ATE383168T1 - Fgf-2 zur behandlung von erkrankungen der peripheralen arterien - Google Patents
Fgf-2 zur behandlung von erkrankungen der peripheralen arterienInfo
- Publication number
- ATE383168T1 ATE383168T1 AT01946663T AT01946663T ATE383168T1 AT E383168 T1 ATE383168 T1 AT E383168T1 AT 01946663 T AT01946663 T AT 01946663T AT 01946663 T AT01946663 T AT 01946663T AT E383168 T1 ATE383168 T1 AT E383168T1
- Authority
- AT
- Austria
- Prior art keywords
- fgf
- peripheral artery
- artery disease
- compositions
- patient
- Prior art date
Links
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 title abstract 5
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 title abstract 5
- 208000005764 Peripheral Arterial Disease Diseases 0.000 title 1
- 208000030613 peripheral artery disease Diseases 0.000 abstract 3
- 206010022562 Intermittent claudication Diseases 0.000 abstract 2
- 208000024980 claudication Diseases 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 208000032064 Chronic Limb-Threatening Ischemia Diseases 0.000 abstract 1
- 102000018233 Fibroblast Growth Factor Human genes 0.000 abstract 1
- 108050007372 Fibroblast Growth Factor Proteins 0.000 abstract 1
- 206010034576 Peripheral ischaemia Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229940126864 fibroblast growth factor Drugs 0.000 abstract 1
- 238000001802 infusion Methods 0.000 abstract 1
- 238000001361 intraarterial administration Methods 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21350400P | 2000-06-22 | 2000-06-22 | |
| US26457201P | 2001-01-26 | 2001-01-26 | |
| US27654901P | 2001-03-16 | 2001-03-16 | |
| US09/886,856 US20020115603A1 (en) | 2000-06-22 | 2001-06-21 | Methods and compositions for the treatment of peripheral artery disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE383168T1 true ATE383168T1 (de) | 2008-01-15 |
Family
ID=27498936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01946663T ATE383168T1 (de) | 2000-06-22 | 2001-06-22 | Fgf-2 zur behandlung von erkrankungen der peripheralen arterien |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20020115603A1 (de) |
| EP (1) | EP1324766B1 (de) |
| JP (1) | JP2004501164A (de) |
| AT (1) | ATE383168T1 (de) |
| AU (1) | AU2001268680A1 (de) |
| CA (1) | CA2414020A1 (de) |
| DE (1) | DE60132343T2 (de) |
| WO (1) | WO2001098346A2 (de) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030166550A1 (en) | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
| US20020072489A1 (en) * | 1998-10-13 | 2002-06-13 | Whitehouse Martha J. | Angiogenically effective unit dose of FGF-2 and method of use |
| US20020115603A1 (en) * | 2000-06-22 | 2002-08-22 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
| US20030004753A1 (en) * | 2001-06-27 | 2003-01-02 | Blackshear William M. | Management method of persons at risk of complications of arterial occlusive disease |
| WO2003087318A2 (en) * | 2002-04-08 | 2003-10-23 | Eugene Levin | Truncated 24 kda basic fibroblast growth factor |
| JP4532092B2 (ja) * | 2003-09-30 | 2010-08-25 | 泰彦 田畑 | 血管新生剤 |
| US7346382B2 (en) | 2004-07-07 | 2008-03-18 | The Cleveland Clinic Foundation | Brain stimulation models, systems, devices, and methods |
| RU2435578C2 (ru) * | 2005-06-29 | 2011-12-10 | Марс, Инкорпорейтед | Возбуждение вазодилатации периферических кровеносных сосудов |
| US20090062309A1 (en) * | 2007-08-28 | 2009-03-05 | Antonio Delgado-Almeida | Therapeutic compositions for the treatment of cardiovascular diseases and methods for use therefor |
| US8812123B2 (en) * | 2007-10-17 | 2014-08-19 | Intelect Medical, Inc. | Patient programmer with input and sensing capabilities |
| US9220889B2 (en) | 2008-02-11 | 2015-12-29 | Intelect Medical, Inc. | Directional electrode devices with locating features |
| US8019440B2 (en) | 2008-02-12 | 2011-09-13 | Intelect Medical, Inc. | Directional lead assembly |
| US9272153B2 (en) | 2008-05-15 | 2016-03-01 | Boston Scientific Neuromodulation Corporation | VOA generation system and method using a fiber specific analysis |
| HUE035700T2 (en) | 2008-11-07 | 2018-05-28 | Galaxy Biotech Llc | Monoclonal antibodies to Fibroblast Growth Factor receptor 2 |
| US8461111B2 (en) * | 2009-05-20 | 2013-06-11 | Florida State University Research Foundation | Fibroblast growth factor mutants having improved functional half-life and methods of their use |
| CA2772330A1 (en) | 2009-08-27 | 2011-03-03 | The Cleveland Clinic Foundation | System and method to estimate region of tissue activation |
| WO2011068997A1 (en) | 2009-12-02 | 2011-06-09 | The Cleveland Clinic Foundation | Reversing cognitive-motor impairments in patients having a neuro-degenerative disease using a computational modeling approach to deep brain stimulation programming |
| WO2011130729A2 (en) | 2010-04-16 | 2011-10-20 | Salk Institute For Biological Studies | Methods for treating metabolic disorders using fgf |
| AU2011267853B2 (en) | 2010-06-14 | 2016-12-08 | Boston Scientific Neuromodulation Corporation | Programming interface for spinal cord neuromodulation |
| JP2014513622A (ja) | 2011-03-29 | 2014-06-05 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | 治療刺激提供システムのための通信インタフェース |
| US9592389B2 (en) | 2011-05-27 | 2017-03-14 | Boston Scientific Neuromodulation Corporation | Visualization of relevant stimulation leadwire electrodes relative to selected stimulation information |
| CA2844081A1 (en) | 2011-08-09 | 2013-02-14 | Boston Scientific Neuromodulation Corporation | Remote control for blind clinical trials of electrical stimulation |
| WO2014025624A1 (en) | 2012-08-04 | 2014-02-13 | Boston Scientific Neuromodulation Corporation | Techniques and methods for storing and transferring registration, atlas, and lead information between medical devices |
| JP6224106B2 (ja) | 2012-08-28 | 2017-11-01 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | リード及び/又は刺激中心に関する臨床効果データの取込み及び可視化 |
| WO2014070290A2 (en) | 2012-11-01 | 2014-05-08 | Boston Scientific Neuromodulation Corporation | Systems and methods for voa model generation and use |
| US9332994B2 (en) | 2013-07-12 | 2016-05-10 | Vasoinnovations, Inc. | Apparatus and method to stop bleeding |
| US20230018664A1 (en) * | 2013-07-12 | 2023-01-19 | Vasoinnovations, Inc. | Method to stop bleeding after a catheterization procedure using a large bore sheath |
| US10213214B2 (en) | 2013-07-12 | 2019-02-26 | Vasoinnovations, Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
| US9668744B2 (en) | 2015-08-05 | 2017-06-06 | Vasoinnovations, Inc. | Apparatus and method to stop bleeding |
| US9308000B2 (en) | 2013-07-12 | 2016-04-12 | Vasoinnovations, Inc. | Method of transradial catheterization, device for ulnar artery compression, and method of use |
| US11564697B2 (en) | 2013-07-12 | 2023-01-31 | Vasoinnovations Inc. | Apparatus and method to stop bleeding |
| US10888334B2 (en) | 2013-07-12 | 2021-01-12 | Vasoinnovations Inc. | Apparatus and method to stop bleeding |
| US9949738B2 (en) | 2013-07-12 | 2018-04-24 | Vasoinnovations, Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
| US10342551B2 (en) * | 2013-07-12 | 2019-07-09 | Vasoinnovations Inc. | Method to stop bleeding, with short hemostasis duration using a low dose of anticoagulant |
| WO2015061331A1 (en) | 2013-10-21 | 2015-04-30 | Salk Institute For Biological Studies | Chimeric fibroblast growth factor (fgf) 2/fgf1 peptides and methods of use |
| US9959388B2 (en) | 2014-07-24 | 2018-05-01 | Boston Scientific Neuromodulation Corporation | Systems, devices, and methods for providing electrical stimulation therapy feedback |
| US10272247B2 (en) | 2014-07-30 | 2019-04-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for stimulation-related volume analysis, creation, and sharing with integrated surgical planning and stimulation programming |
| US10265528B2 (en) | 2014-07-30 | 2019-04-23 | Boston Scientific Neuromodulation Corporation | Systems and methods for electrical stimulation-related patient population volume analysis and use |
| EP3204112A1 (de) | 2014-10-07 | 2017-08-16 | Boston Scientific Neuromodulation Corporation | Systeme, vorrichtungen und verfahren zur elektrischen stimulation mittels rückkopplung zur einstellung von stimulationsparametern |
| EP3268082B1 (de) | 2015-05-26 | 2019-04-17 | Boston Scientific Neuromodulation Corporation | Systeme und verfahren zur analyse von elektrischer stimulation und auswahl oder manipulation von aktivierungsvolumina |
| US10780283B2 (en) | 2015-05-26 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for analyzing electrical stimulation and selecting or manipulating volumes of activation |
| US20160375248A1 (en) | 2015-06-29 | 2016-12-29 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting stimulation parameters based on stimulation target region, effects, or side effects |
| ES2940303T3 (es) | 2015-06-29 | 2023-05-05 | Boston Scient Neuromodulation Corp | Sistemas de selección de parámetros de estimulación por uso de dianas y direccionamiento |
| US10071249B2 (en) | 2015-10-09 | 2018-09-11 | Boston Scientific Neuromodulation Corporation | System and methods for clinical effects mapping for directional stimulation leads |
| WO2017127493A1 (en) * | 2016-01-22 | 2017-07-27 | Salk Institute For Biological Studies | Fgf2 truncations and mutants and uses thereof |
| US10716942B2 (en) | 2016-04-25 | 2020-07-21 | Boston Scientific Neuromodulation Corporation | System and methods for directional steering of electrical stimulation |
| WO2017223505A2 (en) | 2016-06-24 | 2017-12-28 | Boston Scientific Neuromodulation Corporation | Systems and methods for visual analytics of clinical effects |
| WO2018044881A1 (en) | 2016-09-02 | 2018-03-08 | Boston Scientific Neuromodulation Corporation | Systems and methods for visualizing and directing stimulation of neural elements |
| US10780282B2 (en) | 2016-09-20 | 2020-09-22 | Boston Scientific Neuromodulation Corporation | Systems and methods for steering electrical stimulation of patient tissue and determining stimulation parameters |
| EP3493876B1 (de) | 2016-10-14 | 2021-03-17 | Boston Scientific Neuromodulation Corporation | Systeme zur closed-loop-bestimmung von stimulationsparametereinstellungen für ein elektrisches simulationssystem |
| AU2017391436B2 (en) | 2017-01-03 | 2020-06-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for selecting MRI-compatible stimulation parameters |
| US10589104B2 (en) | 2017-01-10 | 2020-03-17 | Boston Scientific Neuromodulation Corporation | Systems and methods for creating stimulation programs based on user-defined areas or volumes |
| US10625082B2 (en) | 2017-03-15 | 2020-04-21 | Boston Scientific Neuromodulation Corporation | Visualization of deep brain stimulation efficacy |
| US11357986B2 (en) | 2017-04-03 | 2022-06-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for estimating a volume of activation using a compressed database of threshold values |
| WO2018200040A1 (en) * | 2017-04-26 | 2018-11-01 | University Of Cincinnati | Compositions of fibroblast growth factor ligands and methods of treating patients unergoing ischemia-reperfusion therapy |
| EP3651849B1 (de) | 2017-07-14 | 2023-05-31 | Boston Scientific Neuromodulation Corporation | Schätzung der klinischen wirkungen von elektrischer stimulation |
| US10960214B2 (en) | 2017-08-15 | 2021-03-30 | Boston Scientific Neuromodulation Corporation | Systems and methods for controlling electrical stimulation using multiple stimulation fields |
| JP7295141B2 (ja) | 2018-04-27 | 2023-06-20 | ボストン サイエンティフィック ニューロモデュレイション コーポレイション | マルチモード電気刺激システム及び製造する及び使用する方法 |
| EP3784332B1 (de) | 2018-04-27 | 2023-04-26 | Boston Scientific Neuromodulation Corporation | Systeme zur visualisierung und programmierung der elektrischen stimulation |
| US12403315B2 (en) | 2021-04-27 | 2025-09-02 | Boston Scientific Neuromodulation Corporation | Systems and methods for automated programming of electrical stimulation |
| WO2022265977A1 (en) | 2021-06-15 | 2022-12-22 | Boston Scientific Neuromodulation Corporation | Methods and systems for estimating neural activation by stimulation using a stimulation system |
| US12527956B2 (en) | 2021-12-09 | 2026-01-20 | Boston Scientific Neuromodulation Corporation | Methods and systems for monitoring or assessing movement disorders or other physiological parameters using a stimulation system |
| US12471831B2 (en) | 2021-12-10 | 2025-11-18 | Boston Scientific Neuromodulation Corporation | Systems and methods for generating and using response maps for electrical stimulation |
| WO2023167872A1 (en) | 2022-03-02 | 2023-09-07 | Boston Scientific Neuromodulation Corporation | Systems and methods for monitoring stimulation drift in an electrical stimulation system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5604293A (en) * | 1985-09-12 | 1997-02-18 | Scios Inc. | Recombinant human basic fibroblast growth factor |
| US5852177A (en) * | 1987-02-24 | 1998-12-22 | Takeda Chemical Industries, Ltd. | Basic fibroblast growth factor (bFGF) muteins |
| CA2202511A1 (en) * | 1994-10-12 | 1996-04-25 | Laurence A. Roth | Targeted delivery via biodegradable polymers |
| US5792453A (en) * | 1995-02-28 | 1998-08-11 | The Regents Of The University Of California | Gene transfer-mediated angiogenesis therapy |
| WO1997023256A1 (en) * | 1995-12-22 | 1997-07-03 | Localmed, Inc. | Localized intravascular delivery of growth factors for promotion of angiogenesis |
| SE9802974D0 (sv) * | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
| EP2123292B1 (de) * | 1998-09-03 | 2016-05-04 | Novartis Vaccines and Diagnostics, Inc. | FGF-2 angiogenische wirksame Einheitdosis und Verfahren zu ihrer Verwendung |
| US20030166550A1 (en) * | 1999-08-27 | 2003-09-04 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
| US6440934B1 (en) | 1998-10-13 | 2002-08-27 | Chiron Corporation | Angiogenically effective unit dose of FGF-2 and method of use |
| JP2002527401A (ja) * | 1998-10-13 | 2002-08-27 | カイロン コーポレイション | Fgfの脈管形成的に有効な単位用量および投与方法 |
| US20020072489A1 (en) * | 1998-10-13 | 2002-06-13 | Whitehouse Martha J. | Angiogenically effective unit dose of FGF-2 and method of use |
| US20020115603A1 (en) * | 2000-06-22 | 2002-08-22 | Chiron Corporation | Methods and compositions for the treatment of peripheral artery disease |
-
2001
- 2001-06-21 US US09/886,856 patent/US20020115603A1/en not_active Abandoned
- 2001-06-22 JP JP2002504301A patent/JP2004501164A/ja not_active Withdrawn
- 2001-06-22 WO PCT/US2001/019978 patent/WO2001098346A2/en not_active Ceased
- 2001-06-22 AU AU2001268680A patent/AU2001268680A1/en not_active Abandoned
- 2001-06-22 CA CA002414020A patent/CA2414020A1/en not_active Abandoned
- 2001-06-22 EP EP01946663A patent/EP1324766B1/de not_active Expired - Lifetime
- 2001-06-22 AT AT01946663T patent/ATE383168T1/de not_active IP Right Cessation
- 2001-06-22 DE DE60132343T patent/DE60132343T2/de not_active Expired - Fee Related
-
2004
- 2004-05-14 US US10/845,911 patent/US7186407B2/en not_active Expired - Fee Related
-
2007
- 2007-02-05 US US11/671,382 patent/US7541337B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20070135348A1 (en) | 2007-06-14 |
| DE60132343T2 (de) | 2008-12-24 |
| US20020115603A1 (en) | 2002-08-22 |
| JP2004501164A (ja) | 2004-01-15 |
| WO2001098346A3 (en) | 2003-05-01 |
| US7186407B2 (en) | 2007-03-06 |
| EP1324766A2 (de) | 2003-07-09 |
| EP1324766B1 (de) | 2008-01-09 |
| US20040209817A1 (en) | 2004-10-21 |
| US7541337B2 (en) | 2009-06-02 |
| AU2001268680A1 (en) | 2002-01-02 |
| CA2414020A1 (en) | 2001-12-27 |
| WO2001098346A2 (en) | 2001-12-27 |
| DE60132343D1 (de) | 2008-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |