IS4754A - Genaferjur og aðferðir fyrir genaflutning inn í frumur - Google Patents
Genaferjur og aðferðir fyrir genaflutning inn í frumurInfo
- Publication number
- IS4754A IS4754A IS4754A IS4754A IS4754A IS 4754 A IS4754 A IS 4754A IS 4754 A IS4754 A IS 4754A IS 4754 A IS4754 A IS 4754A IS 4754 A IS4754 A IS 4754A
- Authority
- IS
- Iceland
- Prior art keywords
- coat protein
- cells
- vector
- methods
- chimeric
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title 2
- 101710132601 Capsid protein Proteins 0.000 abstract 8
- 101710094648 Coat protein Proteins 0.000 abstract 8
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 abstract 8
- 101710125418 Major capsid protein Proteins 0.000 abstract 8
- 101710141454 Nucleoprotein Proteins 0.000 abstract 8
- 101710083689 Probable capsid protein Proteins 0.000 abstract 8
- 241000701161 unidentified adenovirus Species 0.000 abstract 5
- 101710145505 Fiber protein Proteins 0.000 abstract 1
- 101710094396 Hexon protein Proteins 0.000 abstract 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- 101710173835 Penton protein Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000000835 fiber Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/563,368 US5965541A (en) | 1995-11-28 | 1995-11-28 | Vectors and methods for gene transfer to cells |
| US08/701,124 US5846782A (en) | 1995-11-28 | 1996-08-21 | Targeting adenovirus with use of constrained peptide motifs |
| US08/700,846 US5962311A (en) | 1994-09-08 | 1996-08-21 | Short-shafted adenoviral fiber and its use |
| PCT/US1996/019150 WO1997020051A2 (en) | 1995-11-28 | 1996-11-27 | Vectors and methods for gene transfer to cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS4754A true IS4754A (is) | 1998-05-25 |
Family
ID=27415918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS4754A IS4754A (is) | 1995-11-28 | 1998-05-25 | Genaferjur og aðferðir fyrir genaflutning inn í frumur |
Country Status (17)
| Country | Link |
|---|---|
| EP (3) | EP0863987B1 (is) |
| JP (1) | JP3420586B2 (is) |
| AT (1) | ATE382694T1 (is) |
| AU (1) | AU724189B2 (is) |
| BG (1) | BG102554A (is) |
| BR (1) | BR9612685A (is) |
| CA (1) | CA2236912C (is) |
| CZ (1) | CZ162398A3 (is) |
| EA (1) | EA199800475A1 (is) |
| EE (1) | EE9800160A (is) |
| IL (1) | IL124654A0 (is) |
| IS (1) | IS4754A (is) |
| NO (1) | NO982417L (is) |
| NZ (1) | NZ323834A (is) |
| PL (1) | PL327038A1 (is) |
| SK (1) | SK72298A3 (is) |
| WO (1) | WO1997020051A2 (is) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846782A (en) | 1995-11-28 | 1998-12-08 | Genvec, Inc. | Targeting adenovirus with use of constrained peptide motifs |
| US6465253B1 (en) | 1994-09-08 | 2002-10-15 | Genvec, Inc. | Vectors and methods for gene transfer to cells |
| US5962311A (en) * | 1994-09-08 | 1999-10-05 | Genvec, Inc. | Short-shafted adenoviral fiber and its use |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
| FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
| DK1025211T3 (da) | 1997-10-31 | 2005-04-04 | Univ Oklahoma | Hyaluronansyntasegen og anvendelser deraf |
| WO1999036545A2 (en) * | 1998-01-16 | 1999-07-22 | Genzyme Corporation | Adenoviral vectors with modified capsid proteins |
| US20030017138A1 (en) * | 1998-07-08 | 2003-01-23 | Menzo Havenga | Chimeric adenoviruses |
| JP2002523105A (ja) | 1998-08-27 | 2002-07-30 | アバンテイス・フアルマ・エス・アー | 異種遺伝子の運搬用の標的化アデノウイルスベクター |
| IL133032A (en) * | 1998-11-20 | 2007-06-03 | Introgene Bv | Adenoviral gene delivery vectors provided with a tissue tropism for smooth muscle cells and /or endothelial cells |
| EP1020529B1 (en) * | 1998-11-20 | 2005-06-01 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| DE60039683D1 (de) * | 1999-03-04 | 2008-09-11 | Crucell Holland Bv | Verwendung eines adenovirusvektors zur transduktion von synovialen zellen |
| CN1359391A (zh) * | 1999-07-06 | 2002-07-17 | 哥德－A－基因股份公司 | 重组腺病毒 |
| US6955808B2 (en) * | 1999-09-24 | 2005-10-18 | Uab Research Foundation | Capsid-modified recombinant adenovirus and methods of use |
| CA2407518A1 (en) * | 2000-04-26 | 2001-11-01 | Crucell Holland B.V. | Adenovirus vectors with knobless fibers, and their uses |
| AU2001263689B2 (en) * | 2000-05-31 | 2007-03-22 | University Of Saskatchewan | Modified bovine adenovirus having altered tropism |
| US6579522B1 (en) * | 2000-06-27 | 2003-06-17 | Genvec, Inc. | Replication deficient adenoviral TNF vector |
| GB0017720D0 (en) | 2000-07-19 | 2000-09-06 | Got A Gene Ab | Modified virus |
| US6573092B1 (en) | 2000-10-10 | 2003-06-03 | Genvec, Inc. | Method of preparing a eukaryotic viral vector |
| US20030086903A1 (en) | 2001-11-02 | 2003-05-08 | Genvec, Inc. | Therapeutic regimen for treating cancer |
| US20040166091A1 (en) | 2003-02-24 | 2004-08-26 | Genvec, Inc. | Materials and methods for treating disorders of the ear |
| CA2524499A1 (en) | 2003-05-14 | 2004-11-25 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Broadening adenovirus tropism |
| ES2340038T3 (es) | 2003-11-14 | 2010-05-28 | Genvec, Inc. | Composicion farmaceutica para tratar cancer de pancreas localmente avanzado (cpla) no extirpable. |
| JP2007228802A (ja) * | 2004-03-31 | 2007-09-13 | Dnavec Research Inc | 標的細胞への遺伝子の導入方法 |
| AU2005243730B2 (en) | 2004-04-12 | 2010-05-27 | Genvec, Inc. | Method of using adenoviral vectors to induce an immune response |
| CA2567741A1 (en) | 2004-05-25 | 2006-03-30 | Chimeracore, Inc. | Self-assembling nanoparticle drug delivery system |
| WO2007027860A2 (en) | 2005-08-31 | 2007-03-08 | Genvec, Inc. | Adenoviral vector-based malaria vaccines |
| EP1951297A2 (en) | 2005-11-10 | 2008-08-06 | GenVec, Inc. | Adenoviral vector-based foot-and-mouth disease vaccine |
| EP2018156B1 (en) | 2006-04-07 | 2010-03-17 | Chimeros, Inc. | Compositions and methods for treating b- cell malignancies |
| WO2010120874A2 (en) | 2009-04-14 | 2010-10-21 | Chimeros, Inc. | Chimeric therapeutics, compositions, and methods for using same |
| US20120219583A1 (en) | 2009-10-16 | 2012-08-30 | Los Alamos National Security, Llc | Nucleic acid sequences encoding expandable hiv mosaic proteins |
| WO2011057254A2 (en) | 2009-11-09 | 2011-05-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Simian adenoviral vector-based vaccines |
| EA201270607A1 (ru) | 2009-11-09 | 2012-09-28 | Генвек, Инк. | Аденовирус обезьян и способы его использования |
| WO2012021730A2 (en) | 2010-08-11 | 2012-02-16 | Genvec, Inc. | Respiratory syncytial virus (rsv) vaccine |
| WO2012083297A2 (en) | 2010-12-17 | 2012-06-21 | Genvec, Inc. | Adenoviral vectors with modified hexon regions |
| WO2012088041A1 (en) | 2010-12-20 | 2012-06-28 | Genvec, Inc. | Adenoviral vector-based dengue fever vaccine |
| JP2014527072A (ja) | 2011-09-09 | 2014-10-09 | バイオメド リアルティー， エル．ピー． | ウイルスタンパク質の集合を制御するための方法および組成物 |
| US10004811B2 (en) * | 2012-04-13 | 2018-06-26 | Cornell University | Development of a highly efficient second generation nicotine-conjugate vaccine to treat nicotine addiction |
| EP2855669B1 (en) | 2012-05-29 | 2018-10-10 | GenVec, Inc. | Modified serotype 28 adenoviral vectors |
| PL2880160T3 (pl) | 2012-08-03 | 2019-03-29 | Cedars-Sinai Medical Center | Izolowanie wzmacniających transport mutantów białka dostarczającego lek |
| KR102089121B1 (ko) | 2013-03-14 | 2020-03-13 | 더 솔크 인스티튜트 포 바이올로지칼 스터디즈 | 종양살상형 아데노바이러스 조성물 |
| EP3198009B1 (en) | 2014-09-24 | 2021-09-08 | Salk Institute for Biological Studies | Oncolytic tumor viruses and methods of use |
| TWI710635B (zh) | 2014-10-09 | 2020-11-21 | 美商珍維克公司 | 編碼人類無調同源物-1(hath1)之腺病毒載體 |
| EP3390428B1 (en) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| JP7015551B2 (ja) | 2016-02-23 | 2022-02-15 | ソーク インスティテュート フォー バイオロジカル スタディーズ | ウイルス動態への影響を最小限にするための治療用アデノウイルスにおける外因性遺伝子発現 |
| US11155832B2 (en) | 2016-09-30 | 2021-10-26 | Genvec, Inc. | Adenovectors for delivery of therapeutic genetic material into T cells |
| JP7794421B2 (ja) | 2016-12-12 | 2026-01-06 | ソーク インスティテュート フォー バイオロジカル スタディーズ | 腫瘍を標的にする合成アデノウイルスおよびその使用 |
| BR112020019942A2 (pt) | 2018-04-09 | 2021-01-26 | Salk Institute For Biological Studies | composições de adenovírus oncolítico com propriedades de replicação aprimoradas |
| EP3812465A1 (en) * | 2019-10-21 | 2021-04-28 | Universität Ulm | Adenovirus comprising a modified adenovirus hexon protein |
| JP7769388B2 (ja) | 2019-12-12 | 2025-11-13 | ティン セラピューティクス，インコーポレイテッド | 聴覚損失の予防及び治療のための組成物及び方法 |
| WO2024233783A1 (en) | 2023-05-09 | 2024-11-14 | Cornell University | Expression cassette coding for vascular endothelial growth factor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223084D0 (en) * | 1992-11-04 | 1992-12-16 | Imp Cancer Res Tech | Compounds to target cells |
| US5543328A (en) * | 1993-08-13 | 1996-08-06 | Genetic Therapy, Inc. | Adenoviruses having modified fiber proteins |
| US5559099A (en) * | 1994-09-08 | 1996-09-24 | Genvec, Inc. | Penton base protein and methods of using same |
| US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
-
1996
- 1996-11-27 PL PL96327038A patent/PL327038A1/xx unknown
- 1996-11-27 EP EP96940927A patent/EP0863987B1/en not_active Expired - Lifetime
- 1996-11-27 IL IL12465496A patent/IL124654A0/xx unknown
- 1996-11-27 BR BR9612685A patent/BR9612685A/pt not_active Application Discontinuation
- 1996-11-27 JP JP52072097A patent/JP3420586B2/ja not_active Expired - Fee Related
- 1996-11-27 EA EA199800475A patent/EA199800475A1/ru unknown
- 1996-11-27 EP EP05021223A patent/EP1616961A1/en not_active Withdrawn
- 1996-11-27 CZ CZ981623A patent/CZ162398A3/cs unknown
- 1996-11-27 EE EE9800160A patent/EE9800160A/xx unknown
- 1996-11-27 AU AU10868/97A patent/AU724189B2/en not_active Ceased
- 1996-11-27 EP EP04028530A patent/EP1518933A1/en not_active Withdrawn
- 1996-11-27 CA CA002236912A patent/CA2236912C/en not_active Expired - Fee Related
- 1996-11-27 AT AT96940927T patent/ATE382694T1/de not_active IP Right Cessation
- 1996-11-27 NZ NZ323834A patent/NZ323834A/xx unknown
- 1996-11-27 SK SK722-98A patent/SK72298A3/sk unknown
- 1996-11-27 WO PCT/US1996/019150 patent/WO1997020051A2/en not_active Ceased
-
1998
- 1998-05-25 IS IS4754A patent/IS4754A/is unknown
- 1998-05-27 NO NO982417A patent/NO982417L/no not_active Application Discontinuation
- 1998-06-18 BG BG102554A patent/BG102554A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2236912C (en) | 2006-04-25 |
| SK72298A3 (en) | 1998-12-02 |
| EP0863987B1 (en) | 2008-01-02 |
| CZ162398A3 (cs) | 1998-10-14 |
| MX9804203A (es) | 1998-10-31 |
| EA199800475A1 (ru) | 1998-12-24 |
| JPH11501219A (ja) | 1999-02-02 |
| EP1518933A1 (en) | 2005-03-30 |
| NO982417L (no) | 1998-07-06 |
| EE9800160A (et) | 1998-12-15 |
| NZ323834A (en) | 2000-01-28 |
| WO1997020051A3 (en) | 1997-08-28 |
| CA2236912A1 (en) | 1997-06-05 |
| PL327038A1 (en) | 1998-11-09 |
| NO982417D0 (no) | 1998-05-27 |
| WO1997020051A2 (en) | 1997-06-05 |
| BG102554A (en) | 1999-04-30 |
| IL124654A0 (en) | 1998-12-06 |
| AU1086897A (en) | 1997-06-19 |
| AU724189B2 (en) | 2000-09-14 |
| EP0863987A2 (en) | 1998-09-16 |
| JP3420586B2 (ja) | 2003-06-23 |
| EP1616961A1 (en) | 2006-01-18 |
| ATE382694T1 (de) | 2008-01-15 |
| BR9612685A (pt) | 1999-07-20 |
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