ATE383357T1 - Acylderivate von 5-(2-(4-(1,2 benzisothiazol-3- yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2 - indol-2-on mit neuroleptischer wirkung - Google Patents

Acylderivate von 5-(2-(4-(1,2 benzisothiazol-3- yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2 - indol-2-on mit neuroleptischer wirkung

Info

Publication number
ATE383357T1
ATE383357T1 AT03751112T AT03751112T ATE383357T1 AT E383357 T1 ATE383357 T1 AT E383357T1 AT 03751112 T AT03751112 T AT 03751112T AT 03751112 T AT03751112 T AT 03751112T AT E383357 T1 ATE383357 T1 AT E383357T1
Authority
AT
Austria
Prior art keywords
benzisothiazole
indol
piperazinyl
dihydro
chloro
Prior art date
Application number
AT03751112T
Other languages
English (en)
Inventor
Timothy Norris
Roberto Colon-Cruz
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE383357T1 publication Critical patent/ATE383357T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT03751112T 2002-10-24 2003-10-13 Acylderivate von 5-(2-(4-(1,2 benzisothiazol-3- yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2 - indol-2-on mit neuroleptischer wirkung ATE383357T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42084302P 2002-10-24 2002-10-24

Publications (1)

Publication Number Publication Date
ATE383357T1 true ATE383357T1 (de) 2008-01-15

Family

ID=32176638

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03751112T ATE383357T1 (de) 2002-10-24 2003-10-13 Acylderivate von 5-(2-(4-(1,2 benzisothiazol-3- yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2 - indol-2-on mit neuroleptischer wirkung

Country Status (24)

Country Link
US (1) US7019009B2 (de)
EP (1) EP1556378B1 (de)
JP (1) JP2006505578A (de)
KR (1) KR100755625B1 (de)
CN (1) CN100340557C (de)
AR (1) AR041695A1 (de)
AT (1) ATE383357T1 (de)
AU (1) AU2003269331B2 (de)
BR (1) BR0315516A (de)
CA (1) CA2500485C (de)
CO (1) CO5550441A2 (de)
CY (1) CY1107300T1 (de)
DE (1) DE60318602T2 (de)
DK (1) DK1556378T3 (de)
ES (1) ES2297200T3 (de)
MX (1) MXPA05002734A (de)
NO (1) NO20052475L (de)
NZ (1) NZ566615A (de)
PL (1) PL376721A1 (de)
PT (1) PT1556378E (de)
RU (1) RU2005112254A (de)
TW (1) TW200418850A (de)
WO (1) WO2004037819A1 (de)
ZA (1) ZA200502109B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2551346A1 (en) * 2003-12-31 2005-07-21 Warner-Lambert Company Llc N-substituted piperidine and piperazine derivatives
AU2010266018B2 (en) * 2009-06-25 2014-01-09 Alkermes Pharma Ireland Limited Heterocyclic compounds for the treatment of neurological and psychological disorders
US8686009B2 (en) * 2009-06-25 2014-04-01 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
CA2802733C (en) * 2010-06-24 2017-11-21 Alkermes Pharma Ireland Limited Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2019173230A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5312925A (en) * 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
US5206366A (en) * 1992-08-26 1993-04-27 Pfizer Inc. Process for preparing aryl piperazinyl-heterocyclic compounds
DE69726206T2 (de) * 1996-02-13 2004-04-15 Pfizer Inc. Prodrogen von 5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2h-indol-2-on
AU5301199A (en) * 1998-08-20 2000-03-14 Sumitomo Pharmaceuticals Company, Limited Oxindole derivatives as growth hormone releasers

Also Published As

Publication number Publication date
DE60318602D1 (de) 2008-02-21
EP1556378B1 (de) 2008-01-09
MXPA05002734A (es) 2005-05-23
CO5550441A2 (es) 2005-08-31
BR0315516A (pt) 2005-08-23
AR041695A1 (es) 2005-05-26
PL376721A1 (pl) 2006-01-09
CA2500485A1 (en) 2004-05-06
PT1556378E (pt) 2008-02-21
US7019009B2 (en) 2006-03-28
ZA200502109B (en) 2006-05-31
KR20050065618A (ko) 2005-06-29
US20040138232A1 (en) 2004-07-15
CN1705663A (zh) 2005-12-07
AU2003269331B2 (en) 2010-02-18
CA2500485C (en) 2010-03-23
EP1556378A1 (de) 2005-07-27
NO20052475D0 (no) 2005-05-23
WO2004037819A1 (en) 2004-05-06
JP2006505578A (ja) 2006-02-16
CN100340557C (zh) 2007-10-03
NO20052475L (no) 2005-07-25
DE60318602T2 (de) 2009-01-15
NZ566615A (en) 2009-08-28
CY1107300T1 (el) 2012-11-21
DK1556378T3 (da) 2008-03-17
RU2005112254A (ru) 2006-01-20
TW200418850A (en) 2004-10-01
ES2297200T3 (es) 2008-05-01
AU2003269331A1 (en) 2004-05-13
HK1081185A1 (en) 2006-05-12
KR100755625B1 (ko) 2007-09-04

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