ATE382050T1 - Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel - Google Patents

Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel

Info

Publication number
ATE382050T1
ATE382050T1 AT02258083T AT02258083T ATE382050T1 AT E382050 T1 ATE382050 T1 AT E382050T1 AT 02258083 T AT02258083 T AT 02258083T AT 02258083 T AT02258083 T AT 02258083T AT E382050 T1 ATE382050 T1 AT E382050T1
Authority
AT
Austria
Prior art keywords
ester derivatives
buprenorphine
long
production
acting analgesic
Prior art date
Application number
AT02258083T
Other languages
English (en)
Inventor
Jhi-Joung Wang
Original Assignee
Chi Mei Foundation Medical Ct
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chi Mei Foundation Medical Ct filed Critical Chi Mei Foundation Medical Ct
Application granted granted Critical
Publication of ATE382050T1 publication Critical patent/ATE382050T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02258083T 2002-11-25 2002-11-25 Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel ATE382050T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02258083A EP1422230B1 (de) 2002-11-25 2002-11-25 Buprenorphinesterderivate, Verfahren zu ihrer Herstellung, und langwirksame analgetische Arzneimittel

Publications (1)

Publication Number Publication Date
ATE382050T1 true ATE382050T1 (de) 2008-01-15

Family

ID=32187266

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02258083T ATE382050T1 (de) 2002-11-25 2002-11-25 Buprenorphinesterderivate, verfahren zu ihrer herstellung, und langwirksame analgetische arzneimittel

Country Status (3)

Country Link
EP (1) EP1422230B1 (de)
AT (1) ATE382050T1 (de)
DE (1) DE60224288T2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
EP1554290B1 (de) * 2002-10-25 2009-09-30 Euro-Celtique S.A. Analoga und prodrugs von buprenorphin
US7220842B2 (en) * 2004-04-05 2007-05-22 Dade Behring Inc. Immunoassays for buprenorphine and norbuprenorphine
GB0606124D0 (en) 2006-03-28 2006-05-03 Reckitt Benckiser Healthcare Buprenorphine derivatives and uses thereof
ES2549115T3 (es) 2006-09-22 2015-10-23 Zynerba Pharmaceuticals, Inc. Profármacos de buprenorfina administrables por vía transdérmica y composiciones resistentes al consumo excesivo de los mismos
FR2975912B1 (fr) * 2011-05-30 2013-06-14 Flamel Tech Sa Composition a liberation controlee de buprenorphine
AU2015253417B2 (en) 2014-04-28 2020-02-20 Dimerx, Inc. Pharmaceutically active dimers linked through phenolic hydroxyl groups
GB201419091D0 (en) * 2014-10-27 2014-12-10 Camurus Ab Formulations
PL3512518T3 (pl) 2016-09-13 2023-03-27 Alar Pharmaceuticals Inc. Preparaty buprenorfiny o przedłużonym uwalnianiu
TWI838372B (zh) 2018-05-11 2024-04-11 昱展新藥生技股份有限公司 丁基原啡因衍生物之長效注射劑型及結晶型
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US10975099B2 (en) 2018-11-05 2021-04-13 Alkermes Pharma Ireland Limited Thiophene compounds for long-acting injectable compositions and related methods

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3701693B2 (ja) * 1993-12-28 2005-10-05 日本製薬株式会社 鎮痛薬含有注射用徐放性脂肪乳剤
GB9423542D0 (en) * 1994-11-22 1995-01-11 Marples Brian A Pharmaceutical compounds
AU5108596A (en) * 1995-03-14 1996-10-02 Mundipharma Gmbh Morphine-3-esters

Also Published As

Publication number Publication date
EP1422230B1 (de) 2007-12-26
DE60224288T2 (de) 2009-04-16
DE60224288D1 (de) 2008-02-07
EP1422230A1 (de) 2004-05-26

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