ES2157731B1 - Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. - Google Patents

Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Info

Publication number
ES2157731B1
ES2157731B1 ES009801539A ES9801539A ES2157731B1 ES 2157731 B1 ES2157731 B1 ES 2157731B1 ES 009801539 A ES009801539 A ES 009801539A ES 9801539 A ES9801539 A ES 9801539A ES 2157731 B1 ES2157731 B1 ES 2157731B1
Authority
ES
Spain
Prior art keywords
preparation
coating
procedure
compound
oral pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009801539A
Other languages
English (en)
Other versions
ES2157731A1 (es
Inventor
Darder Carlos Picornell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Liconsa SA
Original Assignee
Liconsa Liberacion Controlada de Sustancias Activas SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8304581&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2157731(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liconsa Liberacion Controlada de Sustancias Activas SA filed Critical Liconsa Liberacion Controlada de Sustancias Activas SA
Priority to ES009801539A priority Critical patent/ES2157731B1/es
Priority to SK86-2001A priority patent/SK283279B6/sk
Priority to EP99931261A priority patent/EP1103252B1/en
Priority to JP2000560874A priority patent/JP4190732B2/ja
Priority to MEP-267/08A priority patent/MEP26708A/xx
Priority to BR9912300-2A priority patent/BR9912300A/pt
Priority to HR20010128A priority patent/HRP20010128B1/xx
Priority to RU2001104894/14A priority patent/RU2209628C2/ru
Priority to CZ2001175A priority patent/CZ291938B6/cs
Priority to SI9930282T priority patent/SI1103252T1/xx
Priority to YUP-39/01A priority patent/RS50063B/sr
Priority to MXPA01000681A priority patent/MXPA01000681A/es
Priority to ES99931261T priority patent/ES2194480T3/es
Priority to PCT/ES1999/000230 priority patent/WO2000004881A1/es
Priority to NZ509886A priority patent/NZ509886A/xx
Priority to HK01108330.1A priority patent/HK1037531B/en
Priority to UA2001021260A priority patent/UA64009C2/uk
Priority to EEP200100041A priority patent/EE04415B1/xx
Priority to HU0103708A priority patent/HU228895B1/hu
Priority to CA002337509A priority patent/CA2337509C/en
Priority to PL99345625A priority patent/PL194740B1/pl
Priority to PT99931261T priority patent/PT1103252E/pt
Priority to IL14091099A priority patent/IL140910A/en
Priority to TR2001/00177T priority patent/TR200100177T2/xx
Priority to AT99931261T priority patent/ATE234077T1/de
Priority to DE69905905T priority patent/DE69905905T2/de
Priority to AU47821/99A priority patent/AU750730B2/en
Priority to KR1020017000783A priority patent/KR100572135B1/ko
Priority to US09/744,322 priority patent/US6737082B1/en
Priority to DK99931261T priority patent/DK1103252T3/da
Priority to NO20010289A priority patent/NO320054B1/no
Priority to ZA200101293A priority patent/ZA200101293B/en
Priority to BG105282A priority patent/BG65187B1/bg
Publication of ES2157731A1 publication Critical patent/ES2157731A1/es
Publication of ES2157731B1 publication Critical patent/ES2157731B1/es
Application granted granted Critical
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Preparación farmacéutica oral de un compuesto de actividad antifúngica y procedimiento para su preparación. Comprende un compuesto de actividad antifúngica como principio activo, un núcleo inerte y un recubrimiento que incluye dicho principio activo, y se caracteriza por el hecho de que dicho núcleo inerte presenta un tamaño de partícula comprendido entre 50-600 {mi}m, y por el hecho de que dicho recubrimiento comprende una única capa que se obtiene por nebulización, sobre dicho núcleo inerte, de una solución que comprende un compuesto de actividad antifúngica, un polímero hidrofílico y un agente tensioactivo no iónico. El procedimiento se lleva a cabo mediante un recubrimiento que comprende una única capa de los núcleos inertes de tamaño entre 50 y 600 {mi}m por nebulización de una solución compuesta por el agente antifúngico, el polímero hidrofílico y el agente tensioactivo no iónico a una velocidad de recubrimiento constante durante todo el proceso; y un solo secado de dicho recubrimiento en el mismo equipo.
ES009801539A 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion. Expired - Fee Related ES2157731B1 (es)

Priority Applications (33)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
HU0103708A HU228895B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
CA002337509A CA2337509C (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
JP2000560874A JP4190732B2 (ja) 1998-07-21 1999-07-20 抗真菌活性化合物を含む経口医薬組成物およびその製法
MEP-267/08A MEP26708A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
BR9912300-2A BR9912300A (pt) 1998-07-21 1999-07-20 Composição farmacêutica oral de um composto tendo atividade antifúngica e método para a sua preparação
PT99931261T PT1103252E (pt) 1998-07-21 1999-07-20 Preparacao farmaceutica oral de um composto com actividade antifungica e seu metodo de preparacao
RU2001104894/14A RU2209628C2 (ru) 1998-07-21 1999-07-20 Пероральная фармацевтическая композиция на основе соединения, имеющего антигрибковую активность, и способ ее получения
CZ2001175A CZ291938B6 (cs) 1998-07-21 1999-07-20 Orální farmaceutický prostředek protihoubově účinné sloučeniny a způsob jeho přípravy
SI9930282T SI1103252T1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
YUP-39/01A RS50063B (sr) 1998-07-21 1999-07-20 Oralni farmaceutski preparat sa fungicidnim dejstvom i postupak za njegovo pripremanje
MXPA01000681A MXPA01000681A (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ES99931261T ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
PCT/ES1999/000230 WO2000004881A1 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion
NZ509886A NZ509886A (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of either itraconazole or saperconazole having antifungic activity
HK01108330.1A HK1037531B (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
UA2001021260A UA64009C2 (en) 1998-07-21 1999-07-20 Pharmaceutical composition comprising antifungal agent and method for its production
EEP200100041A EE04415B1 (et) 1998-07-21 1999-07-20 Antimükootilist toimet omava ühendi farmatseutiline peroraalne preparaat ja selle valmistamismeetod
SK86-2001A SK283279B6 (sk) 1998-07-21 1999-07-20 Orálny farmaceutický prostriedok protihubovo účinnej zlúčeniny a spôsob jeho prípravy
PL99345625A PL194740B1 (pl) 1998-07-21 1999-07-20 Doustna kompozycja farmaceutyczna w postaci peletek zawierająca związek o działaniu przeciwgrzybicznym i sposób jej wytwarzania
EP99931261A EP1103252B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
HR20010128A HRP20010128B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
IL14091099A IL140910A (en) 1998-07-21 1999-07-20 An oral pharmaceutical preparation of a compound with antifungal activity and a method of preparation
TR2001/00177T TR200100177T2 (tr) 1998-07-21 1999-07-20 Antifungal Aktiviteye sahip bir bileşimin oral farmasötik kompozisyonu ve bu kompozisyonun hazırlanış metodu.
AT99931261T ATE234077T1 (de) 1998-07-21 1999-07-20 Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung
DE69905905T DE69905905T2 (de) 1998-07-21 1999-07-20 Orale pharmazeutische zusammensetzung enthaltend einen wirkstoff mit antimykotischer wirkung und verfahren zu ihrer herstellung
AU47821/99A AU750730B2 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
KR1020017000783A KR100572135B1 (ko) 1998-07-21 1999-07-20 항진균 활성을 갖는 화합물의 경구용 약제 및 이의 제조방법
US09/744,322 US6737082B1 (en) 1998-07-21 1999-07-20 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method
DK99931261T DK1103252T3 (da) 1998-07-21 1999-07-20 Oral farmaceutisk sammensætning af en forbindelse med en afsvampningsaktivitet og fremgangsmåde til fremstilling deraf
NO20010289A NO320054B1 (no) 1998-07-21 2001-01-17 Oral farmasoytisk sammensetning med en forbindelse som har antisopp aktivitet og en metode for dens fremstilling
ZA200101293A ZA200101293B (en) 1998-07-21 2001-02-15 Pharmaceutical oral preparation of a compound having an antifungic activity, and preparation method.
BG105282A BG65187B1 (bg) 1998-07-21 2001-02-21 Фармацевтичен състав за орално приложение, съдържащ съединения с антифунгицидно действие, и метод за получаването му

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009801539A ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Publications (2)

Publication Number Publication Date
ES2157731A1 ES2157731A1 (es) 2001-08-16
ES2157731B1 true ES2157731B1 (es) 2002-05-01

Family

ID=8304581

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009801539A Expired - Fee Related ES2157731B1 (es) 1998-07-21 1998-07-21 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ES99931261T Expired - Lifetime ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES99931261T Expired - Lifetime ES2194480T3 (es) 1998-07-21 1999-07-20 Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.

Country Status (30)

Country Link
US (1) US6737082B1 (es)
EP (1) EP1103252B1 (es)
JP (1) JP4190732B2 (es)
KR (1) KR100572135B1 (es)
AT (1) ATE234077T1 (es)
AU (1) AU750730B2 (es)
BG (1) BG65187B1 (es)
BR (1) BR9912300A (es)
CA (1) CA2337509C (es)
CZ (1) CZ291938B6 (es)
DE (1) DE69905905T2 (es)
DK (1) DK1103252T3 (es)
EE (1) EE04415B1 (es)
ES (2) ES2157731B1 (es)
HR (1) HRP20010128B1 (es)
HU (1) HU228895B1 (es)
IL (1) IL140910A (es)
ME (1) MEP26708A (es)
MX (1) MXPA01000681A (es)
NO (1) NO320054B1 (es)
NZ (1) NZ509886A (es)
PL (1) PL194740B1 (es)
PT (1) PT1103252E (es)
RS (1) RS50063B (es)
RU (1) RU2209628C2 (es)
SK (1) SK283279B6 (es)
TR (1) TR200100177T2 (es)
UA (1) UA64009C2 (es)
WO (1) WO2000004881A1 (es)
ZA (1) ZA200101293B (es)

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US20040115287A1 (en) * 2002-12-17 2004-06-17 Lipocine, Inc. Hydrophobic active agent compositions and methods
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SI1438960T2 (sl) * 2003-01-14 2013-04-30 Cimex Pharma Ag Sestavek itrakonazola, dispergiranega v hidrofilnem polimeru, z izboljšano biorazpoložljivostjo
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Also Published As

Publication number Publication date
ZA200101293B (en) 2001-08-21
HK1037531A1 (en) 2002-02-15
JP2002521323A (ja) 2002-07-16
NO20010289D0 (no) 2001-01-17
KR20010070990A (ko) 2001-07-28
PT1103252E (pt) 2003-07-31
KR100572135B1 (ko) 2006-04-19
YU3901A (sh) 2003-08-29
EE200100041A (et) 2002-06-17
BR9912300A (pt) 2001-04-17
HU228895B1 (en) 2013-06-28
BG105282A (en) 2001-11-30
EE04415B1 (et) 2005-02-15
CZ2001175A3 (en) 2001-05-16
IL140910A0 (en) 2002-02-10
RU2209628C2 (ru) 2003-08-10
ES2194480T3 (es) 2003-11-16
BG65187B1 (bg) 2007-06-29
IL140910A (en) 2004-03-28
US6737082B1 (en) 2004-05-18
CA2337509A1 (en) 2000-02-03
CZ291938B6 (cs) 2003-06-18
SK862001A3 (en) 2001-08-06
DE69905905D1 (de) 2003-04-17
CA2337509C (en) 2005-12-27
NZ509886A (en) 2002-09-27
RS50063B (sr) 2009-01-22
ES2157731A1 (es) 2001-08-16
NO320054B1 (no) 2005-10-17
EP1103252B1 (en) 2003-03-12
AU750730B2 (en) 2002-07-25
HRP20010128B1 (en) 2003-12-31
WO2000004881A1 (es) 2000-02-03
ATE234077T1 (de) 2003-03-15
HRP20010128A2 (en) 2002-12-31
MEP26708A (en) 2010-06-10
TR200100177T2 (tr) 2001-07-23
HUP0103708A3 (en) 2002-07-29
JP4190732B2 (ja) 2008-12-03
HUP0103708A2 (hu) 2002-02-28
PL194740B1 (pl) 2007-06-29
UA64009C2 (en) 2004-02-16
EP1103252A1 (en) 2001-05-30
PL345625A1 (en) 2002-01-02
NO20010289L (no) 2001-03-07
DK1103252T3 (da) 2003-07-14
MXPA01000681A (es) 2002-04-24
DE69905905T2 (de) 2004-03-04
SK283279B6 (sk) 2003-05-02
AU4782199A (en) 2000-02-14

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