ATE382319T1 - Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs - Google Patents

Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs

Info

Publication number
ATE382319T1
ATE382319T1 AT99935496T AT99935496T ATE382319T1 AT E382319 T1 ATE382319 T1 AT E382319T1 AT 99935496 T AT99935496 T AT 99935496T AT 99935496 T AT99935496 T AT 99935496T AT E382319 T1 ATE382319 T1 AT E382319T1
Authority
AT
Austria
Prior art keywords
conduit
bladder
niche
fluid
inner ear
Prior art date
Application number
AT99935496T
Other languages
English (en)
Inventor
Irving Arenberg
Michael Arenberg
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Application granted granted Critical
Publication of ATE382319T1 publication Critical patent/ATE382319T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/28—Bioelectric electrodes therefor specially adapted for particular uses for electrocardiography [ECG]
    • A61B5/283—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acoustics & Sound (AREA)
  • Biophysics (AREA)
  • Otolaryngology (AREA)
  • Psychology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
AT99935496T 1998-07-23 1999-07-12 Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs ATE382319T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/121,460 US6440102B1 (en) 1998-07-23 1998-07-23 Fluid transfer and diagnostic system for treating the inner ear

Publications (1)

Publication Number Publication Date
ATE382319T1 true ATE382319T1 (de) 2008-01-15

Family

ID=22396877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935496T ATE382319T1 (de) 1998-07-23 1999-07-12 Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs

Country Status (7)

Country Link
US (1) US6440102B1 (de)
EP (1) EP1098614B1 (de)
AT (1) ATE382319T1 (de)
AU (1) AU745505B2 (de)
CA (1) CA2338341C (de)
DE (1) DE69937886T2 (de)
WO (1) WO2000004854A1 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US6770080B2 (en) * 2001-04-26 2004-08-03 Fenestra Medical, Inc. Mechanically registered videoscopic myringotomy/tympanostomy tube placement system
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20060241075A1 (en) * 2001-05-18 2006-10-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
US7517864B2 (en) * 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222066A1 (en) * 2001-05-18 2005-10-06 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20070270579A1 (en) * 2001-05-18 2007-11-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050282188A1 (en) * 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20080161256A1 (en) * 2001-05-18 2008-07-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
ATE342025T1 (de) * 2001-06-18 2006-11-15 Durect Corp Vorrichtung zur abgabe von mikrodosen eines medikaments in das ohr
US6648873B2 (en) * 2001-09-21 2003-11-18 Durect Corp. Aural catheter system including anchor balloon and balloon inflation device
JP4398728B2 (ja) * 2001-10-24 2010-01-13 メド−エル・エレクトロメディツィニシェ・ゲラーテ・ゲーエムベーハー 埋込み式流体配送装置と埋込み式電極
US20070088335A1 (en) * 2001-10-24 2007-04-19 Med-El Elektromedizinische Geraete Gmbh Implantable neuro-stimulation electrode with fluid reservoir
WO2003037212A2 (en) * 2001-10-30 2003-05-08 Lesinski George S Implantation method for a hearing aid microactuator implanted into the cochlea
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
WO2004050166A1 (en) 2002-12-02 2004-06-17 Med-El Elektromedizinsche Geraete Gmbh Fluid switch controlled trans-cutaneously via a magnetic force
DE10305349A1 (de) 2003-02-10 2004-08-26 Cell Center Cologne Gmbh Innenohr-Steckverbindung
WO2005009287A2 (en) * 2003-07-21 2005-02-03 University Of Maryland, Baltimore Drug delivery to the inner ear and methods of using same
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
WO2005115527A2 (en) * 2004-05-24 2005-12-08 Auris Medical, Llc. Combined otic aspirator and medication dispenser
US20120253267A1 (en) * 2004-05-24 2012-10-04 Reed Don C Combined otic and medication dispenser and method for treating otic infections
CA2594963A1 (en) * 2005-01-24 2006-07-27 Neurosystec Corporation Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues
US20060205789A1 (en) * 2005-03-04 2006-09-14 Neurosystec Corporation Gacyclidine formulations
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
US20090176725A1 (en) * 2005-08-17 2009-07-09 Sirna Therapeutics Inc. Chemically modified short interfering nucleic acid molecules that mediate rna interference
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
CA2657380A1 (en) * 2006-07-20 2008-01-24 Neurosystec Corporation Devices, systems and methods for ophthalmic drug delivery
US20080145439A1 (en) * 2006-07-31 2008-06-19 Neurosystec Corporation Nanoparticle drug formulations
US9046192B2 (en) * 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US9216112B2 (en) * 2007-04-19 2015-12-22 Acclarent, Inc. System and method for the simultaneous bilateral placement of pressure equalization tubes
US20090043369A1 (en) * 2007-06-01 2009-02-12 Med-El Elektromedizinische Geraete Gmbh Flexible Biodegradable Coating For Implantable Medical Devices
US8192420B2 (en) 2007-12-20 2012-06-05 Acclarent, Inc. Iontophoresis methods
US9140649B2 (en) * 2008-07-24 2015-09-22 Massachusetts Institute Of Technology Inflatable membrane having non-uniform inflation characteristic
US9170200B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Inflatable membrane with hazard mitigation
US9291565B2 (en) 2008-07-24 2016-03-22 Massachusetts Institute Of Technology Three dimensional scanning using membrane with optical features
US9170199B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Enhanced sensors in three dimensional scanning system
RU2503469C2 (ru) * 2008-07-27 2014-01-10 Аккларент, Инк. Системы и способы анестезирования ткани уха
US8840602B2 (en) * 2008-07-31 2014-09-23 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8452392B2 (en) * 2008-07-31 2013-05-28 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8718785B2 (en) * 2008-10-08 2014-05-06 Med-El Elektromedizinische Geraete Gmbh Cochlear tissue protection from electrode trauma
AU2009305745B9 (en) * 2008-10-15 2013-07-18 Med-El Elektromedizinische Geraete Gmbh Inner ear drug delivery device and method
US20100121256A1 (en) * 2008-11-10 2010-05-13 Med-El Elektromedizinische Geraete Gmbh Implantable and Refillable Drug Delivery Reservoir
US9078783B2 (en) * 2008-12-24 2015-07-14 Acclarent, Inc. Silent effusion removal
WO2010111750A1 (en) 2009-04-01 2010-10-07 Colin Dunlop Improved patient warming system
EP3649995A1 (de) * 2009-07-15 2020-05-13 Tusker Medical, Inc. System zur freisetzung einer trommelfelldruckausgleichsröhre
US9770366B2 (en) 2009-07-15 2017-09-26 Tusker Medical, Inc. Tympanic membrane pressure equalization tube delivery system
US9539146B2 (en) 2009-07-15 2017-01-10 Tusker Medical, Inc. Trigger assembly for tympanostomy tube delivery device
JP5763072B2 (ja) 2009-08-10 2015-08-12 サミュメッド リミテッド ライアビリティ カンパニー Ｗｎｔシグナル経路のインダゾール阻害剤およびその治療的使用
WO2011019648A1 (en) * 2009-08-10 2011-02-17 Epitherix, Llc Indazoles as wnt/b-catenin signaling pathway inhibitors and therapeutic uses thereof
US20110245756A1 (en) 2009-12-03 2011-10-06 Rishi Arora Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
RS56669B1 (sr) 2009-12-21 2018-03-30 Samumed Llc 1h-pirazolo[3,4-b]piridini i njihove terapeutske primene
US20110202120A1 (en) * 2010-02-16 2011-08-18 Med-El Elektromedizinische Geraete Gmbh Electrode Design for Reduced Trauma Insertion
US8550206B2 (en) 2011-05-31 2013-10-08 Virginia Tech Intellectual Properties, Inc. Method and structure for achieving spectrum-tunable and uniform attenuation
USD640374S1 (en) 2010-07-15 2011-06-21 Acclarent, Inc. Tube delivery device
MX354133B (es) 2010-08-18 2018-02-14 Samumed Llc Dicetonas e hidroxicetonas como activadores de la trayectoria de señalizacion de catenina.
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
EP2670456B1 (de) 2011-02-02 2019-12-18 The Charles Stark Draper Laboratory, Inc. Vorrichtung zur wirkstofffreisetzung
EP2736467B1 (de) 2011-07-25 2018-05-30 Tusker Medical, Inc. Personalisierbares system zur anästhetisierung des trommelfells
HUE041576T2 (hu) 2011-09-14 2019-05-28 Samumed Llc Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként
EP2819741B1 (de) * 2012-02-27 2018-03-28 O-Ray Pharma, Inc. Feststoffarzneimittelimplantate zur intracochlearen freisetzung von therapeutika zur behandlung von ohrerkrankungen
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
NZ741907A (en) 2012-05-04 2020-02-28 Samumed Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US9364648B2 (en) 2012-05-30 2016-06-14 Tusker Medical, Inc. Adhesive earplugs useful for sealing the ear canal
CA2897400A1 (en) 2013-01-08 2014-07-17 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the wnt signaling pathway and therapeutic uses thereof
EP3456325A3 (de) 2013-02-22 2019-05-22 Samumed, LLC Gamma-diketone als wnt/beta-catenin-signalisierungspfadaktivatoren
US9320652B2 (en) 2013-03-14 2016-04-26 Tusker Medical, Inc. Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument
US10130808B2 (en) 2013-03-14 2018-11-20 Tusker Medical, Inc. System and method for providing iontophoresis at tympanic membrane
US9681891B2 (en) 2013-03-14 2017-06-20 Tusker Medical, Inc. Tympanostomy tube delivery device with cutting dilator
US9333116B2 (en) 2013-03-15 2016-05-10 Natan Bauman Variable sound attenuator
US10045133B2 (en) 2013-03-15 2018-08-07 Natan Bauman Variable sound attenuator with hearing aid
US9521480B2 (en) 2013-07-31 2016-12-13 Natan Bauman Variable noise attenuator with adjustable attenuation
MX2016012208A (es) 2014-03-20 2017-01-26 Samumed Llc Indazol-3-carboxamidas 5-substituidas y preparacion y uso de las mismas.
GB201412842D0 (en) * 2014-07-18 2014-09-03 Combat Medical Sl Catheter for the delivery of therapeutic fluid
US20160038341A1 (en) 2014-08-08 2016-02-11 Acclarent, Inc. Tympanostomy tube delivery device with elastomeric brake
US10195086B2 (en) 2014-08-11 2019-02-05 Tusker Medical, Inc. Tympanostomy tube delivery device with rotatable
US9833359B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with cutter force clutch
US9833360B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with replaceable shaft portion
SI3206686T1 (sl) 2014-08-20 2020-03-31 Samumed, Llc Gama-diketoni za zdravljenje in preprečevanje staranja kože in gub
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
US10016304B2 (en) 2015-07-16 2018-07-10 Tusker Medical, Inc. Earplug assembly for iontophoresis system
WO2017023993A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10285983B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
WO2017023972A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10392383B2 (en) 2015-08-03 2019-08-27 Samumed, Llc 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10383861B2 (en) 2015-08-03 2019-08-20 Sammumed, LLC 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10350199B2 (en) 2015-08-03 2019-07-16 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023988A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017024004A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10285982B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017023984A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
WO2017024025A1 (en) 2015-08-03 2017-02-09 Sunil Kumar Kc 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023986A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017024003A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10226448B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
US11477560B2 (en) 2015-09-11 2022-10-18 Hear Llc Earplugs, earphones, and eartips
US10899757B2 (en) 2015-11-06 2021-01-26 Samumed, Llc 2-(1H-indazol-3-yl)-3H-imidazo[4,5-C]pyridines and their anti-inflammatory uses thereof
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
RS63813B1 (sr) 2016-06-01 2023-01-31 Biosplice Therapeutics Inc Postupak pripreme n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida
JP2019522539A (ja) * 2016-06-22 2019-08-15 ザ チャールズ スターク ドレイパー ラボラトリー， インク．Ｔｈｅ Ｃｈａｒｌｅｓ Ｓｔａｒｋ Ｄｒａｐｅｒ Ｌａｂｏｒａｔｏｒｙ， Ｉｎｃ． 経正円窓膜注入による内耳薬物送達用のシステム
WO2018050165A1 (de) * 2016-09-16 2018-03-22 David Spiggle Katheter zur applikation eines mediums in das mittelohr
RU2770613C2 (ru) 2016-10-21 2022-04-19 СЭМЬЮМЕД, ЭлЭлСи Способы применения индазол-3-карбоксамидов и их применение в качестве ингибиторов сигнального пути wnt/в-катенина
US10758523B2 (en) 2016-11-07 2020-09-01 Samumed, Llc Single-dose, ready-to-use injectable formulations
WO2019079626A1 (en) 2017-10-19 2019-04-25 Samumed, Llc 6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
US10413537B2 (en) 2017-10-27 2019-09-17 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
US10653688B2 (en) 2017-10-27 2020-05-19 Samumed, Llc 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
US11806493B2 (en) * 2018-02-02 2023-11-07 Tusker Medical, Inc. Systems, apparatus, and methods for transport and delivery of therapeutic substance to middle ear
SG11202008029UA (en) 2018-02-23 2020-09-29 Samumed Llc 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
EP3773381B1 (de) * 2018-04-13 2024-07-03 Stryker European Operations Holdings LLC Systeme zur durchführung einer transkanal-ohroperation
US11273295B2 (en) 2018-04-19 2022-03-15 Spiral Therapeutics, Inc. Inner ear drug delivery devices and methods of use
US10759799B2 (en) 2018-06-15 2020-09-01 Samumed, Llc Indazole containing macrocycles and therapeutic uses thereof
WO2020006429A1 (en) 2018-06-28 2020-01-02 Hepatikos Therapeutics, Llc Ask1 isoindolin-1-one inhibitors and methods of use thereof
WO2020150545A1 (en) 2019-01-17 2020-07-23 Samumed, Llc Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
CN110584609B (zh) * 2019-09-20 2025-02-25 北京卓驰科技有限公司 咽鼓管吹张治疗的监测系统、存储介质及电子设备
AU2021209675B2 (en) 2020-01-24 2026-01-08 Spiral Therapeutics Inc. Visualization devices, systems, and methods for otology and other uses
WO2021168341A1 (en) 2020-02-21 2021-08-26 Samumed, Llc Solid forms of 1-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-dimethylmethanamine
UY39979A (es) 2021-10-12 2023-04-14 Biosplice Therapeutics Inc Pirrolo[2,1-f][1,2,4]triazinas y preparación y usos de las mismas
US20230192686A1 (en) 2021-10-12 2023-06-22 Biosplice Therapeutics, Inc. 1h-pyrrolo[2,3-b]pyridines and preparation and uses thereof
IL317681A (en) 2022-06-23 2025-02-01 Biosplice Therapeutics Inc 4-Alkoxypyrrolo[1,2-F][4,2,1]triazines, their preparation and uses
CN120769855A (zh) 2022-11-03 2025-10-10 生物衔接医疗公司 4-氨基吡咯并[2,1-f][1,2,4]三嗪及其制备和用途
EP4676931A1 (de) 2023-04-07 2026-01-14 BioSplice Therapeutics, Inc. Pyrrolo[2,1-f [1,2,4)triazine und ihre herstellung und verwendung
WO2025137469A1 (en) 2023-12-22 2025-06-26 Biosplice Therapeutics, Inc. 4-alkoxypyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
US20250340575A1 (en) 2024-05-03 2025-11-06 Biosplice Therapeutics, Inc. 4-aminopyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE850341C (de) 1950-04-15 1952-09-25 Gazzoni & Co A Vorrichtung zum Benetzen des aeusseren Gehoerganges mit einer schmerzstillenden Fluessigkeit
GB1204117A (en) 1966-09-08 1970-09-03 Syntex Corp Devices and methods for administering pharmaceutical preparations
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
US4175563A (en) 1977-10-05 1979-11-27 Arenberg Irving K Biological drainage shunt
US4244377A (en) 1978-10-19 1981-01-13 Grams Guenter A Ear probe for use in closed-loop caloric irrigation
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4320758A (en) 1979-05-07 1982-03-23 Alza Corporation Osmotically driven fluid dispenser
US4297748A (en) 1980-01-02 1981-11-03 Moloy Peter J Middle ear balloon
US4419092A (en) 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4610686A (en) 1983-11-02 1986-09-09 Alza Corporation Controlled delivery of haloperidol by an osmotic delivery system
NO165378C (no) 1985-11-22 1991-02-06 Ellingsen O & Co Medikamentavgivende innretning for implantering i menneskekroppen.
ES2039362T3 (es) 1986-11-07 1993-10-01 Barbara Densert Aparato para el tratamiento de la enfermedad de menier.
SE8703694L (sv) 1987-09-25 1989-03-26 Barbara Densert Saett att lufta mellanoerat medelst en insaettbar ventilationstub, ventilationstub foer utfoerande av saettet jaemte anvaendning av en dylik ventilationstub
JP2683750B2 (ja) 1988-06-06 1997-12-03 住友電気工業株式会社 カテーテル用バルーン
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4929246A (en) 1988-10-27 1990-05-29 C. R. Bard, Inc. Method for closing and sealing an artery after removing a catheter
US4976966A (en) 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US4968297A (en) 1989-05-09 1990-11-06 Iomec, Inc. Iontophoretic electrode with solution containment system
US5035694A (en) * 1989-05-15 1991-07-30 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
US5219334A (en) 1989-05-24 1993-06-15 Tsukada Medical Research Co., Ltd. Infuser with balloon for continuously infusing liquid drug
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
AU8074591A (en) 1990-06-15 1992-01-07 Cortrak Medical, Inc. Drug delivery apparatus and method
WO1992011895A1 (en) 1990-12-28 1992-07-23 Boston Scientific Corporation Balloon drug delivery system
US5304134A (en) 1992-01-17 1994-04-19 Danforth Biomedical, Inc. Lubricious yet bondable catheter channel sleeve for over-the-wire catheters
US5368037A (en) 1993-02-01 1994-11-29 Endosonics Corporation Ultrasound catheter
US5419312A (en) 1993-04-20 1995-05-30 Wildflower Communications, Inc. Multi-function endoscope apparatus
US5421818A (en) 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
US5797868A (en) * 1996-07-25 1998-08-25 Cordis Corporation Photodynamic therapy balloon catheter
US6045528A (en) * 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
US5876344A (en) * 1997-12-09 1999-03-02 Endosonics Corporation Modular imaging/treatment catheter assembly and method

Also Published As

Publication number Publication date
EP1098614A1 (de) 2001-05-16
WO2000004854A1 (en) 2000-02-03
US6440102B1 (en) 2002-08-27
CA2338341C (en) 2009-01-13
CA2338341A1 (en) 2000-02-03
DE69937886D1 (de) 2008-02-14
EP1098614A4 (de) 2006-10-25
DE69937886T2 (de) 2008-12-18
AU745505B2 (en) 2002-03-21
AU5096299A (en) 2000-02-14
EP1098614B1 (de) 2008-01-02

Similar Documents

Publication Publication Date Title
ATE382319T1 (de) Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs
ATE431166T1 (de) System zum transfer von flüssigkeit im innenohr und zur diagnose
DE50011757D1 (de) Medizinisches instrument zur behandlung von biologischem gewebe sowie verfahren zum übertragen von druckwellen
ATE450190T1 (de) Vorrichtung zum durchspülen einer körperhöhle
ATE232404T1 (de) Magensonde
DE502004006169D1 (de) Vorrichtung zur Behandlung von Schlaf-Apnoe
EP4292574A3 (de) Vorrichtung und verfahren zur aufnahme von ausgeschiedenem urin
DE60112554D1 (de) Intragastrale vorrichtung zur behandlung der morbiden fettsucht
ATE365024T1 (de) Vorrichtung zur erhaltung des kontaktes zwischen elektrophysiologieelementen und körpergewebe und system dafür
DE69722825D1 (de) Implantierbare Vorrichtung zur Durchflussregelung von Flüssigkeiten innerhalb des Körpers
EP2380621A3 (de) Laparoskopische Einführungsvorrichtung
YU47805B (sr) Postupak i uređaj za sterilizaciju medicinskih uređaja
ATE509649T1 (de) Vorrichtung zur blutbehandlung mit selektiver entfernung gelöster substanzen
WO2004056408A3 (en) Device for withdrawing body fluids
DE60023352D1 (de) Unterbrechungsfreie durchfluss pumpvorrichtung und verfahren
NZ520208A (en) Pneumoperitoneum apparatus with independent gas and heated water line separated by water permeable membrane
ATE286364T1 (de) Flüssigkeitsverbindungsvorrichtung für endoskop mit kontrollierbarer fluidleckage
NZ335745A (en) Human breast milking apparatus
ATE209063T1 (de) Blutsammelsystem
DE69430239D1 (de) Blutbevorratungsverfahren
EP1192954A3 (de) Systeme und Verfahren zur Reinigung, Sterilisierung oder Desinfektion von medizinischen Geräten
EP0948941A3 (de) Versorgungssystem mit Druckwasser und Versorgungsvorrichtung für eine zahnärztliche Behandlungseinheit
ATE271357T1 (de) Einrichtung zur einspeisung von behandlungsflüssigkeit in medizinische geräte
SE0202172L (sv) Anordning och metod för cirkulatorisk isolering och behandling av kroppsdel
SE9500758D0 (sv) Apparat för hypertermibehandling

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1098614

Country of ref document: EP