ATE453622T1 - Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren - Google Patents
Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäurenInfo
- Publication number
- ATE453622T1 ATE453622T1 AT07727328T AT07727328T ATE453622T1 AT E453622 T1 ATE453622 T1 AT E453622T1 AT 07727328 T AT07727328 T AT 07727328T AT 07727328 T AT07727328 T AT 07727328T AT E453622 T1 ATE453622 T1 AT E453622T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- carboxylic acids
- heteroaryl carboxylic
- cyclic beta
- enantiomeric enriched
- Prior art date
Links
- 150000001735 carboxylic acids Chemical class 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- -1 heteroaryl carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrrole Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112171 | 2006-04-03 | ||
| PCT/EP2007/052855 WO2007113155A1 (en) | 2006-04-03 | 2007-03-26 | Process for preparation of enantiomerically enriched cyclic β-aryl or heteroaryl carboxylic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE453622T1 true ATE453622T1 (de) | 2010-01-15 |
Family
ID=36992822
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07727328T ATE453622T1 (de) | 2006-04-03 | 2007-03-26 | Verfahren zur herstellung von enantiomeren angereicherten cyclischen beta-aryl- oder heteroarylcarbonsäuren |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20070232653A1 (de) |
| EP (1) | EP2029541B1 (de) |
| JP (1) | JP5038392B2 (de) |
| KR (1) | KR101087805B1 (de) |
| CN (1) | CN101460461B (de) |
| AT (1) | ATE453622T1 (de) |
| AU (1) | AU2007233814B2 (de) |
| BR (1) | BRPI0709880A2 (de) |
| CA (1) | CA2648246C (de) |
| DE (1) | DE602007004111D1 (de) |
| ES (1) | ES2335710T3 (de) |
| IL (1) | IL194219A (de) |
| MX (1) | MX2008012566A (de) |
| TW (1) | TWI356820B (de) |
| WO (1) | WO2007113155A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010519272A (ja) * | 2007-02-20 | 2010-06-03 | ソルヴィーアス アクチェンゲゼルシャフト | 不斉水素化反応で使用されるビス（フェロセニルホスフィノ）フェロセン配位子 |
| EP2379500A1 (de) * | 2008-12-16 | 2011-10-26 | F. Hoffmann-La Roche AG | Verfahren zur herstellung von pyrrolidin-3-carbonsäuren |
| DK2379491T3 (da) * | 2008-12-18 | 2013-04-08 | Hoffmann La Roche | Fremgangsmåde til syntese af amino-methyl-tetralinderivater |
| JP6551922B2 (ja) * | 2015-04-13 | 2019-07-31 | 国立大学法人名古屋大学 | カルボン酸化合物の水素化によるアルコールの製造方法、及び該製造方法に用いるルテニウム錯体 |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| KR20250010141A (ko) | 2015-10-16 | 2025-01-20 | 애브비 인코포레이티드 | (3S,4R)-3-에틸-4-(3H-이미다조[1,2-a]피롤로[2,3-e]-피라진-8-일)-N-(2,2,2-트리플루오로에틸)피롤리딘-1-카복스아미드및 이의 고체상 형태의 제조 방법 |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| CA3082558A1 (en) * | 2017-11-16 | 2019-05-23 | Syngenta Participations Ag | Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides |
| CN113185440B (zh) * | 2021-05-13 | 2022-04-29 | 南京德克瑞医药化工有限公司 | 一种医药中间体n-boc-3-吡咯啉的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3004058A (en) * | 1954-09-21 | 1961-10-10 | Callery Chemical Co | Separation of trimethyl borate from the trimethyl borate-methanol azeotrope |
| DK350383A (da) * | 1982-08-27 | 1984-02-28 | Hoffmann La Roche | Phosphorforbindelser |
| EP0190496A3 (de) * | 1984-12-13 | 1987-05-27 | Beecham Group Plc | Piperidinderivate mit gastro-intestinaler Wirkung |
| ATE128140T1 (de) * | 1989-05-18 | 1995-10-15 | Hoffmann La Roche | Phosphorverbindungen. |
| DE59206900D1 (de) * | 1991-03-15 | 1996-09-19 | Hoffmann La Roche | Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden |
| US5721251A (en) * | 1993-12-10 | 1998-02-24 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| FR2722194B1 (fr) * | 1994-07-06 | 1996-08-23 | Adir | Nouveaux derives de benzopyrane, leur procede de preparation et les compositions pharmacuetiques qui les contiennent |
| JPH0873400A (ja) * | 1994-09-01 | 1996-03-19 | Sumitomo Chem Co Ltd | 光学活性シクロプロパンカルボン酸誘導体の製造法 |
| US5804578A (en) * | 1996-04-03 | 1998-09-08 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| US5891882A (en) * | 1996-12-06 | 1999-04-06 | Abbott Laboratories | Benzopyranopyrrole and benzopyranopyridine α-1 adenergic compounds |
| GB9924855D0 (en) * | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel processes |
| US6545165B1 (en) * | 2000-02-04 | 2003-04-08 | Roche Colorado Corporation | Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one |
| FR2812638B1 (fr) * | 2000-08-03 | 2003-04-25 | Ppg Sipsy | Utilisation de diphosphines chirales comme ligands optiquement actifs pour la preparation de complexes diphosphino-metalliques, les complexes ainsi obtenus et les procedes de catalyse asymetrique les mettant en oeuvre |
| US7262303B2 (en) * | 2003-09-29 | 2007-08-28 | Hoffman-La Roche Inc. | Process for the production of chiral propionic acid derivatives |
| JPWO2005068427A1 (ja) * | 2004-01-14 | 2007-09-06 | 武田薬品工業株式会社 | カルボキサミド誘導体およびその用途 |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| GB0510810D0 (en) * | 2005-05-26 | 2005-06-29 | Novartis Ag | Organic compounds |
| WO2007016431A2 (en) * | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel benzo [d] [1,3]-dioxol derivatives |
-
2007
- 2007-03-26 AT AT07727328T patent/ATE453622T1/de active
- 2007-03-26 AU AU2007233814A patent/AU2007233814B2/en not_active Ceased
- 2007-03-26 WO PCT/EP2007/052855 patent/WO2007113155A1/en not_active Ceased
- 2007-03-26 CN CN200780020500XA patent/CN101460461B/zh active Active
- 2007-03-26 EP EP07727328A patent/EP2029541B1/de active Active
- 2007-03-26 ES ES07727328T patent/ES2335710T3/es active Active
- 2007-03-26 BR BRPI0709880-4A patent/BRPI0709880A2/pt not_active Application Discontinuation
- 2007-03-26 KR KR1020087024080A patent/KR101087805B1/ko not_active Expired - Fee Related
- 2007-03-26 DE DE602007004111T patent/DE602007004111D1/de active Active
- 2007-03-26 JP JP2009503527A patent/JP5038392B2/ja active Active
- 2007-03-26 CA CA2648246A patent/CA2648246C/en not_active Expired - Fee Related
- 2007-03-26 MX MX2008012566A patent/MX2008012566A/es active IP Right Grant
- 2007-03-30 TW TW096111454A patent/TWI356820B/zh not_active IP Right Cessation
- 2007-03-30 US US11/731,191 patent/US20070232653A1/en not_active Abandoned
-
2008
- 2008-09-18 IL IL194219A patent/IL194219A/en not_active IP Right Cessation
-
2011
- 2011-01-11 US US13/004,478 patent/US20110105758A1/en not_active Abandoned
-
2013
- 2013-05-17 US US13/897,087 patent/US20130253201A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007233814B2 (en) | 2012-08-16 |
| US20070232653A1 (en) | 2007-10-04 |
| US20130253201A1 (en) | 2013-09-26 |
| BRPI0709880A2 (pt) | 2011-07-26 |
| EP2029541A1 (de) | 2009-03-04 |
| ES2335710T3 (es) | 2010-03-31 |
| KR20080100283A (ko) | 2008-11-14 |
| CN101460461A (zh) | 2009-06-17 |
| DE602007004111D1 (de) | 2010-02-11 |
| KR101087805B1 (ko) | 2011-11-29 |
| CN101460461B (zh) | 2012-10-03 |
| TW200806628A (en) | 2008-02-01 |
| IL194219A (en) | 2012-06-28 |
| JP5038392B2 (ja) | 2012-10-03 |
| CA2648246C (en) | 2014-02-18 |
| EP2029541B1 (de) | 2009-12-30 |
| CA2648246A1 (en) | 2007-10-11 |
| JP2009532410A (ja) | 2009-09-10 |
| US20110105758A1 (en) | 2011-05-05 |
| MX2008012566A (es) | 2008-10-10 |
| TWI356820B (en) | 2012-01-21 |
| WO2007113155A1 (en) | 2007-10-11 |
| AU2007233814A1 (en) | 2007-10-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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