ATE382694T1 - Vektoren und methoden zum gentransfer in zellen - Google Patents
Vektoren und methoden zum gentransfer in zellenInfo
- Publication number
- ATE382694T1 ATE382694T1 AT96940927T AT96940927T ATE382694T1 AT E382694 T1 ATE382694 T1 AT E382694T1 AT 96940927 T AT96940927 T AT 96940927T AT 96940927 T AT96940927 T AT 96940927T AT E382694 T1 ATE382694 T1 AT E382694T1
- Authority
- AT
- Austria
- Prior art keywords
- coat protein
- cells
- vector
- methods
- chimeric
- Prior art date
Links
- 239000013598 vector Substances 0.000 title abstract 5
- 108090000623 proteins and genes Proteins 0.000 title 1
- 101710132601 Capsid protein Proteins 0.000 abstract 8
- 101710094648 Coat protein Proteins 0.000 abstract 8
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 abstract 8
- 101710125418 Major capsid protein Proteins 0.000 abstract 8
- 101710141454 Nucleoprotein Proteins 0.000 abstract 8
- 101710083689 Probable capsid protein Proteins 0.000 abstract 8
- 241000701161 unidentified adenovirus Species 0.000 abstract 5
- 101710145505 Fiber protein Proteins 0.000 abstract 1
- 101710094396 Hexon protein Proteins 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- 101710173835 Penton protein Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/563,368 US5965541A (en) | 1995-11-28 | 1995-11-28 | Vectors and methods for gene transfer to cells |
| US08/701,124 US5846782A (en) | 1995-11-28 | 1996-08-21 | Targeting adenovirus with use of constrained peptide motifs |
| US08/700,846 US5962311A (en) | 1994-09-08 | 1996-08-21 | Short-shafted adenoviral fiber and its use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE382694T1 true ATE382694T1 (de) | 2008-01-15 |
Family
ID=27415918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96940927T ATE382694T1 (de) | 1995-11-28 | 1996-11-27 | Vektoren und methoden zum gentransfer in zellen |
Country Status (17)
| Country | Link |
|---|---|
| EP (3) | EP1518933A1 (de) |
| JP (1) | JP3420586B2 (de) |
| AT (1) | ATE382694T1 (de) |
| AU (1) | AU724189B2 (de) |
| BG (1) | BG102554A (de) |
| BR (1) | BR9612685A (de) |
| CA (1) | CA2236912C (de) |
| CZ (1) | CZ162398A3 (de) |
| EA (1) | EA199800475A1 (de) |
| EE (1) | EE9800160A (de) |
| IL (1) | IL124654A0 (de) |
| IS (1) | IS4754A (de) |
| NO (1) | NO982417L (de) |
| NZ (1) | NZ323834A (de) |
| PL (1) | PL327038A1 (de) |
| SK (1) | SK72298A3 (de) |
| WO (1) | WO1997020051A2 (de) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
| US5846782A (en) * | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| EP1025211B1 (de) | 1997-10-31 | 2004-12-15 | The Board of Regents of The University of Oklahoma | Hyaluronan synthase gen und seine verwendung |
| JP2002508967A (ja) * | 1998-01-16 | 2002-03-26 | ジェンザイム・コーポレイション | 修飾カプシド蛋白を有するアデノウイルスベクター |
| US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| KR20020013464A (ko) | 1998-08-27 | 2002-02-20 | 추후제출 | 이종 유전자의 전달을 위한 표적화된 아데노바이러스 벡터 |
| IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
| EP1020529B1 (de) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Genverabreichende Vektoren mit Gewebetropismus für glatte Muskelzellen und/oder Endothelzellen |
| ATE403006T1 (de) * | 1999-03-04 | 2008-08-15 | Crucell Holland Bv | Verwendung eines adenovirusvektors zur transduktion von synovialen zellen |
| AU763733B2 (en) * | 1999-07-06 | 2003-07-31 | Got-A-Gene Ab | Recombinant adenovirus |
| US6955808B2 (en) * | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
| AU2001252766A1 (en) * | 2000-04-26 | 2001-11-07 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
| CA2410665C (en) * | 2000-05-31 | 2017-11-07 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| GB0017720D0 (en) * | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| US6573092B1 (en) | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
| AU2004238979B2 (en) | 2003-05-14 | 2008-12-18 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Broadening adenovirus tropism |
| EP2168603A1 (de) | 2003-11-14 | 2010-03-31 | GenVec, Inc. | Therapeutisches Programm zur Behandlung von Krebs |
| JP2007228802A (ja) * | 2004-03-31 | 2007-09-13 | Dnavec Research Inc | 標的細胞への遺伝子の導入方法 |
| JP2007532656A (ja) | 2004-04-12 | 2007-11-15 | アメリカ合衆国 | アデノウイルスベクターを用いて免疫応答を誘導するための方法 |
| EP1773303A2 (de) | 2004-05-25 | 2007-04-18 | Chimeracore, Inc. | Selbstmontierendes nanopartikel-wirkstofffreisetzungssystem |
| AU2006284756B2 (en) | 2005-08-31 | 2012-06-07 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| CA2629163C (en) | 2005-11-10 | 2017-03-21 | Genvec, Inc. | Adenoviral vector-based foot-and-mouth disease vaccine |
| ATE460922T1 (de) | 2006-04-07 | 2010-04-15 | Chimeros Inc | Zusammensetzungen und verfahren zur behandlung von b-zellen-malignomen |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
| PH12012500908A1 (en) | 2009-11-09 | 2017-08-23 | Genvec Inc | Methods of propagating monkey adenoviral vectors |
| WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
| WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
| WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
| WO2012088041A1 (en) | 2010-12-20 | 2012-06-28 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
| JP2014527072A (ja) | 2011-09-09 | 2014-10-09 | バイオメド リアルティー， エル．ピー． | ウイルスタンパク質の集合を制御するための方法および組成物 |
| US10004811B2 (en) * | 2012-04-13 | 2018-06-26 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
| WO2013181128A1 (en) | 2012-05-29 | 2013-12-05 | Genvec, Inc. | Modified serotype 28 adenoviral vectors |
| CA2881582A1 (en) | 2012-08-03 | 2014-02-06 | Cedars-Sinai Medical Center | Isolating traffic-enhancing mutants of drug delivery protein |
| SG11201507393TA (en) | 2013-03-14 | 2015-10-29 | Salk Inst For Biological Studi | Oncolytic adenovirus compositions |
| PL3198009T3 (pl) | 2014-09-24 | 2022-01-24 | Salk Institute For Biological Studies | Onkolityczne wirusy nowotworowe i sposoby zastosowania |
| TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| JP7054527B2 (ja) | 2016-02-23 | 2022-04-14 | ソーク インスティテュート フォー バイオロジカル スタディーズ | アデノウイルスの複製動態を測定するための高スループットアッセイ |
| CA3038968A1 (en) | 2016-09-30 | 2018-04-05 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into t cells |
| WO2018111767A1 (en) | 2016-12-12 | 2018-06-21 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
| JP7430395B2 (ja) | 2018-04-09 | 2024-02-13 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 複製特質が増強された腫瘍溶解性アデノウイルス組成物 |
| EP3812465A1 (de) * | 2019-10-21 | 2021-04-28 | Universität Ulm | Adenovirus, ein modifiziertes adenovirus-hexon-protein umfassend |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| WO2024233783A1 (en) | 2023-05-09 | 2024-11-14 | Cornell University | Expression cassette coding for vascular endothelial growth factor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1996
- 1996-11-27 JP JP52072097A patent/JP3420586B2/ja not_active Expired - Fee Related
- 1996-11-27 AU AU10868/97A patent/AU724189B2/en not_active Ceased
- 1996-11-27 CZ CZ981623A patent/CZ162398A3/cs unknown
- 1996-11-27 CA CA002236912A patent/CA2236912C/en not_active Expired - Fee Related
- 1996-11-27 PL PL96327038A patent/PL327038A1/xx unknown
- 1996-11-27 IL IL12465496A patent/IL124654A0/xx unknown
- 1996-11-27 EE EE9800160A patent/EE9800160A/xx unknown
- 1996-11-27 SK SK722-98A patent/SK72298A3/sk unknown
- 1996-11-27 EP EP04028530A patent/EP1518933A1/de not_active Withdrawn
- 1996-11-27 BR BR9612685A patent/BR9612685A/pt not_active Application Discontinuation
- 1996-11-27 NZ NZ323834A patent/NZ323834A/xx unknown
- 1996-11-27 EA EA199800475A patent/EA199800475A1/ru unknown
- 1996-11-27 AT AT96940927T patent/ATE382694T1/de not_active IP Right Cessation
- 1996-11-27 EP EP96940927A patent/EP0863987B1/de not_active Expired - Lifetime
- 1996-11-27 WO PCT/US1996/019150 patent/WO1997020051A2/en not_active Ceased
- 1996-11-27 EP EP05021223A patent/EP1616961A1/de not_active Withdrawn
-
1998
- 1998-05-25 IS IS4754A patent/IS4754A/is unknown
- 1998-05-27 NO NO982417A patent/NO982417L/no not_active Application Discontinuation
- 1998-06-18 BG BG102554A patent/BG102554A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1616961A1 (de) | 2006-01-18 |
| NO982417L (no) | 1998-07-06 |
| JP3420586B2 (ja) | 2003-06-23 |
| CA2236912A1 (en) | 1997-06-05 |
| WO1997020051A2 (en) | 1997-06-05 |
| IL124654A0 (en) | 1998-12-06 |
| WO1997020051A3 (en) | 1997-08-28 |
| AU724189B2 (en) | 2000-09-14 |
| JPH11501219A (ja) | 1999-02-02 |
| EP0863987A2 (de) | 1998-09-16 |
| CZ162398A3 (cs) | 1998-10-14 |
| EA199800475A1 (ru) | 1998-12-24 |
| IS4754A (is) | 1998-05-25 |
| NO982417D0 (no) | 1998-05-27 |
| EP0863987B1 (de) | 2008-01-02 |
| BG102554A (en) | 1999-04-30 |
| CA2236912C (en) | 2006-04-25 |
| SK72298A3 (en) | 1998-12-02 |
| BR9612685A (pt) | 1999-07-20 |
| AU1086897A (en) | 1997-06-19 |
| EP1518933A1 (de) | 2005-03-30 |
| PL327038A1 (en) | 1998-11-09 |
| MX9804203A (es) | 1998-10-31 |
| EE9800160A (et) | 1998-12-15 |
| NZ323834A (en) | 2000-01-28 |
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