ATE382858T1 - Mehrfach-reservoir-drucksteuersystem - Google Patents

Mehrfach-reservoir-drucksteuersystem

Info

Publication number
ATE382858T1
ATE382858T1 AT01922248T AT01922248T ATE382858T1 AT E382858 T1 ATE382858 T1 AT E382858T1 AT 01922248 T AT01922248 T AT 01922248T AT 01922248 T AT01922248 T AT 01922248T AT E382858 T1 ATE382858 T1 AT E382858T1
Authority
AT
Austria
Prior art keywords
flow
channels
microfluidic
pressures
channel segments
Prior art date
Application number
AT01922248T
Other languages
English (en)
Inventor
Ring-Ling Chien
J Parce
Andrea Chow
Anne Kopf-Sill
Original Assignee
Caliper Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26880102&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE382858(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Caliper Life Sciences Inc filed Critical Caliper Life Sciences Inc
Application granted granted Critical
Publication of ATE382858T1 publication Critical patent/ATE382858T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/06—Control of flow characterised by the use of electric means
    • G05D7/0617—Control of flow characterised by the use of electric means specially adapted for fluid materials
    • G05D7/0629—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means
    • G05D7/0694—Control of flow characterised by the use of electric means specially adapted for fluid materials characterised by the type of regulator means by action on throttling means or flow sources of very small size, e.g. microfluidics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/025—Align devices or objects to ensure defined positions relative to each other
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/146—Employing pressure sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/082—Active control of flow resistance, e.g. flow controllers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/02—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material
    • G01N11/04—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture
    • G01N11/08—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by measuring flow of the material through a restricted passage, e.g. tube, aperture by measuring pressure required to produce a known flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1044—Using pneumatic means
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/2076—Utilizing diverse fluids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/206—Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]
    • Y10T137/218—Means to regulate or vary operation of device
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T137/00—Fluid handling
    • Y10T137/8593—Systems
    • Y10T137/85978—With pump
    • Y10T137/86131—Plural

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Automation & Control Theory (AREA)
  • Electrochemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Supply Devices, Intensifiers, Converters, And Telemotors (AREA)
  • Valves And Accessory Devices For Braking Systems (AREA)
  • Control Of Fluid Pressure (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Flow Control (AREA)
AT01922248T 2000-02-23 2001-02-23 Mehrfach-reservoir-drucksteuersystem ATE382858T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18439000P 2000-02-23 2000-02-23
US21679300P 2000-07-07 2000-07-07

Publications (1)

Publication Number Publication Date
ATE382858T1 true ATE382858T1 (de) 2008-01-15

Family

ID=26880102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01922248T ATE382858T1 (de) 2000-02-23 2001-02-23 Mehrfach-reservoir-drucksteuersystem

Country Status (11)

Country Link
US (3) US6915679B2 (de)
EP (1) EP1272834B1 (de)
JP (1) JP2003524183A (de)
CN (1) CN1261755C (de)
AT (1) ATE382858T1 (de)
AU (2) AU2001249071B2 (de)
CA (1) CA2399199A1 (de)
DE (1) DE60132185T2 (de)
IL (1) IL151122A0 (de)
MX (1) MXPA02008290A (de)
WO (1) WO2001063270A1 (de)

Families Citing this family (269)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048734A (en) 1995-09-15 2000-04-11 The Regents Of The University Of Michigan Thermal microvalves in a fluid flow method
ATE382858T1 (de) * 2000-02-23 2008-01-15 Caliper Life Sciences Inc Mehrfach-reservoir-drucksteuersystem
US6681616B2 (en) 2000-02-23 2004-01-27 Caliper Technologies Corp. Microfluidic viscometer
JP2004513342A (ja) 2000-10-31 2004-04-30 カリパー・テクノロジーズ・コープ． 現場で材料を濃縮するミクロ流体方法、装置及びシステム
WO2002060754A1 (en) 2001-01-29 2002-08-08 Caliper Technologies Corp. Non-mechanical valves for fluidic systems
US6692700B2 (en) 2001-02-14 2004-02-17 Handylab, Inc. Heat-reduction methods and systems related to microfluidic devices
US7037417B2 (en) * 2001-03-19 2006-05-02 Ecole Polytechnique Federale De Lausanne Mechanical control of fluids in micro-analytical devices
US6852287B2 (en) 2001-09-12 2005-02-08 Handylab, Inc. Microfluidic devices having a reduced number of input and output connections
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
US7323140B2 (en) 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
US8895311B1 (en) 2001-03-28 2014-11-25 Handylab, Inc. Methods and systems for control of general purpose microfluidic devices
US7829025B2 (en) 2001-03-28 2010-11-09 Venture Lending & Leasing Iv, Inc. Systems and methods for thermal actuation of microfluidic devices
GB0116384D0 (en) * 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
US7060171B1 (en) 2001-07-31 2006-06-13 Caliper Life Sciences, Inc. Methods and systems for reducing background signal in assays
US7014744B2 (en) * 2001-08-24 2006-03-21 Applera Corporation Method of purification and concentration using AC fields with a transfer tip
US6662818B2 (en) 2002-02-01 2003-12-16 Perseptive Biosystems, Inc. Programmable tracking pressure regulator for control of higher pressures in microfluidic circuits
DE10204414A1 (de) * 2002-02-04 2003-09-04 Siemens Ag Mikrofluidik-System
EP1485191B1 (de) 2002-03-05 2012-08-01 Caliper Life Sciences, Inc. Misch-modus-Mikrofluidsystem und Verfahren
US7303727B1 (en) 2002-03-06 2007-12-04 Caliper Life Sciences, Inc Microfluidic sample delivery devices, systems, and methods
US8241883B2 (en) 2002-04-24 2012-08-14 Caliper Life Sciences, Inc. High throughput mobility shift
US7235164B2 (en) 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7115776B2 (en) 2002-07-18 2006-10-03 Basf Aktiengesellschaft Heterogeneously catalyzed gas-phase partial oxidation of at least one organic compound
US7452507B2 (en) * 2002-08-02 2008-11-18 Sandia Corporation Portable apparatus for separating sample and detecting target analytes
US20040053315A1 (en) * 2002-08-12 2004-03-18 Caliper Technologies Corp. Methods and systems for monitoring molecular interactions
WO2004101152A1 (en) 2003-05-09 2004-11-25 Caliper Life Sciences, Inc. Automated sample analysis
GB0315094D0 (en) * 2003-06-27 2003-07-30 Imp College Innovations Ltd Powder injection system and method
WO2005011867A2 (en) 2003-07-31 2005-02-10 Handylab, Inc. Processing particle-containing samples
EP1668355A4 (de) * 2003-08-28 2011-11-09 Celula Inc Verfahren und vorrichtung zur sortierung von zellen unter verwendung eines optischen schalters in einem mikrofluidischen kanalnetzwerk
GB0320337D0 (en) * 2003-08-29 2003-10-01 Syrris Ltd A microfluidic system
JP4286094B2 (ja) * 2003-09-24 2009-06-24 オリンパス株式会社 生体関連物質の反応装置
SG10201405756WA (en) * 2004-01-25 2014-11-27 Fluidigm Corp Crystal forming devices and systems and methods for making and using the same
US20050223783A1 (en) * 2004-04-06 2005-10-13 Kavlico Corporation Microfluidic system
US8852862B2 (en) 2004-05-03 2014-10-07 Handylab, Inc. Method for processing polynucleotide-containing samples
ES2572382T3 (es) 2004-05-03 2016-05-31 Handylab Inc Un dispositivo microfluídico para el procesamiento de muestras que contienen polinucleótidos
EP1783202B1 (de) * 2004-08-25 2013-10-02 Panasonic Corporation Sonde zum messen des elektrischen potentials einer zelle
US20070243627A1 (en) * 2004-09-30 2007-10-18 Shuichi Takayama Computerized control method and system for microfluidics and computer program product for use therein
US7727477B2 (en) * 2004-12-10 2010-06-01 Bio-Rad Laboratories, Inc. Apparatus for priming microfluidics devices with feedback control
US7429317B2 (en) * 2004-12-20 2008-09-30 Eksigent Technologies Llc Electrokinetic device employing a non-newtonian liquid
DE102005008224B3 (de) * 2005-02-23 2006-06-14 Directif Gmbh Vorrichtung und Verfahren zur automatischen Betätigung einer mikrofluidischen Einrichtung
US20060193730A1 (en) * 2005-02-25 2006-08-31 Jacob Rosenstein Method and apparatus for controlling microfluidic flow
JP4543986B2 (ja) * 2005-03-24 2010-09-15 コニカミノルタエムジー株式会社 マイクロ総合分析システム
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
KR101637140B1 (ko) 2005-05-09 2016-07-06 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US9388374B2 (en) 2005-07-07 2016-07-12 Emd Millipore Corporation Microfluidic cell culture systems
US8257964B2 (en) 2006-01-04 2012-09-04 Cell ASIC Microwell cell-culture device and fabrication method
US9354156B2 (en) 2007-02-08 2016-05-31 Emd Millipore Corporation Microfluidic particle analysis method, device and system
EP3029135B1 (de) 2005-07-07 2021-03-17 The Regents of the University of California Vorrichtung für zellkultur-array
US9637715B2 (en) 2005-07-07 2017-05-02 Emd Millipore Corporation Cell culture and invasion assay method and system
US20100064780A1 (en) * 2005-07-27 2010-03-18 Howard A Stone Pressure Determination In Microfludic Systems
US20090148348A1 (en) * 2005-08-11 2009-06-11 Eksigent Technologies, Llc Plastic surfaces and apparatuses for reduced adsorption of solutes and methods of preparing the same
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
US8152477B2 (en) 2005-11-23 2012-04-10 Eksigent Technologies, Llc Electrokinetic pump designs and drug delivery systems
FR2897282B1 (fr) * 2006-02-16 2008-05-30 Commissariat Energie Atomique Procede de controle de l'avancee d'un liquide dans un compos ant microfluidique
US11806718B2 (en) 2006-03-24 2023-11-07 Handylab, Inc. Fluorescence detector for microfluidic diagnostic system
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US10900066B2 (en) 2006-03-24 2021-01-26 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
DK3088083T3 (en) 2006-03-24 2018-11-26 Handylab Inc Method of carrying out PCR down a multi-track cartridge
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US8137626B2 (en) 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
US7744762B2 (en) * 2006-08-24 2010-06-29 Virginia Tech Intellectual Properties, Inc. Microfluidic devices and methods facilitating high-throughput, on-chip detection and separation techniques
US8187541B2 (en) * 2006-09-18 2012-05-29 California Institute Of Technology Apparatus for detecting target molecules and related methods
FR2907226B1 (fr) * 2006-10-13 2008-12-12 Rhodia Recherches & Tech Dispositif d'analyse fluidique,dispositif de determination de caracteristiques d'un fluide comprenant ce dispositif d'analyse,procedes de mise en oeuvre et procede de criblage correspondants
WO2008060604A2 (en) 2006-11-14 2008-05-22 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US8709787B2 (en) 2006-11-14 2014-04-29 Handylab, Inc. Microfluidic cartridge and method of using same
US20080127717A1 (en) * 2006-11-30 2008-06-05 Chevron Oronite S.A. Alternative pressure viscometer device
US7752895B2 (en) * 2006-11-30 2010-07-13 Chevron Oronite S.A. Method for using an alternate pressure viscometer
EP1850129A1 (de) * 2006-12-08 2007-10-31 Agilent Technologies, Inc. Fluid-Trennsystem mit mehreren Fließkanälen
US8691592B2 (en) * 2006-12-14 2014-04-08 The Trustees Of The University Of Pennsylvania Mechanically actuated diagnostic device
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
WO2008119184A1 (en) 2007-04-02 2008-10-09 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
US8691164B2 (en) * 2007-04-20 2014-04-08 Celula, Inc. Cell sorting system and methods
US9410975B2 (en) * 2007-05-15 2016-08-09 Ael Mining Services Limited Pressure manifold to equalize pressure in integration PCR-CE microfluidic devices
CN101821322B (zh) 2007-06-22 2012-12-05 Fio公司 制备量子点掺杂的聚合物微珠的系统和方法
JP5507454B2 (ja) * 2007-07-09 2014-05-28 フィオ コーポレイション 試験サンプル中の標的分子の蛍光検出の向上のためのシステムおよび方法
US8105783B2 (en) 2007-07-13 2012-01-31 Handylab, Inc. Microfluidic cartridge
US20090136385A1 (en) 2007-07-13 2009-05-28 Handylab, Inc. Reagent Tube
US9618139B2 (en) 2007-07-13 2017-04-11 Handylab, Inc. Integrated heater and magnetic separator
USD621060S1 (en) 2008-07-14 2010-08-03 Handylab, Inc. Microfluidic cartridge
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8182763B2 (en) 2007-07-13 2012-05-22 Handylab, Inc. Rack for sample tubes and reagent holders
AU2008276211B2 (en) 2007-07-13 2015-01-22 Handylab, Inc. Polynucleotide capture materials, and methods of using same
US8016260B2 (en) 2007-07-19 2011-09-13 Formulatrix, Inc. Metering assembly and method of dispensing fluid
EP2186031A4 (de) * 2007-07-23 2014-03-26 Fio Corp Verfahren und system zur kollatierung, speicherung, analyse und freigabe für gesammelte und analysierte daten in zusammenhang mit testsubjekten für biologische tests und umwelttests
CN101842159B (zh) * 2007-08-09 2014-09-24 赛路拉公司 关联的多参数单细胞测定及残余生物材料回收的方法和装置
US7784330B2 (en) * 2007-10-05 2010-08-31 Schlumberger Technology Corporation Viscosity measurement
WO2009046540A1 (en) * 2007-10-12 2009-04-16 Fio Corporation Flow focusing method and system for forming concentrated volumes of microbeads, and microbeads formed further thereto
CN101281191B (zh) 2007-11-14 2012-10-10 石西增 一种对磁敏传感生物芯片进行自动测量的仪器
WO2009076134A1 (en) 2007-12-11 2009-06-18 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
WO2009079108A1 (en) * 2007-12-14 2009-06-25 Caliper Life Sciences, Inc. Filter and solid phase extraction plate clogged well detection
EP3173787B1 (de) * 2008-01-03 2021-06-02 EMD Millipore Corporation Zellkultur-array-system für automatisierte assays und verfahren zum betrieb und dessen herstellung
US8188416B2 (en) * 2008-01-14 2012-05-29 The Charles Stark Draper Laboratory, Inc. Engineered phantoms for perfusion imaging applications
US20090250347A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic devices & processes for electrokinetic transport
US20090250345A1 (en) * 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
US20110005605A1 (en) * 2008-04-09 2011-01-13 Arkray, Inc. Liquid delivery control method and liquid delivery control system
US20090269800A1 (en) * 2008-04-29 2009-10-29 Todd Covey Device and method for processing cell samples
WO2009134786A2 (en) * 2008-04-30 2009-11-05 The Board Of Regents Of The University Of Texas System Quality control method and micro/nano-channeled devices
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
KR100953474B1 (ko) 2008-06-28 2010-04-16 건국대학교 산학협력단 미세유동칩과 마이크로 ｐｉｖ 시스템을 이용한 전자인쇄용잉크의 레올로지 모델 선정방법
US8122901B2 (en) * 2008-06-30 2012-02-28 Canon U.S. Life Sciences, Inc. System and method for microfluidic flow control
US9183237B2 (en) 2008-07-10 2015-11-10 Nodality, Inc. Methods and apparatus related to gate boundaries within a data space
US20100014741A1 (en) * 2008-07-10 2010-01-21 Banville Steven C Methods and apparatus related to gate boundaries within a data space
US20100030719A1 (en) * 2008-07-10 2010-02-04 Covey Todd M Methods and apparatus related to bioinformatics data analysis
GB2474613A (en) * 2008-07-10 2011-04-20 Nodality Inc Methods and apparatus related to management of experiments
USD618820S1 (en) 2008-07-11 2010-06-29 Handylab, Inc. Reagent holder
USD787087S1 (en) 2008-07-14 2017-05-16 Handylab, Inc. Housing
US8697007B2 (en) * 2008-08-06 2014-04-15 The Trustees Of The University Of Pennsylvania Biodetection cassette with automated actuator
CA2730902C (en) * 2008-08-08 2016-09-20 Kci Licensing, Inc. Reduced-pressure treatment systems with reservoir control
US9459200B2 (en) 2008-08-29 2016-10-04 Fio Corporation Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples
US7819838B2 (en) * 2008-09-02 2010-10-26 Hospira, Inc. Cassette for use in a medication delivery flow sensor assembly and method of making the same
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
EP4512526A3 (de) 2008-09-23 2025-06-04 Bio-Rad Laboratories, Inc. Tropfenbasiertes assaysystem
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US12090480B2 (en) 2008-09-23 2024-09-17 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US12162008B2 (en) 2008-09-23 2024-12-10 Bio-Rad Laboratories, Inc. Partition-based method of analysis
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9034257B2 (en) * 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
RU2578023C2 (ru) 2009-01-13 2016-03-20 Эф-Ай-Оу Корпорейшн Портативный диагностический прибор и способ его применения с электронным устройством и диагностическим картриджем при диагностическом экспресс-исследовании
US8100293B2 (en) 2009-01-23 2012-01-24 Formulatrix, Inc. Microfluidic dispensing assembly
DE102009015395B4 (de) 2009-03-23 2022-11-24 Thinxxs Microtechnology Gmbh Flusszelle zur Behandlung und/oder Untersuchung eines Fluids
DE112010002222B4 (de) 2009-06-04 2024-01-25 Leidos Innovations Technology, Inc. (n.d.Ges.d. Staates Delaware) Mehr-Proben-Mikrofluidchip fur DNA-Analyse
CN102472697A (zh) * 2009-07-06 2012-05-23 索尼公司 微流体装置
US9353342B2 (en) 2010-01-21 2016-05-31 Emd Millipore Corporation Cell culture and gradient migration assay methods and devices
CA2767182C (en) 2010-03-25 2020-03-24 Bio-Rad Laboratories, Inc. Droplet generation for droplet-based assays
EP2552585B1 (de) * 2010-03-31 2016-05-25 GE Healthcare BioProcess R&D AB Paralleles trennsystem
JP5956977B2 (ja) * 2010-03-31 2016-07-27 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 並列分離システム
CA3016967C (en) * 2010-04-16 2021-08-31 Opko Diagnostics, Llc Systems and devices for analysis of samples
WO2011139719A2 (en) * 2010-04-26 2011-11-10 Rheosense, Inc. Portable viscometer
WO2011156500A2 (en) * 2010-06-08 2011-12-15 The Board Of Trustees Of The University Of Illinois Electrochemical methods for wire bonding
GB2485965A (en) * 2010-08-03 2012-06-06 Univ Manchester Rheometry apparatus for measuring the viscosity and elasticity of liquids
GB201016992D0 (en) * 2010-10-08 2010-11-24 Paraytec Ltd Viscosity measurement apparatus and method
GB2497501A (en) 2010-10-15 2013-06-12 Lockheed Corp Micro fluidic optic design
WO2012064809A1 (en) * 2010-11-12 2012-05-18 Siemens Healthcare Diagnostics Inc. Real time measurements of fluid volume and flow rate using two pressure transducers
US10118149B2 (en) * 2011-01-13 2018-11-06 Patheon Austria Gmbh & Co Kg Oscillating flow minireactor
US12097495B2 (en) 2011-02-18 2024-09-24 Bio-Rad Laboratories, Inc. Methods and compositions for detecting genetic material
US9295988B2 (en) * 2011-03-08 2016-03-29 Colorado State University Research Foundation Microfluidic cytochemical staining system
US10526572B2 (en) 2011-04-01 2020-01-07 EMD Millipore Corporaticn Cell culture and invasion assay method and system
ES2769028T3 (es) 2011-04-15 2020-06-24 Becton Dickinson Co Termociclador microfluídico de barrido en tiempo real
JP2014519570A (ja) 2011-05-05 2014-08-14 エクシジェント テクノロジーズ， エルエルシー 動電学的送出システム用のゲル結合部
GB201109203D0 (en) * 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
CN102928320B (zh) * 2011-08-09 2014-11-26 中国石油化工股份有限公司 一种在钻井取心现场测试稠油粘度的方法和装置
EP2724144B1 (de) * 2011-08-25 2018-04-11 Sony Corporation Charakterisierung von bewegungsfehlern in einem strom bewegter mikroeinheiten
ES2645966T3 (es) 2011-09-30 2017-12-11 Becton, Dickinson And Company Tira reactiva unificada
USD692162S1 (en) 2011-09-30 2013-10-22 Becton, Dickinson And Company Single piece reagent holder
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CA2854758C (en) * 2011-11-08 2019-10-15 Schlumberger Canada Limited Apparatus and method for measuring phase behavior
CN104284723B (zh) 2011-11-14 2016-06-01 梅特勒-托利多索顿公司 用于微流控芯片的流体和电气接口
CN107345204B (zh) 2011-12-03 2021-02-12 Emd密理博公司 用于微流体细胞培养的微型培育系统和方法
AU2013214849B2 (en) 2012-02-03 2016-09-01 Becton, Dickinson And Company External files for distribution of molecular diagnostic tests and determination of compatibility between tests
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
EP2825309B1 (de) * 2012-03-16 2018-05-16 Stat-Diagnostica & Innovation, S.L. Messkartousche mit trasportmodul
US10174280B2 (en) 2012-04-06 2019-01-08 Corsolutions Llc Apparatus, system, and method providing fluid flow for cell growth
WO2013180245A1 (ja) * 2012-05-31 2013-12-05 天竜精機株式会社 粘度計
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
AU2013302756C1 (en) 2012-08-14 2018-05-17 10X Genomics, Inc. Microcapsule compositions and methods
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
WO2014031639A1 (en) * 2012-08-20 2014-02-27 The United States Of America, As Represented By The Secretary, Department Of Health And Humain Services Capillary viscometer and multiscale pressure differential measuring device
