ATE556085T1 - Phosphoramiditverbindung und verfahren zur herstellung von oligo-rna - Google Patents
Phosphoramiditverbindung und verfahren zur herstellung von oligo-rnaInfo
- Publication number
- ATE556085T1 ATE556085T1 AT05780944T AT05780944T ATE556085T1 AT E556085 T1 ATE556085 T1 AT E556085T1 AT 05780944 T AT05780944 T AT 05780944T AT 05780944 T AT05780944 T AT 05780944T AT E556085 T1 ATE556085 T1 AT E556085T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphoramidite compound
- rna
- different
- same
- general formula
- Prior art date
Links
- -1 PHOSPHORAMIDITE COMPOUND Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000006575 electron-withdrawing group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
- C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004246185 | 2004-08-26 | ||
| JP2005110817 | 2005-04-07 | ||
| JP2005193313 | 2005-07-01 | ||
| PCT/JP2005/015420 WO2006022323A1 (ja) | 2004-08-26 | 2005-08-25 | ホスホロアミダイト化合物及びオリゴｒｎａの製法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE556085T1 true ATE556085T1 (de) | 2012-05-15 |
Family
ID=35967530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05780944T ATE556085T1 (de) | 2004-08-26 | 2005-08-25 | Phosphoramiditverbindung und verfahren zur herstellung von oligo-rna |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8691970B2 (de) |
| EP (1) | EP1795536B1 (de) |
| JP (1) | JP5157168B2 (de) |
| KR (1) | KR101281836B1 (de) |
| CN (1) | CN101048423B (de) |
| AT (1) | ATE556085T1 (de) |
| AU (1) | AU2005275801B2 (de) |
| BR (1) | BRPI0514644A (de) |
| CA (1) | CA2577922C (de) |
| ES (1) | ES2386709T3 (de) |
| MX (1) | MX2007002245A (de) |
| WO (1) | WO2006022323A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1995252A1 (de) * | 2006-02-27 | 2008-11-26 | Nippon Shinyaku Co., Ltd. | Verfahren zum entfernen einer nukleinsäureschutzgruppe |
| JP5187189B2 (ja) * | 2006-02-27 | 2013-04-24 | 日本新薬株式会社 | 核酸保護基の脱離方法 |
| EP2053054B1 (de) * | 2006-08-02 | 2014-12-17 | Nippon Shinyaku Co., Ltd. | Verfahren zur einführung einer nukleinsäureschutzgruppe |
| JP2008174524A (ja) * | 2007-01-22 | 2008-07-31 | Nippon Shinyaku Co Ltd | リボ核酸化合物の製造方法 |
| US9394333B2 (en) | 2008-12-02 | 2016-07-19 | Wave Life Sciences Japan | Method for the synthesis of phosphorus atom modified nucleic acids |
| MX342945B (es) | 2009-07-06 | 2016-10-18 | Ontorii Inc * | Profármacos de ácido nucleico novedosos y métodos de uso de los mismos. |
| EP2479182B8 (de) * | 2009-09-16 | 2016-07-13 | Wave Life Sciences Japan, Inc. | Neue schutzgruppe für synthese von rna und derivat daraus |
| JP5847700B2 (ja) * | 2010-03-05 | 2016-01-27 | 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ | リボヌクレオシドホスホロチオエートの製造方法 |
| DK2620428T3 (da) | 2010-09-24 | 2019-07-01 | Wave Life Sciences Ltd | Asymmetrisk hjælpegruppe |
| WO2012073857A1 (ja) * | 2010-11-30 | 2012-06-07 | 株式会社キラルジェン | ２'－ｏ－修飾ｒｎａ |
| US9605019B2 (en) | 2011-07-19 | 2017-03-28 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| ES2802996T3 (es) * | 2011-08-25 | 2021-01-22 | Bonac Corp | Compuesto de tioéter para la protección del grupo 2'-hidroxi en nucleósidos que van a ser utilizados en la síntesis de oligonucleótidos |
| SG11201500243WA (en) | 2012-07-13 | 2015-04-29 | Shin Nippon Biomedical Lab Ltd | Chiral nucleic acid adjuvant |
| KR20240148947A (ko) | 2012-07-13 | 2024-10-11 | 웨이브 라이프 사이언시스 리미티드 | 키랄 제어 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| CN105916873B (zh) * | 2013-09-14 | 2020-06-19 | 坎姆根公司 | 使用反向法高效合成长rna |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| EP3095460A4 (de) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chirales nukleinsäureadjuvans mit antiallergischer wirkung und antiallergikum |
| ES2917473T3 (es) | 2014-01-16 | 2022-07-08 | Wave Life Sciences Ltd | Diseño quiral |
| CN104211741B (zh) * | 2014-09-05 | 2017-05-31 | 河南师范大学 | 一种氘代核苷亚磷酰胺单体的合成方法 |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| KR102670605B1 (ko) | 2018-04-24 | 2024-05-29 | 스미또모 가가꾸 가부시끼가이샤 | 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법 |
| WO2020050411A1 (ja) | 2018-09-07 | 2020-03-12 | 住友化学株式会社 | 配糖体化合物の製造方法 |
| KR20220079832A (ko) | 2019-10-11 | 2022-06-14 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
| WO2021075423A1 (ja) * | 2019-10-18 | 2021-04-22 | 富士フイルム和光純薬株式会社 | ホスホロアミダイト活性化剤 |
| WO2021079617A1 (ja) | 2019-10-23 | 2021-04-29 | 住友化学株式会社 | 配糖体化合物、アミダイト化合物、およびこれら化合物を用いたポリヌクレオチドの製造方法 |
| US20230312635A1 (en) | 2020-01-29 | 2023-10-05 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7667788B2 (ja) * | 2020-01-29 | 2025-04-23 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| WO2021193954A1 (ja) | 2020-03-27 | 2021-09-30 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| WO2021210408A1 (ja) | 2020-04-14 | 2021-10-21 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| EP4137501A4 (de) | 2020-04-14 | 2024-05-22 | Sumitomo Chemical Company, Limited | Zusammensetzung mit nukleinsäureoligomer |
| WO2022009959A1 (ja) | 2020-07-09 | 2022-01-13 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| CN116209668A (zh) * | 2020-09-24 | 2023-06-02 | 住友化学株式会社 | 核酸寡聚物的制造方法 |
| US20240300993A1 (en) | 2021-07-06 | 2024-09-12 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| JPWO2023054350A1 (de) | 2021-09-28 | 2023-04-06 | ||
| JPWO2023149564A1 (de) | 2022-02-04 | 2023-08-10 | ||
| US20250136635A1 (en) | 2022-02-04 | 2025-05-01 | Nitto Denko Corporation | Method for producing oligonucleotide |
| JPWO2023182274A1 (de) | 2022-03-23 | 2023-09-28 | ||
| EP4559925A1 (de) | 2022-07-22 | 2025-05-28 | Sumitomo Chemical Company, Limited | Verfahren zur herstellung von oligonukleotiden |
| JPWO2024024873A1 (de) | 2022-07-28 | 2024-02-01 | ||
| CN115010769B (zh) * | 2022-08-04 | 2022-11-15 | 上海百力格生物技术有限公司 | 固相亚磷酰胺三酯法合成长链rna核酸的方法 |
| KR20250092173A (ko) | 2022-10-27 | 2025-06-23 | 스미또모 가가꾸 가부시끼가이샤 | 올리고뉴클레오티드의 제조 방법 |
| KR20250128304A (ko) | 2022-12-26 | 2025-08-27 | 스미또모 가가꾸 가부시끼가이샤 | 올리고뉴클레오티드의 제조 방법 |
| CN119264195B (zh) * | 2024-12-12 | 2025-04-08 | 天津奥瑞芙生物医药有限公司 | 一种亚磷酰胺单体的纯化方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3956500A (en) | 1973-04-03 | 1976-05-11 | Union Carbide Corporation | Carbamate pesticidal compositions |
| US4629814A (en) | 1985-08-27 | 1986-12-16 | Rohm And Haas Company | Process for preparing bis-bromoalkyl ethers |
| US4925856A (en) * | 1987-07-28 | 1990-05-15 | Sri International | Aldoxime-substituted imidazolium derivatives useful in the treatment of poisoning by phosphorus-containing chemicals |
| JP2794461B2 (ja) | 1989-08-17 | 1998-09-03 | 有機合成薬品工業株式会社 | ホスホアミダイト化合物及びそれを用いたオリゴリボヌクレオチドの固相合成法 |
| GB9126355D0 (en) * | 1991-12-11 | 1992-02-12 | Ici Plc | Production of hydrofluorocarbons |
| US5637776A (en) | 1992-12-10 | 1997-06-10 | Imperial Chemical Industries Plc | Production of hydrofluorocarbons |
| AR037328A1 (es) | 2001-10-23 | 2004-11-03 | Dow Agrosciences Llc | Compuesto de [7-bencil-2,6-dioxo-1,5-dioxonan-3-il]-4-metoxipiridin-2-carboxamida, composicion que lo comprende y metodo que lo utiliza |
-
2005
- 2005-08-25 CA CA2577922A patent/CA2577922C/en not_active Expired - Fee Related
- 2005-08-25 MX MX2007002245A patent/MX2007002245A/es active IP Right Grant
- 2005-08-25 KR KR1020077006676A patent/KR101281836B1/ko not_active Expired - Lifetime
- 2005-08-25 BR BRPI0514644-5A patent/BRPI0514644A/pt not_active IP Right Cessation
- 2005-08-25 WO PCT/JP2005/015420 patent/WO2006022323A1/ja not_active Ceased
- 2005-08-25 EP EP05780944A patent/EP1795536B1/de not_active Expired - Lifetime
- 2005-08-25 AU AU2005275801A patent/AU2005275801B2/en not_active Ceased
- 2005-08-25 CN CN2005800363733A patent/CN101048423B/zh not_active Expired - Lifetime
- 2005-08-25 ES ES05780944T patent/ES2386709T3/es not_active Expired - Lifetime
- 2005-08-25 US US11/574,308 patent/US8691970B2/en active Active
- 2005-08-25 AT AT05780944T patent/ATE556085T1/de active
- 2005-08-25 JP JP2006531972A patent/JP5157168B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1795536A4 (de) | 2009-04-08 |
| KR101281836B1 (ko) | 2013-07-03 |
| EP1795536A1 (de) | 2007-06-13 |
| MX2007002245A (es) | 2007-04-20 |
| AU2005275801A1 (en) | 2006-03-02 |
| CN101048423A (zh) | 2007-10-03 |
| CN101048423B (zh) | 2011-06-08 |
| US20070282097A1 (en) | 2007-12-06 |
| CA2577922C (en) | 2013-06-25 |
| AU2005275801A2 (en) | 2006-03-02 |
| CA2577922A1 (en) | 2006-03-02 |
| WO2006022323A1 (ja) | 2006-03-02 |
| JPWO2006022323A1 (ja) | 2008-05-08 |
| JP5157168B2 (ja) | 2013-03-06 |
| AU2005275801B2 (en) | 2012-05-10 |
| BRPI0514644A (pt) | 2008-06-17 |
| EP1795536B1 (de) | 2012-05-02 |
| KR20070054688A (ko) | 2007-05-29 |
| ES2386709T3 (es) | 2012-08-27 |
| US8691970B2 (en) | 2014-04-08 |
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