ATE525472T1 - Verfahren zur homologen rekombination - Google Patents

Verfahren zur homologen rekombination

Info

Publication number
ATE525472T1
ATE525472T1 AT01918578T AT01918578T ATE525472T1 AT E525472 T1 ATE525472 T1 AT E525472T1 AT 01918578 T AT01918578 T AT 01918578T AT 01918578 T AT01918578 T AT 01918578T AT E525472 T1 ATE525472 T1 AT E525472T1
Authority
AT
Austria
Prior art keywords
agent
alteration
antibody
homologous recombination
end joining
Prior art date
Application number
AT01918578T
Other languages
English (en)
Inventor
Evguenii Ivanov
Original Assignee
Shire Human Genetic Therapies
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shire Human Genetic Therapies filed Critical Shire Human Genetic Therapies
Application granted granted Critical
Publication of ATE525472T1 publication Critical patent/ATE525472T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4712—Cystic fibrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Led Devices (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT01918578T 2000-03-14 2001-03-13 Verfahren zur homologen rekombination ATE525472T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/525,160 US6569681B1 (en) 2000-03-14 2000-03-14 Methods of improving homologous recombination
PCT/US2001/007870 WO2001068882A2 (en) 2000-03-14 2001-03-13 Methods for homologous recombination

Publications (1)

Publication Number Publication Date
ATE525472T1 true ATE525472T1 (de) 2011-10-15

Family

ID=24092175

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01918578T ATE525472T1 (de) 2000-03-14 2001-03-13 Verfahren zur homologen rekombination

Country Status (10)

Country Link
US (1) US6569681B1 (de)
EP (1) EP1263972B1 (de)
JP (1) JP2003526376A (de)
AT (1) ATE525472T1 (de)
AU (1) AU2001245637A1 (de)
CA (1) CA2403113A1 (de)
DK (1) DK1263972T3 (de)
MX (1) MXPA02009044A (de)
TR (1) TR200202196T2 (de)
WO (1) WO2001068882A2 (de)

Families Citing this family (33)

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WO2002010364A2 (en) * 2000-07-27 2002-02-07 University Of Delaware Methods for enhancing targeted gene alteration using oligonucleotides
EP1395669B1 (de) * 2001-01-26 2009-07-22 Selexis S.A. Matrix-anheftungsregionen und verfahren zu deren verwendung
ATE548461T1 (de) * 2002-01-18 2012-03-15 Morphotek Inc Verfahren zur erzeugung manipulierter zellen zur locus-spezifischen genregulation und analyse
GB0214896D0 (en) * 2002-06-27 2002-08-07 Novartis Forschungsstiftung Gene for increased somatic recombination
FR2846337B1 (fr) 2002-10-28 2007-06-22 Centre Nat Rech Scient Procede pour inserer un acide nucleique d'interet dans une cellule procaryote ou eucaryote par recombinaison homologue
WO2004061077A2 (en) * 2002-12-24 2004-07-22 North Carolina State University Increasing gamete production with a gene switch
PL1959011T3 (pl) 2003-10-24 2012-07-31 Selexis Sa Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy
JP4050712B2 (ja) 2004-02-27 2008-02-20 独立行政法人科学技術振興機構 相同組換えを行わせる方法
WO2005095624A2 (en) * 2004-04-02 2005-10-13 Dsm Ip Assets B.V. Filamentous fungal mutants with improved homologous recombination efficiency
US20060110390A1 (en) * 2004-08-25 2006-05-25 Myogen, Inc. Inhibition of Ku as a treatment for cardiovascular diseases
JP4625318B2 (ja) * 2004-12-06 2011-02-02 財団法人野田産業科学研究所 相同組換え頻度が上昇した形質転換菌
EP2045327B8 (de) 2005-03-08 2012-03-14 BASF Plant Science GmbH Expressionsverstärkende Intron-Sequenz
US20060269998A1 (en) 2005-04-15 2006-11-30 North Carolina State University Methods and compositions to modulate adhesion and stress tolerance in bacteria
JP2007222055A (ja) * 2006-02-22 2007-09-06 Noda Inst For Scient Res 染色体領域欠失株の作製方法
JP2008263927A (ja) * 2007-04-25 2008-11-06 Noda Inst For Scient Res 染色体大領域の欠失方法
WO2008138835A1 (en) * 2007-05-09 2008-11-20 Novozymes A/S Expression cloning method suitable for selecting library clones producing a polypeptide of interest
CA2691785C (en) 2007-06-27 2017-01-10 Marine Polymer Technologies Inc. Complexes of il-15 and il-15ralpha and uses thereof
ES2550202T3 (es) * 2009-08-03 2015-11-05 Recombinetics, Inc. Métodos y composiciones para la modificación dirigida de genes
AU2010282340B2 (en) 2009-08-13 2016-12-22 The Johns Hopkins University Methods of modulating immune function
WO2011078662A1 (en) * 2009-12-21 2011-06-30 Keygene N.V. Dsrna for improved genetic modification of plant dna
AU2010335107B2 (en) * 2009-12-21 2014-07-03 Keygene N.V. Improved techniques for transfecting protoplasts
GB201009732D0 (en) * 2010-06-10 2010-07-21 Gene Bridges Gmbh Direct cloning
US20140304847A1 (en) * 2011-06-07 2014-10-09 Ralf Kühn Recombination efficiency by inhibition of nhej dna repair
EP2814969A4 (de) * 2012-02-10 2016-02-17 Univ Minnesota Dna-assimilation
WO2014066527A2 (en) 2012-10-24 2014-05-01 Admune Therapeutics Llc Il-15r alpha forms, cells expressing il-15r alpha forms, and therapeutic uses of il-15r alpha and il-15/il-15r alpha complexes
WO2015066205A1 (en) * 2013-10-29 2015-05-07 Rutgers, The State University Of New Jersey Fast genetically modified organism and systems for precise genome editing and targeted genetic manipulation through enhanced homologous recombination
WO2016018920A1 (en) 2014-07-29 2016-02-04 Admune Therapeutics Llc Il-15 and il-15ralpha heterodimer dose escalation regimens for treating conditions
EP3200816A1 (de) 2014-09-29 2017-08-09 Alexion Pharmaceuticals, Inc. Verfahren zur behandlung von mukopolysaccharidose iiib (mpsiiib)
EP3420080B1 (de) 2016-02-22 2019-08-21 Caribou Biosciences, Inc. Verfahren zur modulation von dna-reparaturergebnissen
EP3570870A1 (de) 2017-01-20 2019-11-27 Novartis AG Kombinationstherapie zur behandlung von krebs
JP2020505350A (ja) 2017-01-20 2020-02-20 ノバルティス アーゲー 癌の治療のための組合せ療法
JP7084021B2 (ja) * 2018-01-24 2022-06-14 公立大学法人大阪 ターゲティングベクター
US20210244821A1 (en) 2020-02-05 2021-08-12 Novartis Ag Cho cell expressed het il-15

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
US6010908A (en) 1992-08-21 2000-01-04 The Regents Of The University Of California Gene therapy by small fragment homologous replacement
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
AU4115693A (en) * 1992-04-24 1993-11-29 Sri International In vivo homologous sequence targeting in eukaryotic cells
US5780296A (en) 1995-01-17 1998-07-14 Thomas Jefferson University Compositions and methods to promote homologous recombination in eukaryotic cells and organisms
GB9700574D0 (en) 1997-01-13 1997-03-05 Cancer Res Campaign Tech Methods and means relating to retrotransposon and retroviral integration
CA2277481A1 (en) 1997-01-13 1998-07-16 Kudos Pharmaceuticals Limited Assays, agents, therapy and diagnosis relating to modulation of cellular dna repair activity
AU743305C (en) * 1997-01-17 2006-03-30 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
US5986055A (en) 1997-11-13 1999-11-16 Curagen Corporation CDK2 interactions
DE19755952C1 (de) 1997-12-16 1998-12-10 Curt Niebling Dünnwandiges, elektro-magnetisch abschirmendes, tiefgezogenes Formteil, Verfahren zu dessen Herstellung, und ein bei diesem Verfahren einsetzbares Zwischenprodukt
AU2018999A (en) 1997-12-31 1999-07-19 Medical College Of Georgia Research Institute, Inc. Oligomers that bind to ku protein
US6180850B1 (en) 1998-09-02 2001-01-30 Pioneer Hi-Bred International, Inc. Maize Ku70 orthologue and uses thereof
CA2333434A1 (en) 1999-05-05 2000-11-16 Pioneer Hi-Bred International, Inc. Maize rad50 orthologue and uses thereof

Also Published As

Publication number Publication date
WO2001068882A2 (en) 2001-09-20
US6569681B1 (en) 2003-05-27
EP1263972A2 (de) 2002-12-11
AU2001245637A1 (en) 2001-09-24
TR200202196T2 (tr) 2003-01-21
CA2403113A1 (en) 2001-09-20
MXPA02009044A (es) 2003-04-25
JP2003526376A (ja) 2003-09-09
WO2001068882A3 (en) 2002-03-14
DK1263972T3 (da) 2012-01-02
EP1263972B1 (de) 2011-09-21

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