ATE383336T1 - Arylpyrrol mit antitubulinwirkung, arylfulran- und arylthiopenderivate, verfahren zur herstellung und verwendung als antimitotikum - Google Patents
Arylpyrrol mit antitubulinwirkung, arylfulran- und arylthiopenderivate, verfahren zur herstellung und verwendung als antimitotikumInfo
- Publication number
- ATE383336T1 ATE383336T1 AT05770861T AT05770861T ATE383336T1 AT E383336 T1 ATE383336 T1 AT E383336T1 AT 05770861 T AT05770861 T AT 05770861T AT 05770861 T AT05770861 T AT 05770861T AT E383336 T1 ATE383336 T1 AT E383336T1
- Authority
- AT
- Austria
- Prior art keywords
- antimitotic
- arylthiopene
- arylfulrane
- arylpyrrole
- antitubulin
- Prior art date
Links
- 230000002927 anti-mitotic effect Effects 0.000 title abstract 2
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0405278A FR2870237B1 (fr) | 2004-05-14 | 2004-05-14 | Derives arylpyrroliques, arylfulraniques et arylthiopheniques a action antitubuline, procede de preparation et utilisation en tant qu'antimitotique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE383336T1 true ATE383336T1 (de) | 2008-01-15 |
Family
ID=34946451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05770861T ATE383336T1 (de) | 2004-05-14 | 2005-05-13 | Arylpyrrol mit antitubulinwirkung, arylfulran- und arylthiopenderivate, verfahren zur herstellung und verwendung als antimitotikum |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8106089B2 (de) |
| EP (1) | EP1751100B1 (de) |
| AT (1) | ATE383336T1 (de) |
| CA (1) | CA2566038A1 (de) |
| DE (1) | DE602005004278T2 (de) |
| FR (1) | FR2870237B1 (de) |
| WO (1) | WO2005115979A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9944597B2 (en) | 2013-09-16 | 2018-04-17 | The Board Of Regents Of The University Of Texas System | Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1472992A (fr) | 1964-03-25 | 1967-03-17 | Fujisawa Pharmaceutical Co | Dérivés du (phényl substitué)-3-pyrrole et procédés pour leur préparation |
| FR2636063B1 (fr) * | 1988-09-05 | 1993-04-30 | Centre Nat Rech Scient | Composes phenylpyrroliques utiles en tant que medicaments, leur preparation et leur application |
| US6258841B1 (en) * | 1998-06-29 | 2001-07-10 | Parker Hughes Institute | Tubulin binding compounds (COBRA) |
| US6559374B2 (en) * | 2000-07-21 | 2003-05-06 | North Carolina State University | Trans beta substituted chlorins and methods of making and using the same |
| KR20050053694A (ko) * | 2002-09-27 | 2005-06-08 | 얀센 파마슈티카 엔.브이. | 3, 4-이치환된 피롤 및 염증 질환을 치료하기 위한 그의용도 |
-
2004
- 2004-05-14 FR FR0405278A patent/FR2870237B1/fr not_active Expired - Fee Related
-
2005
- 2005-05-13 WO PCT/FR2005/001207 patent/WO2005115979A1/fr not_active Ceased
- 2005-05-13 US US11/596,224 patent/US8106089B2/en not_active Expired - Fee Related
- 2005-05-13 EP EP05770861A patent/EP1751100B1/de not_active Expired - Lifetime
- 2005-05-13 CA CA002566038A patent/CA2566038A1/fr not_active Abandoned
- 2005-05-13 AT AT05770861T patent/ATE383336T1/de not_active IP Right Cessation
- 2005-05-13 DE DE602005004278T patent/DE602005004278T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US8106089B2 (en) | 2012-01-31 |
| EP1751100B1 (de) | 2008-01-09 |
| FR2870237A1 (fr) | 2005-11-18 |
| WO2005115979A1 (fr) | 2005-12-08 |
| FR2870237B1 (fr) | 2008-09-26 |
| EP1751100A1 (de) | 2007-02-14 |
| CA2566038A1 (fr) | 2005-12-08 |
| DE602005004278D1 (de) | 2008-02-21 |
| DE602005004278T2 (de) | 2008-12-24 |
| US20080275103A1 (en) | 2008-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |