ATE382610T1 - Cristallinsalze von 7-[4-(4-fluorophenyl)-6- isopropyl-2-[methyl(methylsulfonyl)amino pyrimidin-5-yl -(3r,5s)-3,5-dihydroxyhept-6- ensäure - Google Patents

Cristallinsalze von 7-[4-(4-fluorophenyl)-6- isopropyl-2-[methyl(methylsulfonyl)amino pyrimidin-5-yl -(3r,5s)-3,5-dihydroxyhept-6- ensäure

Info

Publication number
ATE382610T1
ATE382610T1 AT01904167T AT01904167T ATE382610T1 AT E382610 T1 ATE382610 T1 AT E382610T1 AT 01904167 T AT01904167 T AT 01904167T AT 01904167 T AT01904167 T AT 01904167T AT E382610 T1 ATE382610 T1 AT E382610T1
Authority
AT
Austria
Prior art keywords
enene
dihydroxyhept
methylsulfonyl
fluorophenyl
isopropyl
Prior art date
Application number
AT01904167T
Other languages
English (en)
Inventor
Nigel Taylor
Tetsuo Okada
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE382610T1 publication Critical patent/ATE382610T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01904167T 2000-02-15 2001-02-12 Cristallinsalze von 7-[4-(4-fluorophenyl)-6- isopropyl-2-[methyl(methylsulfonyl)amino pyrimidin-5-yl -(3r,5s)-3,5-dihydroxyhept-6- ensäure ATE382610T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0003305.0A GB0003305D0 (en) 2000-02-15 2000-02-15 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
ATE382610T1 true ATE382610T1 (de) 2008-01-15

Family

ID=9885517

Family Applications (2)

Application Number Title Priority Date Filing Date
AT07118593T ATE449079T1 (de) 2000-02-15 2001-02-12 Pharmazeutische zusammensetzungen beinhaltend kristallsalze von 7-ä4-(4-fluorophenyl)-6- isopropyl-2-
AT01904167T ATE382610T1 (de) 2000-02-15 2001-02-12 Cristallinsalze von 7-[4-(4-fluorophenyl)-6- isopropyl-2-[methyl(methylsulfonyl)amino pyrimidin-5-yl -(3r,5s)-3,5-dihydroxyhept-6- ensäure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT07118593T ATE449079T1 (de) 2000-02-15 2001-02-12 Pharmazeutische zusammensetzungen beinhaltend kristallsalze von 7-ä4-(4-fluorophenyl)-6- isopropyl-2-

Country Status (35)

