ATE382147T1 - Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden - Google Patents

Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden

Info

Publication number
ATE382147T1
ATE382147T1 AT03760533T AT03760533T ATE382147T1 AT E382147 T1 ATE382147 T1 AT E382147T1 AT 03760533 T AT03760533 T AT 03760533T AT 03760533 T AT03760533 T AT 03760533T AT E382147 T1 ATE382147 T1 AT E382147T1
Authority
AT
Austria
Prior art keywords
target sample
capacitive sensor
binding site
substrate
conductive
Prior art date
Application number
AT03760533T
Other languages
English (en)
Inventor
Denis Flandre
Luis Hagelsieb
Remi Pampin
David Bourgeois
Jose Remacle
Pierre-Emmannuel Lobert
Original Assignee
Univ Catholique Louvain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Catholique Louvain filed Critical Univ Catholique Louvain
Application granted granted Critical
Publication of ATE382147T1 publication Critical patent/ATE382147T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/221Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/226Construction of measuring vessels; Electrodes therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555Hetero-N
    • Y10T436/147777Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/16Phosphorus containing
    • Y10T436/163333Organic [e.g., chemical warfare agents, insecticides, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/17Nitrogen containing
    • Y10T436/173845Amine and quaternary ammonium

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT03760533T 2002-06-24 2003-06-24 Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden ATE382147T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02447122A EP1376111A1 (de) 2002-06-24 2002-06-24 Verfahren und Vorrichtung für die hochempfindliche Bestimmung von DNA und anderen Testsubstanzen

Publications (1)

Publication Number Publication Date
ATE382147T1 true ATE382147T1 (de) 2008-01-15

Family

ID=29717039

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03760533T ATE382147T1 (de) 2002-06-24 2003-06-24 Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden

Country Status (6)

Country Link
US (1) US7943394B2 (de)
EP (2) EP1376111A1 (de)
AT (1) ATE382147T1 (de)
AU (1) AU2003243843A1 (de)
DE (1) DE60318313T2 (de)
WO (1) WO2004001403A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0114399D0 (en) * 2001-06-13 2001-08-08 Univ Liverpool Substrates, biomaterials and methods
EP1376111A1 (de) 2002-06-24 2004-01-02 Universite Catholique De Louvain Verfahren und Vorrichtung für die hochempfindliche Bestimmung von DNA und anderen Testsubstanzen
WO2005066613A1 (en) * 2003-12-31 2005-07-21 President And Fellows Of Harvard College Assay device and method
US7773404B2 (en) 2005-01-07 2010-08-10 Invisage Technologies, Inc. Quantum dot optical devices with enhanced gain and sensitivity and methods of making same
US7742322B2 (en) 2005-01-07 2010-06-22 Invisage Technologies, Inc. Electronic and optoelectronic devices with quantum dot films
US7326908B2 (en) 2004-04-19 2008-02-05 Edward Sargent Optically-regulated optical emission using colloidal quantum dot nanocrystals
US7746681B2 (en) 2005-01-07 2010-06-29 Invisage Technologies, Inc. Methods of making quantum dot films
DE102004045210A1 (de) * 2004-09-17 2006-04-06 Infineon Technologies Ag Sensor-Anordnung und Verfahren zum Ermitteln eines Sensorereignisses
KR100678291B1 (ko) * 2004-11-11 2007-02-02 삼성전자주식회사 나노입자를 이용한 수광소자
CA2519608A1 (en) 2005-01-07 2006-07-07 Edward Sargent Quantum dot-polymer nanocomposite photodetectors and photovoltaics
DE102005027245A1 (de) * 2005-06-13 2006-12-21 Siemens Ag Schaltkreisanordnung
CN101198870A (zh) * 2005-06-17 2008-06-11 皇家飞利浦电子股份有限公司 精密磁性生物传感器
RU2008101774A (ru) * 2005-06-17 2009-07-27 Конинклейке Филипс Электроникс Н.В. (Nl) Быстродействующий магнитный биодатчик с интегрированным измерением времени поступления
KR100714988B1 (ko) * 2005-08-09 2007-05-09 삼성전자주식회사 산화막이 표면에 형성된 실리콘 구조물 표면을 이용한dna 정제 방법 및 정제장치
ITPD20050365A1 (it) * 2005-12-14 2007-06-15 Univ Degli Studi Trieste Metodo e sistema di riconoscimento di pattern genetici
CN101443656B (zh) * 2006-03-16 2013-08-14 环球纳米传感器技术公司 介电传感方法和系统
KR100777973B1 (ko) * 2006-07-13 2007-11-29 한국표준과학연구원 다중선형전극 센서 유닛으로 이루어진 바이오센서
EP1898211A1 (de) * 2006-09-08 2008-03-12 Université Catholique de Louvain Isolierter Substratimpedanzwandler
EP2017609A1 (de) * 2007-07-18 2009-01-21 Université Catholique de Louvain Verfahren und Vorrichtung zum hochempfindlichen quantitativen Nachweis von chemischen/biologischen Molekülen
US8159347B2 (en) * 2008-09-25 2012-04-17 General Electric Company Sensors having gap based sensing devices and methods of making and using the same
EP2182359B1 (de) * 2008-10-30 2015-03-04 Sysmex Corporation Verfahren zur analytdetektion
US8736287B2 (en) 2009-03-04 2014-05-27 Universal Nanosensor Technologies Inc. Conductance detection system and method
US8744568B2 (en) * 2009-12-22 2014-06-03 Boston Scientific Scimed, Inc. Medical device with electroactive polymer powered by photovoltaic cell
JP2011232328A (ja) * 2010-04-09 2011-11-17 Hitachi Ltd 生体物質検出アレイ、計測装置および計測方法
WO2011149249A2 (ko) * 2010-05-24 2011-12-01 한국생명공학연구원 극미량 시료 검출용 전기 바이오센서
CN102888454B (zh) * 2011-09-13 2015-04-22 中国水产科学研究院黄海水产研究所 非接触式基因扩增电化学快速检测方法
US8986523B2 (en) 2012-01-19 2015-03-24 International Business Machines Corporation Biosensor capacitor
US9382579B2 (en) * 2012-03-02 2016-07-05 Nokomis, Inc. DNA/nanoparticle complex enhanced radio frequency transponder: structure of mark for detecting hybridization state and authenticating and tracking articles, method of preparing the same, and method of authenticating the same
US10641721B2 (en) 2014-03-07 2020-05-05 Board Of Regents, The University Of Texas System Tri-electrode apparatus and methods for molecular analysis
US10004433B2 (en) * 2014-07-07 2018-06-26 Verily Life Sciences Llc Electrochemical sensor chip
CA3021580A1 (en) 2015-06-25 2016-12-29 Barry L. Merriman Biomolecular sensors and methods
KR101754239B1 (ko) * 2015-12-28 2017-07-06 한국과학기술연구원 수용체와 표적 생체물질의 반응을 이용한 교차 전극 바이오센서
US11624725B2 (en) 2016-01-28 2023-04-11 Roswell Blotechnologies, Inc. Methods and apparatus for measuring analytes using polymerase in large scale molecular electronics sensor arrays
EP4137808A1 (de) 2016-01-28 2023-02-22 Roswell Biotechnologies, Inc. Verfahren zur herstellung einer dna-sequenzierungsvorrichtung
WO2017139493A2 (en) 2016-02-09 2017-08-17 Roswell Biotechnologies, Inc. Electronic label-free dna and genome sequencing
US10597767B2 (en) 2016-02-22 2020-03-24 Roswell Biotechnologies, Inc. Nanoparticle fabrication
US9829456B1 (en) 2016-07-26 2017-11-28 Roswell Biotechnologies, Inc. Method of making a multi-electrode structure usable in molecular sensing devices
US10585094B2 (en) * 2016-09-01 2020-03-10 The Governors Of The University Of Alberta Devices and methods for nanoparticle enhanced impedance-based molecular sensing
EP3339833B1 (de) * 2016-12-22 2021-11-10 Heraeus Nexensos GmbH Sensor, insbesondere russsensor, verfahren zur herstellung eines sensors, insbesondere eines russsensors, und verwendung
WO2018132457A1 (en) 2017-01-10 2018-07-19 Roswell Biotechnologies, Inc. Methods and systems for dna data storage
US11656197B2 (en) 2017-01-19 2023-05-23 Roswell ME Inc. Solid state sequencing devices comprising two dimensional layer materials
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
EP3615685B1 (de) 2017-04-25 2025-02-19 Roswell Biotechnologies, Inc Enzymatische schaltungen für molekulare sensoren
KR102606670B1 (ko) 2017-05-09 2023-11-24 로스웰 바이오테크놀로지스 인코포레이티드 분자 센서들을 위한 결합 프로브 회로들
US11371955B2 (en) 2017-08-30 2022-06-28 Roswell Biotechnologies, Inc. Processive enzyme molecular electronic sensors for DNA data storage
KR102717872B1 (ko) 2017-10-10 2024-10-14 로스웰 엠이 아이엔씨. 무증폭 dna 데이터 저장을 위한 방법, 장치 및 시스템
CN109142462B (zh) * 2018-06-22 2021-05-04 思贝科斯(北京)科技有限公司 电导探针及其制造方法
US11471789B2 (en) 2018-07-12 2022-10-18 Abb Schweiz Ag Material phase with electrical lead
US11247165B2 (en) 2018-07-12 2022-02-15 Abb Schweiz Ag Material phase between conductive layers
WO2020210832A1 (en) 2019-04-12 2020-10-15 Roswell Biotechnologies, Inc. Polycyclic aromatic bridges for molecular electronic sensors
US12146852B2 (en) 2019-09-06 2024-11-19 Roswell Biotechnologies, Inc. Methods of fabricating nanoscale structures usable in molecular sensors and other devices
KR102286263B1 (ko) * 2019-10-23 2021-08-04 가천대학교 산학협력단 나노소재를 이용한 정전용량형 화학센서 및 그의 제조방법
GB202003649D0 (en) * 2020-03-13 2020-04-29 Imperial College Innovations Ltd Cleanroom-free integrated trimdol silicon transducer for genetic detection of pathogens
US20240006756A1 (en) * 2020-11-27 2024-01-04 Nokia Shanghai Bell Co., Ltd. Decoupling apparatus, a radiation unit and antenna
JPWO2024101320A1 (de) * 2022-11-07 2024-05-16
EP4474808A1 (de) * 2023-06-07 2024-12-11 ETH Zurich Kapazitive mikroelektrodenvorrichtung zur erfassung einer biologischen aktivität in einer probe und verfahren zur verwendung solch einer mikroelektrodenvorrichtung

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS621967A (ja) 1985-06-25 1987-01-07 松下電工株式会社 屋根の軒先瓦とけらば瓦との交差部の構造
JPS6219767A (ja) * 1985-07-19 1987-01-28 Hitachi Ltd パタ−ン検出型dna分離検出装置
CA2002660A1 (en) 1988-11-10 1990-05-10 Susan J. Mroczkowski Method for electrical detection of a binding reaction
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
US5965452A (en) * 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
WO1997021094A1 (en) * 1995-12-01 1997-06-12 Innogenetics N.V. Impedimetric detection system and method of production thereof
US5917264A (en) * 1996-09-05 1999-06-29 Nagano Keiki Co Ltd Electrostatic capacitance type transducer and method for producing the same
US5922537A (en) * 1996-11-08 1999-07-13 N.o slashed.AB Immunoassay, Inc. Nanoparticles biosensor
US6495892B2 (en) * 1997-08-08 2002-12-17 California Institute Of Technology Techniques and systems for analyte detection
DE69828803T2 (de) * 1997-08-08 2006-01-05 Cyrano Sciences Inc., Pasadena Techniken und systeme zum nachweis von analyten
CA2300268A1 (en) * 1997-08-12 1999-02-18 Robert D. Macphee Electrochemical reporter system for detecting analytical immunoassay and molecular biology procedures
US20020166764A1 (en) * 1997-08-12 2002-11-14 University Of Southern California Electrochemical sensor devices and methods for fast, reliable, and sensitive detection and quantitation of analytes
BE1011776A3 (nl) * 1998-03-06 2000-01-11 Vito Sensor voor toepassing in metaalsmelten.
CA2325886C (en) * 1998-04-09 2009-07-21 California Institute Of Technology Electronic techniques for analyte detection
US6236096B1 (en) * 1998-10-06 2001-05-22 National Science Council Of Republic Of China Structure of a three-electrode capacitive pressure sensor
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
WO2000072018A1 (en) * 1999-05-19 2000-11-30 Advanced Array Technologies S.A. Method for the identification and/or the quantification of a target compound
US20010053522A1 (en) * 2000-04-28 2001-12-20 Fuji Photo Film Co., Ltd. DNA chip and reactive electrode
JP2002131155A (ja) * 2000-10-30 2002-05-09 Denso Corp 感圧抵抗センサ
JP2002174611A (ja) * 2000-12-08 2002-06-21 Matsushita Electric Ind Co Ltd 免疫電極センサー
US20020096119A1 (en) * 2001-01-23 2002-07-25 Kolozsvari Kevin L. Pet Chair
US7531136B2 (en) * 2001-11-26 2009-05-12 Sony Deutschland Gmbh Chemical sensor
EP1376111A1 (de) 2002-06-24 2004-01-02 Universite Catholique De Louvain Verfahren und Vorrichtung für die hochempfindliche Bestimmung von DNA und anderen Testsubstanzen
CN101443656B (zh) * 2006-03-16 2013-08-14 环球纳米传感器技术公司 介电传感方法和系统
EP1898211A1 (de) * 2006-09-08 2008-03-12 Université Catholique de Louvain Isolierter Substratimpedanzwandler

Also Published As

Publication number Publication date
EP1516174A1 (de) 2005-03-23
WO2004001403A1 (en) 2003-12-31
EP1376111A1 (de) 2004-01-02
DE60318313T2 (de) 2008-12-11
DE60318313D1 (de) 2008-02-07
US20050227373A1 (en) 2005-10-13
US7943394B2 (en) 2011-05-17
EP1516174B1 (de) 2007-12-26
AU2003243843A1 (en) 2004-01-06

Similar Documents

Publication Publication Date Title
ATE382147T1 (de) Verfahren und einrichtung zur hochempfindlichen detektion der anwesenheit von dna und weitere sonden
ATE515693T1 (de) Nachweis einer zielsubstanz in einer probe
WO2005056613A3 (en) Site selectively tagged and templated molecularly imprinted polymers for sensor applications
CY1113686T1 (el) Συσκευη bio-αισθητηρα και οι μεθοδοι χρησης της
ATE326697T1 (de) Sensor und methode zur messung der flächendichte von magnetischen nanopartikeln auf einem mikroarray
WO2005027714A3 (en) Sensitive and rapid biodetection
DE602007004666D1 (de) Verfahren zum analytennachweis unter verwendung von proximitätssonden
DE60133111D1 (de) Verfahren zur erkennung und zum assay von nukleinsäuresequenzen
DE69928949D1 (de) Vorrichtung zur festellung der anwesenheit von feuchtigkeit
EP2148191A4 (de) Impedanzmesser und anwendungen dafür
WO2005026681A3 (en) Magnetostrictive ligand sensor devices and uses thereof
EP1306449A3 (de) Verfahren und Sensor zur Bestimmung der Bindung von Biomolekülen durch Messung der Scherbelastung
DE60023539D1 (de) Immunologischer nachweis von rna:dna hybriden auf mikroarrays
ATE427067T1 (de) Verfahren zur detektierung von temperaturanderungen
DE50003766D1 (de) Verfahren und vorrichtung zum nachweis und zur quantifizierung von biomolekülen
WO2006116111A3 (en) Interdigitated chemical sensors, and methods of making and using the same
DE602004013864D1 (de) Sensor mit Schaltung zur Feststellung von Fehlern
EP2047259A4 (de) Biosensor mit interdigitalen elektrodensensoreinheiten
ATE486137T1 (de) Verbessertes einfangen und detektion von zielnukleinsäuren in verfahren mit teststreifen
ATE420211T1 (de) Vorrichtung und verfahren zum nachweis von geladenen makromolekülen
ATE529533T1 (de) Verfahren zum nachweis von analyten in einer probe
DE60325382D1 (de) Verfahren zur diagnose von gebärmutterhalskrebs
ATE492650T1 (de) Verfahren und vorrichtung zur detektion von markierungselementen in einer probe
DE602004017317D1 (de) Verwendung der proteine proteinase 3 (prn3) und leukozyten elastatse inhibitor (ileu) als marker für kolorektale karzinome
WO2007094805A3 (en) Method for electrocatalytic protein detection

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties