ATE384720T1 - Chinucledin - derivate und deren verwendung - Google Patents

Chinucledin - derivate und deren verwendung

Info

Publication number: ATE384720T1
Authority: AT; Austria
Prior art keywords: diseases; disorders; nervous system; derivatives; disorders related
Prior art date: 2002-08-14

Application number

AT03787742T

Other languages

English (en)

Inventor

Dan Peters

Gunnar M Olsen

Elsebet Ostergaard Nielsen

Philip K Ahring

Tino Dyhring Jorgensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-14

Filing date

2003-08-13

Publication date

2008-02-15

2003-08-13 Application filed by Neurosearch As filed Critical Neurosearch As

2008-02-15 Application granted granted Critical

2008-02-15 Publication of ATE384720T1 publication Critical patent/ATE384720T1/de

Links

208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 8
201000010099 disease Diseases 0.000 abstract 4
208000035475 disorder Diseases 0.000 abstract 4
210000003169 central nervous system Anatomy 0.000 abstract 2
210000001428 peripheral nervous system Anatomy 0.000 abstract 2
208000017701 Endocrine disease Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000002193 Pain Diseases 0.000 abstract 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
230000001713 cholinergic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
208000030172 endocrine system disease Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000004770 neurodegeneration Effects 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
150000008584 quinuclidines Chemical class 0.000 abstract 1
230000016160 smooth muscle contraction Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Pregnancy & Childbirth (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Physical Education & Sports Medicine (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Hospice & Palliative Care (AREA)
Urology & Nephrology (AREA)
Child & Adolescent Psychology (AREA)
Vascular Medicine (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT03787742T 2002-08-14 2003-08-13 Chinucledin - derivate und deren verwendung ATE384720T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA200201208		2002-08-14
DKPA200201472		2002-10-02

Publications (1)

Publication Number	Publication Date
ATE384720T1 true ATE384720T1 (de)	2008-02-15

Family

ID=31889349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03787742T ATE384720T1 (de)	2002-08-14	2003-08-13	Chinucledin - derivate und deren verwendung

Country Status (18)

Country	Link
US (2)	US20050245567A1 (de)
EP (2)	EP1532144B1 (de)
JP (1)	JP2005538187A (de)
KR (1)	KR20050055711A (de)
CN (1)	CN100513406C (de)
AT (1)	ATE384720T1 (de)
AU (1)	AU2003250322B2 (de)
BR (1)	BR0313153A (de)
CA (1)	CA2493245A1 (de)
DE (1)	DE60318860T2 (de)
IL (1)	IL166254A0 (de)
IS (1)	IS7742A (de)
MX (1)	MXPA05001702A (de)
NO (1)	NO20051264L (de)
NZ (1)	NZ538058A (de)
PL (1)	PL375533A1 (de)
RU (1)	RU2323217C2 (de)
WO (1)	WO2004016608A1 (de)

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WO2004083388A2 (en)	2003-03-14	2004-09-30	Bristol-Myers Squibb Company	Polynucleotide encoding a novel human g-protein coupled receptor variant of hm74, hgprbmy74
ATE496050T1 (de)	2003-08-13	2011-02-15	Neurosearch As	Neue chinuklidinderivative und deren pharmazeutische verwendung
US7160876B2 (en)	2003-12-22	2007-01-09	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
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US20050137203A1 (en) *	2003-12-22	2005-06-23	Jianguo Ji	3-quinuclidinyl amino-substituted biaryl derivatives
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US7655657B2 (en)	2003-12-22	2010-02-02	Abbott Laboratories	Fused bicycloheterocycle substituted quinuclidine derivatives
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AR049401A1 (es)	2004-06-18	2006-07-26	Novartis Ag	Aza-biciclononanos
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US8314119B2 (en)	2006-11-06	2012-11-20	Abbvie Inc.	Azaadamantane derivatives and methods of use
SA08290475B1 (ar)	2007-08-02	2013-06-22	Targacept Inc	(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
US8383657B2 (en)	2007-12-21	2013-02-26	Abbott Laboratories	Thiazolylidine urea and amide derivatives and methods of use thereof
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
US20120157464A1 (en) *	2009-07-23	2012-06-21	Novartis Ag	Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives for the treatment or prevention of ataxia
TWI558398B (zh)	2009-09-22	2016-11-21	諾華公司	菸鹼乙醯膽鹼受體α７活化劑之用途
NZ603625A (en)	2010-05-17	2014-10-31	Envivo Pharmaceuticals Inc	A crystalline form of (r)-7-chloro-n-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide hydrochloride monohydrate
KR20130108586A (ko)	2010-09-23	2013-10-04	애브비 인코포레이티드	아자아다만탄 유도체의 일수화물
US20120220729A1 (en) *	2011-02-28	2012-08-30	Boehringer Ingelheim International Gmbh	Liquid phase separation of plasmid dna isoforms and topoisomers
EP3666272A1 (de)	2012-05-08	2020-06-17	Forum Pharmaceuticals Inc.	Verwendung von encenicline bei der behandlung von kognitiver behinderung, alzheimer-krankheit, speicherdefizit
CN105246485B (zh) *	2013-01-15	2019-03-15	诺华有限公司	α7烟碱型乙酰胆碱受体激动剂的应用
BR112015016994A8 (pt) *	2013-01-15	2018-01-23	Novartis Ag	uso de agonistas do receptor alfa 7 nicotínico de acetilcolina
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CA2971413A1 (en)	2014-12-16	2016-06-23	Axovant Sciences Gmbh	Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
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JP4616971B2 (ja) *	2000-07-18	2011-01-19	田辺三菱製薬株式会社	１−アザビシクロアルカン化合物およびその医薬用途
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2003
- 2003-08-13 AU AU2003250322A patent/AU2003250322B2/en not_active Ceased
- 2003-08-13 RU RU2005101748/04A patent/RU2323217C2/ru not_active IP Right Cessation
- 2003-08-13 JP JP2005502013A patent/JP2005538187A/ja active Pending
- 2003-08-13 CA CA002493245A patent/CA2493245A1/en not_active Abandoned
- 2003-08-13 BR BR0313153-0A patent/BR0313153A/pt not_active IP Right Cessation
- 2003-08-13 AT AT03787742T patent/ATE384720T1/de not_active IP Right Cessation
- 2003-08-13 CN CNB038190788A patent/CN100513406C/zh not_active Expired - Fee Related
- 2003-08-13 DE DE60318860T patent/DE60318860T2/de not_active Expired - Lifetime
- 2003-08-13 EP EP03787742A patent/EP1532144B1/de not_active Expired - Lifetime
- 2003-08-13 NZ NZ538058A patent/NZ538058A/en not_active IP Right Cessation
- 2003-08-13 KR KR1020057002514A patent/KR20050055711A/ko not_active Ceased
- 2003-08-13 EP EP08100204A patent/EP1905771A3/de not_active Withdrawn
- 2003-08-13 US US10/522,150 patent/US20050245567A1/en not_active Abandoned
- 2003-08-13 MX MXPA05001702A patent/MXPA05001702A/es active IP Right Grant
- 2003-08-13 PL PL03375533A patent/PL375533A1/xx not_active Application Discontinuation
- 2003-08-13 WO PCT/DK2003/000538 patent/WO2004016608A1/en not_active Ceased
2005
- 2005-01-12 IL IL16625405A patent/IL166254A0/xx unknown
- 2005-03-11 NO NO20051264A patent/NO20051264L/no not_active Application Discontinuation
- 2005-03-14 IS IS7742A patent/IS7742A/is unknown
2008
- 2008-09-08 US US12/206,302 patent/US20090005390A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MXPA05001702A (es)	2005-04-19
NZ538058A (en)	2006-11-30
RU2323217C2 (ru)	2008-04-27
CN100513406C (zh)	2009-07-15
DE60318860D1 (de)	2008-03-13
US20050245567A1 (en)	2005-11-03
HK1080860A1 (zh)	2006-05-04
CA2493245A1 (en)	2004-02-26
DE60318860T2 (de)	2008-05-21
WO2004016608A1 (en)	2004-02-26
EP1905771A2 (de)	2008-04-02
JP2005538187A (ja)	2005-12-15
RU2005101748A (ru)	2006-01-20
PL375533A1 (en)	2005-11-28
NO20051264L (no)	2005-05-18
BR0313153A (pt)	2005-06-28
IL166254A0 (en)	2006-01-15
AU2003250322A1 (en)	2004-03-03
US20090005390A1 (en)	2009-01-01
EP1532144A1 (de)	2005-05-25
KR20050055711A (ko)	2005-06-13
EP1905771A3 (de)	2008-11-26
CN1675205A (zh)	2005-09-28
AU2003250322B2 (en)	2010-01-21
IS7742A (is)	2005-03-14
EP1532144B1 (de)	2008-01-23

Legal Events

Date	Code	Title	Description
2008-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

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