WO2014054207A1 (ja) * 2012-10-01 2014-04-10 日本電気株式会社 分析装置
EP2720103B1 (de) * 2012-10-10 2020-06-17 Fluigent SA Strömungskalibrierung und Regelung in einem mikrofluidischen Gerät
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20200140929A (ko) 2013-02-08 2020-12-16 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
US20140273045A1 (en) * 2013-03-15 2014-09-18 Lester F. Ludwig Modular Biochemical Signaling Laboratory Breadboard for Disease Research, Drug Discovery, Cell Biology, and Other Applications
JP5667230B2 (ja) * 2013-03-15 2015-02-12 ファナック株式会社 工作機械の切削液管理装置
US9415175B2 (en) * 2013-03-15 2016-08-16 Carefusion 303, Inc. System and method for verifying alignment of drug pump and fluid supply
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
US20150133861A1 (en) 2013-11-11 2015-05-14 Kevin P. McLennan Thermal management system and method for medical devices
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
US9399216B2 (en) * 2013-12-30 2016-07-26 General Electric Company Fluid transport in microfluidic applications with sensors for detecting fluid presence and pressure
JP6572559B2 (ja) * 2014-03-12 2019-09-11 株式会社リコー 光変調素子、撮像装置及び画像投影装置
BR112016023625A2 (pt) 2014-04-10 2018-06-26 10X Genomics, Inc. dispositivos fluídicos, sistemas e métodos para encapsular e particionar reagentes, e aplicações dos mesmos
WO2015157698A1 (en) 2014-04-11 2015-10-15 Rheosense, Inc. Viscometer and methods for using the same
CA2953469A1 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2015200893A2 (en) 2014-06-26 2015-12-30 10X Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2016010861A1 (en) * 2014-07-14 2016-01-21 President And Fellows Of Harvard College Systems and methods for improved performance of fluidic and microfluidic systems
US10143795B2 (en) 2014-08-18 2018-12-04 Icu Medical, Inc. Intravenous pole integrated power, control, and communication system and method for an infusion pump
CA2966415C (en) * 2014-10-31 2023-03-28 University Of Iowa Research Foundation Fluid handling systems for application of fluid shear stress to a fluid sample
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
US20170328924A1 (en) 2014-11-26 2017-11-16 Ronald Jones Automated microscopic cell analysis
US12005441B1 (en) 2014-11-26 2024-06-11 Medica Corporation Automated microscopic cell analysis
US11478789B2 (en) 2014-11-26 2022-10-25 Medica Corporation Automated microscopic cell analysis
US10625259B1 (en) 2014-11-26 2020-04-21 Medica Corporation Automated microscopic cell analysis
JP6769969B2 (ja) 2015-01-12 2020-10-14 １０エックス ジェノミクス， インコーポレイテッド 核酸配列決定ライブラリーを作製するためのプロセス及びシステム、並びにこれらを使用して作製したライブラリー
CA2978727C (en) 2015-03-04 2023-05-02 Daniel Levner Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers
WO2016189419A1 (en) 2015-05-26 2016-12-01 Hospira, Nc. Disposable infusion fluid delivery device for programmable large volume drug delivery
CN108290154B (zh) * 2015-07-24 2021-07-30 Hj科技公司 可重新配置的微流体系统：均质分析
CN114540192A (zh) 2015-08-26 2022-05-27 仿真股份有限公司 灌注歧管组件
US11371094B2 (en) 2015-11-19 2022-06-28 10X Genomics, Inc. Systems and methods for nucleic acid processing using degenerate nucleotides
EP3383535B1 (de) 2015-11-30 2019-11-27 Rqmicro AG Schnittstellenkomponente für eine mikrofluidische vorrichtung
CN108430318B (zh) * 2016-01-29 2021-06-29 惠普发展公司，有限责任合伙企业 微流体系统
WO2017138984A1 (en) 2016-02-11 2017-08-17 10X Genomics, Inc. Systems, methods, and media for de novo assembly of whole genome sequence data
JP6980691B2 (ja) * 2016-04-06 2021-12-15 フルイディック・アナリティクス・リミテッド フローバランスの改善またはそれに関連した改善
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
US11097272B2 (en) 2016-07-26 2021-08-24 Hewlett-Packard Development Company, L.P. Microfluidic apparatuses for fluid movement control
GB201615472D0 (en) 2016-09-12 2016-10-26 Fluidic Analytics Ltd Improvements in or relating to a reagent cartridge
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
WO2018136819A1 (en) * 2017-01-20 2018-07-26 The General Hospital Corporation Portable wide field fluorimeter systems
EP4029939B1 (de) 2017-01-30 2023-06-28 10X Genomics, Inc. Verfahren und systeme für eine einzelzellbarcodierung auf tröpfchenbasis
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
US10995333B2 (en) 2017-02-06 2021-05-04 10X Genomics, Inc. Systems and methods for nucleic acid preparation
JP7150739B2 (ja) * 2017-02-17 2022-10-11 ライフ テクノロジーズ コーポレーション サンプル分析機器の自動品質管理およびスペクトル誤差補正
FR3064621B1 (fr) * 2017-04-03 2022-02-18 Fluigent Dispositif microfluidique
JP6710850B1 (ja) 2017-04-20 2020-06-17 バイオフルイディカ、インコーポレイテッド 液体サンプルからバイオマーカーを単離するための流体密封性フローシステム
EP4435113B1 (de) 2017-05-18 2025-12-10 10X Genomics, Inc. Verfahren und systeme zum sortieren von tröpfchen und kügelchen
US10544413B2 (en) 2017-05-18 2020-01-28 10X Genomics, Inc. Methods and systems for sorting droplets and beads
CN107271329A (zh) * 2017-06-07 2017-10-20 大连北方分析仪器有限公司 高温高剪切粘度测定仪
US10343161B2 (en) * 2017-06-23 2019-07-09 International Business Machines Corporation Customizable microfluidic device with programmable microfluidic nodes
US10610865B2 (en) 2017-08-22 2020-04-07 10X Genomics, Inc. Droplet forming devices and system with differential surface properties
US10837047B2 (en) 2017-10-04 2020-11-17 10X Genomics, Inc. Compositions, methods, and systems for bead formation using improved polymers
WO2019083852A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. MICROFLUIDIC CHANNEL NETWORKS FOR PARTITIONING
WO2019084043A1 (en) 2017-10-26 2019-05-02 10X Genomics, Inc. METHODS AND SYSTEMS FOR NUCLEIC ACID PREPARATION AND CHROMATIN ANALYSIS
EP3700672B1 (de) 2017-10-27 2022-12-28 10X Genomics, Inc. Verfahren zur probenvorbereitung und -analyse
SG11201913654QA (en) 2017-11-15 2020-01-30 10X Genomics Inc Functionalized gel beads
US11047845B1 (en) 2017-11-15 2021-06-29 Medica Corporation Control material and methods for cell analyzers
WO2019108851A1 (en) 2017-11-30 2019-06-06 10X Genomics, Inc. Systems and methods for nucleic acid preparation and analysis
EP3724658A1 (de) 2017-12-12 2020-10-21 10X Genomics, Inc. Systeme und verfahren zur einzelzellverarbeitung
CN111712579B (zh) 2017-12-22 2024-10-15 10X基因组学有限公司 用于处理来自一个或多个细胞的核酸分子的系统和方法
SG11202007686VA (en) 2018-02-12 2020-09-29 10X Genomics Inc Methods characterizing multiple analytes from individual cells or cell populations
US11639928B2 (en) 2018-02-22 2023-05-02 10X Genomics, Inc. Methods and systems for characterizing analytes from individual cells or cell populations
WO2019169028A1 (en) 2018-02-28 2019-09-06 10X Genomics, Inc. Transcriptome sequencing through random ligation
CN112262218B (zh) 2018-04-06 2024-11-08 10X基因组学有限公司 用于单细胞处理中的质量控制的系统和方法
US11443085B2 (en) * 2018-04-11 2022-09-13 University Of Central Florida Research Foundation, Inc. Model for fluid and mass transport in a recirculating microfluidic system
WO2019217758A1 (en) 2018-05-10 2019-11-14 10X Genomics, Inc. Methods and systems for molecular library generation
US11932899B2 (en) 2018-06-07 2024-03-19 10X Genomics, Inc. Methods and systems for characterizing nucleic acid molecules
US11703427B2 (en) 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US12188014B1 (en) 2018-07-25 2025-01-07 10X Genomics, Inc. Compositions and methods for nucleic acid processing using blocking agents
US20200032335A1 (en) 2018-07-27 2020-01-30 10X Genomics, Inc. Systems and methods for metabolome analysis
SG11202101164TA (en) 2018-08-03 2021-03-30 10X Genomics Inc Methods and systems to minimize barcode exchange
US12065688B2 (en) 2018-08-20 2024-08-20 10X Genomics, Inc. Compositions and methods for cellular processing
WO2020041148A1 (en) 2018-08-20 2020-02-27 10X Genomics, Inc. Methods and systems for detection of protein-dna interactions using proximity ligation
US11459607B1 (en) 2018-12-10 2022-10-04 10X Genomics, Inc. Systems and methods for processing-nucleic acid molecules from a single cell using sequential co-partitioning and composite barcodes
US12169198B2 (en) 2019-01-08 2024-12-17 10X Genomics, Inc. Systems and methods for sample analysis
US11845983B1 (en) 2019-01-09 2023-12-19 10X Genomics, Inc. Methods and systems for multiplexing of droplet based assays
WO2020167862A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transfer of reagents between droplets
US11851683B1 (en) 2019-02-12 2023-12-26 10X Genomics, Inc. Methods and systems for selective analysis of cellular samples
EP3924505B1 (de) 2019-02-12 2025-12-17 10X Genomics, Inc. Verfahren zur verarbeitung von nukleinsäuremolekülen
US12305239B2 (en) 2019-02-12 2025-05-20 10X Genomics, Inc. Analysis of nucleic acid sequences
US12275993B2 (en) 2019-02-12 2025-04-15 10X Genomics, Inc. Analysis of nucleic acid sequences
WO2020167866A1 (en) 2019-02-12 2020-08-20 10X Genomics, Inc. Systems and methods for transposon loading
US11467153B2 (en) 2019-02-12 2022-10-11 10X Genomics, Inc. Methods for processing nucleic acid molecules
US11655499B1 (en) 2019-02-25 2023-05-23 10X Genomics, Inc. Detection of sequence elements in nucleic acid molecules
SG11202111242PA (en) 2019-03-11 2021-11-29 10X Genomics Inc Systems and methods for processing optically tagged beads
EP3947722A1 (de) 2019-03-27 2022-02-09 10X Genomics, Inc. Systeme und verfahren zur verarbeitung von rna aus zellen
USD939079S1 (en) 2019-08-22 2021-12-21 Icu Medical, Inc. Infusion pump
US12235262B1 (en) 2019-09-09 2025-02-25 10X Genomics, Inc. Methods and systems for single cell protein analysis
WO2021072306A1 (en) 2019-10-10 2021-04-15 1859, Inc. Methods and systems for microfluidic screening
KR102381134B1 (ko) * 2019-11-27 2022-03-31 주식회사 바이오티엔에스 유체 분석용 마이크로 칩 및 이를 이용한 유전자 증폭 방법
US12449419B1 (en) 2020-02-12 2025-10-21 10X Genomics, Inc. Methods for detecting binding of peptide-MHC monomers to T cells
US11851700B1 (en) 2020-05-13 2023-12-26 10X Genomics, Inc. Methods, kits, and compositions for processing extracellular molecules
EP4164795A4 (de) 2020-06-12 2024-01-24 BioFluidica, Inc. Thermoplastische mikrofluidische vorrichtung mit zwei tiefen und zugehörige systeme und verfahren
US12480158B1 (en) 2020-11-05 2025-11-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12084715B1 (en) 2020-11-05 2024-09-10 10X Genomics, Inc. Methods and systems for reducing artifactual antisense products
CN114622264B (zh) * 2020-12-10 2023-06-27 矽磐微电子(重庆)有限公司 流体监测装置
US12398262B1 (en) 2021-01-22 2025-08-26 10X Genomics, Inc. Triblock copolymer-based cell stabilization and fixation system and methods of use thereof
CN117015617B (zh) 2021-02-23 2025-04-04 10X基因组学有限公司 基于探针的核酸和蛋白质分析
WO2022201485A1 (ja) * 2021-03-26 2022-09-29 国立大学法人九州工業大学 粘度や表面張力を測定するシステム、および粘度や表面張力を測定する方法
US12078582B2 (en) 2021-05-10 2024-09-03 Rheosense, Inc. Viscometer with reduced dead-volume and high dynamic range
DE102021005140A1 (de) * 2021-10-14 2023-04-20 Evorion Biotechnologies Gmbh Vorrichtung zur Steuerung der Strömung einer Flüssigkeit durch eine mikrofluidische Verbindungsvorrichtung
USD1052728S1 (en) 2021-11-12 2024-11-26 Icu Medical, Inc. Medical fluid infusion pump
WO2024073839A1 (en) * 2022-10-06 2024-04-11 Interface Fluidics Ltd. Base for a microfluidic manifold, microfluidic manifold, and method for manufacturing a base for a microfluidic manifold
WO2025257197A1 (en) * 2024-06-10 2025-12-18 Cellboxlab Ltd Differential pressure based microfluidic pumping
CN120135694B (zh) * 2025-05-16 2025-08-15 山东平阴丰源炭素有限责任公司 一种资源化生产预焙阳极的糊料输送设备及方法

Family Cites Families (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390403A (en) * 1981-07-24 1983-06-28 Batchelder J Samuel Method and apparatus for dielectrophoretic manipulation of chemical species
US4908112A (en) * 1988-06-16 1990-03-13 E. I. Du Pont De Nemours & Co. Silicon semiconductor wafer for analyzing micronic biological samples
US5126022A (en) * 1990-02-28 1992-06-30 Soane Tecnologies, Inc. Method and device for moving molecules by the application of a plurality of electrical fields
DE59105165D1 (de) * 1990-11-01 1995-05-18 Ciba Geigy Ag Vorrichtung zur Aufbereitung oder Vorbereitung von flüssigen Proben für eine chemische Analyse.
US5304487A (en) 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5639423A (en) 1992-08-31 1997-06-17 The Regents Of The University Of Calfornia Microfabricated reactor
US5482608A (en) * 1993-01-19 1996-01-09 Hewlett Packard Company Capillary electrophoresis flow control system
US5328578A (en) * 1993-06-15 1994-07-12 Hewlett-Packard Company Capillary electrophoresis with tracking separation field
US6001229A (en) 1994-08-01 1999-12-14 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis
US5603351A (en) * 1995-06-07 1997-02-18 David Sarnoff Research Center, Inc. Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device
US5573651A (en) 1995-04-17 1996-11-12 The Dow Chemical Company Apparatus and method for flow injection analysis
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5726404A (en) * 1996-05-31 1998-03-10 University Of Washington Valveless liquid microswitch
US5863801A (en) * 1996-06-14 1999-01-26 Sarnoff Corporation Automated nucleic acid isolation
CN1173776C (zh) 1996-06-28 2004-11-03 卡钳技术有限公司 在微规模流体性设备里的高通过量的筛选分析系统
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US6110343A (en) * 1996-10-04 2000-08-29 Lockheed Martin Energy Research Corporation Material transport method and apparatus
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
WO1998049548A1 (en) 1997-04-25 1998-11-05 Caliper Technologies Corporation Microfluidic devices incorporating improved channel geometries
US5974867A (en) 1997-06-13 1999-11-02 University Of Washington Method for determining concentration of a laminar sample stream
US5876675A (en) * 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US6012902A (en) * 1997-09-25 2000-01-11 Caliper Technologies Corp. Micropump
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE29807803U1 (de) 1998-04-30 1998-07-30 Hung, Yau-Jean, Hua-Lien Schlauchkupplung
US6132685A (en) 1998-08-10 2000-10-17 Caliper Technologies Corporation High throughput microfluidic systems and methods
US6149787A (en) 1998-10-14 2000-11-21 Caliper Technologies Corp. External material accession systems and methods
US6062261A (en) * 1998-12-16 2000-05-16 Lockheed Martin Energy Research Corporation MicrofluIdic circuit designs for performing electrokinetic manipulations that reduce the number of voltage sources and fluid reservoirs
US20020019059A1 (en) 1999-01-28 2002-02-14 Calvin Y.H. Chow Devices, systems and methods for time domain multiplexing of reagents
ATE556149T1 (de) * 1999-02-23 2012-05-15 Caliper Life Sciences Inc Manipulation von mikropartikeln in mikrofluidischen systemen
US6500323B1 (en) * 1999-03-26 2002-12-31 Caliper Technologies Corp. Methods and software for designing microfluidic devices
US6322683B1 (en) * 1999-04-14 2001-11-27 Caliper Technologies Corp. Alignment of multicomponent microfabricated structures
US6375817B1 (en) * 1999-04-16 2002-04-23 Perseptive Biosystems, Inc. Apparatus and methods for sample analysis
US6458259B1 (en) * 1999-05-11 2002-10-01 Caliper Technologies Corp. Prevention of surface adsorption in microchannels by application of electric current during pressure-induced flow
US6592821B1 (en) * 1999-05-17 2003-07-15 Caliper Technologies Corp. Focusing of microparticles in microfluidic systems
EP1179087B1 (de) * 1999-05-17 2019-03-27 Caliper Life Sciences, Inc. Fokusierung von mikropartikeln in mikrofluidischen systemen
EP1185871A4 (de) * 1999-06-01 2003-01-15 Caliper Techn Corp Assays im kleinstformat und mikrofluidische vorrichtungen für aktivitäten von transportern, gradienten und bindungsassays
US7601270B1 (en) * 1999-06-28 2009-10-13 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6385739B1 (en) 1999-07-19 2002-05-07 Tivo Inc. Self-test electronic assembly and test system
ATE382858T1 (de) * 2000-02-23 2008-01-15 Caliper Life Sciences Inc Mehrfach-reservoir-drucksteuersystem
US6561208B1 (en) * 2000-04-14 2003-05-13 Nanostream, Inc. Fluidic impedances in microfluidic system
US6481453B1 (en) * 2000-04-14 2002-11-19 Nanostream, Inc. Microfluidic branch metering systems and methods
US6520197B2 (en) * 2000-06-02 2003-02-18 The Regents Of The University Of California Continuous laminar fluid mixing in micro-electromechanical systems
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
US6289914B1 (en) * 2000-08-16 2001-09-18 Novartis Ag Microflow splitter
US20020112959A1 (en) * 2000-10-04 2002-08-22 Qifeng Xue Unbiased sample injection for microfluidic applications
US6623860B2 (en) * 2000-10-10 2003-09-23 Aclara Biosciences, Inc. Multilevel flow structures

Also Published As

Publication number Publication date
AU2001249071B2 (en) 2005-09-08
WO2001063270B1 (en) 2001-11-08
US20050005684A1 (en) 2005-01-13
CN1449491A (zh) 2003-10-15
IL151122A0 (en) 2003-04-10
EP1272834B1 (de) 2008-01-02
US7171983B2 (en) 2007-02-06
EP1272834A1 (de) 2003-01-08
AU4907101A (en) 2001-09-03
CN1261755C (zh) 2006-06-28
US20070157973A1 (en) 2007-07-12
WO2001063270A1 (en) 2001-08-30
DE60132185T2 (de) 2009-01-02
JP2003524183A (ja) 2003-08-12
US20010052460A1 (en) 2001-12-20
MXPA02008290A (es) 2004-09-10
DE60132185D1 (de) 2008-02-14
US6915679B2 (en) 2005-07-12
EP1272834A4 (de) 2003-06-25
CA2399199A1 (en) 2001-08-30

Similar Documents

Publication Publication Date Title
ATE382858T1 (de) Mehrfach-reservoir-drucksteuersystem
WO2007070884A3 (en) Digital flow control
GB2583275A8 (en) Methods and systems for monitoring drilling fluid rheological characteristics
DE69927156D1 (de) Strömungswächter für ein element
MXPA03010317A (es) Metodo y sistema para marcar y determinar la autencidad de hidrocarburos liquidos.
BR0109748A (pt) Dispositivo e método para medição da taxa de fluxo de um fluido num furo de poço
ATE473051T1 (de) Mikrofluidische anordnung zum dosieren von flüssigkeiten
ATE419924T1 (de) Dosiersystem für eine beschichtungsanlage
CY1113615T1 (el) Βαλβιδα για την αποτροπη χαμηλων ρυθμων ροης διαμεσου ροομετρου
WO2004105827A3 (en) Drug delivery device and method
WO2004010086A3 (en) Fluid flow measuring and proportional fluid flow control device
ATE302349T1 (de) Poröses mikroventil
DE60221375D1 (de) Massenströmungsmessersysteme und -verfahren
EA200400901A1 (ru) Устройство для управления потоком текучей среды
EA201390238A1 (ru) Устройство и способ распределения жидкого продукта, наносимого на поверхность
SA519410313B1 (ar) نظام حماية الضغط العالي والنوعية لخط السوائل
ATE360597T1 (de) Ventil zur verwendung in mikrofluiden strukturen
WO2014055598A3 (en) Apparatus, system, and method for controlling the flow of drilling fluid in a wellbore
WO2007124324A3 (en) Flow controller delivery of a specified quantity of a fluid
WO2008127438A3 (en) Parallel flow control (pfc) approach for active control, characterization, and manipulation of nanofluidics
EP1898210A3 (de) Drucksteuerungssystem für mehrere Behälter
DE502007003920D1 (de) Poröses Dosierelement mit Beschichtung
ATE358823T1 (de) Kapillarsperre
DE50204175D1 (de) Vorrichtung und verfahren zum dosieren kleiner flüssigkeitsmengen
WO2016190939A3 (en) Fluidic device for quantifying the dynamic permeability and hydraulic conductivity of living tissue layers

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties