ATE381927T1 - Oral anzuwendendes arzneimittel bestehend aus einer vielzahl von mikrokapseln für die verzögerte verabreichung von wirkstoffen - Google Patents

Oral anzuwendendes arzneimittel bestehend aus einer vielzahl von mikrokapseln für die verzögerte verabreichung von wirkstoffen

Info

Publication number
ATE381927T1
ATE381927T1 AT03750852T AT03750852T ATE381927T1 AT E381927 T1 ATE381927 T1 AT E381927T1 AT 03750852 T AT03750852 T AT 03750852T AT 03750852 T AT03750852 T AT 03750852T AT E381927 T1 ATE381927 T1 AT E381927T1
Authority
AT
Austria
Prior art keywords
microcapsules
core
active principle
release
coated
Prior art date
Application number
AT03750852T
Other languages
English (en)
Inventor
Florence Guimberteau
Catherine Castan
Remi Meyrueix
Original Assignee
Flamel Tech Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Flamel Tech Sa filed Critical Flamel Tech Sa
Application granted granted Critical
Publication of ATE381927T1 publication Critical patent/ATE381927T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03750852T 2002-07-26 2003-07-28 Oral anzuwendendes arzneimittel bestehend aus einer vielzahl von mikrokapseln für die verzögerte verabreichung von wirkstoffen ATE381927T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0209532A FR2842736B1 (fr) 2002-07-26 2002-07-26 Formulation pharmaceutique orale sous forme d'une pluralite de microcapsules permettant la liberation prolongee de principe(s) actif(s) peu soluble(s)

Publications (1)

Publication Number Publication Date
ATE381927T1 true ATE381927T1 (de) 2008-01-15

Family

ID=30011529

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03750852T ATE381927T1 (de) 2002-07-26 2003-07-28 Oral anzuwendendes arzneimittel bestehend aus einer vielzahl von mikrokapseln für die verzögerte verabreichung von wirkstoffen

Country Status (17)

Country Link
US (1) US8652523B2 (de)
EP (1) EP1524968B1 (de)
JP (2) JP5430815B2 (de)
KR (1) KR20050026515A (de)
CN (1) CN1678295B (de)
AT (1) ATE381927T1 (de)
AU (1) AU2003269067B2 (de)
BR (1) BR0312995A (de)
CA (1) CA2493453C (de)
DE (1) DE60318316T2 (de)
ES (1) ES2298551T3 (de)
FR (1) FR2842736B1 (de)
IL (1) IL166383A0 (de)
MX (1) MXPA05001077A (de)
PT (1) PT1524968E (de)
WO (1) WO2004010983A2 (de)
ZA (1) ZA200500693B (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
ES2314227T7 (es) 2002-04-09 2012-11-19 Flamel Technologies Formulacion farmaceutica oral en forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de amoxilicina.
JP4732696B2 (ja) 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
CA2563533C (en) 2004-04-15 2013-10-01 Shmuel A. Ben-Sasson Compositions capable of facilitating penetration across a biological barrier
FR2889810A1 (fr) * 2005-05-24 2007-02-23 Flamel Technologies Sa Forme medicamenteuse orale, microparticulaire, anti-mesurage
FR2881652B1 (fr) * 2005-02-08 2007-05-25 Flamel Technologies Sa Forme pharmaceutique orale microparticulaire anti-mesuage
FR2882260A1 (fr) * 2005-02-21 2006-08-25 Flamel Technologies Sa Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii
CA2598410A1 (fr) * 2005-02-21 2006-08-24 Flamel Technologies Forme pharmaceutique orale de losartan
FR2884145A1 (fr) * 2005-04-06 2006-10-13 Flamel Technologies Sa Forme pharmaceutique orale de losartan
FR2882259A1 (fr) * 2005-02-21 2006-08-25 Flamel Technologies Sa Forme pharmaceutique orale multimicroparticulaire a liberation modifiee de losartan
FR2885526B1 (fr) * 2005-05-13 2007-07-27 Flamel Technologies Sa Medicament oral a base d'inhibiteur de pompe a protons
WO2006133733A1 (en) 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
EP2522343A1 (de) 2006-03-28 2012-11-14 Javelin Pharmaceuticals, Inc. Formulierungen aus niedrigdosiertem Diclofenac und Beta-Cyclodextrin
US9023400B2 (en) * 2006-05-24 2015-05-05 Flamel Technologies Prolonged-release multimicroparticulate oral pharmaceutical form
RU2678833C2 (ru) * 2008-09-17 2019-02-04 Киазма Инк. Фармацевтические композиции и соответствующие способы доставки
FR2936709B1 (fr) * 2008-10-02 2012-05-11 Ethypharm Sa Comprimes alcoolo-resistants.
FR2945945B1 (fr) * 2009-05-29 2011-07-29 Flamel Tech Sa Procede de preparation de particules creuses et leurs applications
FR2945947B1 (fr) * 2009-05-29 2011-07-29 Flamel Tech Sa Compositions pharmaceutiques flottantes a liberation controlee
GB2479213B (en) 2010-04-01 2013-07-10 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
SI2659881T1 (en) * 2012-04-30 2018-03-30 Tillotts Pharma Ag Formulation of the delayed release medicinal product
SI3253401T1 (sl) 2015-02-03 2025-07-31 Amryt Endo, Inc. Zdravljenje akromegalije z oralnim oktreotidom
KR102600541B1 (ko) 2016-01-20 2023-11-08 테라비다, 인코포레이티드 다한증을 치료하기 위한 방법 및 조성물
US12186296B1 (en) 2016-07-22 2025-01-07 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
UY37341A (es) 2016-07-22 2017-11-30 Flamel Ireland Ltd Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada
US11504347B1 (en) 2016-07-22 2022-11-22 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11986451B1 (en) 2016-07-22 2024-05-21 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12478604B1 (en) 2016-07-22 2025-11-25 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602513B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11602512B1 (en) 2016-07-22 2023-03-14 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US12161754B2 (en) 2017-12-20 2024-12-10 Purdue Pharma L.P. Abuse deterrent morphine sulfate dosage forms
KR102327750B1 (ko) * 2018-12-19 2021-11-18 대화제약 주식회사 Glp-1 유사체를 포함하는 경구투여용 약제학적 조성물
BR112021013766A2 (pt) 2019-03-01 2021-09-21 Flamel Ireland Limited Composições de gama-hidroxibutirato com farmacocinética melhorada no estado alimentado
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
US11779557B1 (en) 2022-02-07 2023-10-10 Flamel Ireland Limited Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics
US11583510B1 (en) 2022-02-07 2023-02-21 Flamel Ireland Limited Methods of administering gamma hydroxybutyrate formulations after a high-fat meal

