ATE384700T1 - Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren - Google Patents

Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren

Info

Publication number: ATE384700T1
Authority: AT; Austria
Prior art keywords: tetrahydroisocinoline; igf; inhibitors; tetrahydrobenzazepine derivatives; tetrahydrobenzazepine
Prior art date: 2004-03-12

Application number

AT04719900T

Other languages

English (en)

Inventor

Jan Gunzinger

Kurt Leander

Original Assignee

Analytecon Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-12

Filing date

2004-03-12

Publication date

2008-02-15

2004-03-12 Application filed by Analytecon Sa filed Critical Analytecon Sa

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384700T1 publication Critical patent/ATE384700T1/de

Links

MZBVNYACSSGXID-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1-benzazepine Chemical class N1CCCCC2=CC=CC=C21 MZBVNYACSSGXID-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Immunology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Dermatology (AREA)
Transplantation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

AT04719900T 2004-03-12 2004-03-12 Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren ATE384700T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/CH2004/000147 WO2005087743A1 (en)	2004-03-12	2004-03-12	Tetrahydroisoquinoline-and tetrahydrobenzazepine derivatives as igf-1r inhibitors

Publications (1)

Publication Number	Publication Date
ATE384700T1 true ATE384700T1 (de)	2008-02-15

Family

ID=34957074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04719900T ATE384700T1 (de)	2004-03-12	2004-03-12	Tetrahydroisochinolin- und tetrahydrobenzazepin derivative als igf-1r inhibitoren

Country Status (21)

Country	Link
US (1)	US7875631B2 (de)
EP (1)	EP1732898B1 (de)
JP (1)	JP2007528877A (de)
CN (1)	CN100590118C (de)
AR (1)	AR049323A1 (de)
AT (1)	ATE384700T1 (de)
AU (1)	AU2004317166B2 (de)
BR (1)	BRPI0418462A (de)
CA (1)	CA2555745C (de)
DE (1)	DE602004011578T2 (de)
DK (1)	DK1732898T3 (de)
EA (1)	EA200601687A1 (de)
ES (1)	ES2299825T3 (de)
IL (1)	IL177307A (de)
NO (1)	NO20063794L (de)
PL (1)	PL1732898T3 (de)
PT (1)	PT1732898E (de)
SI (1)	SI1732898T1 (de)
TW (1)	TW200530213A (de)
WO (1)	WO2005087743A1 (de)
ZA (1)	ZA200607198B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2009507820A (ja) *	2005-09-09	2009-02-26	アナリットコンエスアー	Ｉｇｆ−１ｒ阻害剤としてのイソキノリン誘導体
AU2006288846B2 (en) *	2005-09-09	2011-08-18	Analytecon Sa	Isoquinolines as IGF-1R inhibitors
WO2009073203A1 (en)	2007-12-04	2009-06-11	Amgen Inc.	Trp-m8 receptor ligands and their use in treatments
JP2013522215A (ja)	2010-03-09	2013-06-13	オーエスアイ・ファーマシューティカルズ，エルエルシー	組合わせ抗癌療法
TW201201805A (en) *	2010-07-05	2012-01-16	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin D2 receptor modulators
US20140037642A1 (en)	2011-02-02	2014-02-06	Amgen Inc.	Methods and compositions relating to inhibition of igf-1r
EP2776042B1 (de)	2011-11-11	2019-03-20	Duke University	Wirkstoffkombinationstherapie zur behandlung von soliden tumoren
EP2794563B1 (de)	2011-12-21	2017-02-22	Actelion Pharmaceuticals Ltd	Heterocyclyl-derivate und ihre verwendung als prostaglandin-d2-rezeptormodulatoren
WO2014006585A1 (en)	2012-07-05	2014-01-09	Actelion Pharmaceuticals Ltd	1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
US8980259B2 (en)	2012-07-20	2015-03-17	Novartis Ag	Combination therapy
CN104672136B (zh) *	2013-11-30	2017-01-25	沈阳药科大学	1‑取代菲基‑n‑烷基(酰基)‑6,7‑二甲氧基‑1,2,3,4‑四氢异喹啉衍生物及其制备方法和用途
WO2017129763A1 (en)	2016-01-28	2017-08-03	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods and pharmaceutical compositions for the treatment of signet ring cell gastric cancer
CN112500345B (zh) *	2020-12-18	2022-06-21	西安石油大学	α-氰基季碳取代四氢异喹啉化合物的合成方法
CN117776987A (zh) *	2022-09-27	2024-03-29	苏州阿尔脉生物科技有限公司	苯并[7]环烯类衍生物、包含其的药物组合物及其医药用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4349472A (en)	1979-04-27	1982-09-14	Schering Corporation	(S)-8(1-Adamantanecarbonyloxy)-7-chloro-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CA1330560C (en) *	1986-05-21	1994-07-05	Maurits E. A. Vandewalle	Di- and tetrahydroisoquinoline derivatives
WO1990002119A1 (fr) *	1988-08-18	1990-03-08	Banyu Pharmaceutical Co., Ltd.	Derives de 1,2,3,4-tetrahydro-isoquinoline
WO2000035455A1 (en) *	1998-12-15	2000-06-22	Telik, Inc.	Heteroaryl-aryl ureas as igf-1 receptor antagonists
EP1113007A1 (de) *	1999-12-24	2001-07-04	Pfizer Inc.	Tetrahydroisochinolin-Verbindungen zur Verwendung als Östrogen-Agonisten/-Antagonisten
JP2004515494A (ja) *	2000-12-07	2004-05-27	アストラゼネカ・アクチエボラーグ	治療剤
SE0102168D0 (sv)	2001-06-19	2001-06-19	Karolinska Innovations Ab	New use and new compounds
SE0104140D0 (sv)	2001-12-07	2001-12-07	Astrazeneca Ab	Novel Compounds
GB0212303D0 (en)	2002-05-28	2002-07-10	Isis Innovation	Molecular targetting of IGF-1 receptor

2004
- 2004-03-12 US US10/591,174 patent/US7875631B2/en not_active Expired - Fee Related
- 2004-03-12 CA CA2555745A patent/CA2555745C/en not_active Expired - Fee Related
- 2004-03-12 AT AT04719900T patent/ATE384700T1/de active
- 2004-03-12 EA EA200601687A patent/EA200601687A1/ru unknown
- 2004-03-12 DE DE602004011578T patent/DE602004011578T2/de not_active Expired - Lifetime
- 2004-03-12 BR BRPI0418462-9A patent/BRPI0418462A/pt not_active IP Right Cessation
- 2004-03-12 PL PL04719900T patent/PL1732898T3/pl unknown
- 2004-03-12 CN CN200480042030A patent/CN100590118C/zh not_active Expired - Fee Related
- 2004-03-12 SI SI200430684T patent/SI1732898T1/sl unknown
- 2004-03-12 JP JP2007502162A patent/JP2007528877A/ja active Pending
- 2004-03-12 DK DK04719900T patent/DK1732898T3/da active
- 2004-03-12 EP EP04719900A patent/EP1732898B1/de not_active Expired - Lifetime
- 2004-03-12 ES ES04719900T patent/ES2299825T3/es not_active Expired - Lifetime
- 2004-03-12 AU AU2004317166A patent/AU2004317166B2/en not_active Ceased
- 2004-03-12 WO PCT/CH2004/000147 patent/WO2005087743A1/en not_active Ceased
- 2004-03-12 PT PT04719900T patent/PT1732898E/pt unknown
2005
- 2005-02-25 TW TW094105813A patent/TW200530213A/zh unknown
- 2005-03-10 AR ARP050100920A patent/AR049323A1/es not_active Application Discontinuation
2006
- 2006-08-06 IL IL177307A patent/IL177307A/en not_active IP Right Cessation
- 2006-08-24 NO NO20063794A patent/NO20063794L/no not_active Application Discontinuation
- 2006-08-29 ZA ZA2006/07198A patent/ZA200607198B/en unknown

Also Published As

Publication number	Publication date
CA2555745A1 (en)	2005-09-22
EP1732898A1 (de)	2006-12-20
WO2005087743A1 (en)	2005-09-22
IL177307A (en)	2011-09-27
IL177307A0 (en)	2006-12-10
AU2004317166B2 (en)	2010-11-11
ES2299825T3 (es)	2008-06-01
TW200530213A (en)	2005-09-16
SI1732898T1 (sl)	2008-06-30
EP1732898B1 (de)	2008-01-23
BRPI0418462A (pt)	2007-06-05
PT1732898E (pt)	2008-04-07
CA2555745C (en)	2011-05-31
EA200601687A1 (ru)	2007-04-27
DE602004011578T2 (de)	2009-02-19
PL1732898T3 (pl)	2008-06-30
US20070129399A1 (en)	2007-06-07
NO20063794L (no)	2006-12-12
CN100590118C (zh)	2010-02-17
CN1922147A (zh)	2007-02-28
JP2007528877A (ja)	2007-10-18
ZA200607198B (en)	2008-04-30
DK1732898T3 (da)	2008-05-13
DE602004011578D1 (de)	2008-03-13
AR049323A1 (es)	2006-07-19
AU2004317166A1 (en)	2005-09-22
US7875631B2 (en)	2011-01-25

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2008-07-15

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