Country Link
US (2) US6841554B2 (de)
EP (2) EP1873148B1 (de)
JP (1) JP4099333B2 (de)
KR (1) KR100708262B1 (de)
CN (1) CN1210266C (de)
AR (1) AR029228A1 (de)
AT (2) ATE449079T1 (de)
AU (1) AU775569B2 (de)
BG (1) BG65562B1 (de)
BR (1) BR0108378A (de)
CA (1) CA2397450C (de)
CO (1) CO5280213A1 (de)
CY (2) CY1107225T1 (de)
CZ (1) CZ302136B6 (de)
DE (2) DE60140581D1 (de)
DK (2) DK1873148T3 (de)
EE (1) EE05288B1 (de)
ES (2) ES2298214T3 (de)
GB (1) GB0003305D0 (de)
HU (1) HU228422B1 (de)
IL (2) IL150807A0 (de)
IS (1) IS2592B (de)
MX (1) MXPA02007819A (de)
MY (1) MY129018A (de)
NO (1) NO323770B1 (de)
NZ (1) NZ520032A (de)
PL (1) PL206729B1 (de)
PT (2) PT1263739E (de)
RU (1) RU2265599C2 (de)
SA (1) SA01220166B1 (de)
SI (2) SI1873148T1 (de)
SK (1) SK287144B6 (de)
UA (1) UA74567C2 (de)
WO (1) WO2001060804A1 (de)
ZA (1) ZA200205331B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
MXPA04000322A (es) 2001-07-13 2005-09-08 Astrazeneca Uk Ltd Preparacion de compuestos de aminopirimidina.
EA200401533A1 (ru) * 2002-05-21 2005-06-30 Ранбакси Лабораторис Лимитед Способ получения росувастатина
ATE409476T1 (de) * 2002-06-13 2008-10-15 Novartis Pharma Gmbh Calciumsalze von statinen aus indol
GB0218781D0 (en) * 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
KR101060215B1 (ko) 2002-12-16 2011-08-29 아스트라제네카 유케이 리미티드 피리미딘 화합물의 제조 방법
GB0312896D0 (en) * 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
WO2005021511A1 (en) * 2003-08-27 2005-03-10 Hetero Drugs Limited A novel process for amorphous rosuvastatin calcium
CA2537271A1 (en) 2003-08-28 2005-03-17 Teva Pharmaceutical Industries, Ltd. Process for preparation of rosuvastatin calcium
UY28501A1 (es) * 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) * 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
EP1678148A1 (de) * 2003-10-22 2006-07-12 Ranbaxy Laboratories Limited Verfahren zur herstellung von amorphen rosuvastatin-calcium
GB0324791D0 (en) * 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
WO2005077916A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Salts of hmg-coa reductase inhibitors and use thereof
CA2546701C (en) * 2003-11-24 2010-07-27 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
CN1894221B (zh) 2003-12-02 2012-08-08 特瓦制药工业有限公司 用于表征罗苏伐他汀的参照标准品
WO2005077917A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Amorphous salts of rosuvastatin
US7241800B2 (en) 2004-03-17 2007-07-10 Mai De Ltd. Anhydrous amorphous form of fluvastatin sodium
GB0406757D0 (en) * 2004-03-26 2004-04-28 Avecia Ltd Process and compounds
JP2007508379A (ja) 2004-07-13 2007-04-05 テバ ファーマシューティカル インダストリーズ リミティド Ｔｅｍｐｏ媒介型酸化段階を包含するロスバスタチンの調製方法
EP1797046A2 (de) * 2004-09-27 2007-06-20 Ranbaxy Laboratories Limited Neue verfahren zur herstellung von amorphem rosuvastatincalcium und neue polymorphe form von rosuvastatinnatrium
GB0428328D0 (en) 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
US7612203B2 (en) 2005-02-22 2009-11-03 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
CA2499047A1 (en) * 2005-03-01 2006-09-01 Apotex Pharmachem Inc. Process for producing atorvastatin hemicalcium
CA2612587C (en) * 2005-06-24 2013-02-19 Lek Pharmaceuticals D.D. Process for preparing amorphous rosuvastatin calcium free of impurities
WO2006136408A2 (en) * 2005-06-24 2006-12-28 Lek Pharmaceuticals D.D. Process for preparing pure amorphous rosuvastatin calcium
KR20070062996A (ko) 2005-08-16 2007-06-18 테바 파마슈티컬 인더스트리즈 리미티드 결정성 로수바스타틴 중간체
HU227696B1 (en) * 2006-04-13 2011-12-28 Egyt Gyogyszervegyeszeti Gyar Zinc salt of rosuvastatin, process for its preparation and pharmaceutical compositions containing it
EP2024341B1 (de) 2006-05-03 2015-12-02 MSN Laboratories Private Limited Neue verfahren für statine und deren pharmazeutisch unbedenkliche salze
EP1948618A1 (de) * 2006-09-18 2008-07-30 Teva Pharmaceutical Industries Ltd. Kristallines rosuvastatin-kalzium
WO2008038132A1 (en) * 2006-09-28 2008-04-03 Aurobindo Pharma Limited Crystalline diamine salts of rosuvastatin
US8404841B2 (en) 2006-10-09 2013-03-26 Msn Laboratories Limited Process for the preparation of statins and their pharmaceutically acceptable salts thereof
EP2086946A2 (de) * 2006-11-29 2009-08-12 Dr. Reddy's Laboratories Ltd. Rosuvastatin-dehydroabietylaminsalz
HU230981B1 (hu) * 2007-10-12 2019-08-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás rosuvastatin só előállítására
EP2298745B1 (de) 2008-05-27 2014-09-03 Changzhou Pharmaceutical Factory Verfahren zur herstellung von rosuvastatin-calcium und dessen zwischenprodukten
WO2010035284A2 (en) * 2008-09-26 2010-04-01 Matrix Laboratories Ltd An improved process for the preparation of rosuvastatin calcium
PL2387566T3 (pl) * 2009-01-14 2014-10-31 Krka Tovarna Zdravil D D Novo Mesto Sposób przygotowania rosuwastatyny
EP2389365A1 (de) * 2009-01-15 2011-11-30 Egis Gyógyszergyár Nyilvánosan Müködö Verfahren zur herstellung von rosuvastatinsalzen
WO2010089770A2 (en) 2009-01-19 2010-08-12 Msn Laboratories Limited Improved process for the preparation of highly pure (3r,5s)-7-[2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl]-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
HUP0900285A2 (en) 2009-05-07 2011-01-28 Egis Gyogyszergyar Nyilvanosan Mukoedoe Reszvenytarsasag Rosuvastatin salts and preparation thereof
US8987444B2 (en) 2010-01-18 2015-03-24 Msn Laboratories Private Limited Process for the preparation of amide intermediates and their use thereof
CN101935304B (zh) * 2010-06-22 2012-04-18 重庆博腾制药科技股份有限公司 瑞舒伐他汀甘氨酸叔丁酯盐及其制备方法
WO2012063115A2 (en) 2010-11-11 2012-05-18 Jubilant Life Sciences Ltd. Process for the preparation of rosuvastatin calcium via novel amine intermediate
HU230737B1 (hu) 2010-11-16 2018-01-29 EGIS Gyógyszergyár Nyrt Eljárás rosuvastatin só előállítására
HU230987B1 (hu) 2010-11-29 2019-08-28 Egis Gyógyszergyár Nyrt. Eljárás nagy tisztaságú gyógyszeripari intermedierek előállítására
HU229260B1 (en) 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
WO2012073256A1 (en) * 2010-11-29 2012-06-07 Cadila Healthcare Limited Salts of rosuvastatin
WO2012176218A1 (en) * 2011-06-24 2012-12-27 Ind-Swift Laboratories Limited Process for preparing rosuvastatin calcium through novel amine salt
EP2602249B1 (de) * 2011-12-06 2015-08-12 F.I.S. Fabbrica Italiana Sintetici S.p.A. Synthese von Rosuvastatin mit Kokristallen
EP3103878A4 (de) 2014-02-06 2017-08-16 API Corporation Rosuvastatincalcium und verfahren zur herstellung eines zwischenprodukts davon
CN106397335A (zh) * 2016-08-31 2017-02-15 湖北祥云(集团)化工股份有限公司 瑞舒伐他汀中间体的制备方法
USD841087S1 (en) 2016-11-17 2019-02-19 Ccl Label, Inc. Label sheet with a feed edge assembly
CN109651259B (zh) * 2018-12-29 2020-05-19 浙江永太科技股份有限公司 一种瑞舒伐他汀钙关键中间体的纯化方法
CN111518034A (zh) * 2019-10-21 2020-08-11 山东理工职业学院 他汀类化合物及其中间体的制备方法
CN115417824A (zh) * 2022-09-21 2022-12-02 安徽美诺华药物化学有限公司 一种瑞舒伐他汀中间体的高纯度制备方法

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4294846A (en) 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
EP0051471B2 (de) * 1980-11-03 1991-11-21 Monsanto Company Widerstandsfähige thermoplastische Nylon-Zusammensetzungen und Verfahren zu ihrer Herstellung
JPS57185275A (en) 1981-05-07 1982-11-15 Sankyo Co Ltd Tetrahydro-dum-4 and tetrahydro-isodum-4 and their derivatives
US4668699A (en) 1985-08-05 1987-05-26 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
US4940727A (en) 1986-06-23 1990-07-10 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4997848A (en) 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
US4868185A (en) 1987-12-10 1989-09-19 Warner-Lambert Company 6-[[Substituted)pyrimidinyl)ethyl]- and ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis
NZ227743A (en) 1988-01-27 1991-01-29 May & Baker Ltd Isoquinolinone derivatives and their pharmaceutical compositions
EP0326388A3 (de) 1988-01-29 1990-11-28 Johnson Matthey, Inc., Abhitzewiedergewinnung mit kombinierter CO- und NOX-Beseitigungsanlage und Methode
US5003080A (en) 1988-02-22 1991-03-26 Warner-Lambert Company Process for trans-6-(2-(substituted-pyrrol-1-yl)alkyl)pryan-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5089523A (en) 1990-05-11 1992-02-18 E. R. Squibb & Sons, Inc. Fluorinated derivatives of mevinic acids
CA2043525A1 (en) 1990-06-24 1991-12-25 Donald S. Karanewsky Phosphorus-containing hmg-coa reductase inhibitors, new intermediates and method
US5223415A (en) 1990-10-15 1993-06-29 Merck & Co., Inc. Biosynthetic production of 7-[1',2',6',7',8',8a'(R)-hexahydro-2'(S),6'(R)-dimethyl-8'(S)-hydroxy-1'(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid)
GB9027018D0 (en) * 1990-12-12 1991-01-30 Ici Plc Heterocyclic compounds
US5177080A (en) 1990-12-14 1993-01-05 Bayer Aktiengesellschaft Substituted pyridyl-dihydroxy-heptenoic acid and its salts
JP3528186B2 (ja) 1991-06-24 2004-05-17 日産化学工業株式会社 光学活性キノリンメバロン酸のジアステレオマー塩
JP2648897B2 (ja) * 1991-07-01 1997-09-03 塩野義製薬株式会社 ピリミジン誘導体
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
US5369123A (en) 1992-10-09 1994-11-29 E. R. Squibb & Sons, Inc. Nitrogen-substituted mevinic acid derivatives useful as HMG-CoA reductase inhibitors
CA2137049A1 (en) 1993-12-15 1995-06-16 John K. Thottathil Amino acid salts of and methods for preparing antihypercholesterolemic tetrazole compounds
US5385929A (en) 1994-05-04 1995-01-31 Warner-Lambert Company [(Hydroxyphenylamino) carbonyl] pyrroles
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GEP20002029B (en) 1995-07-17 2000-04-10 Warner Lambert Company Us (54) Crystalline [R-(R*,R*,]–2-(4-Fluorophenyl)-Beta,Delta-Dihydroxy-5-(1-Methyl-Ethyl)-3-Phenyl–4-{Phenylamino) Carbonyl} - 1H - Pyrrole - 1 - Heptanoic Acid Hemi Calcium Salt (Atorvastatin)
AT403375B (de) 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
SI20070A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Nove soli inhibitorjev HMG-CoA reduktaze
GB9900339D0 (en) * 1999-01-09 1999-02-24 Zeneca Ltd Chemical compounds
GB0001662D0 (en) 1999-02-06 2000-03-15 Zeneca Ltd Pharmaceutical compositions
AR022462A1 (es) 1999-02-06 2002-09-04 Astrazeneca Uk Ltd Uso de un agente que disminuye el colesterol
GB0000710D0 (en) 1999-02-06 2000-03-08 Zeneca Ltd Drug combination
GB9903472D0 (en) 1999-02-17 1999-04-07 Zeneca Ltd Chemical process
US6579984B1 (en) * 1999-07-13 2003-06-17 Lonza Ag Process for preparing 2-amino-4-(4-fluorphenyl)-6-alkylpyrimidine-5-carboxylate
GB0001621D0 (en) 2000-01-26 2000-03-15 Astrazeneca Ab Pharmaceutical compositions
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
GB0028429D0 (en) 2000-11-22 2001-01-10 Astrazeneca Ab Therapy
GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
US6814554B1 (en) * 2003-06-04 2004-11-09 Rechi Precision Co., Ltd. Vortex compressor
GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
UY28501A1 (es) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd Compuestos químicos
GB0321827D0 (en) 2003-09-18 2003-10-15 Astrazeneca Uk Ltd Chemical compounds
GB0322552D0 (en) 2003-09-26 2003-10-29 Astrazeneca Uk Ltd Therapeutic treatment
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process

Also Published As

Publication number Publication date
IS6494A (is) 2002-08-09
EE05288B1 (et) 2010-04-15
CN1418198A (zh) 2003-05-14
US7129352B2 (en) 2006-10-31
UA74567C2 (uk) 2006-01-16
RU2265599C2 (ru) 2005-12-10
PT1263739E (pt) 2008-02-19
EE200200445A (et) 2003-12-15
CO5280213A1 (es) 2003-05-30
CZ20022754A3 (cs) 2002-11-13
ES2335542T3 (es) 2010-03-29
US20030045718A1 (en) 2003-03-06
HK1051532A1 (en) 2003-08-08
SK287144B6 (sk) 2010-01-07
AU775569B2 (en) 2004-08-05
DE60132178D1 (de) 2008-02-14
EP1263739B9 (de) 2008-10-29
US6841554B2 (en) 2005-01-11
SI1873148T1 (sl) 2010-02-26
IL150807A (en) 2007-07-04
CZ302136B6 (cs) 2010-11-10
ES2298214T3 (es) 2008-05-16
EP1263739A1 (de) 2002-12-11
SK11742002A3 (sk) 2003-02-04
NZ520032A (en) 2004-03-26
PL206729B1 (pl) 2010-09-30
ZA200205331B (en) 2003-10-03
CA2397450C (en) 2009-11-17
EP1263739B1 (de) 2008-01-02
DK1263739T3 (da) 2008-03-17
BR0108378A (pt) 2003-03-11
CY1107225T1 (el) 2013-04-18
SI1263739T1 (sl) 2008-04-30
DE60132178T2 (de) 2008-12-18
PT1873148E (pt) 2010-01-20
ATE449079T1 (de) 2009-12-15
NO323770B1 (no) 2007-07-02
AU3208401A (en) 2001-08-27
BG106969A (en) 2003-04-30
CA2397450A1 (en) 2001-08-23
GB0003305D0 (en) 2000-04-05
DE60140581D1 (de) 2009-12-31
JP2003523334A (ja) 2003-08-05
PL356472A1 (en) 2004-06-28
MXPA02007819A (es) 2004-09-10
EP1873148A1 (de) 2008-01-02
HK1055958A1 (en) 2004-01-30
HUP0204051A3 (en) 2003-07-28
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