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2313915A1 (fr) 1976-01-26 1977-01-07 Corneille Gilbert Nouvelle forme galenique d'administration de la vincamine et de ses derives, son procede de preparation et medicaments comprenant cette nouvelle forme
US4321253A (en) 1980-08-22 1982-03-23 Beatty Morgan L Suspension of microencapsulated bacampicillin acid addition salt for oral, especially pediatric, administration
HU187215B (en) 1983-01-26 1985-11-28 Egyt Gyogyszervegyeszeti Gyar Method for producing pharmaceutical product of high actor content and prolonged effect
US4894240A (en) * 1983-12-22 1990-01-16 Elan Corporation Plc Controlled absorption diltiazem formulation for once-daily administration
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
LU85943A1 (fr) 1985-06-12 1987-01-13 Galephar Comprimes pharmaceutiques permettant l'administration aisee de pellets, leur preparation et leur utilisation
SE8601624D0 (sv) 1986-04-11 1986-04-11 Haessle Ab New pharmaceutical preparations
US4752470A (en) * 1986-11-24 1988-06-21 Mehta Atul M Controlled release indomethacin
GB8705083D0 (en) 1987-03-04 1987-04-08 Euro Celtique Sa Spheroids
IT1227899B (it) 1988-12-23 1991-05-14 Poli Ind Chimica Spa Rivestimento totale o parziale di principi attivi farmaceutici e relative composizioni
US5084278A (en) * 1989-06-02 1992-01-28 Nortec Development Associates, Inc. Taste-masked pharmaceutical compositions
FI922107A0 (fi) * 1991-05-10 1992-05-08 Faulding F H & Co Ltd Mikrokapselkomposition och foerfarande.
US5286497A (en) * 1991-05-20 1994-02-15 Carderm Capital L.P. Diltiazem formulation
SE9402422D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New beads for controlled release and a pharmaceutical preparation containing the same
JPH0873345A (ja) 1994-09-05 1996-03-19 Terumo Corp 医薬製剤
FR2725623A1 (fr) * 1994-10-18 1996-04-19 Flamel Tech Sa Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
FR2732218B1 (fr) * 1995-03-28 1997-08-01 Flamel Tech Sa Particules a base de polyaminoacide(s) et susceptibles d'etre utilisees comme vecteurs de principe(s) actif(s) et leurs procedes de preparation
JPH09188617A (ja) 1996-01-08 1997-07-22 Pola Chem Ind Inc 徐放性医薬組成物
CA2258683C (en) 1996-06-28 2007-07-31 Schering Corporation Oral composition comprising a triazole antifungal compound
AU719076B2 (en) 1996-12-19 2000-05-04 Daiichi Pharmaceutical Co., Ltd. Pharmaceutical composition for oral administration
AU761205B2 (en) 1998-03-30 2003-05-29 Skyepharma Canada Inc. Composition and method of preparing microparticles of water-insoluble substances
TW407058B (en) 1998-07-17 2000-10-01 Dev Center Biotechnology Oral cisapride dosage forms with an extended duration
ES2157731B1 (es) 1998-07-21 2002-05-01 Liconsa Liberacion Controlada Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
AU6283299A (en) 1998-10-01 2000-04-17 Elan Pharma International Limited Controlled release nanoparticulate compositions
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6544556B1 (en) * 2000-09-11 2003-04-08 Andrx Corporation Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor
FR2816840B1 (fr) * 2000-11-17 2004-04-09 Flamel Tech Sa Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation
WO2002085335A1 (en) * 2001-04-18 2002-10-31 Nostrum Pharmaceuticals Inc. A novel coating for a sustained release pharmaceutical composition
FR2825023B1 (fr) 2001-05-23 2005-04-15 Flamel Tech Sa Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif
JP4732696B2 (ja) * 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
ES2314227T7 (es) 2002-04-09 2012-11-19 Flamel Technologies Formulacion farmaceutica oral en forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de amoxilicina.

Also Published As

Publication number Publication date
JP5430815B2 (ja) 2014-03-05
EP1524968B1 (de) 2007-12-26
MXPA05001077A (es) 2005-06-06
FR2842736B1 (fr) 2005-07-22
FR2842736A1 (fr) 2004-01-30
JP2014005289A (ja) 2014-01-16
CN1678295A (zh) 2005-10-05
AU2003269067B2 (en) 2009-01-08
US20060165809A1 (en) 2006-07-27
KR20050026515A (ko) 2005-03-15
WO2004010983A3 (fr) 2004-04-08
AU2003269067A1 (en) 2004-02-16
IL166383A0 (en) 2006-01-16
ZA200500693B (en) 2006-07-26
CN1678295B (zh) 2010-04-28
CA2493453C (fr) 2012-05-22
CA2493453A1 (fr) 2004-02-05
DE60318316T2 (de) 2008-12-11
EP1524968A2 (de) 2005-04-27
BR0312995A (pt) 2005-06-28
PT1524968E (pt) 2008-03-13
US8652523B2 (en) 2014-02-18
ES2298551T3 (es) 2008-05-16
JP2006500332A (ja) 2006-01-05
WO2004010983A2 (fr) 2004-02-05
DE60318316D1 (de) 2008-02-07

Similar Documents

Publication Publication Date Title
DE60318316D1 (de) Oral anzuwendendes arzneimittel bestehend aus einer vielzahl von mikrokapseln für die verzögerte verabreichung von wirkstoffen
WO2004010984A3 (fr) Microcapsules a liberation modifiee de principes actifs peu solubles pour administration per os
US9572773B2 (en) Layered drug delivery device
US9084731B2 (en) Preparation in film form for biphasic release of pharmacologically active or other substances
Maheshwari et al. Chitosan encrusted nonionic surfactant based vesicular formulation for topical administration of ofloxacin
CA2543324A1 (en) Rapidly disintegrating films for delivery of pharmaceutical or cosmetic agents
EP2968401B1 (de) Getönte antiseptische lösungen mit verbesserter stabilität
WO2005070394A3 (en) Ternary non-lamellar lipid compositions
HRP20140097T1 (hr) Farmaceutski sastav jakog hcv-inhibitora za oralnu primjenu
CA2769046A1 (en) Coating agent for the dip coating of capsule halves
AU2006310213A1 (en) Multi-layered coating technology for taste masking
KR20070007868A (ko) 경구 섭취 가능한 기질용 장용성 피복
FI86373B (fi) Belaeggning foer en farmaceutiskt tablett med foerdroejd effekt och foerfarande foer framstaellning av en tablett.
CH678273A5 (de)
FI2180887T3 (fi) Farmaseuttisia preparaatioita sisältäen voimakkaasti volatiilisia silikoneja
ATE522204T1 (de) Beschichtete pellets
DE60200202D1 (de) Ein Chinolonderivat enthaltendes Arzneimittel und Verfahren zu dessen Herstellung
WO2009072334A1 (ja) 製剤用核粒子
JP6780412B2 (ja) コーティング組成物ならびにコーティング製剤及びその製造方法
KR890007746A (ko) 치환된 디히드로피리딘류의 채널 차단제에 대한 지속적 방출 전달 시스템
Muschert et al. Improved long term stability of aqueous ethylcellulose film coatings: importance of the type of drug and starter core
NO331643B1 (no) Mikrogranuler som ikke er loselige i magesaft, fremgangsmater for a oppna det samme og farmasoytiske preparater
JP2019523290A5 (de)
TW201731492A (zh) 防沾黏材
JP2008542256A5 (de)

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1524968

Country of ref document: EP