-19 | 江南大学 | 一种适用于枯草芽孢杆菌的非天然氨基酸利用工具 |
| KR102557569B1 (ko) * | 2021-03-04 | 2023-07-20 | 전남대학교산학협력단 | 메타노사에타 콘실리에서 유래한 티로실-tRNA 합성효소 및 이를 이용한 단백질 생산방법 |
| JP7692615B2 (ja) * | 2022-06-20 | 2025-06-16 | 国立研究開発法人農業・食品産業技術総合研究機構 | カイコ、非天然アミノ酸含有タンパク質の製造方法、及びシルクタンパク質 |
-
2003
- 2003-10-31 US US10/532,948 patent/US7566555B2/en not_active Expired - Fee Related
- 2003-10-31 CA CA002503749A patent/CA2503749A1/en not_active Abandoned
- 2003-10-31 WO PCT/JP2003/014028 patent/WO2004039989A1/ja not_active Ceased
- 2003-10-31 JP JP2004548112A patent/JP4467435B2/ja not_active Expired - Fee Related
- 2003-10-31 EP EP03809875A patent/EP1557469B1/de not_active Expired - Lifetime
- 2003-10-31 AT AT03809875T patent/ATE381623T1/de not_active IP Right Cessation
- 2003-10-31 DE DE60318240T patent/DE60318240T2/de not_active Expired - Lifetime
-
2009
- 2009-06-19 US US12/488,136 patent/US7666640B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090286311A1 (en) | 2009-11-19 |
| DE60318240D1 (de) | 2008-01-31 |
| EP1557469B1 (de) | 2007-12-19 |
| US7666640B2 (en) | 2010-02-23 |
| JP4467435B2 (ja) | 2010-05-26 |
| CA2503749A1 (en) | 2004-05-13 |
| US20060234339A1 (en) | 2006-10-19 |
| US7566555B2 (en) | 2009-07-28 |
| JPWO2004039989A1 (ja) | 2006-03-02 |
| WO2004039989A1 (ja) | 2004-05-13 |
| DE60318240T2 (de) | 2008-12-04 |
| EP1557469A1 (de) | 2005-07-27 |
| EP1557469A4 (de) | 2005-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |