ATE382038T1 - Für die behandlung von krankheiten wie krebs und atherosclerose geeignete substituierte isochinoline - Google Patents
Für die behandlung von krankheiten wie krebs und atherosclerose geeignete substituierte isochinolineInfo
- Publication number
- ATE382038T1 ATE382038T1 AT04797977T AT04797977T ATE382038T1 AT E382038 T1 ATE382038 T1 AT E382038T1 AT 04797977 T AT04797977 T AT 04797977T AT 04797977 T AT04797977 T AT 04797977T AT E382038 T1 ATE382038 T1 AT E382038T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- isochinolines
- atherosclerosis
- cancer
- diseases
- Prior art date
Links
- 201000001320 Atherosclerosis Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0326964.4A GB0326964D0 (en) | 2003-11-19 | 2003-11-19 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE382038T1 true ATE382038T1 (de) | 2008-01-15 |
Family
ID=29764099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04797977T ATE382038T1 (de) | 2003-11-19 | 2004-11-17 | Für die behandlung von krankheiten wie krebs und atherosclerose geeignete substituierte isochinoline |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090291949A1 (de) |
| EP (1) | EP1689717B1 (de) |
| JP (1) | JP2007511571A (de) |
| AT (1) | ATE382038T1 (de) |
| DE (1) | DE602004010931T2 (de) |
| ES (1) | ES2297512T3 (de) |
| GB (1) | GB0326964D0 (de) |
| WO (1) | WO2005049576A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007005668A2 (en) * | 2005-06-30 | 2007-01-11 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
| EP1746096A1 (de) * | 2005-07-15 | 2007-01-24 | 4Sc Ag | 2-Arylbenzothiazol-Analoge zur Verwendung als Antikrebsmittel |
| JP5301999B2 (ja) * | 2005-10-31 | 2013-09-25 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｃｅｔｐ阻害薬 |
| KR20100032496A (ko) * | 2008-09-18 | 2010-03-26 | 주식회사 이큐스팜 | 신규 5-(4-아미노페닐)-이소퀴놀린 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 Ｒａｆ 키나제의 과활성에 의해 유발되는 질환의 예방 또는 치료용 조성물 |
| CN105153162B (zh) * | 2012-04-25 | 2017-05-03 | 南京圣和药业股份有限公司 | 作为蛋白激酶抑制剂的苯基脲类化合物及其应用 |
| WO2013192423A2 (en) | 2012-06-20 | 2013-12-27 | Eutropics Pharmaceuticals, Inc. | Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives |
| US20160038503A1 (en) | 2012-11-21 | 2016-02-11 | David Richard | Methods and compositions useful for treating diseases involving bcl-2 family proteins with isoquinoline and quinoline derivatives |
| US10732182B2 (en) | 2013-08-01 | 2020-08-04 | Eutropics Pharmaceuticals, Inc. | Method for predicting cancer sensitivity |
| JP6538044B2 (ja) | 2013-10-30 | 2019-07-03 | ユートロピクス ファーマシューティカルズ， インコーポレイテッド | 化学療法感受性および化学毒性を判定する方法 |
| CN105503744B (zh) * | 2016-01-12 | 2019-03-01 | 西安交通大学 | 一种含有喹唑啉酮的联苯脲化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9721964D0 (en) * | 1997-10-16 | 1997-12-17 | Pfizer Ltd | Isoquinolines |
| PT1107964E (pt) * | 1998-08-11 | 2010-06-11 | Novartis Ag | Derivados de isoquinolina com actividade inibidora da angiogénese |
-
2003
- 2003-11-19 GB GBGB0326964.4A patent/GB0326964D0/en not_active Ceased
-
2004
- 2004-11-17 ES ES04797977T patent/ES2297512T3/es not_active Expired - Lifetime
- 2004-11-17 US US10/595,912 patent/US20090291949A1/en not_active Abandoned
- 2004-11-17 WO PCT/EP2004/013075 patent/WO2005049576A1/en not_active Ceased
- 2004-11-17 AT AT04797977T patent/ATE382038T1/de not_active IP Right Cessation
- 2004-11-17 JP JP2006540320A patent/JP2007511571A/ja not_active Withdrawn
- 2004-11-17 EP EP04797977A patent/EP1689717B1/de not_active Expired - Lifetime
- 2004-11-17 DE DE602004010931T patent/DE602004010931T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090291949A1 (en) | 2009-11-26 |
| EP1689717B1 (de) | 2007-12-26 |
| JP2007511571A (ja) | 2007-05-10 |
| ES2297512T3 (es) | 2008-05-01 |
| DE602004010931D1 (de) | 2008-02-07 |
| GB0326964D0 (en) | 2003-12-24 |
| EP1689717A1 (de) | 2006-08-16 |
| DE602004010931T2 (de) | 2009-01-02 |
| WO2005049576A1 (en) | 2005-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |