ATE382319T1 - Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs - Google Patents

Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs

Info

Publication number
ATE382319T1
ATE382319T1 AT99935496T AT99935496T ATE382319T1 AT E382319 T1 ATE382319 T1 AT E382319T1 AT 99935496 T AT99935496 T AT 99935496T AT 99935496 T AT99935496 T AT 99935496T AT E382319 T1 ATE382319 T1 AT E382319T1
Authority
AT
Austria
Prior art keywords
conduit
bladder
niche
fluid
inner ear
Prior art date
Application number
AT99935496T
Other languages
English (en)
Inventor
Irving Arenberg
Michael Arenberg
Original Assignee
Durect Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durect Corp filed Critical Durect Corp
Application granted granted Critical
Publication of ATE382319T1 publication Critical patent/ATE382319T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0541—Cochlear electrodes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Biophysics (AREA)
  • Acoustics & Sound (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • External Artificial Organs (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
AT99935496T 1998-07-23 1999-07-12 Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs ATE382319T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/121,460 US6440102B1 (en) 1998-07-23 1998-07-23 Fluid transfer and diagnostic system for treating the inner ear

Publications (1)

Publication Number Publication Date
ATE382319T1 true ATE382319T1 (de) 2008-01-15

Family

ID=22396877

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935496T ATE382319T1 (de) 1998-07-23 1999-07-12 Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs

Country Status (7)

Country Link
US (1) US6440102B1 (de)
EP (1) EP1098614B1 (de)
AT (1) ATE382319T1 (de)
AU (1) AU745505B2 (de)
CA (1) CA2338341C (de)
DE (1) DE69937886T2 (de)
WO (1) WO2000004854A1 (de)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8197461B1 (en) 1998-12-04 2012-06-12 Durect Corporation Controlled release system for delivering therapeutic agents into the inner ear
US6770080B2 (en) 2001-04-26 2004-08-03 Fenestra Medical, Inc. Mechanically registered videoscopic myringotomy/tympanostomy tube placement system
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US7517864B2 (en) * 2001-05-18 2009-04-14 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20080161256A1 (en) * 2001-05-18 2008-07-03 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20070270579A1 (en) * 2001-05-18 2007-11-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222066A1 (en) * 2001-05-18 2005-10-06 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US9994853B2 (en) 2001-05-18 2018-06-12 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20050282188A1 (en) * 2001-05-18 2005-12-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20060241075A1 (en) * 2001-05-18 2006-10-26 Sirna Therapeutics, Inc. RNA interference mediated inhibition of desmoglein gene expression using short interfering nucleic acid (siNA)
ES2271278T3 (es) * 2001-06-18 2007-04-16 Durect Corporation Dispositivo para administrar microdosis de agentes en el oido.
US6648873B2 (en) * 2001-09-21 2003-11-18 Durect Corp. Aural catheter system including anchor balloon and balloon inflation device
US20070088335A1 (en) * 2001-10-24 2007-04-19 Med-El Elektromedizinische Geraete Gmbh Implantable neuro-stimulation electrode with fluid reservoir
EP2226043B1 (de) * 2001-10-24 2014-12-31 MED-EL Elektromedizinische Geräte GmbH Implantierbare Flussigkeits-Verabreichungs-Vorrichtung und implantierbare Elektrode
US8147544B2 (en) * 2001-10-30 2012-04-03 Otokinetics Inc. Therapeutic appliance for cochlea
US9181551B2 (en) 2002-02-20 2015-11-10 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US9657294B2 (en) 2002-02-20 2017-05-23 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP1572287B1 (de) 2002-12-02 2011-02-23 Med-El Elektromedizinische Geräte GmbH Transdermal durch magnetische kraft kontrollierter flüssigkeitsschalter
DE10305349A1 (de) 2003-02-10 2004-08-26 Cell Center Cologne Gmbh Innenohr-Steckverbindung
WO2005009287A2 (en) * 2003-07-21 2005-02-03 University Of Maryland, Baltimore Drug delivery to the inner ear and methods of using same
US7351246B2 (en) * 2004-01-20 2008-04-01 Epley John M Minimally invasive, sustained, intra-tympanic drug delivery system
WO2005072793A1 (en) * 2004-01-29 2005-08-11 The Charles Stark Draper Laboratory, Inc. Implantable drug delivery apparatus
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US10508277B2 (en) 2004-05-24 2019-12-17 Sirna Therapeutics, Inc. Chemically modified multifunctional short interfering nucleic acid molecules that mediate RNA interference
US20120253267A1 (en) * 2004-05-24 2012-10-04 Reed Don C Combined otic and medication dispenser and method for treating otic infections
WO2005115527A2 (en) * 2004-05-24 2005-12-08 Auris Medical, Llc. Combined otic aspirator and medication dispenser
JP2008537684A (ja) * 2005-01-24 2008-09-25 ニューロシステック コーポレイション 内耳およびその他の組織へ治療薬および/またはその他の薬剤を送達するための装置および方法
EP2932971A1 (de) 2005-03-04 2015-10-21 Otonomy, Inc. Ketaminformulierungen
US8309057B2 (en) * 2005-06-10 2012-11-13 The Invention Science Fund I, Llc Methods for elevating neurotrophic agents
US20090176725A1 (en) * 2005-08-17 2009-07-09 Sirna Therapeutics Inc. Chemically modified short interfering nucleic acid molecules that mediate rna interference
US8267905B2 (en) * 2006-05-01 2012-09-18 Neurosystec Corporation Apparatus and method for delivery of therapeutic and other types of agents
US7803148B2 (en) 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
US20080152694A1 (en) * 2006-07-20 2008-06-26 Neurosystec Corporation Devices, Systems and Methods for Ophthalmic Drug Delivery
WO2008016602A2 (en) * 2006-07-31 2008-02-07 Neurosystec Corporation Free base gacyclidine nanoparticles
US9046192B2 (en) * 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
US8249700B2 (en) 2007-04-19 2012-08-21 Acclarent, Inc. System and method for the simultaneous bilateral integrated tympanic drug delivery and guided treatment of target tissues within the ears
WO2008150974A1 (en) * 2007-06-01 2008-12-11 Med-El Elektromedizinische Geraete Gmbh Biodegradable flexible coating for implantable medical devices
US8192420B2 (en) * 2007-12-20 2012-06-05 Acclarent, Inc. Iontophoresis methods
US9170200B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Inflatable membrane with hazard mitigation
US9170199B2 (en) 2008-07-24 2015-10-27 Massachusetts Institute Of Technology Enhanced sensors in three dimensional scanning system
US9291565B2 (en) 2008-07-24 2016-03-22 Massachusetts Institute Of Technology Three dimensional scanning using membrane with optical features
US9140649B2 (en) * 2008-07-24 2015-09-22 Massachusetts Institute Of Technology Inflatable membrane having non-uniform inflation characteristic
RU2503469C2 (ru) * 2008-07-27 2014-01-10 Аккларент, Инк. Системы и способы анестезирования ткани уха
US8840602B2 (en) * 2008-07-31 2014-09-23 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8452392B2 (en) * 2008-07-31 2013-05-28 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
WO2010042569A2 (en) * 2008-10-08 2010-04-15 Med-El Elektromedizinische Geraete Gmbh Cochlear tissue protection from electrode trauma
US20100106134A1 (en) * 2008-10-15 2010-04-29 Med-El Elektromedizinische Geraete Gmbh Inner Ear Drug Delivery Device and Method
CA2745453C (en) 2008-11-10 2015-06-16 Med-El Elektromedizinische Geraete Gmbh Hydrogel-filled drug delivery reservoirs
US9078783B2 (en) * 2008-12-24 2015-07-14 Acclarent, Inc. Silent effusion removal
GB2503835B (en) 2009-04-01 2014-06-18 Colin Dunlop Improved patient warming system
US9770366B2 (en) 2009-07-15 2017-09-26 Tusker Medical, Inc. Tympanic membrane pressure equalization tube delivery system
EP3649995A1 (de) * 2009-07-15 2020-05-13 Tusker Medical, Inc. System zur freisetzung einer trommelfelldruckausgleichsröhre
US9539146B2 (en) 2009-07-15 2017-01-10 Tusker Medical, Inc. Trigger assembly for tympanostomy tube delivery device
BR112012002942A2 (pt) * 2009-08-10 2015-10-13 Epitherix Llc indazóis como inibidores da trilha de sinalização de wnt/b-catenina e empregos terapêuticos destes.
ES2835553T3 (es) 2009-08-10 2021-06-22 Biosplice Therapeutics Inc Inhibidores de indazol de la vía de señalización de Wnt y sus usos terapéuticos
US20110245756A1 (en) 2009-12-03 2011-10-06 Rishi Arora Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
SMT201700581T1 (it) 2009-12-21 2018-01-11 Samumed Llc 1h-pirazolo[3,4-b]piridine e loro usi terapeutici
US20110202120A1 (en) * 2010-02-16 2011-08-18 Med-El Elektromedizinische Geraete Gmbh Electrode Design for Reduced Trauma Insertion
US8550206B2 (en) 2011-05-31 2013-10-08 Virginia Tech Intellectual Properties, Inc. Method and structure for achieving spectrum-tunable and uniform attenuation
USD640374S1 (en) 2010-07-15 2011-06-21 Acclarent, Inc. Tube delivery device
EP3915367A1 (de) 2010-08-18 2021-12-01 BioSplice Therapeutics, Inc. Diketone und hydroxyketone als cateninsignalweg-aktivatoren
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012106501A1 (en) 2011-02-02 2012-08-09 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
JP2014525795A (ja) * 2011-07-25 2014-10-02 アクラレント インコーポレイテッド 個人化可能鼓膜麻酔システム及び方法
HUE041576T2 (hu) 2011-09-14 2019-05-28 Samumed Llc Indazol-3-karboxamid-származékok és alkalmazásuk Wnt/b-katenin szignalizáló útvonal inhibitorokként
EP2819741B1 (de) * 2012-02-27 2018-03-28 O-Ray Pharma, Inc. Feststoffarzneimittelimplantate zur intracochlearen freisetzung von therapeutika zur behandlung von ohrerkrankungen
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
SG11201407148XA (en) 2012-05-04 2014-11-27 Samumed Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US9364648B2 (en) 2012-05-30 2016-06-14 Tusker Medical, Inc. Adhesive earplugs useful for sealing the ear canal
US9908867B2 (en) 2013-01-08 2018-03-06 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
PE20151721A1 (es) 2013-02-22 2015-12-07 Samumed Llc Y-dicetonas como activadores de la ruta de senalizacion de wnt/b-catenina
US9681891B2 (en) 2013-03-14 2017-06-20 Tusker Medical, Inc. Tympanostomy tube delivery device with cutting dilator
US9320652B2 (en) 2013-03-14 2016-04-26 Tusker Medical, Inc. Features to improve and sense tympanic membrane apposition by tympanostomy tube delivery instrument
US10130808B2 (en) 2013-03-14 2018-11-20 Tusker Medical, Inc. System and method for providing iontophoresis at tympanic membrane
US10045133B2 (en) 2013-03-15 2018-08-07 Natan Bauman Variable sound attenuator with hearing aid
US9521480B2 (en) 2013-07-31 2016-12-13 Natan Bauman Variable noise attenuator with adjustable attenuation
US9333116B2 (en) 2013-03-15 2016-05-10 Natan Bauman Variable sound attenuator
BR112016021626A2 (pt) 2014-03-20 2018-05-15 Samumed, Llc indazol-3-carboxamidas 5-substituídas e preparação e uso das mesmas
GB201412842D0 (en) * 2014-07-18 2014-09-03 Combat Medical Sl Catheter for the delivery of therapeutic fluid
US20160038341A1 (en) 2014-08-08 2016-02-11 Acclarent, Inc. Tympanostomy tube delivery device with elastomeric brake
US10195086B2 (en) 2014-08-11 2019-02-05 Tusker Medical, Inc. Tympanostomy tube delivery device with rotatable
US9833359B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with cutter force clutch
US9833360B2 (en) 2014-08-12 2017-12-05 Tusker Medical, Inc. Tympanostomy tube delivery device with replaceable shaft portion
DK3206686T3 (da) 2014-08-20 2019-12-16 Samumed Llc Gamma-diketoner til behandling og forebyggelse af ældning af huden og rynker
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
US10016304B2 (en) 2015-07-16 2018-07-10 Tusker Medical, Inc. Earplug assembly for iontophoresis system
US10350199B2 (en) 2015-08-03 2019-07-16 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
US10188634B2 (en) 2015-08-03 2019-01-29 Samumed, Llc 3-(3H-imidazo[4,5-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10195185B2 (en) 2015-08-03 2019-02-05 Samumed, Llc 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023993A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-indol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10285983B2 (en) 2015-08-03 2019-05-14 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[3,4-B] pyridines and therapeutic uses thereof
US10231956B2 (en) 2015-08-03 2019-03-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023989A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017024025A1 (en) 2015-08-03 2017-02-09 Sunil Kumar Kc 3-(1h-pyrrolo[2,3-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10206908B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10206909B2 (en) 2015-08-03 2019-02-19 Samumed, Llc 3-(1H-pyrrolo[2,3-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10604512B2 (en) 2015-08-03 2020-03-31 Samumed, Llc 3-(1H-indol-2-yl)-1H-indazoles and therapeutic uses thereof
US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10383861B2 (en) 2015-08-03 2019-08-20 Sammumed, LLC 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
WO2017023987A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US11477560B2 (en) 2015-09-11 2022-10-18 Hear Llc Earplugs, earphones, and eartips
WO2017079759A1 (en) 2015-11-06 2017-05-11 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-c]pyridines and their anti-inflammatory uses thereof
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
MY199242A (en) 2016-06-01 2023-10-22 Samumed Llc Process for preparing n-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-indazol-5-yl)pyridin-3-yl)-3-methylbutanamide
EP3474941A1 (de) * 2016-06-22 2019-05-01 The Charles Stark Draper Laboratory, Inc. System zur arzneimittelabgabe in das innenohr mittels injektion durch die rundfenstermembran
EP3512592B1 (de) * 2016-09-16 2021-03-31 David Spiggle Katheter zur applikation eines mediums in das mittelohr
BR112019008061A2 (pt) 2016-10-21 2019-09-17 Samumed Llc métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina
MA46696A (fr) 2016-11-07 2019-09-11 Samumed Llc Formulations injectables à dose unique prêtes à l'emploi
US10604514B2 (en) 2017-10-19 2020-03-31 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl carboxamides and preparation and use thereof
US10413537B2 (en) 2017-10-27 2019-09-17 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
US10653688B2 (en) 2017-10-27 2020-05-19 Samumed, Llc 6-(6-membered heteroaryl and aryl)isoquinolin-3-yl carboxamides and preparation and use thereof
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
WO2019152866A1 (en) * 2018-02-02 2019-08-08 Tusker Medical, Inc. Systems, apparatus, and methods for transport and delivery of therapeutic substance to middle ear
JP7369132B2 (ja) 2018-02-23 2023-10-25 サミュメッド リミテッド ライアビリティ カンパニー 5-ヘテロアリール置換イミダゾール-3-カルボキサミドならびにその調製および使用の方法
EP3773381B1 (de) * 2018-04-13 2024-07-03 Stryker European Operations Holdings LLC Systeme zur durchführung einer transkanal-ohroperation
AU2019256527B2 (en) 2018-04-19 2025-01-23 Spiral Therapeutics, Inc. Inner ear drug delivery devices and methods of use
WO2019241540A1 (en) 2018-06-15 2019-12-19 Samumed, Llc Indazole containing macrocycles and therapeutic uses thereof
WO2020006429A1 (en) 2018-06-28 2020-01-02 Hepatikos Therapeutics, Llc Ask1 isoindolin-1-one inhibitors and methods of use thereof
WO2020150545A1 (en) 2019-01-17 2020-07-23 Samumed, Llc Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
CN110584609B (zh) * 2019-09-20 2025-02-25 北京卓驰科技有限公司 咽鼓管吹张治疗的监测系统、存储介质及电子设备
CN115426991A (zh) 2020-01-24 2022-12-02 斯皮拉尔诊疗有限公司 用于治疗耳部疾病的装置、系统和方法
WO2021168341A1 (en) 2020-02-21 2021-08-26 Samumed, Llc Solid forms of 1-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-dimethylmethanamine
MX2024004552A (es) 2021-10-12 2024-06-04 Biosplice Therapeutics Inc Pirrolo[2,1-f][1,2,4]triazinas y preparación y usos de las mismas.
WO2023064349A1 (en) 2021-10-12 2023-04-20 Biosplice Therapeutics, Inc. 1h-pyrrolo[2,3-b]pyridines as dyrk1a inhibitors
EP4543886A1 (de) 2022-06-23 2025-04-30 BioSplice Therapeutics, Inc. 4-alkoxypyrrolo[2,1-f [1,2,4)triazine und ihre herstellung und verwendung
KR20250133646A (ko) 2022-11-03 2025-09-08 바이오스플라이스 테라퓨틱스, 인크. 4-아미노피롤로[2,1-f][1,2,4]트라이아진 및 이의 제조 및 용도
WO2024211797A1 (en) 2023-04-07 2024-10-10 Biosplice Therapeutics, Inc. Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
US20250206746A1 (en) 2023-12-22 2025-06-26 Biosplice Therapeutics, Inc. 4-alkoxypyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
WO2025231425A1 (en) 2024-05-03 2025-11-06 Biosplice Therapeutics, Inc. 4-aminopyrrolo[2,l-f][l,2,4]triazines and preparation and uses thereof

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE850341C (de) 1950-04-15 1952-09-25 Gazzoni & Co A Vorrichtung zum Benetzen des aeusseren Gehoerganges mit einer schmerzstillenden Fluessigkeit
GB1204117A (en) 1966-09-08 1970-09-03 Syntex Corp Devices and methods for administering pharmaceutical preparations
US4034759A (en) 1975-08-27 1977-07-12 Xomed, Inc. Moisture-expandable prosthesis
US4159719A (en) 1977-05-09 1979-07-03 Xomed, Inc. Moisture-expandable ear wick
US4175563A (en) 1977-10-05 1979-11-27 Arenberg Irving K Biological drainage shunt
US4244377A (en) 1978-10-19 1981-01-13 Grams Guenter A Ear probe for use in closed-loop caloric irrigation
US4250878A (en) 1978-11-22 1981-02-17 Motion Control, Inc. Non-invasive chemical species delivery apparatus and method
US4320758A (en) 1979-05-07 1982-03-23 Alza Corporation Osmotically driven fluid dispenser
US4297748A (en) 1980-01-02 1981-11-03 Moloy Peter J Middle ear balloon
US4419092A (en) 1981-11-06 1983-12-06 Motion Control, Inc. Iontophoretic electrode structure
US4610686A (en) 1983-11-02 1986-09-09 Alza Corporation Controlled delivery of haloperidol by an osmotic delivery system
NO165378C (no) 1985-11-22 1991-02-06 Ellingsen O & Co Medikamentavgivende innretning for implantering i menneskekroppen.
EP0266474B1 (de) 1986-11-07 1993-03-31 DENSERT, Barbara Einrichtung zum Behandeln der Menièreschen Krankheit
SE8703694L (sv) 1987-09-25 1989-03-26 Barbara Densert Saett att lufta mellanoerat medelst en insaettbar ventilationstub, ventilationstub foer utfoerande av saettet jaemte anvaendning av en dylik ventilationstub
JP2683750B2 (ja) 1988-06-06 1997-12-03 住友電気工業株式会社 カテーテル用バルーン
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4929246A (en) 1988-10-27 1990-05-29 C. R. Bard, Inc. Method for closing and sealing an artery after removing a catheter
US4976966A (en) 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US4968297A (en) 1989-05-09 1990-11-06 Iomec, Inc. Iontophoretic electrode with solution containment system
US5035694A (en) * 1989-05-15 1991-07-30 Advanced Cardiovascular Systems, Inc. Dilatation catheter assembly with heated balloon
KR0141688B1 (ko) 1989-05-24 1998-06-15 스까다 쇼오에이 액체형 약제를 연속적으로 주입하기 위한 기구를 가진 주입기
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US5350580A (en) 1990-03-05 1994-09-27 Minnesota Mining And Manufacturing Company Device and method for extended delivery of pharmacologically active agents to the ear
US5236413B1 (en) 1990-05-07 1996-06-18 Andrew J Feiring Method and apparatus for inducing the permeation of medication into internal tissue
DE69110467T2 (de) 1990-06-15 1996-02-01 Cortrak Medical Inc Vorrichtung zur abgabe von medikamenten.
WO1992011895A1 (en) 1990-12-28 1992-07-23 Boston Scientific Corporation Balloon drug delivery system
US5304134A (en) 1992-01-17 1994-04-19 Danforth Biomedical, Inc. Lubricious yet bondable catheter channel sleeve for over-the-wire catheters
US5368037A (en) 1993-02-01 1994-11-29 Endosonics Corporation Ultrasound catheter
US5419312A (en) 1993-04-20 1995-05-30 Wildflower Communications, Inc. Multi-function endoscope apparatus
US5421818A (en) 1993-10-18 1995-06-06 Inner Ear Medical Delivery Systems, Inc. Multi-functional inner ear treatment and diagnostic system
US5797868A (en) * 1996-07-25 1998-08-25 Cordis Corporation Photodynamic therapy balloon catheter
US6045528A (en) * 1997-06-13 2000-04-04 Intraear, Inc. Inner ear fluid transfer and diagnostic system
US5876344A (en) * 1997-12-09 1999-03-02 Endosonics Corporation Modular imaging/treatment catheter assembly and method

Also Published As

Publication number Publication date
EP1098614B1 (de) 2008-01-02
AU745505B2 (en) 2002-03-21
EP1098614A4 (de) 2006-10-25
EP1098614A1 (de) 2001-05-16
WO2000004854A1 (en) 2000-02-03
CA2338341A1 (en) 2000-02-03
AU5096299A (en) 2000-02-14
DE69937886T2 (de) 2008-12-18
US6440102B1 (en) 2002-08-27
DE69937886D1 (de) 2008-02-14
CA2338341C (en) 2009-01-13

Similar Documents

Publication Publication Date Title
DE69937886D1 (de) Flüssigkeitsübertragung und diagnosesystem zur behandlung des innenohrs
ATE431166T1 (de) System zum transfer von flüssigkeit im innenohr und zur diagnose
DE50011757D1 (de) Medizinisches instrument zur behandlung von biologischem gewebe sowie verfahren zum übertragen von druckwellen
DE50312176D1 (de) Vorrichtung zum Durchspülen einer Körperhöhle
ATE232404T1 (de) Magensonde
DE502004006169D1 (de) Vorrichtung zur Behandlung von Schlaf-Apnoe
DE60232380D1 (de)
EP4292574A3 (de) Vorrichtung und verfahren zur aufnahme von ausgeschiedenem urin
DE60112554D1 (de) Intragastrale vorrichtung zur behandlung der morbiden fettsucht
ATE365024T1 (de) Vorrichtung zur erhaltung des kontaktes zwischen elektrophysiologieelementen und körpergewebe und system dafür
DE69722825D1 (de) Implantierbare Vorrichtung zur Durchflussregelung von Flüssigkeiten innerhalb des Körpers
EP2380621A3 (de) Laparoskopische Einführungsvorrichtung
YU47805B (sr) Postupak i uređaj za sterilizaciju medicinskih uređaja
WO2004056408A3 (en) Device for withdrawing body fluids
DE60023352D1 (de) Unterbrechungsfreie durchfluss pumpvorrichtung und verfahren
NZ520208A (en) Pneumoperitoneum apparatus with independent gas and heated water line separated by water permeable membrane
ATE286364T1 (de) Flüssigkeitsverbindungsvorrichtung für endoskop mit kontrollierbarer fluidleckage
ATE209063T1 (de) Blutsammelsystem
DE69703744D1 (de) Vorrichtung zur behandlung des hydrocephalus
DE69430239D1 (de) Blutbevorratungsverfahren
EP1192954A3 (de) Systeme und Verfahren zur Reinigung, Sterilisierung oder Desinfektion von medizinischen Geräten
MY119538A (en) Compressed water supply system and supply device for dental unit-chair
ATE271357T1 (de) Einrichtung zur einspeisung von behandlungsflüssigkeit in medizinische geräte
SE9500758D0 (sv) Apparat för hypertermibehandling
BR0313193A (pt) Sistema para a limpeza do intestino de um paciente, montagem de bocal; e método para a limpeza de um estoma

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1098614

Country of ref document: EP